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  • The regulation of energy intake and utilization at the cellular and organismic level is of profound importance to human health, and disrupted metabolic pathways contribute to cancer. Members of our department use a combination of biochemical, genetic, and computational techniques to define key molecules and pathways that govern cellular and whole-body metabolism.

    • The Spiegelman Lab defines the transcriptional programs governing development of adipocytes, as well as their roles in regulating energy balance and homeostasis.
    • The Danial Lab determines the functions of BCL2 family proteins that operate at the intersection of metabolic and cell death pathways.
    • The Puigserver Lab identifies the transcriptional mechanisms that regulate metabolic and longevity pathways.
    • The Chouchani Lab innovates metabolomics technologies to address mitochondrial and metabolic pathways in normal and disease states.