CPDM has a large collection of primary and metastatic brain tumor models (230+ PDCLs and 90+ PDXs).
Primary Brain Tumor Models
Our primary brain tumor models cover various gliomas and include several rare IDH1 R132H models, as well as rare models of oligodendroglioma, medulloblastoma, and pineoblastoma, atypical teratoid/rhabdoid tumor.
Many of the brain tumor models have been previously published in various studies including Cancer Cell 2011; Nature 2012;
Br J Cancer 2014; Oncotarget 2015; Cell Rep. 2016;
Cell 2016; Clin Cancer Res. 2016; Nat Biotechnol. 2016;
Cell Rep. 2017; PNAS 2017; Cancer Res. 2018;
Genome Biol. 2018; Nature Commun. 2019; Ferrer-Luna et al., 2019 (in revision); Touat
et al., 2019 (accepted in Nature 2020); and De Smet et al., 2019 (manuscript in preparation). A subset of the glioblastoma and oligodendroglioma spheroid models are currently characterized in the Cancer Dependency Map Project.
Metastatic Brain Tumor Models
Our metastatic brain tumor models have diverse origins of primary cancers (lung, skin, breast, colon, esophagus, testis, and others) – from the most common breast carcinoma and lung adenocarcinoma to the rare neuroendocrine carcinoma, prostate adenocarcinoma, yolk sac tumor, and small cell lung carcinoma.
These PDX and spheroid/organoid models are available for distribution to both academia and industry. Please register to access the CPDM Pan-Cancer Patient Derived Models cBioPortal database; browse the clinical/genomic data of these models and submit a model request.
Learn more about ordering and licensing these models, or email us at email@example.com to submit an inquiry.