Research

CPDM has a collection of PDX/PDCL models that have patient-matched PBMCs (peripheral blood mononuclear cells) available. We have ongoing efforts to collect patient-matched PBMCs for the new cancer models that we are generating, and to make modification on the patient-matched immune cells amendable for immuno-oncology studies.

The cell line and xenograft models can be co-cultured with activated immune cells from PBMCs in various cell-based assays. Patient derived serum preparation is also available to be paired with these cell-based assays.

We are interested in partnering with academia and industry collaborators to develop studies around this exciting collection of cancer models and PBMCs.

The following summarizes the cancer models for which we have patient-matching PBMCs:

Please email us at models@dfci.harvard.edu for more information.