Research

Many of our patient derived models are available for both academia and industry users.

Options for Exploring and Ordering CPDM's Cancer Model Collection

• View summaries of our PDX/PDCL collections
  • Brain (Primary and Metastatic) PDX and Spheroid, Organoid Models
  • Hematologic PDX Models
  • Solid Tumor PDX Models
  • Pediatric PDX, PDCL Models
• Email your model specifications to us at models@dfci.harvard.edu and we will send back our suggestions
  -or-
  Submit your model request information using our model request form
  -or-
  Register to access the CPDM Pan-Cancer Patient Derived Models cBioPortal database; browse the clinical/genomic data of these models and submit a model request.

Our cancer model request process is as follows:

• Explore model collection
• Submit model request
• CPDM confirms availability of model inventory and usage restriction
• Initiation of MTA process
• Payment and model shipment

See CPDM's SOPs for expanding and conducting studies with our models.

cBioPortal: A Genomic Data Portal for PDX and PDCL Models

This data portal hosts three distinct model collections of brain tumors, liquid tumors, and other solid tumors:

• Brain tumor PDX and PDCL (spheroid and organoid) models (manuscripts in preparation)
• Liquid tumor PDX models (Cancer Cell. 2016)
• Other solid tumor PDX models (Nat Med. 2015)

To see the list of our cancer models, please register to access the CPDM Pan-Cancer Patient Derived Models cBioPortal database. Once you receive a confirmation email from our team, please log in to Dana-Farber's private cBioPortal platform. See our User Guide for instructions for logging in and using CPDM's database.