Research

Small Molecule Probes, Inhibitors, and Degraders

Our chemical biology efforts focus on developing new classes of small molecule modulators, like allosteric and covalent inhibitors and the degrader molecules, for challenging targets. We customize our chemical solutions to fit the biological and/or clinical questions being asked.

Protein-Protein Interactions

Protein-protein interactions (PPIs) mediate many of the cellular processes that are misfiring in cancer and other diseases. Yet, PPIs are notoriously difficult to target with small molecules. Our researchers are developing stapled peptides and other innovative strategies to better understand, control, and target PPIs.

Structural Biology, Protein Engineering and Design, and Proteomics

Our structural biology and proteomics faculty solve structures of key molecular players that drive cancer and map their interactions. We use structural and proteomics information to frame and assist small molecule development and design, and as a window into selectivity, specificity, and the mechanism of action. Our program houses the Structural Biology Core, the NMR Spectroscopy Core, and the Blais Proteomics Center.

Medicinal Chemistry

Development of new pharmacologic agents requires extensive exploration of the chemical space to optimize the drug-like properties. Our medicinal chemistry faculty and the Medicinal Chemistry Core have expertise in transforming tool compounds into preclinical candidates.

Basic Chemistry and Chemical Biology

Our faculty is developing new organic and analytical methodologies, as well as investigating basic principles of chemical and biological mechanisms, which serve as an essential fuel for our translational efforts.

Chemical Biology Interest Group

At monthly faculty meetings, chemical biologists and their guests discuss ongoing research in their labs to foster collaboration and translation of chemical biology principles into basic and clinical advancements.

Support Our Cancer Research

To learn more about the many ways you can support Dana-Farber's research initiatives with a philanthropic gift, please contact Rebecca Shortle at 617-632-4215 or rebecca_shortle@dfci.harvard.edu.

Contact Us