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We use structural biology and proteomics to solve structures of key molecular players that drive cancer, and to map their interactions with other cellular partners, as well as the small molecules and degraders.
We use this information to frame and assist small molecule development and design, and employ proteomic analysis as a window into selectivity and specificity of the small molecule inhibitors and degraders. The Chemical Biology Program includes the
Structural Biology Core and the NMR Spectroscopy Core, which support the entire Institute. We also have a close relationship with Dana-Farber's Blais Proteomics Center.
Our structural biology and proteomics faculty has extensive expertise in mass spectrometry (MS), nuclear magnetic resonance (NMR) spectroscopy, X-ray crystallography, and electron microscopy (EM):