Center for Patient Derived Models Publications
Featured Studies
2026
A compendium of next-generation patient-derived models for diverse cancers. Nature. 2026 August
A dependency map enhanced with next-generation 3D cancer models. Nature. 2026 August
Related News: Collaborative Team Doubles Number of In Vitro Patient-Derived Cancer Models Available for Research
A collaborative team developed 665 next-generation patient-derived cancer models across 27 common and rare forms of cancer and made the models plus relevant clinical and molecular data available as a resource to researchers around the globe to accelerate cancer advances.
2025
High-throughput single-cell density measurements enable dynamic profiling of immune cell and drug response from patient samples. Nat Biomed Eng. 2025 May
2023
Investigative needle core biopsies for multi-omics in Glioblastoma. medRxiv [Preprint]. 2023 Dec
Dynamic BH3 profiling identifies pro-apoptotic drug combinations for the treatment of malignant pleural mesothelioma. Nat Commun. 2023 May
Cancer-associated fibroblasts are the main contributors to epithelial-to-mesenchymal signatures in the tumor microenvironment. Sci Rep. 2023 Feb
2022
VRK1 as a synthetic lethal target in VRK2 promoter-methylated cancers of the nervous system. JCI Insight. 2022 Oct
2021
FGFR-inhibitor-mediated dismissal of SWI/SNF complexes from YAP-dependent enhancers induces adaptive therapeutic resistance. Nat Cell Biol. 2021 Nov
Functional drug susceptibility testing using single-cell mass predicts treatment outcome in patient-derived cancer neurosphere models. Cell Rep. 2021 Oct
Enhanced Efficacy of Aurora Kinase Inhibitors in G2/M Checkpoint Deficient TP53 Mutant Uterine Carcinomas Is Linked to the Summation of LKB1-AKT-p53 Interactions. Cancers (Basel). 2021 May
2020
Mechanisms and therapeutic implications of hypermutation in gliomas. Nature. 2020 Apr
Generation of patient-derived models from a metastatic pediatric diffuse leptomeningeal glioneuronal tumor with KIAA1549::BRAF fusion. Acta Neuropathol. 2022 Oct
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