Current studies include:
Helping Ourselves, Helping Others
In 2006, Ann Partridge, MD, MPH, launched the first multi-institutional cohort study of young women with breast cancer in the United States. The Young Women's Breast Cancer Study (known to participants as Helping Ourselves, Helping Others) has
enrolled more than 1300 young women. While the cohort is no longer enrolling patients, researchers will continue to survey participants for at least 10 years, tracking the medical and psychosocial issues these women face at diagnosis, through treatment,
and into survivorship.
To date, the study has explored several issues particular to young women, including fertility concerns, sexual functioning, body image, genetic testing, differences in the time frame of diagnosis, and surgical decisions. Ongoing research includes a survey
of patients' partners to better understand their concerns and needs as caregivers.
Participants are also asked to provide blood and tissue samples for biological analyses to better understand the unique biology of breast cancer in young women. Some areas of interest include genetic risk factors that disproportionally affect young women
diagnosed with breast cancer, as well a better understanding the biology of metastatic disease, HER2+ tumors, and triple negative disease.
Dr. Partridge is collaborating with
Nikhil Wagle, MD, a medical oncologist at Dana-Farber and a scientist at the Broad Institute, to examine genetic changes in very young women using blood and tumor samples collected through the cohort. Through
this work, the investigators are searching for novel genetic markers, beyond BRCA1 and BRCA2, which might explain why some women develop breast cancer at a young age. We hope findings from this research will lead to the identification
of potential targets for tailored prevention and treatment strategies.
Improving Surgical Decision-Making in Young Women with Breast Cancer
Shoshana Rosenberg, ScD, is the principal investigator of a study, sponsored in part by the Agency for Healthcare Research and Quality, that includes a qualitative assessment of surgical decision-making by young women, from both the patient and physician
perspective. Dr. Rosenberg is conducting in-person interviews with young women prior to surgery as well as focus groups with breast cancer survivors about their surgical decision and experience.
Additionally, she is interviewing surgical oncologists, plastic surgeons, and medical and radiation oncologists about their experiences and how they communicate with breast cancer patients about local therapy decisions. Collectively, results from this
qualitative assessment will inform a future phase of the research involving the design and development of a decision aid to help women make informed choices about their breast cancer surgery.
The POSITIVE (Pregnancy Outcome and Safety of Interrupting Therapy for Women with Endocrine Responsive Breast Cancer) Trial
Dr. Ann Partridge is the North American Principal Investigator for the POSITIVE trial. This clinical trial is a prospective observational study designed to support and evaluate disease, reproductive, and psychosocial outcomes for young women who desire
a pregnancy and at the same time are advised to receive 5-10 years of endocrine therapy for hormone receptor-positive early stage breast cancer. Enrolled women would stop taking endocrine therapy between 18-30 months into this treatment in order to
become pregnant. They would restart endocrine therapy to complete the planned duration of therapy.
Studies that are closed to enrollment, but are in data analysis, include:
The Virtual Young Women's Initiative
Dr. Partridge received a three-year, American Society of Clinical Oncology (ASCO) Cancer Foundation Improving Cancer Care Grant to expand the domain of the Program for Young Women with Breast Cancer into a national, virtual program called the Young and
The virtual program provided educational and support materials for young women with breast cancer and their providers. The study compared a young women's intervention arm to a contact-time, physical activity intervention arm. Women in each arm were given
a booklet, which included resource links, as well as access to a study website, which included videos from experts in the field. Print and website content was intended to help patients and their doctors understand and address the concerns of young
This study is now closed to enrollment and is in data analysis. There have been three papers published to date. The team will use the findings to continue to refine the model of care for the Program for Young Women with Breast Cancer to community cancer
settings and study the effect of the expanded program on fertility issues and other measures of quality of care, satisfaction, and quality of life.
Young Women and Fertility Issues
An internet-based survey of 1,700 young breast cancer survivors from across the United States identified a desire for better communication about fertility issues, as well as a need for research into treatments that preserve fertility among young breast
cancer survivors. Other research regarding fertility and preservation strategies is being conducted in conjunction with the Brigham and Women's Reproductive Endocrinology and Infertility program as well as in collaboration with both national and international