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  • Stem Cell Transplantation Program

    Dana-Farber/Brigham and Women's Cancer Care

    The Stem Cell Transplantation Program has performed more than 8,200 stem cell and bone marrow transplants for the treatment of cancer since our program began in 1972. Our experts are highly regarded in the field of hematopoietic stem cell transplants, and will work to address your needs throughout treatment and beyond.

    About the Stem Cell Transplantation Program

    Stem cell transplant patient with a clinician

    Located in Boston, Massachusetts, the Stem Cell Transplantation program at Dana-Farber/Brigham and Women's Cancer Center is one of the largest and most experienced stem cell transplant programs in the world. We have performed more than 8,200 transplants for the treatment of blood cancers and related disorders since our program began in 1972. Our center-specific outcomes have been recognized as among the best in the United States.

    The doctors, researchers, and patient care staff in our treatment team are highly regarded in the field of hematopoietic stem cell transplant procedures. They will collaborate with our hematologic malignancies care teams and your referring physician to create the most effective treatment strategies.

    An experienced team of dedicated stem cell transplant specialists will follow you through the continuum of transplant services in both the inpatient and outpatient settings.

    Our stem cell transplant services include:

    • Autologous transplant, using your own stem cells;
    • Allogeneic transplant, using stem cells from a family member, unrelated matching donor, or umbilical cord blood;
    • Comprehensive services for related and unrelated donors;
    • Access to our extensive offering of specialized stem cell transplant clinical trials;
    • Transplantation for adults over age 60.

    What is a stem cell transplant?

    Stem cell transplantation refers to a procedure where healthy stem cells are transplanted from one individual to another, or using an individual's own stem cells. Sources of stem cells include bone marrow, peripheral blood or umbilical cord blood. You may hear the procedure referred to as a bone marrow transplant (BMT) or peripheral blood stem cell transplant (PBSCT) or umbilical cord blood transplantation (UCBT), depending on the source of the cells that are transplanted.

    Hematopoietic stem cells can grow into any of the cells found within the bloodstream. They make blood cells and the components that your immune system needs to function. During a transplant, your body is infused with healthy stem cells which then grow and produce all of the different parts of the blood that both your body and your immune system need.

    You may need a stem cell transplant when:

    • Your body cannot make the blood cells it needs because your bone marrow or stem cells have failed.
    • Your bone marrow or blood cells have become diseased and need to be replaced.
    • You have a disease that is treated with high doses of chemotherapy and/or radiation treatment, which destroys both cancerous and stem cells at the same time.

    When you undergo a stem cell transplant, doctors replace your stem cells with healthy new stem cells from a volunteer stem cell donor. Here’s a brief overview of what happens:

    • You will receive chemotherapy and/or radiation to kill the diseased cells. This treatment, known as conditioning, will damage and possibly destroy your bone marrow/blood stem cells.
    • You will receive new, healthy stem cells (in a process called an infusion, which is similar to a blood transfusion) to replace the destroyed cells. Unlike other forms of organ transplant (e.g. heart, kidney, etc.) surgery is not required for a stem cell transplant.
    • The transplanted cells will begin to grow and produce healthy red and white blood cells and platelets.
    • The process of growing new blood cells generally takes between two and four weeks; during this time you may be hospitalized so that doctors can monitor your progress.

    In some cases, your own stem cells may be suitable for the procedure; this is called an autologous transplant. If you need stem cells from a donor (an allogeneic transplant) we will help coordinate that process through our comprehensive donor services program. Your physician will decide what type of transplant should be used for your treatment and the source of the transplanted stem cells.

    Accreditation and credentials

    • Charter member of the Blood and Marrow Transplant Clinical Trials Network (BMT CTN) of the National Institutes of Health (NIH)
    • Member of the Center for International Blood and Marrow Transplant Research (CIBMTR)
    • Member of the Alliance for Clinical Trials in Oncology (formerly CALGB)
    • Fully accredited with the National Marrow Donor Program (NMDP)
    • Accredited by the Foundation for the Accreditation of Cellular Therapy (FACT)

    Read our Insight blog for information and inspiration about stem cell transplantation at Dana-Farber.


    Our Approach to Stem Cell Transplant

    The Stem Cell Transplantation program at Dana-Farber/Brigham and Women's Cancer Center in Boston, Massachusetts combines the clinical expertise, focus, and innovation of one of the nation's leading cancer centers with the world-class care and services of one of the nation's leading hospitals. This collaboration enables us to provide superior care and support to our patients and their families.

    Our services include:

    • Autologous transplant, using your own stem cells;
    • Allogeneic transplant, using stem cells from a family member, unrelated matching donor, or umbilical cord blood;
    • Comprehensive services for related and unrelated donors;
    • Access to our extensive offering of specialized clinical trials;
    • Transplantation for adults over age 60.

    Your treatment team will work closely together to provide the highest standard of patient care. As a patient, you and your family will play an active role in decisions about your treatment plan.

    Our team of stem cell transplant specialists are dedicated to excellent and compassionate care. Throughout your treatment, you and your family will have access to support services and education programs, patient and family resource centers, financial counseling, and short- and long-term housing. A variety of services and complementary programs support your care, including:

    • Pharmacy services
    • Comprehensive donor services, including recruitment, registration, education, search and selection
    • Care coordination
    • Nutrition services
    • Emotional support and counseling services
    • Integrated therapies, such as massage and Reiki
    • Pain management
    • Long-term survivorship support through the Adult Survivorship Program.

    Our Stem Cell Transplant Team

    Our providers work together across a range of specialty areas to coordinate fully integrated, personalized care. A dedicated team of clinicians that specializes in your type of blood cancer works with you throughout your treatment, from diagnosis through long-term follow-up and specialized survivorship support.

    Patients receive world-class care from a team of specialists, including medical oncologists, radiation oncologists, hematopathologists, infectious disease specialists, hematologists, physician assistants, nurses, oral surgeons, pharmacists, nutritionists, physical therapists, search coordinators, care coordinators, financial counselors, and clinical social workers.

    Your entire care team has extensive experience in stem cell transplantation. Our specialists work closely together and collaborate regularly to ensure that your care plan offers the best possible outcomes and that all your needs are met.

    Stem Cell Transplantation Leadership

    Joseph Antin, MD, Chief and Program Director, Stem Cell Transplant Program

    Robert J. Soiffer, MD, Co-Chief, Stem Cell Transplant Program
    Chief, Hematologic Malignancies Division

    Edwin Alyea, MD, Associate Director, Stem Cell Transplant Program

    Vincent Ho, MD, Clinical Director, Stem Cell Transplant Program

    Amy Emmert, MScPH, Vice President, Hematopoietic Stem Cell Transplantation and Cell Therapies

    Stem Cell Transplant Physicians

    Edwin Alyea, MD
    Joseph H. Antin, MD
    Philippe Armand, MD, PhD
    Bradley Blaser, MD, PhD
    Jennifer R. Brown, MD, PhD
    Corey Cutler, MD, MPH, FRCPC
    Matthew Davids, MD, MMSc 
    David C. Fisher, MD
    Arnold S. Freedman, MD
    Irene Ghobrial, MD
    Brett Glotzbecker, MD
    Vincent Ho, MD
    Eric Jacobsen, MD
    Caron Jacobson, MD
    John Koreth, MBBS, D Phil
    Ann LaCasce, MD
    Andrew Lane, MD, PhD
    Jacob Laubach, MD
    Jens Lohr, MD
    Nikhil Munshi, MD
    Prashant Nageshwar, MD
    Sarah Nikiforow, MD, PhD
    Claudia Paba-Prada, MD
    Paul Richardson, MD
    Jerome Ritz, MD
    Robert Sackstein, MD, PhD
    Robert L. Schlossman, MD
    Margaret Shipp, MD
    Robert J. Soiffer, MD
    David Weinstock, MD
    Catherine Wu, MD

    Stem Cell Research Scientists

    Jerome Ritz, MD
    Catherine Wu, MD

    Stem Cell Transplant Nurses

    Patricia Byrne, RN
    Stacey Chuma, RN
    Kristen Cummings, RN
    Heidi DiPietro, RN
    Kathleen Finn, RN
    Irene Heffernan, RN, BSN, OCN
    Kathleen McDermott, RN
    Susan Twohig, RN

    Stem Cell Transplant Nurse Practitioners/Physician Assistants

    Melissa Cochran, MS, FNP
    Virginia Dalton, NP
    Bonne Dirr, NP
    Tina Flaherty, NP
    Jeffrey Hellman, PA-C
    Amy Joyce, MSN, NP, AOCN
    Mary McKenney, NP
    Kim Noonan, NP
    Emily Scranton, NP
    Katherine Stephans, RN, MS, CS, OCN
    Lisa Stewart, NP
    Barbara Virchick, NP

    Stem Cell Transplant Research Nurses

    Mildred Pasek, RN, OCN, MM
    Sue Stephenson, RN, OCN

    Inpatient Stem Cell Transplant Physician Assistants

    Sara Close, PA-C

    Shauna Curran, PA-C
    Hilary Donahue, PA-C
    Raquel Donnelly, PA-C
    Mikaela Elia, PA-C
    Jennifer Fahey, PA-C
    Kristine Gauthier, PA-C
    Laura House, PA-C
    Megan Krug, PA-C
    Alexis Landry, PA-C
    Elyse Lawlor, PA-C
    Michelle Lisano, PA-C
    Alexandra Lynch, PA-C
    Janice MacGillivray, PA-C
    Kimberly MacKenzie, PA-C
    Bronwyn Mastrangelo, PA-C
    Kelly O'Connell, PA-C
    Andrea Ramsey, PA-C
    Caitlin Stanford, PA-C
    Jennifer Starr, PA-C

    Stem Cell Transplant Oral Medicine Team

    Hani Mawardi, DMD, DMSc
    Stephen Sonis, DMD, DMSC
    Nathaniel Treister, DMD, DMSc
    Alessandro Villa, DDS, PhD, MPH
    Sook-Bin Woo, DMD, MMSc

    Stem Cell Transplant Clinical Coordinators

    Pamela Kostaras, Operations Manager
    Catherine Andrade
    Charlotte Davis
    Robert Durand
    Stephanie Li
    Blossom Marshall

    Stem Cell Transplant Donor Services

    Eric Jacobsen, MD, Donor Services Medical Director
    Lauren Gurschick, NP, Donor Services Clinician
    Cindy Albert, Associate Director, Stem Cell Transplant Donor Services
    Cristina Balboni, Allogeneic Donor Search Coordinator
    Jane Antin, Donor Services Financial Coordinator
    Greg Bourdeau, Stem Cell Transplant Donor Search Lead Coordinator
    Shana Cuddy, Stem Cell Transplant Donor Collection Coordinator
    Lisa Koed, Be The Match Coordinator
    Patricia Kovalski, Be The Match/NMDP Donor Center Coordinator
    Peggy Powers, Stem Cell Transplant Donor Collection Lead Coordinator
    Anna Rubin, Donor Collection Coordinator
    Susanne Smith, PA-C, Donor Services Clinician
    Leigh Sullivan, Be The Match/NMDP Donor Education & Community Engagement Specialist
    Lauren Taber, Stem Cell Transplant Donor Search Coordinator

    Care Coordination

    Social Work

    Rachel Allende, MSW, LICSW
    Holly Barron, MSW, LICSW
    Elizabeth Farrell, MSW, LICSW
    Kelly Giles, MSW, LICW
    Larisa Patacchiola, MSW, LICSW, OSW-C

    Ambulatory Pharmacy Resource Specialist
    Darlene Holland, BSW, LSW

    Ambulatory RN Care Coordination

    Cinda Gaumer, RN, BSN

    Inpatient RN Care Coordination

    Donna Gately
    Alice Morrison, RN
    Terri O’Sullivan, RN

    Ambulatory Resource Office

    Hannah Kitzmiller

    Inpatient Resource Office

    Mary O’Neill-Kerrigan

    Financial Counselors

    Melissa Montrond
    Kevonyia Perkins
    Lisa Quashie
    Denyzes Williams


    Stem Cell Transplant Research

    We are committed to increasing access to stem cell transplant procedures, making it safer and more effective for patients, reducing transplant-related complications and improving immune system recovery.

    Our stem cell transplant clinical trials are nationally recognized for major advances in cancer treatment as a result of our research, including:

    • Developing new drugs to prevent or help manage graft-versus-host disease (GVHD). Graft-versus-host disease (GVHD): a common and potentially severe side effect of stem cell transplants in which donor immune cells attack healthy patient cells and tissues.
    • Using cord blood transplant to increase treatment options for patients without other suitable matched donors
    • Developing cancer vaccine strategies for use along with transplant to stimulate the graft-versus-leukemia (GVL) effect and minimize disease relapse. Graft-versus-leukemia (GVL) effect: a therapeutic effect in which transplanted immune cells attack residual leukemia or other tumor cells.

    We're also home to the Connell and O'Reilly Families Cell Manipulation Core Facility, which is New England's only state-of-the-art cell manipulation facility. This facility processes hematopoietic stem cells for transplant, generate modified tumor cells as therapeutic vaccines, and prepare immune cell populations for adoptive therapy.

    Learn about current stem cell transplant clinical trials at Dana-Farber/Brigham and Women's Cancer Center

    Contact the Stem Cell Transplantation Program

    New patients and referring physicians

    For stem cell and bone marrow transplant inquiries, please call 617-632-5138.

    Fax: 617-632-3730

    You may also request an appointment or second opinion using our secure online form.

    Mailing address:

    Center for Hematologic Oncology/Stem Cell Transplantation Program
    Dana-Farber Cancer Institute
    450 Brookline Avenue, Dana 2
    Boston, MA 02215

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