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Glioblastoma Multiformes (GBMs) and anaplastic astrocytomas are high-grade gliomas that arise from the brain's supportive tissue, known as glial cells. These are aggressive tumors that rapidly infiltrate adjacent healthy brain tissue and, as a result, are difficult to treat.
Childhood glioblastoma multiformes and anaplastic astrocytomas usually develop between the ages of 5 and 9. GBMs and anaplastic astrocytoma occur with increased frequency in children with certain genetic syndromes, including neurofibromatosis 1, Li-Fraumeni syndrome, hereditary nonpolyposis colon cancer and tuberous sclerosis. Most of these tumors, however, have no known cause.
Children with GBMs or anaplastic astrocytoma are treated at Dana-Farber/Boston Children's through our Glioma Program, one of the world's largest treatment programs focused on childhood gliomas. Our glioma specialists have extensive expertise in treating all types of gliomas, including GBMs. Our patients receive multidisciplinary care from neuro-oncologists, neurosurgeons, neurologists, and pediatric subspecialists.
Find more in-depth information on glioblastoma multiforme (GBM) on the Dana-Farber/Boston Children’s website, including glioblastoma multiforme causes, diagnosis, treatment and latest research.