Osteosarcoma is the most common type of bone cancer in children and young adults. It usually occurs in the long bones, such as the arms or legs, though it can also occur in the pelvis, spine, jaw or other locations in the body.
How Dana-Farber/Boston Children's approaches osteosarcoma in children
Dana-Farber/Boston Children's Cancer and Blood Disorders Center was one of the first centers in the United States to use adjuvant chemotherapy and perform limb salvage surgery for patients with osteosarcoma. Our multidisciplinary approach through our Bone and Soft Tissue Program ensures in-depth discussion of each case and personalized treatment plans for every patient. We integrate expertise from pediatric oncologists, oncologic orthopedists, pediatric specialists, psychologists, social workers, and oncologic surgeons.
Treatments for osteosarcoma in children
Treatments for osteocarcoma may involve a combination of therapies including surgery, radiation and/or chemotherapy. In most cases, children receive chemotherapy before surgery (neoadjuvant), a surgical procedure to remove the tumor and additional chemotherapy after surgery (adjuvant). Treatment options will vary greatly, depending on your child's situation. Your child's doctor and other members of your care team will discuss the options with you in-depth. Prompt medical attention and aggressive therapy are important for the best prognosis.
Depending on the size and location of the tumor and whether the tumor has spread, your child may receive one of the surgical treatments necessary to combat it including limb salvage surgery, amputation, or a rotationplasty. If the osteosarcoma has spread to other parts of the body, such as the lungs, additional surgery may be required, and our oncologic surgeons will remove any metastases that may have formed.
Chemotherapy for osteosarcoma
Chemotherapy is a group of drugs that interfere with the cancer cell's ability to grow or reproduce. Different groups of chemotherapy drugs work in varied ways to fight cancer cells and shrink tumors. Chemotherapy is systemic treatment, meaning it is introduced to the bloodstream and travels throughout the body to kill cancer cells. Chemotherapy can be given orally, as an injection into the muscle or fat tissue, directly to the bloodstream, or with a needle directly into the fluid surrounding the spine.
Osteosarcoma research and clinical trials
We also are conducting numerous research studies to help better understand and treat osteosarcoma. Our researchers are directing and participating in national and international clinical trials to develop new treatments for patients with newly diagnosed, non-metastatic and metastatic osteosarcoma – using surgery, radiation therapy and chemotherapy to more effectively overcome cancer.
Find more in-depth information on osteosarcoma on the Dana-Farber/Boston Children's website.