Li-Fraumeni syndrome (LFS) is a hereditary condition which is often associated with a pathogenic or likely pathogenic variant (mutation) in the TP53 gene (TP53 positive genetic test result or TP53+ result). People with LFS have greatly increased risks of various cancers over their lifetimes. Some people have a TP53+ result identified in their genetic testing, but their personal and family cancer histories do not look like typical LFS. Traditionally, people with TP53+ results were thought to have a diagnosis of LFS, however, more recent evidence has shown that not all people with TP53+ results have LFS. Our center is designed for both groups of people.
Contact us for an appointment if you or a family member may have LFS or a TP53+ result.