Research Studies
The Lynch Syndrome Registry (Enrolling)
The Lynch Syndrome Registry is enrolling patients with known or suspected Lynch syndrome in a research study that collects clinical information and samples to help researchers learn more about Lynch syndrome, with the goal of developing strategies that can improve prevention, early detection, and treatment of cancer. See www.Isregistry.org for more information.
The High-Risk Pancreas Screening Study (Enrolling)
This study is enrolling patients with known genetic or familial risk to pancreatic cancer to collect clinical information and samples that will help researchers learn more about pancreatic cancer early detection biomarkers and novel screening strategies.
CAPS5: Cancer of the Pancreas Screening-5 (Enrolling)
This study is evaluating the early detection of pancreatic cancer using research sample collections, clinical data, and standard-of-care Endoscopic Ultrasound and abdominal Magnetic Resonance Imaging (MRI/MRCP). These procedures will be performed as part of your clinical care and covered by your insurance. The study will cover the cost of research collections.
IMPACT: Identification of Men with a Genetic Predisposition to Prostate Cancer: Targeted Screening in Men at Higher Genetic Risk and Controls (Not enrolling)
This study will help us learn whether Lynch syndrome increases the risk for prostate cancer. We currently do not know whether men with mutations in MMR genes (MLH1, MSH2, or MSH6) have an increased risk for developing prostate cancer. Our hope is that by conducting this study, we will gain a better understanding of the link between Lynch syndrome and prostate cancer, allowing patients with Lynch syndrome to adopt early screening and prevention strategies. You will be asked to provide an annual donation of blood and urine samples, as well as complete an annual medical history survey.
Clinical Trials
INT21-05-01 TriAd5. Testing A Combination of Vaccines for Cancer Prevention in Lynch Syndrome (Not enrolling)
The usual approach for patients with Lynch syndrome is to be followed closely by their doctor with regular colonoscopies, pelvic imaging (ultrasounds), urine tests, computerized tomography scans (CT scans), and skin examinations to watch for the development of cancer. Removal of the colon or uterus before cancer develops is also part of the usual approach. We are doing this study because we want to find out if the vaccines, we are testing will be effective at preventing colon polyps and cancers of the colon and other organs.
The purpose of this study is to compare the safety and effects of the Tri-Ad5 vaccines alone, or in combination with N-803, versus placebo on the risk of developing colon and other cancers in patients with Lynch syndrome. The Tri-Ad5 vaccines and N-803 are not FDA-approved. This study has completed enrollment.