Our scientists and physicians conduct extensive laboratory and clinical research to identify new treatments and improve therapies for children with hematologic malignancies. Our team's achievements include:
- Improving leukemia cure rates and reducing chemotherapy-associated side effects
- Developing treatment protocols that offer the best published cure rates for children with acute lymphoblastic leukemia
- Conducting innovative clinical trials of new, promising agents in children with relapsed and refractory leukemia and lymphoma
- Reducing the risk of late effects of treatment (learning disabilities, heart dysfunction, and bone problems) in leukemia survivors
- Discovering unique genetic mutations associated with histiocytosis and working to develop treatments based on this discovery
We lead an internationally recognized clinical trials consortium for children and adolescents with newly diagnosed acute lymphoblastic leukemia — the DFCI/ALL Consortium — consisting of 9 institutions in the United States and Canada. We are a founding member of a small national consortium of leading medical centers that investigate new treatments for children with Hodgkin lymphoma, including innovative drug combinations (and reduced exposure to radiation) that deliver results with fewer long-term complications. In addition, we participate in clinical trials conducted by the Histiocyte Society for patients with Langerhans cell histiocytosis.
Featured Leukemia Clinical Trial
Ribociclib in Combination with Everolimus and Dexamethasone in Relapsed ALL
This research study is a Phase I clinical trial evaluating a drug called ribociclib (LEE011) given in combination with everolimus and other standard of care chemotherapy drugs as a possible treatment for relapsed or refractory acute lymphoblastic leukemia (ALL).
PI: Andrew E. Place, MD, PhD