The Cancer of the Pancreas Screening-5 (CAPS 5) Study

Johns Hopkins clinical research office quality assurance group will monitor and audit this
study at Johns Hopkins. The Sub Investigator at each site will be responsible for internal
monitoring at their site.

Inclusion Criteria:

- Hereditary Pancreatitis or

- Peutz-Jeghers Syndrome or

- Strong family history of pancreas cancer on one side of the family tree or

- Confirmed germline mutation carrier (BRCA2, FAMMM, PALB2, BRCA1, HNPCC, PRSS1/2, or
CTRC

- Endoscopic evaluation of pancreas scheduled

Exclusion Criteria:

- Medical comorbidities or coagulopathy that contraindicate endoscopy

- Prior surgery that prevent optimal endoscopic ultrasound such as partial or complete
gastrectomy with Bilroth or Roux-en-Y anastomosis

- Stricture or obstruction in the upper GI tract that does not allow passage of the
echoendoscope

- Poor performance status

- Inability to provide informed consent

- Pregnancy.