A First in Human Dose Escalation and Cohort Expansion Study of DLL3-directed Chimeric Antigen Receptor T-cells in Subjects with Extensive Stage Small Cell Lung Cancer

Protocol # :
Small Cell Lung Cancer Extensive Stage
Large Cell Neuroendocrine Carcinoma of the Lung
Disease Sites
Principal Investigator
Sands, Jacob

Trial Description

This is a phase 1, first-in-human, open-label, multicenter, dose escalation and expansion
study of DLL3-targeted chimeric antigen receptor T-cells in subjects with extensive stage
small cell lung cancer or large cell neuroendocrine lung cancer.

Eligibility Requirements

Inclusion Criteria:

- Be at least 18 years of age and willing and able to provide a written informed

- Have histologically/cytologically confirmed unresectable small cell lung carcinoma
(SCLC), large cell neuroendocrine lung carcinoma (LCNEC), combined SCLC, or combined
LCNEC as per WHO 2021 criteria

- Subjects who have at least one prior line of standard treatment, and have progressed
after or have had an insufficient response, and for whom standard treatment is
intolerable, unlikely to confer significant clinical benefit, is no longer
effective, or the subject declines further standard treatment

- Have available formalin-fixed, paraffin-embedded tumor specimen in a tissue block or
unstained serial slides accompanied by an associated pathology report prior to
enrollment. Archival or fresh biopsy tissue is required

- Presence of ≥ 1 radiologically measurable lesion per Response Evaluation Criteria In
Solid Tumors (RECIST) Version 1.1

- Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1

- Life expectancy of at least 4 months

- Have adequate organ function

- Women of childbearing potential must have a negative pregnancy test at screening
using a highly sensitive serum pregnancy test (β-human chorionic gonadotropin

- All subjects must agree to practice a highly effective method of contraception
(failure rate of <1% per year when used consistently and correctly) from the time of
signing the informed consent form (ICF) to 1 year after receiving a LB2102 infusion

- Women and men must agree not to donate eggs (ova, oocytes) or sperm, respectively,
until at least 1 year after receiving a LB2102 infusion

- Must have adequate leukapheresis material of non-mobilized cells available for

Exclusion Criteria:

- Prior treatment with cellular immunotherapy (e.g., CAR-T) or gene therapy product

- Prior treatment with DLL3-targeted therapy

- Prior history of checkpoint inhibitor associated pneumonitis

- Clinically significant ascites, pleural or peritoneal effusions

- Primary acquired or inherited immunodeficiency syndromes

- Known leptomeningeal metastases

- Active or symptomatic brain metastasis. Subjects with treated brain metastasis are
eligible provided additional requirements are met per protocol.

- Active autoimmune disease receiving immunomodulatory treatments (e.g., cyclosporine
or high dose systemic steroids)

- Impaired cardiac function or clinically significant cardiac disease not controlled
by medications

- Previous or concurrent malignancy, excluding certain exceptions

- Serious and /or uncontrolled medical condition that, in the Investigator's judgment,
would cause unacceptable safety risk, interfere with study procedures or results, or
compromise compliance with the protocol

- Subjects with known active infection with HIV, hepatitis B, and/or hepatitis C virus
(HBV/HCV) are not eligible unless additional protocol requirements are met.

- Contraindications or life-threatening allergies, hypersensitivity, or intolerance to
LB2102 excipients, such as dimethyl sulfoxide; or to fludarabine, cyclophosphamide,
or tocilizumab

- Ongoing toxicity of organ functions from previous anticancer therapy that has not
resolved to Grade 1 or less, except for alopecia

- Major surgery within 4 weeks prior to apheresis, or planned within 4 weeks after
LB2102 administration

- Pregnant or breast-feeding

- Plans to become pregnant or breastfeed, or father a child within 1 year after
receiving a LB2102 infusion

- Previous history of allogeneic hematopoietic stem cell transplantation (HSCT), organ
transplant, or in preparation for organ transplant