The Value of Advanced Magnetic Resonance Imaging in Gynecological Malignancies

This research is being done to test new MRI methods called Magnetic Resonance Fingerprinting
and Q-space Trajectory Imaging in gynecological abnormalities. The purpose of this research
study is to evaluate if these new MRI methods can give additional information in
characterizing gynecological tumors compared with conventional MRI.

Inclusion Criteria:

- Participants with suspected or histologically confirmed diagnosis of primary or
recurrent gynecological cancer including uterine endometrial, cervical, vaginal,
vulvar, ovarian, and smooth-muscle tumors undergoing routine clinical standard of care
pelvic MRI

- Control subjects with benign fibroids undergoing routine clinical standard of care
pelvic MRI

- Age ≥ 18 years

- ECOG performance status of ≤ 2, based on treating physician's discretion (Appendix A)

- Ability to understand and the willingness to sign a written informed consent document

Exclusion Criteria:

- Contraindication to MRI identified by the MR procedure screening form, such as a
pacemaker, aneurysm clip, inner ear implant, neurostimulator, or other MR
non-compatible device or implant

- Uncontrolled intercurrent illness including, but not limited to ongoing or active
infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac
arrhythmia, or psychiatric illness/social situations that would limit compliance with
study requirements

- Adults unable to consent

- Non-english speaking subjects

- Pregnant women

- Prisoners