Preventative Skin Care for Children Undergoing Targeted Therapy for CNS and PNS Tumors

This research study is examining a preventive skin care regimen for children diagnosed with a
brain tumor and receiving anti-cancer therapy with a MEK, Pan-RAF, or BRAF inhibitor.

Inclusion Criteria:

- Diagnosed with a brain tumor between ages 6 months old -18 years old and will undergo
treatment with at least one of the following:

1. Targeted BRAF inhibitor therapy to treat the brain tumor

2. Targeted MEK inhibitor therapy to treat the brain tumor

3. Targeted pan-RAF inhibitor therapy to treat the brain tumor

- Subjects may participate in other studies, including therapeutic trials.

- Ability to comply with PSCR including sun protection, gentle skin care and every other
day dilute bleach baths.

- Ability to understand and/or the willingness of their parent or legally authorized
representative to sign a written informed consent document.

Exclusion Criteria:

- Diagnosed with brain tumor at > 18 years old

- No data in medical records regarding treatment exposures

- Treated with a BRAF, MEK or pan-RAF inhibitor in the last three months

- Past or present allergic reaction to bleach

- Past or present allergic reactions to sunscreen and/or creams, lotions, emollients to
be utilized in this study