A Phase 1b Dose-Escalation Study of Cabozantinib (XL184) Administered Alone or in Combination with Atezolizumab to Subjects with Locally Advanced or Metastatic Solid TumorsTrial Description: This is a multicenter Phase 1b, open-label study to assess safety, tolerability, preliminary efficacy, and pharmacokinetics (PK) of cabozantinib taken in combination with atezolizumab in subjects with multiple tumor types, including advanced urothelial carcinoma (UC) (including bladder, renal pelvis, ureter, urethra), renal cell carcinoma (RCC), castration-resistant prostate cancer (CRPC), non-small-cell lung cancer (NSCLC), triple negative breast cancer (TNBC), ovarian cancer (OC), endometrial cancer (EC), hepatocellular cancer (HCC), gastric cancer/gastroesophageal
- Conditions: castration-resistant prostate cancer, colorectal cancer, differentiated thyroid cancer, endometrial cancer, gastric cancer, gastroesophageal junction adenocarcinoma, head and neck cancer, hepatocellular carcinoma, lower esophageal cancer, non-small cell lung cancer, ovarian cancer, renal cell carcinoma, triple negative breast cancer, urothelial carcinoma
- Phase: I
- Trial ID: NCT03170960
- Protocol ID: 17-492