Brandon Huffman, MD

Brandon Huffman, MD

Medical Oncology

Contact Information

Fax

617-632-5370

Appointments

857-215-3334

Biography

Brandon Huffman, MD

Dr. Brandon Huffman is a medical oncologist in the Gastrointestinal Cancer Center of Dana-Farber Cancer Institute and a faculty member at Harvard Medical School. He earned his undergraduate and medical degrees from the University of Missouri and completed his Internal Medicine training at the Mayo Clinic in Rochester, Minnesota, where he also served as a chief medical resident. Dr. Huffman completed his fellowship in Medical Oncology at Dana-Farber Cancer Institute, serving as a chief fellow. Dr. Huffman is dedicated to providing personalized, compassionate care to patients and their families. As a clinical investigator and translational researcher, he focuses on translating preclinical research into clinical practice by designing and conducting innovative clinical trials. His research aims to develop improved treatments and strategies by studying the genetic and immune characteristics of gastrointestinal cancers. He leads and develops clinical trials that test anticancer medicines targeting cancers driven by these genetic and immune changes. Collaborating with colleagues across various specialties, Dr. Huffman strives to create optimal treatment plans to enhance the chances of curing gastrointestinal cancer. 

Researcher

Physician

Physician
Instructor in Medicine, Harvard Medical School

Centers/Programs

Clinical Interests

Circulating tumor DNA, Gastrointestinal cancer, Pancreatic cancer, Targeted therapies, Translational oncology

Board Certification

  • Internal Medicine, 2019
  • Medical Oncology, 2022

Fellowship

  • Dana-Farber Cancer Institute, Chief Fellow
  • Dana-Farber Cancer Institute/Brigham and Women's Hospital/Massachusetts General Hospital, Medical Oncology

Residency

  • Mayo Clinic, Chief Resident
  • Mayo Clinic, Internal Medicine

Medical School

  • University of Missouri

Research

    Dr. Huffman embodies Dana-Farber’s mission as he develops clinical trials translating innovative laboratory ideas into novel treatment regimens improving outcomes for patients. In this work, he partners with laboratory scientists and is the lead investigator on several early-phase trials. He is currently focused on characterizing sensitivity and resistance of novel targeted therapy combinations as well as immunotherapy combinations in gastrointestinal cancers. 

    He has first and co-authored papers in journals such as Clinical Cancer Research, Cancer Immunology Research, Journal for Immunotherapy of Cancer, and JAMA Network Open. 

     

    Research Departments

    Support my research

    Publications

      • A Phase I Trial of Trebananib, an Angiopoietin 1 and 2 Neutralizing Peptibody, Combined with Pembrolizumab in Patients with Advanced Ovarian and Colorectal Cancer. Cancer Immunol Res. 2025 Jan 09; 13(1):9-22. View in: Pubmed

      • Circulating Tumor DNA as a Prognostic Biomarker for Recurrence in Patients With Locoregional Esophagogastric Cancers With a Pathologic Complete Response. JCO Precis Oncol. 2024 Dec; 8:e2400288. View in: Pubmed

      • Clinical and Genomic Features of Classical and Basal Transcriptional Subtypes in Pancreatic Cancer. Clin Cancer Res. 2024 Nov 01; 30(21):4932-4942. View in: Pubmed

      • Blockade of IL1ß and PD1 with Combination Chemotherapy Reduces Systemic Myeloid Suppression in Metastatic Pancreatic Cancer with Heterogeneous Effects in the Tumor. Cancer Immunol Res. 2024 Sep 03; 12(9):1221-1235. View in: Pubmed

      • Immunological Checkpoint Blockade in Anal Squamous Cell Carcinoma: Dramatic Responses Tempered By Frequent Resistance. Curr Oncol Rep. 2024 Aug; 26(8):967-976. View in: Pubmed

      • Transcriptionally Active Human Papillomavirus Infection in a Minority of Esophageal Squamous Cell Carcinomas in North America. Am J Surg Pathol. 2024 Jul 01; 48(7):883-889. View in: Pubmed

      • Author Correction: Mutational signature-based identification of DNA repair deficient gastroesophageal adenocarcinomas for therapeutic targeting. NPJ Precis Oncol. 2024 May 06; 8(1):98. View in: Pubmed

      • RAS/RAF Comutation and ERBB2 Copy Number Modulates HER2 Heterogeneity and Responsiveness to HER2-directed Therapy in Colorectal Cancer. Clin Cancer Res. 2024 Apr 15; 30(8):1669-1684. View in: Pubmed

      • Mutational signature-based identification of DNA repair deficient gastroesophageal adenocarcinomas for therapeutic targeting. NPJ Precis Oncol. 2024 Apr 08; 8(1):87. View in: Pubmed

      • Biomarkers of pembrolizumab efficacy in advanced anal squamous cell carcinoma: analysis of a phase II clinical trial and a cohort of long-term responders. J Immunother Cancer. 2024 01 25; 12(1). View in: Pubmed

      • A Phase I Expansion Cohort Study Evaluating the Safety and Efficacy of the CHK1 Inhibitor LY2880070 with Low-dose Gemcitabine in Patients with Metastatic Pancreatic Adenocarcinoma. Clin Cancer Res. 2023 12 15; 29(24):5047-5056. View in: Pubmed

      • Replicative stress in gastroesophageal cancer is associated with chromosomal instability and sensitivity to DNA damage response inhibitors. iScience. 2023 Nov 17; 26(11):108169. View in: Pubmed

      • Supportive learning environments, impression management and 'strategic imposterism': A word of caution. Med Educ. 2023 12; 57(12):1170-1172. View in: Pubmed

      • Highly Sensitive Circulating Tumor DNA Assay Aids Clinical Management of Radiographically Occult Isolated Peritoneal Metastases in Patients With GI Cancer. JCO Precis Oncol. 2023 06; 7:e2200572. View in: Pubmed

      • Replicative stress in gastroesophageal adenocarcinoma is associated with chromosomal instability and sensitivity to DNA damage response inhibitors. bioRxiv. 2023 Mar 28. View in: Pubmed

      • Reply to S. Chakrabarti and A. Mahipal. JCO Precis Oncol. 2023 03; 7:e2300043. View in: Pubmed

      • Effect of a MUC5AC Antibody (NPC-1C) Administered With Second-Line Gemcitabine and Nab-Paclitaxel on the Survival of Patients With Advanced Pancreatic Ductal Adenocarcinoma: A Randomized Clinical Trial. JAMA Netw Open. 2023 01 03; 6(1):e2249720. View in: Pubmed

      • Emerging Role of Targeted Therapy in Metastatic Pancreatic Adenocarcinoma. Cancers (Basel). 2022 Dec 16; 14(24). View in: Pubmed

      • Analysis of Circulating Tumor DNA to Predict Risk of Recurrence in Patients With Esophageal and Gastric Cancers. JCO Precis Oncol. 2022 12; 6:e2200420. View in: Pubmed

      • Secondary IDH1 resistance mutations and oncogenic IDH2 mutations cause acquired resistance to ivosidenib in cholangiocarcinoma. NPJ Precis Oncol. 2022 Sep 02; 6(1):61. View in: Pubmed

      • Early TP53 Alterations Shape Gastric and Esophageal Cancer Development. Cancers (Basel). 2021 Nov 24; 13(23). View in: Pubmed

      • Opportunities for Utilization of DNA Repair Inhibitors in Homologous Recombination Repair-Deficient and Proficient Pancreatic Adenocarcinoma. Clin Cancer Res. 2021 12 15; 27(24):6622-6637. View in: Pubmed

      • Coaching Versus Competency to Facilitate Professional Identity Formation. Acad Med. 2020 10; 95(10):1511-1514. View in: Pubmed

      • Resident impression management within feedback conversations: A qualitative study. Med Educ. 2021 02; 55(2):266-274. View in: Pubmed

      • Clinicopathological features and outcomes of fibrolamellar hepatocellular carcinoma. J Gastrointest Oncol. 2019 Jun; 10(3):554-561. View in: Pubmed

      • Novel Prognostic Factors in Resected Small Bowel Adenocarcinoma. Clin Colorectal Cancer. 2019 09; 18(3):218-225. View in: Pubmed

      • Local excision for patients with stage I anal canal squamous cell carcinoma can be curative. J Gastrointest Oncol. 2019 Apr; 10(2):171-178. View in: Pubmed

      • Solid Pseudopapillary Neoplasms of the Pancreas: A Large American Cohort. Pancreas. 2019 04; 48(4):e21-e22. View in: Pubmed

      • Survival and Prognostic Factors in Patients With Solid Pseudopapillary Neoplasms of the Pancreas. Pancreas. 2018 09; 47(8):1003-1007. View in: Pubmed

      • Hepatotoxicity After Immune Checkpoint Inhibitor Therapy in Melanoma: Natural Progression and Management. Am J Clin Oncol. 2018 08; 41(8):760-765. View in: Pubmed

      • Gastrointestinal Bleeding Secondary to Iliac Artery Pseudoaneurysm in a Patient With Remote Pancreas Transplant: A Case Report. Transplant Proc. 2018 Dec; 50(10):4087-4089. View in: Pubmed

      • Feeling run down: exercise-induced pancytopenia. Br J Haematol. 2017 06; 177(5):672. View in: Pubmed

      • Risk stratification using cytomorphologic features in endoscopic ultrasonographic-guided fine-needle aspiration diagnosis of pancreatic ductal adenocarcinoma. Diagn Cytopathol. 2015 Aug; 43(8):613-21. View in: Pubmed

      • Occult pulmonary mucosa-associated lymphoid tissue lymphoma presenting as catastrophic antiphospholipid antibody syndrome. Oncol Lett. 2013 Nov; 6(5):1261-1264. View in: Pubmed

      Locations

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      Dana-Farber Cancer Institute

      450 Brookline Avenue Boston, MA 02215
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      Dana-Farber Cancer Institute - Chestnut Hill

      300 Boylston Street Newton, MA 02459
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      Dana-Farber Cancer Institute

      Location Avtar

      Dana-Farber Cancer Institute

      450 Brookline Avenue Boston, MA 02215
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      42.3374, -71.1083

      Dana-Farber Cancer Institute - Chestnut Hill

      Location Avtar

      Dana-Farber Cancer Institute - Chestnut Hill

      300 Boylston Street Newton, MA 02459
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      42.3192, -71.1798

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