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Charles D. Stiles, PhD


Researcher

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Researcher

  • Professor of Neurobiology, Harvard Medical School

Contact Information

  • Office Phone Number617-632-3512
  • Fax617-632-4663

Bio

Dr. Stiles received his PhD in 1973 from the University of Tennessee at the Oak Ridge National Laboratories. Following his postdoctoral research at the University of California, San Diego, from 1973-1976, he joined the faculty of Harvard and DFCI, where he currently is co-chair of the Department of Cancer Biology. His laboratory is cloning and characterizing growth factor-responsive genes that regulate brain development.

Recent Awards:

  • BBS Teaching Award, Harvard Medical School 2000
  • BBS Mentoring Award, Harvard Medical School 2007

Research

Genetics of Brain Development

Primary cancers of the brain are the third leading cause of cancer-related death among men 15 to 54 years of age and the fourth leading cause of death among women 15 to 34 years of age. Among children younger than 15, the impact of central nervous system cancer is even more pronounced. Primary brain tumors are actually the most common solid tumor of childhood and the second leading cause of cancer death after leukemia. For the past 15 years, our research group has focused on brain cancers. We are attacking this clinical problem by addressing a fundamental question in basic science: Which genes regulate the development of the normal brain? We currently are cloning and characterizing genes that "instruct" brain progenitor cells to develop into mature neurons, astrocytes, and oligodendrocytes - the cellular components of a mature brain. We reason that the genes that give rise to a normal, functioning brain are the same genes that give rise to cancer of the brain when their expression is perturbed. Given a defined genetic target, scientists can screen large libraries of chemically diverse compounds to identify drugs that interact with the protein encoded by that specific gene. These genetically targeted compounds are "smart drugs" that can kill tumor cells without collateral damage to normal cells. We also hypothesize that genetic perturbations within genes that regulate brain development may underlie a broader range of inborn brain dysfunctions including childhood mental retardation, Alzheimer's disease, and schizophrenia. Thus, fundamental work on the genetics of brain development conducted under the auspices of brain cancer research could eventually have impact on health problems outside the cancer field.

Mitogenic and progenitor gene programmes in single pilocytic astrocytoma cells. Nat Commun. 2019 08 19; 10(1):3731.
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Clinical targeted exome-based sequencing in combination with genome-wide copy number profiling: precision medicine analysis of 203 pediatric brain tumors. Neuro Oncol. 2017 Jul 01; 19(7):986-996.
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A brain-penetrant RAF dimer antagonist for the noncanonical BRAF oncoprotein of pediatric low-grade astrocytomas. Neuro Oncol. 2017 06 01; 19(6):774-785.
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Population Control: Cortical Interneurons Modulate Oligodendrogenesis. Neuron. 2017 May 03; 94(3):415-417.
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A Sequentially Priming Phosphorylation Cascade Activates the Gliomagenic Transcription Factor Olig2. Cell Rep. 2017 03 28; 18(13):3167-3177.
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Establishment and application of a novel patient-derived KIAA1549:BRAF-driven pediatric pilocytic astrocytoma model for preclinical drug testing. Oncotarget. 2017 Feb 14; 8(7):11460-11479.
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Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability. Elife. 2017 02 08; 6.
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Challenges in Targeting a Basic Helix-Loop-Helix Transcription Factor with Hydrocarbon-Stapled Peptides. ACS Chem Biol. 2016 11 18; 11(11):3146-3153.
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Tyrosine receptor kinase B is a drug target in astrocytomas. Neuro Oncol. 2017 01; 19(1):22-30.
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Gliomas "Dope Up" for Growth. Cancer Cell. 2016 06 13; 29(6):778-780.
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MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism. Nat Genet. 2016 Mar; 48(3):273-82.
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A Brain Tumor/Organotypic Slice Co-culture System for Studying Tumor Microenvironment and Targeted Drug Therapies. J Vis Exp. 2015 Nov 07; (105):e53304.
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Of Brains and Blood: Developmental Origins of Glioma Diversity? Cancer Cell. 2015 Oct 12; 28(4):403-404.
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Expression profiles of 151 pediatric low-grade gliomas reveal molecular differences associated with location and histological subtype. Neuro Oncol. 2015 Nov; 17(11):1486-96.
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An amino terminal phosphorylation motif regulates intranuclear compartmentalization of Olig2 in neural progenitor cells. J Neurosci. 2014 Jun 18; 34(25):8507-18.
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Pediatric low-grade gliomas: how modern biology reshapes the clinical field. Biochim Biophys Acta. 2014 Apr; 1845(2):294-307.
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Olig1 function is required to repress dlx1/2 and interneuron production in Mammalian brain. Neuron. 2014 Feb 05; 81(3):574-87.
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New progenitors NESTIN(g) in the EGL. Nat Neurosci. 2013 Dec; 16(12):1710-2.
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Molecular imaging of drug transit through the blood-brain barrier with MALDI mass spectrometry imaging. Sci Rep. 2013 Oct 04; 3:2859.
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Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1. Proc Natl Acad Sci U S A. 2013 May 14; 110(20):8188-93.
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Separated at birth? The functional and molecular divergence of OLIG1 and OLIG2. Nat Rev Neurosci. 2012 Dec; 13(12):819-31.
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Asleep at the switch: MEK kinases control transit to gliogenesis in developing cortex. Neuron. 2012 Sep 20; 75(6):940-2.
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Prospective, high-throughput molecular profiling of human gliomas. J Neurooncol. 2012 Oct; 110(1):89-98.
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Identification of molecular compartments and genetic circuitry in the developing mammalian kidney. Development. 2012 May; 139(10):1863-73.
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Detection of KIAA1549-BRAF fusion transcripts in formalin-fixed paraffin-embedded pediatric low-grade gliomas. J Mol Diagn. 2011 Nov; 13(6):669-77.
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Report from the fifth National Cancer Institute Mouse Models of Human Cancers Consortium Nervous System Tumors Workshop. Neuro Oncol. 2011 Jul; 13(7):692-9.
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Phosphorylation state of Olig2 regulates proliferation of neural progenitors. Neuron. 2011 Mar 10; 69(5):906-17.
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The central nervous system-restricted transcription factor Olig2 opposes p53 responses to genotoxic damage in neural progenitors and malignant glioma. Cancer Cell. 2011 Mar 08; 19(3):359-71.
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Lonafarnib (SCH66336) improves the activity of temozolomide and radiation for orthotopic malignant gliomas. J Neurooncol. 2011 Aug; 104(1):179-89.
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Germline mutations in TMEM127 confer susceptibility to pheochromocytoma. Nat Genet. 2010 Mar; 42(3):229-33.
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Phase II study of imatinib mesylate for recurrent meningiomas (North American Brain Tumor Consortium study 01-08). Neuro Oncol. 2009 Dec; 11(6):853-60.
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Profiling critical cancer gene mutations in clinical tumor samples. PLoS One. 2009 Nov 18; 4(11):e7887.
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A genome-wide screen for spatially restricted expression patterns identifies transcription factors that regulate glial development. J Neurosci. 2009 Sep 09; 29(36):11399-408.
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Efficacy of the HSP90 inhibitor 17-AAG in human glioma cell lines and tumorigenic glioma stem cells. Neuro Oncol. 2009 Apr; 11(2):109-21.
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Glioma stem cells: a midterm exam. Neuron. 2008 Jun 26; 58(6):832-46.
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Molecular pathogenesis of adult brain tumors and the role of stem cells. Neurol Clin. 2007 Nov; 25(4):891-924, vii.
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"Smad"eningly erratic: target gene methylation determines whether TGFbeta promotes or suppresses malignant glioma. Dev Cell. 2007 Mar; 12(3):324-5.
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Olig2-regulated lineage-restricted pathway controls replication competence in neural stem cells and malignant glioma. Neuron. 2007 Feb 15; 53(4):503-17.
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Phase I/II study of imatinib mesylate for recurrent malignant gliomas: North American Brain Tumor Consortium Study 99-08. Clin Cancer Res. 2006 Aug 15; 12(16):4899-907.
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The bad seed: PDGF receptors link adult neural progenitors to glioma stem cells. Neuron. 2006 Jul 20; 51(2):151-3.
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Development of NG2 neural progenitor cells requires Olig gene function. Proc Natl Acad Sci U S A. 2006 May 16; 103(20):7853-8.
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Evidence for motoneuron lineage-specific regulation of Olig2 in the vertebrate neural tube. Dev Biol. 2006 Apr 01; 292(1):152-64.
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Targeted molecular therapy of malignant gliomas. Curr Oncol Rep. 2006 Jan; 8(1):58-70.
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Novel pheochromocytoma susceptibility loci identified by integrative genomics. Cancer Res. 2005 Nov 01; 65(21):9651-8.
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A HIF1alpha regulatory loop links hypoxia and mitochondrial signals in pheochromocytomas. PLoS Genet. 2005 Jul; 1(1):72-80.
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A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. BMC Dev Biol. 2005 Jul 20; 5:14.
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Targeted molecular therapy of malignant gliomas. Curr Neurol Neurosci Rep. 2005 May; 5(3):186-97.
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Distinct temporal genetic signatures of neurogenic and gliogenic cues in cortical stem cell cultures. J Neurobiol. 2005 Jan; 62(1):121-33.
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Mouse brain organization revealed through direct genome-scale TF expression analysis. Science. 2004 Dec 24; 306(5705):2255-7.
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bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS. Science. 2004 Dec 17; 306(5704):2111-5.
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The oligodendroglial lineage marker OLIG2 is universally expressed in diffuse gliomas. J Neuropathol Exp Neurol. 2004 May; 63(5):499-509.
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Expression of the guanine nucleotide exchange factor, mr-gef, is regulated during the differentiation of specific subsets of telencephalic neurons. Brain Res Dev Brain Res. 2003 Dec 19; 146(1-2):107-18.
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Lost in space: misregulated positional cues create tripotent neural progenitors in cell culture. Neuron. 2003 Oct 30; 40(3):447-9.
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Cross-repressive interaction of the Olig2 and Nkx2.2 transcription factors in developing neural tube associated with formation of a specific physical complex. J Neurosci. 2003 Oct 22; 23(29):9547-56.
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Basic helix-loop-helix factors in cortical development. Neuron. 2003 Jul 03; 39(1):13-25.
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High-resolution imaging demonstrates dynein-based vesicular transport of activated Trk receptors. J Neurobiol. 2002 Jun 15; 51(4):302-12.
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Molecular mechanisms controlling cortical gliogenesis. Curr Opin Neurobiol. 2002 Jun; 12(3):244-9.
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Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection. Cell. 2002 Apr 05; 109(1):75-86.
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Ectopic expression of Olig1 promotes oligodendrocyte formation and reduces neuronal survival in developing mouse cortex. Nat Neurosci. 2001 Oct; 4(10):973-4.
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Sonic hedgehog is required during an early phase of oligodendrocyte development in mammalian brain. Mol Cell Neurosci. 2001 Oct; 18(4):434-41.
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Olig bHLH proteins interact with homeodomain proteins to regulate cell fate acquisition in progenitors of the ventral neural tube. Curr Biol. 2001 Sep 18; 11(18):1413-20.
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Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors. Proc Natl Acad Sci U S A. 2001 Sep 11; 98(19):10851-6.
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Hedgehog-dependent oligodendrocyte lineage specification in the telencephalon. Development. 2001 Jul; 128(13):2545-54.
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Oligodendrocyte development in the spinal cord and telencephalon: common themes and new perspectives. Int J Dev Neurosci. 2001 Jul; 19(4):379-85.
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Schwann cell proliferative responses to cAMP and Nf1 are mediated by cyclin D1. J Neurosci. 2001 Feb 15; 21(4):1110-6.
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Intracranial inhibition of platelet-derived growth factor-mediated glioblastoma cell growth by an orally active kinase inhibitor of the 2-phenylaminopyrimidine class. Cancer Res. 2000 Sep 15; 60(18):5143-50.
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Growth inhibition and modulation of kinase pathways of small cell lung cancer cell lines by the novel tyrosine kinase inhibitor STI 571. Oncogene. 2000 Jul 20; 19(31):3521-8.
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A developmentally regulated switch directs regenerative growth of Schwann cells through cyclin D1. Neuron. 2000 May; 26(2):405-16.
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Sonic hedgehog--regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system. Neuron. 2000 Feb; 25(2):317-29.
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Bipotent cortical progenitor cells process conflicting cues for neurons and glia in a hierarchical manner. J Neurosci. 1999 Dec 01; 19(23):10383-9.
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Platelet-derived growth factor stimulation of monocyte chemoattractant protein-1 gene expression is mediated by transient activation of the phosphoinositide 3-kinase signal transduction pathway. J Biol Chem. 1999 Oct 22; 274(43):31062-7.
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TrkA glycosylation regulates receptor localization and activity. J Neurobiol. 1999 May; 39(2):323-36.
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PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanismsin haematological malignancies. Hum Mol Genet. 1999 Feb; 8(2):185-93.
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Activation of neurotrophin-3 receptor TrkC induces apoptosis in medulloblastomas. Cancer Res. 1999 Feb 01; 59(3):711-9.
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Cancer of the central nervous system. Review of an AACR special conference in cancer research with the joint section on tumors of the AANS/CNS (San Diego, CA, June 7-11, 1997). Biochim Biophys Acta. 1998 Feb 20; 1377(1):R1-10.
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Activation of ErbB2 during wallerian degeneration of sciatic nerve. J Neurosci. 1997 Nov 01; 17(21):8293-9.
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Detection of activated platelet-derived growth factor receptors in human meningioma. Cancer Res. 1997 Sep 15; 57(18):4141-7.
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Trk receptors function as rapid retrograde signal carriers in the adult nervous system. J Neurosci. 1997 Sep 15; 17(18):7007-16.
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Phosphorylation-directed antibodies in high-flux screens for compounds that modulate signal transduction. Biotechniques. 1997 Sep; 23(3):490-3.
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A PDGF-regulated immediate early gene response initiates neuronal differentiation in ventricular zone progenitor cells. Neuron. 1997 Apr; 18(4):553-62.
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Temporal and spatial specificity of PDGF alpha receptor promoter in transgenic mice. Gene Expr. 1997; 6(5):301-14.
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Differential utilization of Trk autophosphorylation sites. J Biol Chem. 1996 Aug 16; 271(33):20175-81.
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Platelet-derived growth factor induction of the immediate-early gene MCP-1 is mediated by NF-kappaB and a 90-kDa phosphoprotein coactivator. J Biol Chem. 1996 Jul 19; 271(29):17417-24.
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Applications of electroporation of adherent cells in situ, on a partly conductive slide. Mol Biotechnol. 1995 Oct; 4(2):129-38.
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Axonal growth and fasciculation linked to differential expression of BDNF and NT3 receptors in developing cerebellar granule cells. J Neurosci. 1995 Jul; 15(7 Pt 1):4970-81.
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Expression of platelet derived growth factor and platelet derived growth factor receptor mRNA in a glioblastoma from a patient with Li-Fraumeni syndrome. J Neurol Neurosurg Psychiatry. 1995 Jun; 58(6):711-4.
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Expression of PDGF and PDGF receptors in human astrocytoma operation specimens supports the existence of an autocrine loop. Int J Cancer. 1995 Jan 17; 60(2):168-73.
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Electroporation of peptides into adherent cells in situ. Biotechniques. 1995 Jan; 18(1):104, 106, 108, 110 passim.
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A new platelet-derived growth factor-regulated genomic element which binds a serine/threonine phosphoprotein mediates induction of the slow immediate-early gene MCP-1. Mol Cell Biol. 1995 Jan; 15(1):315-25.
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Transdominant negative mutations. Methods Enzymol. 1995; 254:565-76.
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Expression of the neurotrophin receptor TrkC is linked to a favorable outcome in medulloblastoma. Proc Natl Acad Sci U S A. 1994 Dec 20; 91(26):12867-71.
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Platelet-derived growth factor alpha receptor gene expression: isolation and characterization of the promoter and upstream regulatory elements. Proc Natl Acad Sci U S A. 1994 Jul 19; 91(15):7061-5.
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Identification of an activity that interacts with the 3'-untranslated region of c-myc mRNA and the role of its target sequence in mediating rapid mRNA degradation. J Biol Chem. 1994 Feb 11; 269(6):4532-8.
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Dominant-negative mutants of platelet-derived growth factor revert the transformed phenotype of human astrocytoma cells. Mol Cell Biol. 1993 Dec; 13(12):7203-12.
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Regulation of platelet-derived growth factor A messenger RNA translation in differentiating F9 teratocarcinoma cells. Cell Growth Differ. 1993 Oct; 4(10):871-7.
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PDGF and its receptors in the developing rodent retina and optic nerve. Development. 1993 Jun; 118(2):539-52.
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The Xenopus platelet-derived growth factor alpha receptor: cDNA cloning and demonstration that mesoderm induction establishes the lineage-specific pattern of ligand and receptor gene expression. Dev Genet. 1993; 14(3):185-93.
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Expression of mouse PDGF-A and PDGF alpha-receptor genes during pre- and post-implantation development: evidence for a developmental shift from an autocrine to a paracrine mode of action. Mech Dev. 1992 Dec; 39(3):181-91.
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A novel 7-nucleotide motif located in 3' untranslated sequences of the immediate-early gene set mediates platelet-derived growth factor induction of the JE gene. Mol Cell Biol. 1992 Dec; 12(12):5288-300.
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Synthetic phosphopeptide immunogens yield activation-specific antibodies to the c-erbB-2 receptor. Proc Natl Acad Sci U S A. 1992 Nov 01; 89(21):10435-9.
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Extracellular calcium mimics the actions of platelet-derived growth factor on mouse fibroblasts. Cell Growth Differ. 1992 Mar; 3(3):157-64.
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Recombinant PDGF from lower vertebrates: receptor binding and immunochemical analysis with metabolically labeled growth factor. Growth Factors. 1992; 7(4):279-88.
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Human keratinocyte growth-promoting activity on the surface of fibroblasts. J Cell Physiol. 1991 Oct; 149(1):110-6.
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Platelet-derived growth factor receptor alpha-subunit gene (Pdgfra) is deleted in the mouse patch (Ph) mutation. Proc Natl Acad Sci U S A. 1991 Jan 01; 88(1):6-10.
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Retinoic acid promotes transcription of the platelet-derived growth factor alpha-receptor gene. Mol Cell Biol. 1990 Dec; 10(12):6781-4.
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Dominant-negative mutants of a platelet-derived growth factor gene. Genes Dev. 1990 Dec; 4(12B):2333-41.
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Modulation of a Mr 175,000 c-neu receptor isoform in G8/DHFR cells by serum starvation. J Biol Chem. 1990 Jun 25; 265(18):10746-51.
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Selective expression of PDGF A and its receptor during early mouse embryogenesis. Dev Biol. 1990 Mar; 138(1):114-22.
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The beta-interferon-mediated antimitogenic state resembles the anti-viral state. Oncogene Res. 1990; 5(4):323-8.
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A clinical virology database for a regional virology service. J Virol Methods. 1989 Dec; 26(3):255-67.
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Interleukin-1 is a potent regulator of JE and KC gene expression in quiescent BALB/c fibroblasts. J Cell Physiol. 1989 Oct; 141(1):154-9.
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Environment-dependent growth inhibition of human epidermal keratinocytes by recombinant human transforming growth factor-beta. J Cell Physiol. 1989 Jun; 139(3):455-62.
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Evidence for a novel signal transduction pathway activated by platelet-derived growth factor and by double-stranded RNA. Mol Cell Biol. 1989 Apr; 9(4):1705-13.
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The platelet-derived growth factor-inducible KC gene encodes a secretory protein related to platelet alpha-granule proteins. J Biol Chem. 1989 Mar 05; 264(7):4133-7.
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Regulation of 2',5'-oligoadenylate synthetase gene expression by interferons and platelet-derived growth factor. Mol Cell Biol. 1989 Mar; 9(3):1060-8.
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Labile repressors are involved in the transcriptional control of PDGF-responsive genes. Oncogene Res. 1989; 4(3):177-84.
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Serum-inducible genes. Adv Cancer Res. 1989; 53:1-32.
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Platelet-derived growth factor A chain is maternally encoded in Xenopus embryos. Science. 1988 Sep 02; 241(4870):1223-5.
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Comparison of fibroblast and T-cell activation genes. Cell Immunol. 1988 Sep; 115(2):481-3.
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Cloning and expression of JE, a gene inducible by platelet-derived growth factor and whose product has cytokine-like properties. Proc Natl Acad Sci U S A. 1988 Jun; 85(11):3738-42.
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Growth factor superfamilies and mammalian embryogenesis. Development. 1988 Mar; 102(3):451-60.
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Regulation of c-myc and c-fos proto-oncogene expression by animal cell growth factors. In Vitro Cell Dev Biol. 1988 Feb; 24(2):81-4.
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Molecular regulation of growth control: implications for wound healing. Prog Clin Biol Res. 1988; 266:19-22.
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Platelet-derived growth factor generates at least two distinct intracellular signals that modulate gene expression. Cold Spring Harb Symp Quant Biol. 1988; 53 Pt 1:531-6.
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A cell-cycle constraint on the regulation of gene expression by platelet-derived growth factor. Science. 1987 Nov 27; 238(4831):1269-71.
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Platelet-derived growth factor-inducible genes respond differentially to at least two distinct intracellular second messengers. J Biol Chem. 1987 Nov 05; 262(31):15302-8.
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Molecular cloning of gene sequences that are regulated by insulin-like growth factor I. J Biol Chem. 1987 Aug 15; 262(23):11252-60.
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Regulation of c-myc and c-fos mRNA levels by polyomavirus: distinct roles for the capsid protein VP1 and the viral early proteins. Proc Natl Acad Sci U S A. 1987 Mar; 84(5):1210-4.
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Differential colony hybridization: molecular cloning from a zero data base. Methods Enzymol. 1987; 147:64-85.
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Cell cycle dependent genes inducible by different mitogens in cells from different species. Mol Cell Biochem. 1986 Jun; 71(1):61-9.
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Platelet-derived growth factor and double-stranded ribonucleic acids stimulate expression of the same genes in 3T3 cells. Cell. 1985 Dec; 43(3 Pt 2):793-800.
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The biological role of oncogenes--insights from platelet-derived growth factor: Rhoads Memorial Award lecture. Cancer Res. 1985 Nov; 45(11 Pt 1):5215-8.
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The PDGF-inducible 'competence genes': intracellular mediators of the mitogenic response. Ciba Found Symp. 1985; 116:87-97.
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Expression of the c-fos gene and of an fos-related gene is stimulated by platelet-derived growth factor. Science. 1984 Nov 30; 226(4678):1080-2.
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Autocrine control of growth? Nature. 1984 Oct 18-24; 311(5987):604-5.
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Functional role for c-myc in mitogenic response to platelet-derived growth factor. Nature. 1984 Aug 23-29; 310(5979):655-60.
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Regulation of cytoskeletal architecture by platelet-derived growth factor, insulin and epidermal growth factor. Exp Cell Res. 1984 Jul; 153(1):186-97.
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Use of defined media for analysis of the action of platelet-derived growth factor on fibroblasts. Prog Clin Biol Res. 1984; 154:133-41.
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The regulation of c-myc by growth signals. Curr Top Microbiol Immunol. 1984; 113:117-26.
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Regulation of gene expression by serum and serum growth factors. Symp Fundam Cancer Res. 1984; 37:71-85.
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Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor. Cell. 1983 Dec; 35(3 Pt 2):603-10.
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Molecular cloning of gene sequences regulated by platelet-derived growth factor. Cell. 1983 Jul; 33(3):939-47.
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The molecular biology of platelet-derived growth factor. Cell. 1983 Jul; 33(3):653-5.
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Persistence of the mitogenic response to platelet-derived growth factor (competence) does not reflect a long-term interaction between the growth factor and the target cell. J Cell Biol. 1983 May; 96(5):1497-502.
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Phylogenetic analysis of platelet-derived growth factor by radio-receptor assay. J Cell Biol. 1982 Nov; 95(2 Pt 1):667-71.
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Growth factors adherent to cell substrate are mitogenically active in situ. Nature. 1982 Mar 11; 296(5853):154-6.
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Post-transcriptional control of protein synthesis in Balb/c-3T3 cells by platelet-derived growth factor and platelet-poor plasma. J Cell Physiol. 1981 Dec; 109(3):429-38.
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Cytoplasmic transfer of the mitogenic response to platelet-derived growth factor. Proc Natl Acad Sci U S A. 1981 Jul; 78(7):4363-7.
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Effect of ouabain on growth regulation by serum components in Balb/c-3T3 cells: inhibition of entry into S phase by decreased protein synthesis. J Cell Physiol. 1980 Dec; 105(3):439-48.
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Regulation of the Balb/c-3T3 cell cycle-effects of growth factors. J Supramol Struct. 1980; 13(4):489-99.
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Roles of the T antigens in transformation by SV40. Cold Spring Harb Symp Quant Biol. 1980; 44 Pt 1,:311-24.
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Initiation of cell replication by cationic polypeptide hormones. Soc Gen Physiol Ser. 1980; 35:39-54.
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Centriole deciliation associated with the early response of 3T3 cells to growth factors but not to SV40. Cell. 1979 Dec; 18(4):1065-72.
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Platelet-derived growth factor prevents G0 growth arrest. Nature. 1979 Oct 04; 281(5730):390-2.
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The tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate enhances the proliferative response of Balb/c-3T3 cells to hormonal growth factors. J Cell Physiol. 1979 Sep; 100(3):413-24.
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Platelet-derived growth factor and the regulation of the mammalian fibroblast cell cycle. Biochim Biophys Acta. 1979 Aug 10; 560(2):217-41.
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Platelet alpha granules contain a growth factor for fibroblasts. Blood. 1979 Jun; 53(6):1043-52.
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Control of the Balb/c-3T3 cell cycle by nutrients and serum factors: analysis using platelet-derived growth factor and platelet-poor plasma. J Cell Physiol. 1979 Jun; 99(3):395-405.
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Growth of nontumorigenic cells in Millipore diffusion chambers implanted in mice and implications for in vivo growth regulation. Cancer Res. 1979 May; 39(5):1467-73.
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Purification of human platelet-derived growth factor. Proc Natl Acad Sci U S A. 1979 Apr; 76(4):1809-13.
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Dual control of cell growth by somatomedins and platelet-derived growth factor. Proc Natl Acad Sci U S A. 1979 Mar; 76(3):1279-83.
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Regulation of the mammalian fibroblast cell cycle by a platelet-derived growth factor. Prog Clin Biol Res. 1979; 31:611-20.
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Transforming viruses directly reduce the cellular growth requirement for a platelet derived growth factor. J Cell Physiol. 1978 Dec; 97(3 Pt 1):371-80.
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An ordered sequence of events is required before BALB/c-3T3 cells become committed to DNA synthesis. Proc Natl Acad Sci U S A . 1978; (75):2839-43.

Induction of DNA synthesis in BALB/c 3T3 cells by serum components: reevaluation of the commitment process. Proc Natl Acad Sci U S A. 1977 Oct; 74(10):4481-5.
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Relationship of cell growth behavior in vitro to tumorigenicity in athymic nude mice. Cancer Res. 1976 Sep; 36(9 pt.1):3300-5.
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Growth control of heterologous tissue culture cells in the congenitally athymic nude mouse. Cancer Res. 1976 Apr; 36(4):1353-60.
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Growth regulation and suppression of metastasis in the congenitally athymic nude mouse. Hamatol Bluttransfus. 1976; 19:185-94.
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Failure of human cells transformed by simian virus 40 to form tumors in athymic nude mice. Proc Natl Acad Sci U S A. 1975 Dec; 72(12):4971-5.
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Further evidence against post-transcriptional control of inducible tyrosine aminotransferase synthesis in cultured hepatoma cells. Nat New Biol. 1973 Dec 19; 246(155):208-10.
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Further evidence against post-transcriptional control of inducible tyrosine aminotransferase synthesis in cultured hepatoma cells. Nat New Biol . 1973; (246):208-10.

Degradation of messenger RNA in mammalian cells. Acta Endocrinol Suppl (Copenh). 1972; 168:369-80.
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Dana-Farber Cancer Institute
450 Brookline Avenue
Smith 1070
Boston, MA 02215
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