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Dana H. Gabuzda, MD


Researcher


Researcher

  • Professor of Neurology, Harvard Medical School

Contact Information

  • Office Phone Number617-632-2154
  • Fax617-632-4338

Bio

Dr. Gabuzda received her MD from Harvard Medical School in 1983 and did her postgraduate training in internal medicine and neurology at Massachusetts General Hospital. After completing research fellowships at Johns Hopkins University and DFCI, she joined the DFCI faculty in 1991. She is primarily involved in basic laboratory research on HIV replication and disease mechanisms in AIDS.

Research

HIV Molecular Biology and Pathogenesis

The Gabuzda lab uses genetic, biochemical, metabolomic, systems biology, and computational approaches to study HIV infection and comorbidities including cancer. Research interests include understanding viral, host, and environmental factors that determine clinical outcomes, therapeutic responses, and accelerated aging. Current projects include studies on:

  1. virus-host interactions during HIV replication and pathogenesis that impact immune control, inflammation, metabolic disorders, and comorbidities
  2. role of exosomes in cell-cell communication, immune regulation, stress responses, and disease pathophysiology
  3. mechanisms involved in HIV-associated neurological disorders and accelerated aging
  4. cancer risk and etiologies in aging populations with HIV

The lab is proficient at bioinformatic, computational, and systems biology approaches including generation, analysis, interpretation, and visualization of large data sets, big data handling, and using bioinformatic software and R programs for data integration, network prediction, pathway analysis, and modeling. The lab also uses machine learning and other computational approaches to model longitudinal trajectories and identify new predictors of clinical outcomes. The long-term goal is gaining multidisciplinary knowledge that leads to progress in personalized medicine for HIV-infected and aging populations.

Complete Publications List: http://www.ncbi.nlm.nih.gov/sites/myncbi/dana.gabuzda.1/collections/47703338/public/

Location

Dana-Farber Cancer Institute
450 Brookline Avenue
CLS 1010
Boston, MA 02215
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