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Dana H. Gabuzda, MD


Researcher

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Researcher

  • Principal Investigator, Cancer Immunology and Virology, Dana-Farber Cancer Institute
  • Professor of Neurology, Brigham and Women’s Hospital
  • Associate Physician of Neurology, Brigham And Women's Hospital

Contact Information

  • Office Phone Number617-632-2154
  • Fax617-632-4338

Bio

Dr. Gabuzda received her MD from Harvard Medical School in 1983 and did her postgraduate training in internal medicine and neurology at Massachusetts General Hospital. After completing research fellowships at Johns Hopkins University and DFCI, she joined the DFCI faculty in 1991. She is primarily involved in basic laboratory research on HIV replication and disease mechanisms in AIDS.

Research

HIV Molecular Biology and Pathogenesis

The Gabuzda lab uses genetic, biochemical, metabolomic, systems biology, and computational approaches to study HIV infection and comorbidities including cancer. Research interests include understanding viral, host, and environmental factors that determine clinical outcomes, therapeutic responses, and accelerated aging. Current projects include studies on:

  1. virus-host interactions during HIV replication and pathogenesis that impact immune control, inflammation, metabolic disorders, and comorbidities
  2. role of exosomes in cell-cell communication, immune regulation, stress responses, and disease pathophysiology
  3. mechanisms involved in HIV-associated neurological disorders and accelerated aging
  4. cancer risk and etiologies in aging populations with HIV

The lab is proficient at bioinformatic, computational, and systems biology approaches including generation, analysis, interpretation, and visualization of large data sets, big data handling, and using bioinformatic software and R programs for data integration, network prediction, pathway analysis, and modeling. The lab also uses machine learning and other computational approaches to model longitudinal trajectories and identify new predictors of clinical outcomes. The long-term goal is gaining multidisciplinary knowledge that leads to progress in personalized medicine for HIV-infected and aging populations.

Complete Publications List: http://www.ncbi.nlm.nih.gov/sites/myncbi/dana.gabuzda.1/collections/47703338/public/

Multimorbidity networks associated with frailty among middle aged and older people with HIV. AIDS. 2021 Jul 28.
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Low Neuroactive Steroids Identifies a Biological Subtype of Depression in Adults with Human Immunodeficiency Virus on Suppressive Antiretroviral Therapy. J Infect Dis. 2021 May 20; 223(9):1601-1611.
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Genomic Landscape of Primary and Recurrent Anal Squamous Cell Carcinomas in Relation to HPV Integration, Copy-Number Variation, and DNA Damage Response Genes. Mol Cancer Res. 2021 Aug; 19(8):1308-1321.
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Dual Pathways of Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Trafficking Modulate the Selective Exclusion of Uncleaved Oligomers from Virions. J Virol. 2021 01 13; 95(3).
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Acrolein and other toxicant exposures in relation to cardiovascular disease among marijuana and tobacco smokers in a longitudinal cohort of HIV-positive and negative adults. EClinicalMedicine. 2021 Jan; 31:100697.
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NIH Workshop on HIV-Associated Comorbidities, Coinfections, and Complications: Summary and Recommendation for Future Research. J Acquir Immune Defic Syndr. 2021 01 01; 86(1):11-18.
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Small RNA sequencing of extracellular vesicles identifies circulating miRNAs related to inflammation and oxidative stress in HIV patients. BMC Immunol. 2020 11 11; 21(1):57.
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Efficacy and safety of two-drug regimens for treatment of HIV in the central nervous system. AIDS. 2020 11 01; 34(13):1975-1977.
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Pathogenesis of Aging and Age-related Comorbidities in People with HIV: Highlights from the HIV ACTION Workshop. Pathog Immun. 2020; 5(1):143-174.
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Proteomic analysis of cerebrospinal fluid extracellular vesicles reveals synaptic injury, inflammation, and stress response markers in HIV patients with cognitive impairment. J Neuroinflammation. 2019 Dec 05; 16(1):254.
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Transcriptomic analysis of monocytes from HIV-positive men on antiretroviral therapy reveals effects of tobacco smoking on interferon and stress response systems associated with depressive symptoms. Hum Genomics. 2019 11 28; 13(1):59.
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White Matter Abnormalities Linked to Interferon, Stress Response, and Energy Metabolism Gene Expression Changes in Older HIV-Positive Patients on Antiretroviral Therapy. Mol Neurobiol. 2020 Feb; 57(2):1115-1130.
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Cerebrospinal fluid extracellular vesicles and neurofilament light protein as biomarkers of central nervous system injury in HIV-infected patients on antiretroviral therapy. AIDS. 2019 03 15; 33(4):615-625.
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Increased risk of anal squamous cell carcinoma in HIV-positive men with prior hepatitis B virus infection. AIDS. 2019 01 27; 33(1):145-152.
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Effect of marijuana smoking on pulmonary disease in HIV-infected and uninfected men: a longitudinal cohort study. EClinicalMedicine. 2019 Jan; 7:55-64.
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Effect of marijuana smoking on pulmonary disease in HIV-infected and uninfected men: a longitudinal cohort study. EClinicalMedicine. 2019; Jan 24.

Low T-cell subsets prior to development of virus-associated cancer in HIV-seronegative men who have sex with men. Cancer Causes Control. 2018 Nov; 29(11):1131-1142.
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Impact of Antiretroviral Regimens on Cerebrospinal Fluid Viral Escape in a Prospective Multicohort Study of Antiretroviral Therapy-Experienced Human Immunodeficiency Virus-1-Infected Adults in the United States. Clin Infect Dis. 2018 09 28; 67(8):1182-1190.
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Exosome markers associated with immune activation and oxidative stress in HIV patients on antiretroviral therapy. Sci Rep. 2018 05 08; 8(1):7227.
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In vivo characterization of macrophage-tropic simian immunodeficiency virus molecular clones in rhesus macaques. J Neurovirol. 2018 08; 24(4):411-419.
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Marijuana Use Impacts Midlife Cardiovascular Events in HIV-Infected Men. Clin Infect Dis. 2017 Aug 15; 65(4):626-635.
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Longitudinal Modeling of Depressive Trajectories Among HIV-Infected Men Using Cocaine. AIDS Behav. 2017 Jul; 21(7):1985-1995.
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Temporal Patterns and Drug Resistance in CSF Viral Escape Among ART-Experienced HIV-1 Infected Adults. . 2017 06 01; 75(2):246-255.
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Long-term nitrite inhalant exposure and cancer risk in MSM. AIDS. 2017 05 15; 31(8):1169-1180.
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Racial differences in prostate cancer risk in young HIV-positive and HIV-negative men: a prospective cohort study. Cancer Causes Control. 2017 Jul; 28(7):767-777.
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Brain and liver pathology, amyloid deposition, and interferon responses among older HIV-positive patients in the late HAART era. BMC Infect Dis. 2017 02 17; 17(1):151.
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Highlights of the Global HIV-1 CSF Escape Consortium Meeting, 9 June 2016, Bethesda, MD, USA. J Virus Erad. 2016 Oct 05; 2(4):243-250.
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Lipid Profiles and APOE4 Allele Impact Midlife Cognitive Decline in HIV-Infected Men on Antiretroviral Therapy. Clin Infect Dis. 2016 10 15; 63(8):1130-1139.
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Redoxal, an inhibitor of de novo pyrimidine biosynthesis, augments APOBEC3G antiviral activity against human immunodeficiency virus type 1. Virology. 2015 Oct; 484:276-287.
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Altered Monoamine and Acylcarnitine Metabolites in HIV-Positive and HIV-Negative Subjects With Depression. . 2015 May 01; 69(1):18-28.
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Bioinformatic analysis of neurotropic HIV envelope sequences identifies polymorphisms in the gp120 bridging sheet that increase macrophage-tropism through enhanced interactions with CCR5. Virology. 2015 Jul; 481:210-22.
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Identification of a novel HIV-1 inhibitor targeting Vif-dependent degradation of human APOBEC3G protein. J Biol Chem. 2015 Apr 17; 290(16):10504-17.
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Cerebrospinal fluid metabolomics reveals altered waste clearance and accelerated aging in HIV patients with neurocognitive impairment. AIDS. 2014 Jul 17; 28(11):1579-91.
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Identification and characterization of a macrophage-tropic SIV envelope glycoprotein variant in blood from early infection in SIVmac251-infected macaques. Virology. 2014 Jun; 458-459:53-68.
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Loss of a conserved N-linked glycosylation site in the simian immunodeficiency virus envelope glycoprotein V2 region enhances macrophage tropism by increasing CD4-independent cell-to-cell transmission. J Virol. 2014 May; 88(9):5014-28.
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Applications and limitations of inflammatory biomarkers for studies on neurocognitive impairment in HIV infection. J Neuroimmune Pharmacol. 2013 Dec; 8(5):1087-97.
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Plasma metabolomics identifies lipid abnormalities linked to markers of inflammation, microbial translocation, and hepatic function in HIV patients receiving protease inhibitors. BMC Infect Dis. 2013 May 04; 13:203.
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Physiology: Inflammation links ageing to the brain. Nature. 2013 May 09; 497(7448):197-8.
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Dendritic cell-specific intercellular adhesion molecule-3 grabbing nonintegrin mediates HIV-1 infection of and transmission by M2a-polarized macrophages in vitro. AIDS. 2013 Mar 13; 27(5):707-16.
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A machine learning approach for identifying amino acid signatures in the HIV env gene predictive of dementia. PLoS One. 2012; 7(11):e49538.
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Monocyte activation markers in cerebrospinal fluid associated with impaired neurocognitive testing in advanced HIV infection. . 2012 Jul 01; 60(3):234-43.
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Proteomic analysis of HIV-1 Nef cellular binding partners reveals a role for exocyst complex proteins in mediating enhancement of intercellular nanotube formation. Retrovirology. 2012 Jun 22; 9:33.
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Integrative analysis of gene and miRNA expression profiles with transcription factor-miRNA feed-forward loops identifies regulators in human cancers. Nucleic Acids Res. 2012 Sep 01; 40(17):e135.
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A plasma biomarker signature of immune activation in HIV patients on antiretroviral therapy. PLoS One. 2012; 7(2):e30881.
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Plasma sCD14 is a biomarker associated with impaired neurocognitive test performance in attention and learning domains in HIV infection. . 2011 Aug 15; 57(5):371-9.
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Nef-mediated enhancement of cellular activation and human immunodeficiency virus type 1 replication in primary T cells is dependent on association with p21-activated kinase 2. Retrovirology. 2011 Aug 05; 8:64.
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HIVBrainSeqDB: a database of annotated HIV envelope sequences from brain and other anatomical sites. AIDS Res Ther. 2010 Dec 14; 7:43.
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CD4 and MHC class 1 down-modulation activities of nef alleles from brain- and lymphoid tissue-derived primary HIV-1 isolates. J Neurovirol. 2011 Feb; 17(1):82-91.
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Serological markers for inflammatory bowel disease in AIDS patients with evidence of microbial translocation. PLoS One. 2010 Nov 15; 5(11):e15533.
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Evidence for adaptive evolution at the divergence between lymphoid and brain HIV-1 nef genes. AIDS Res Hum Retroviruses. 2010 Apr; 26(4):495-500.
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Transcriptional profiling reveals developmental relationship and distinct biological functions of CD16+ and CD16- monocyte subsets. BMC Genomics. 2009 Aug 27; 10:403.
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Enhanced macrophage tropism of HIV in brain and lymphoid tissues is associated with sensitivity to the broadly neutralizing CD4 binding site antibody b12. Retrovirology. 2009 Jul 20; 6:69.
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Planning Future Strategies for Domestic and International NeuroAIDS Research, July 24-25, 2008. J Neuroimmune Pharmacol. 2009 Sep; 4(3):283-97.
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Soluble CD4 and CD4-mimetic compounds inhibit HIV-1 infection by induction of a short-lived activated state. PLoS Pathog. 2009 Apr; 5(4):e1000360.
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Tissue-specific sequence alterations in the human immunodeficiency virus type 1 envelope favoring CCR5 usage contribute to persistence of dual-tropic virus in the brain. J Virol. 2009 Jun; 83(11):5430-41.
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Regulation of APOBEC3 proteins by a novel YXXL motif in human immunodeficiency virus type 1 Vif and simian immunodeficiency virus SIVagm Vif. J Virol. 2009 Mar; 83(5):2374-81.
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Evolution of the aging brain transcriptome and synaptic regulation. PLoS One. 2008 Oct 02; 3(10):e3329.
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Bioinformatic prediction programs underestimate the frequency of CXCR4 usage by R5X4 HIV type 1 in brain and other tissues. AIDS Res Hum Retroviruses. 2008 Sep; 24(9):1215-20.
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Microbial translocation is associated with increased monocyte activation and dementia in AIDS patients. PLoS One. 2008 Jun 25; 3(6):e2516.
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The HIV-1 Vif protein mediates degradation of Vpr and reduces Vpr-induced cell cycle arrest. DNA Cell Biol. 2008 May; 27(5):267-77.
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Asn 362 in gp120 contributes to enhanced fusogenicity by CCR5-restricted HIV-1 envelope glycoprotein variants from patients with AIDS. Retrovirology. 2007 Dec 12; 4:89.
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Identification of an APOBEC3G binding site in human immunodeficiency virus type 1 Vif and inhibitors of Vif-APOBEC3G binding. J Virol. 2007 Dec; 81(23):13235-41.
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Pathogenicity and immunogenicity of attenuated, nef-deleted HIV-1 strains in vivo. Retrovirology. 2007 Sep 23; 4:66.
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Phenotype and envelope gene diversity of nef-deleted HIV-1 isolated from long-term survivors infected from a single source. Virol J. 2007 Jul 16; 4:75.
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Loss of the N-linked glycosylation site at position 386 in the HIV envelope V4 region enhances macrophage tropism and is associated with dementia. Virology. 2007 Oct 10; 367(1):222-34.
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Viral phenotypes and antibody responses in long-term survivors infected with attenuated human immunodeficiency virus type 1 containing deletions in the nef and long terminal repeat regions. J Virol. 2007 Sep; 81(17):9268-78.
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High frequency of defective vpu compared with tat and rev genes in brain from patients with HIV type 1-associated dementia. AIDS Res Hum Retroviruses. 2007 Apr; 23(4):575-80.
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Changes in the V3 region of gp120 contribute to unusually broad coreceptor usage of an HIV-1 isolate from a CCR5 Delta32 heterozygote. Virology. 2007 May 25; 362(1):163-78.
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Reconstitution of human immunodeficiency virus-induced neurodegeneration using isolated populations of human neurons, astrocytes, and microglia and neuroprotection mediated by insulin-like growth factors. J Neurovirol. 2006 Dec; 12(6):472-91.
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Macrophage entry mediated by HIV Envs from brain and lymphoid tissues is determined by the capacity to use low CD4 levels and overall efficiency of fusion. Virology. 2007 Mar 30; 360(1):105-19.
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CD16+ monocytes produce IL-6, CCL2, and matrix metalloproteinase-9 upon interaction with CX3CL1-expressing endothelial cells. J Leukoc Biol. 2006 Nov; 80(5):1156-64.
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The HIV Env variant N283 enhances macrophage tropism and is associated with brain infection and dementia. Proc Natl Acad Sci U S A. 2006 Oct 10; 103(41):15160-5.
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CD4 and MHC-I downregulation are conserved in primary HIV-1 Nef alleles from brain and lymphoid tissues, but Pak2 activation is highly variable. Virology. 2007 Feb 05; 358(1):119-35.
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Mechanisms of HIV-1 neurotropism. Curr HIV Res. 2006 Jul; 4(3):267-78.
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Elicitation from virus-naive individuals of cytotoxic T lymphocytes directed against conserved HIV-1 epitopes. Med Immunol. 2006 May 18; 5:1.
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CD16+ monocyte-derived macrophages activate resting T cells for HIV infection by producing CCR3 and CCR4 ligands. J Immunol. 2006 May 15; 176(10):5760-71.
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A zinc-binding region in Vif binds Cul5 and determines cullin selection. J Biol Chem. 2006 Jun 23; 281(25):17259-17265.
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Genetic and functional analysis of R5X4 human immunodeficiency virus type 1 envelope glycoproteins derived from two individuals homozygous for the CCR5delta32 allele. J Virol. 2006 Apr; 80(7):3684-91.
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Use of laser capture microdissection to detect integrated HIV-1 DNA in macrophages and astrocytes from autopsy brain tissues. J Neurovirol. 2006 Apr; 12(2):146-52.
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A hydrophobic binding surface on the human immunodeficiency virus type 1 Nef core is critical for association with p21-activated kinase 2. J Virol. 2006 Mar; 80(6):3050-61.
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CD16+ monocytes exposed to HIV promote highly efficient viral replication upon differentiation into macrophages and interaction with T cells. Virology. 2006 Jan 20; 344(2):267-76.
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HIV-1 envelope pseudotyped viral vectors and infectious molecular clones expressing the same envelope glycoprotein have a similar neutralization phenotype, but culture in peripheral blood mononuclear cells is associated with decreased neutralization sensitivity. Virology. 2005 Sep 01; 339(2):226-38.
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Nuclear localization of HIV type 1 Vif isolated from a long-term asymptomatic individual and potential role in virus attenuation. AIDS Res Hum Retroviruses. 2005 Jun; 21(6):565-74.
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Distinct mechanisms of CD4+ and CD8+ T-cell activation and bystander apoptosis induced by human immunodeficiency virus type 1 virions. J Virol. 2005 May; 79(10):6299-311.
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Pathogenesis of macrophage tropic HIV-1. Curr HIV Res. 2005 Jan; 3(1):53-60.
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Phosphorylation of a novel SOCS-box regulates assembly of the HIV-1 Vif-Cul5 complex that promotes APOBEC3G degradation. Genes Dev. 2004 Dec 01; 18(23):2861-6.
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Camelized rabbit-derived VH single-domain intrabodies against Vif strongly neutralize HIV-1 infectivity. J Mol Biol. 2004 Jul 09; 340(3):525-42.
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N-linked glycosylation in the CXCR4 N-terminus inhibits binding to HIV-1 envelope glycoproteins. Virology. 2004 Jun 20; 324(1):140-50.
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Contribution of proteoglycans to human immunodeficiency virus type 1 brain invasion. J Virol. 2004 Jun; 78(12):6567-84.
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Apoptosis of bystander T cells induced by human immunodeficiency virus type 1 with increased envelope/receptor affinity and coreceptor binding site exposure. J Virol. 2004 May; 78(9):4541-51.
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Transendothelial migration of CD16+ monocytes in response to fractalkine under constitutive and inflammatory conditions. Immunobiology. 2004; 209(1-2):11-20.
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Vif overcomes the innate antiviral activity of APOBEC3G by promoting its degradation in the ubiquitin-proteasome pathway. J Biol Chem. 2004 Feb 27; 279(9):7792-8.
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Genetic and functional analysis of full-length human immunodeficiency virus type 1 env genes derived from brain and blood of patients with AIDS. J Virol. 2003 Nov; 77(22):12336-45.
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Fractalkine preferentially mediates arrest and migration of CD16+ monocytes. J Exp Med. 2003 Jun 16; 197(12):1701-7.
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CD2 engagement induces dendritic cell activation: implications for immune surveillance and T-cell activation. Blood. 2003 Sep 01; 102(5):1745-52.
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Increased CCR5 affinity and reduced CCR5/CD4 dependence of a neurovirulent primary human immunodeficiency virus type 1 isolate. J Virol. 2002 Jun; 76(12):6277-92.
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Functional neutralization of HIV-1 Vif protein by intracellular immunization inhibits reverse transcription and viral replication. J Biol Chem. 2002 Aug 30; 277(35):32036-45.
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Persistence of dual-tropic HIV-1 in an individual homozygous for the CCR5 Delta 32 allele. Lancet. 2002 May 25; 359(9320):1832-4.
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Human immunodeficiency virus type 1 neutralization measured by flow cytometric quantitation of single-round infection of primary human T cells. J Virol. 2002 May; 76(10):4810-21.
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Regulation of CC chemokine receptor 5 and CD4 expression and human immunodeficiency virus type 1 replication in human macrophages and microglia by T helper type 2 cytokines. J Infect Dis. 2002 Apr 01; 185(7):885-97.
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Macrophage tropism of human immunodeficiency virus type 1 isolates from brain and lymphoid tissues predicts neurotropism independent of coreceptor specificity. J Virol. 2001 Nov; 75(21):10073-89.
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Opposite effects of IL-10 on the ability of dendritic cells and macrophages to replicate primary CXCR4-dependent HIV-1 strains. J Immunol. 2001 Mar 15; 166(6):4244-53.
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Role of Vif in stability of the human immunodeficiency virus type 1 core. J Virol. 2000 Dec; 74(23):11055-66.
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Chemokine receptors and mechanisms of cell death in HIV neuropathogenesis. J Neurovirol. 2000 May; 6 Suppl 1:S24-32.
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Cell-dependent mechanisms restrict the HIV type 1 coreceptor activity of US28, a chemokine receptor homolog encoded by human cytomegalovirus. AIDS Res Hum Retroviruses. 2000 Jan 01; 16(1):27-35.
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Chemokine receptors and virus entry in the central nervous system. J Neurovirol. 1999 Dec; 5(6):643-58.
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Circulating CD2+ monocytes are dendritic cells. J Immunol. 1999 Dec 01; 163(11):5920-8.
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ERK MAP kinase links cytokine signals to activation of latent HIV-1 infection by stimulating a cooperative interaction of AP-1 and NF-kappaB. J Biol Chem. 1999 Sep 24; 274(39):27981-8.
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Regulation of human immunodeficiency virus type 1 infectivity by the ERK mitogen-activated protein kinase signaling pathway. J Virol. 1999 Apr; 73(4):3460-6.
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Apoptosis induced by infection of primary brain cultures with diverse human immunodeficiency virus type 1 isolates: evidence for a role of the envelope. J Virol. 1999 Feb; 73(2):897-906.
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The CXC-chemokine, H174: expression in the central nervous system. J Neurovirol. 1998 Dec; 4(6):575-85.
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Mitogen-activated protein kinase phosphorylates and regulates the HIV-1 Vif protein. J Biol Chem. 1998 Nov 06; 273(45):29879-87.
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Neuronal apoptosis induced by HIV-1 Tat protein and TNF-alpha: potentiation of neurotoxicity mediated by oxidative stress and implications for HIV-1 dementia. J Neurovirol. 1998 Jun; 4(3):281-90.
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Chemokine receptors in HIV-1 infection of the central nervous system. Semin Immunol. 1998 Jun; 10(3):203-13.
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Localization of HIV-1 co-receptors CCR5 and CXCR4 in the brain of children with AIDS. Am J Pathol. 1998 Jan; 152(1):167-78.
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Human immunodeficiency virus type 1 Vif protein binds to the Pr55Gag precursor. J Virol. 1997 Dec; 71(12):9358-65.
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Ultrastructure of HIV-1 genomic RNA. Virology. 1997 Jul 07; 233(2):271-9.
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Astrocyte apoptosis induced by HIV-1 transactivation of the c-kit protooncogene. Proc Natl Acad Sci U S A. 1997 Apr 15; 94(8):3954-9.
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CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia. Nature. 1997 Feb 13; 385(6617):645-9.
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Role of Vif in human immunodeficiency virus type 1 reverse transcription. J Virol. 1996 Dec; 70(12):8701-9.
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Apoptosis induced by HIV-1 infection of the central nervous system. J Clin Invest. 1996 Nov 01; 98(9):1979-90.
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Phosphorylation of Vif and its role in HIV-1 replication. J Biol Chem. 1996 Apr 26; 271(17):10121-9.
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Biological activity of human immunodeficiency virus type 1 Vif requires membrane targeting by C-terminal basic domains. J Virol. 1995 Nov; 69(11):7196-204.
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Essential role of vif in establishing productive HIV-1 infection in peripheral blood T lymphocytes and monocyte/macrophages. J Acquir Immune Defic Syndr (1988). 1994 Sep; 7(9):908-15.
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The intracytoplasmic domain of gp41 mediates polarized budding of human immunodeficiency virus type 1 in MDCK cells. J Virol. 1994 Aug; 68(8):4857-61.
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Role of vif during packing of the core of HIV-1. Virology. 1994 Jun; 201(2):349-55.
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Inhibition of energy metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivative. J Biol Chem. 1994 May 06; 269(18):13623-8.
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Subcellular localization of the Vif protein of human immunodeficiency virus type 1. J Virol. 1994 Feb; 68(2):704-12.
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Lentivirus infection of macrophages. Immunol Ser. 1994; 60:589-600.
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Inhibition of beta-amyloid production by activation of protein kinase C. J Neurochem. 1993 Dec; 61(6):2326-9.
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Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells. Proc Natl Acad Sci U S A. 1993 Mar 01; 90(5):2092-6.
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Role of vif in replication of human immunodeficiency virus type 1 in CD4+ T lymphocytes. J Virol. 1992 Nov; 66(11):6489-95.
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Effects of CD4 synthetic peptides on HIV type I envelope glycoprotein function. J Immunol. 1992 Sep 01; 149(5):1809-16.
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Effects of deletions in the cytoplasmic domain on biological functions of human immunodeficiency virus type 1 envelope glycoproteins. J Virol. 1992 Jun; 66(6):3306-15.
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Allelic variation in the effects of the nef gene on replication of human immunodeficiency virus type 1. Proc Natl Acad Sci U S A. 1991 Dec 01; 88(23):10971-5.
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Characterization of a discontinuous human immunodeficiency virus type 1 gp120 epitope recognized by a broadly reactive neutralizing human monoclonal antibody. J Virol. 1991 Nov; 65(11):6188-93.
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Effects of changes in gp120-CD4 binding affinity on human immunodeficiency virus type 1 envelope glycoprotein function and soluble CD4 sensitivity. J Virol. 1991 Sep; 65(9):5007-12.
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Identification of membrane anchorage domains of the HIV-1 gp160 envelope glycoprotein precursor. J Acquir Immune Defic Syndr (1988). 1991; 4(1):34-40.
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Changes in the transmembrane region of the human immunodeficiency virus type 1 gp41 envelope glycoprotein affect membrane fusion. J Virol. 1990 Dec; 64(12):6314-8.
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Cell type specific and viral regulation of visna virus gene expression. Virus Res. 1990 Jun; 16(2):175-83.
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Neurologic disorders associated with HIV infections. J Am Acad Dermatol. 1990 Jun; 22(6 Pt 2):1232-6.
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Rapid complementation assays measuring replicative potential of human immunodeficiency virus type 1 envelope glycoprotein mutants. J Virol. 1990 May; 64(5):2416-20.
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Cellular regulation of visna virus gene expression and its role in pathogenesis. Dev Biol Stand. 1990; 72:207-12.
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Regulation of the visna virus long terminal repeat in macrophages involves cellular factors that bind sequences containing AP-1 sites. Mol Cell Biol. 1989 Jun; 9(6):2728-33.
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Peripheral neuropathy in the acquired immunodeficiency syndrome. Ann Neurol. 1988 May; 23(5):485-92.
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Electroencephalography in AIDS and AIDS-related complex. Clin Electroencephalogr. 1988 Jan; 19(1):1-6.
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HIV antigen in brains of patients with AIDS. Ann Neurol. 1987 Nov; 22(5):668.
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Neurologic manifestations of infection with human immunodeficiency virus. Clinical features and pathogenesis. Ann Intern Med. 1987 Sep; 107(3):383-91.
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Fever caused by lithium in a patient with neuroleptic malignant syndrome. J Clin Psychopharmacol. 1987 Aug; 7(4):283-4.
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Immunohistochemical identification of HTLV-III antigen in brains of patients with AIDS. Ann Neurol. 1986 Sep; 20(3):289-95.
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Cerebral granulomatous angiitis associated with isolation of human T-lymphotropic virus type III from the central nervous system. Ann Neurol. 1986 Sep; 20(3):362-4.
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