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David M. Livingston, MD


Researcher

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Researcher

  • Charles A. Dana Chair in Human Cancer Genetics
  • Emil Frei III Distinguished Professor of Medicine, Harvard Medical School

Contact Information

  • Office Phone Number(617) 632-3074
  • Fax(617) 632-4381

Bio

David Livingston is Deputy Director of the Dana-Farber/Harvard Cancer Center; Chief of the Charles A. Dana Division of Human Cancer Genetics, and the Emil Frei Professor of Genetics and Medicine at Harvard Medical School. From 1996 to 2000, he served as Chairman of the Executive Committee for Research at the Dana-Farber Cancer Institute, leading the senior faculty group that oversees all aspects of the Institute's research program. He reassumed that post in 2005 and has been in it since that time. Dr. Livingston has been a Harvard faculty member continuously since 1973.Dr. Livingston received an A.B. cum laude from Harvard College in 1961, an M.D., magna cum laude, from Tufts University School of Medicine in 1965, and served his internship and residency in internal medicine at the Peter Bent Brigham Hospital in Boston (now Brigham and Women's Hospital). In 1967, he became a Research Associate at the National Cancer Institute (NCI) in molecular biology and biochemistry; he continued his work as a Research Fellow in Biological Chemistry at Harvard Medical School in 1969. Dr. Livingston returned to NCI in 1971 as a Senior Staff Fellow where he began his career in cancer research. He was recruited to Dana-Farber (then the Childrens Cancer Research Foundation) in 1973.Dr. Livingston is an internationally recognized expert on genes that regulate cell growth in the body - genes that, when they go awry, can lead to cancer. These genes are called oncogenes and tumor suppressor genes. Through his research, Dr. Livingston has uncovered detailed biochemical steps required to initiate and maintain the transformation of these cells into tumor cells. His focus is on the regulatory controls of signal transduction - the smooth and coordinated flow of special chemical signals from the surrounding environment to the cell, where it is transduced into specific commands that tell cells whether or not to grow - and their role in cancer development. In recent years, his work has centered on those key molecular steps that trigger the development of breast and ovarian cancer. Dr. Livingston is the recipient of numerous awards and honors. He has been elected to the Institute of Medicine of the National Academy of Sciences, the National Academy of Sciences, itself, and the American Academy of Arts and Sciences. He sits on multiple editorial boards, the science advisory boards of other research institutions, and is a member of the Association of American Physicians, the American Society for Clinical Investigation, the American Society for Microbiology, and the American Academy of Microbiology. He is also a Foreign Associate of the European Molecular Biology Organization and serves as Vice Chair of the Board of the Damon Runyan Cancer Research Foundation. Dr. Livingston has authored more than195 scientific publications.

Recent Awards:

  • Baxter Award for Distinguished Research in the Biomedical Sciences, AAMC 1997
  • Lila Gruber Honor Award for Cancer Research, American Academy of Dermatology 2001
  • Member, American Academy of Arts and Sciences 2001
  • AACR-G.H.A. Clowes Award 2005
  • Boveri Award for Molecular Cancer Genetics, German Cancer Society 2005

Research

Molecular Pathogenesis of Breast and Ovarian Cancer

Our laboratory is dedicated to the study of processes that, when defective, allow human cells to develop malignant characteristics. These processes are, in part, controlled by tumor suppressor loci. We continue to concentrate our efforts on a subset of these loci, all of which exert their functions in the nucleus. Some participate in the control of cell proliferation, others in the control of genome integrity, and still others in mechanisms that underlie the ability of cells to thrive in low-oxygen environments and under other stresses. Based on some unexpected results, we have extended our work over the past two years to explore the events that give stem cells of certain tissues the ability to self-renew.A fraction of our effort is dedicated to understanding the genetics of breast and ovarian cancer development. In particular, we are studying the in vivo biochemical and biological functions of four genes - BRCA1, BRCA2, BACH1, and BARD1 - which encode large nuclear proteins that interact specifically with one another. At least three and likely all four of these proteins are products of tumor suppressing loci. Together, they function as parts of large nuclear complexes that participate in the response of cells to DNA damage, and perhaps in other basic functions as well. When BRCA1, BARD1, or BRCA2 is rendered defective by germline mutation in females, tumor development develops at higher than normal frequencies in the breast and the ovary. A major segment of our ongoing work is aimed at trying to understand how, in biochemical terms, BRCA1 and BRCA2 perform their tumor suppressing effects and why, in the case of BRCA1, these effects are detected in the cells of women but not men.

BRCA1 binds TERRA RNA and suppresses R-Loop-based telomeric DNA damage. Nat Commun. 2021 06 10; 12(1):3542.
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BRCA1 and RNAi factors promote repair mediated by small RNAs and PALB2-RAD52. Nature. 2021 Mar; 591(7851):665-670.
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Opening a Door to PARP Inhibitor-Induced Lethality in HR-Proficient Human Tumor Cells. Cancer Cell. 2020 02 10; 37(2):139-140.
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RAP80 and BRCA1 PARsylation protect chromosome integrity by preventing retention of BRCA1-B/C complexes in DNA repair foci. Proc Natl Acad Sci U S A. 2020 01 28; 117(4):2084-2091.
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Inadequate DNA Damage Repair Promotes Mammary Transdifferentiation, Leading to BRCA1 Breast Cancer. Cell. 2019 06 27; 178(1):135-151.e19.
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BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1a activation. Proc Natl Acad Sci U S A. 2018 10 09; 115(41):E9600-E9609.
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Trauma-Induced Acute X Chromosome Skewing in White Blood Cells Represents an Immuno-Modulatory Mechanism Unique to Females and a Likely Contributor to Sex-Based Outcome Differences. Shock. 2017 04; 47(4):402-408.
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Two familial ALS proteins function in prevention/repair of transcription-associated DNA damage. Proc Natl Acad Sci U S A. 2016 11 29; 113(48):E7701-E7709.
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Establishment of Patient-Derived Tumor Xenograft Models of Epithelial Ovarian Cancer for Preclinical Evaluation of Novel Therapeutics. Clin Cancer Res. 2017 Mar 01; 23(5):1263-1273.
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BRCA1/FANCD2/BRG1-Driven DNA Repair Stabilizes the Differentiation State of Human Mammary Epithelial Cells. Mol Cell. 2016 07 21; 63(2):277-292.
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Injury in the aged: Geriatric trauma care at the crossroads. J Trauma Acute Care Surg. 2015 Jun; 78(6):1197-209.
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26th Pezcoller symposium: cancers driven by hormones. Cancer Res. 2015 Apr 01; 75(7):1177-80.
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BRCA1 recruitment to transcriptional pause sites is required for R-loop-driven DNA damage repair. Mol Cell. 2015 Feb 19; 57(4):636-647.
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Papillomavirus E7 oncoproteins share functions with polyomavirus small T antigens. J Virol. 2015 Mar; 89(5):2857-65.
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An in-tumor genetic screen reveals that the BET bromodomain protein, BRD4, is a potential therapeutic target in ovarian carcinoma. Proc Natl Acad Sci U S A. 2015 Jan 06; 112(1):232-7.
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BRCA1 haploinsufficiency for replication stress suppression in primary cells. Nat Commun. 2014 Nov 17; 5:5496.
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PARP1-driven poly-ADP-ribosylation regulates BRCA1 function in homologous recombination-mediated DNA repair. Cancer Discov. 2014 Dec; 4(12):1430-47.
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SMCX and components of the TIP60 complex contribute to E2 regulation of the HPV E6/E7 promoter. Virology. 2014 Nov; 468-470:311-321.
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Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage. Genes Dev. 2014 Sep 01; 28(17):1957-75.
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BRCA1 pathway function in basal-like breast cancer cells. Mol Cell Biol. 2014 Oct; 34(20):3828-42.
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Polyoma small T antigen triggers cell death via mitotic catastrophe. Oncogene. 2015 May 07; 34(19):2483-92.
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PP2A-mediated regulation of Ras signaling in G2 is essential for stable quiescence and normal G1 length. Mol Cell. 2014 Jun 19; 54(6):932-45.
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Physiological modulation of endogenous BRCA1 p220 abundance suppresses DNA damage during the cell cycle. Genes Dev. 2013 Oct 15; 27(20):2274-91.
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Twenty-fifth annual Pezcoller Symposium: Metabolism and tumorigenesis. Cancer Res. 2013 Oct 15; 73(20):6124-7.
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Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer. Proc Natl Acad Sci U S A. 2013 May 21; 110(21):8632-7.
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Twenty-fourth annual Pezcoller symposium: Molecular basis for resistance to targeted agents. Cancer Res. 2013 Feb 01; 73(3):1046-9.
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Is low-molecular-weight heparin safe for venous thromboembolism prophylaxis in patients with traumatic brain injury? A Western Trauma Association multicenter study. J Trauma Acute Care Surg. 2012 Sep; 73(3):625-8.
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Proteomic identification of a direct role for cyclin d1 in DNA damage repair. Cancer Res. 2012 Sep 01; 72(17):4289-93.
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Mechanisms of BRCA1 tumor suppression. Cancer Discov. 2012 Aug; 2(8):679-84.
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Polyubiquitinated PCNA recruits the ZRANB3 translocase to maintain genomic integrity after replication stress. Mol Cell. 2012 Aug 10; 47(3):396-409.
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The temporal course of intracranial haemorrhage progression: how long is observation necessary? Injury. 2012 Dec; 43(12):2122-5.
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Twenty-third annual Pezcoller Symposium: engineering influences in cancer research. Cancer Res. 2012 Feb 15; 72(4):841-4.
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BRCA1 is required for postreplication repair after UV-induced DNA damage. Mol Cell. 2011 Oct 21; 44(2):235-51.
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A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers. Nature. 2011 Jun 08; 474(7350):230-4.
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Crebbp haploinsufficiency in mice alters the bone marrow microenvironment, leading to loss of stem cells and excessive myelopoiesis. Blood. 2011 Jul 07; 118(1):69-79.
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RAP80-directed tuning of BRCA1 homologous recombination function at ionizing radiation-induced nuclear foci. Genes Dev. 2011 Apr 01; 25(7):685-700.
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DICER1 mutations in familial multinodular goiter with and without ovarian Sertoli-Leydig cell tumors. JAMA. 2011 Jan 05; 305(1):68-77.
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Twenty-second annual Pezcoller Symposium: RNA biology and cancer. Cancer Res. 2010 Dec 15; 70(24):10034-7.
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Centrosomal protein of 192 kDa (Cep192) promotes centrosome-driven spindle assembly by engaging in organelle-specific Aurora A activation. Proc Natl Acad Sci U S A. 2010 Dec 07; 107(49):21022-7.
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BRCA1 and BRCA2: breast/ovarian cancer susceptibility gene products and participants in DNA double-strand break repair. Carcinogenesis. 2010 Jun; 31(6):961-7.
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An activated ErbB3/NRG1 autocrine loop supports in vivo proliferation in ovarian cancer cells. Cancer Cell. 2010 Mar 16; 17(3):298-310.
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Twenty-first annual Pezcoller Symposium: Unconventional Therapeutic Targets in Cancer. Cancer Res. 2010 Jan 01; 70(1):14-7.
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Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1. Nature. 2009 Nov 05; 462(7269):108-12.
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Cancer. Complicated supercomplexes. Science. 2009 May 01; 324(5927):602-3.
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X chromosome inactivation in the absence of Dicer. Proc Natl Acad Sci U S A. 2009 Jan 27; 106(4):1122-7.
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Small DNA tumor viruses: large contributors to biomedical sciences. Virology. 2009 Feb 20; 384(2):256-9.
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Penetrance analysis of the PALB2 c.1592delT founder mutation. Clin Cancer Res. 2008 Jul 15; 14(14):4667-71.
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Spinal injuries in pedestrians struck by motor vehicles. J Spinal Disord Tech. 2008 Jun; 21(4):281-7.
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Cancer: crossing over to drug resistance. Nature. 2008 Feb 28; 451(7182):1066-7.
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Network modeling links breast cancer susceptibility and centrosome dysfunction. Nat Genet. 2007 Nov; 39(11):1338-49.
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Effect of an educational video on emergency department patient stroke knowledge. J Emerg Med. 2008 Feb; 34(2):215-20.
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p21 transcription is regulated by differential localization of histone H2A.Z. Genes Dev. 2007 Aug 01; 21(15):1869-81.
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The disappearing Barr body in breast and ovarian cancers. Nat Rev Cancer. 2007 08; 7(8):628-33.
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RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites. Science. 2007 May 25; 316(5828):1198-202.
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Analysis of PALB2/FANCN-associated breast cancer families. Proc Natl Acad Sci U S A. 2007 Apr 17; 104(16):6788-93.
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Further evidence for BRCA1 communication with the inactive X chromosome. Cell. 2007 Mar 09; 128(5):991-1002.
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A recurrent mutation in PALB2 in Finnish cancer families. Nature. 2007 Mar 15; 446(7133):316-9.
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Fanconi anemia is associated with a defect in the BRCA2 partner PALB2. Nat Genet. 2007 Feb; 39(2):159-61.
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The BRCA1/BARD1 heterodimer modulates ran-dependent mitotic spindle assembly. Cell. 2006 Nov 03; 127(3):539-52.
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A prospective evaluation of the value of repeat cranial computed tomography in patients with minimal head injury and an intracranial bleed. J Trauma. 2006 Oct; 61(4):862-7.
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Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2. Mol Cell. 2006 Jun 23; 22(6):719-729.
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X chromosomal abnormalities in basal-like human breast cancer. Cancer Cell. 2006 Feb; 9(2):121-32.
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Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes. Genes Dev. 2006 Jan 01; 20(1):34-46.
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Aberrant T cell differentiation in the absence of Dicer. J Exp Med. 2005 Jul 18; 202(2):261-9.
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Promoter usage of BRCA1-IRIS. Nat Cell Biol. 2005 Apr; 7(4):326.
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p400 is required for E1A to promote apoptosis. J Biol Chem. 2005 Jun 10; 280(23):21915-23.
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Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing. Genes Dev. 2005 Feb 15; 19(4):489-501.
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The p400 E1A-associated protein is a novel component of the p53 --> p21 senescence pathway. Genes Dev. 2005 Jan 15; 19(2):196-201.
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Abnormalities of the inactive X chromosome are a common feature of BRCA1 mutant and sporadic basal-like breast cancer. Cold Spring Harb Symp Quant Biol. 2005; 70:93-7.
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Identification of BRCA1-IRIS, a BRCA1 locus product. Nat Cell Biol. 2004 Oct; 6(10):954-67.
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Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway. Cancer Cell. 2004 Jul; 6(1):33-43.
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SV40 T antigen interacts with Nbs1 to disrupt DNA replication control. Genes Dev. 2004 Jun 01; 18(11):1305-16.
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E2F-dependent histone acetylation and recruitment of the Tip60 acetyltransferase complex to chromatin in late G1. Mol Cell Biol. 2004 May; 24(10):4546-56.
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The BRCA1-associated protein BACH1 is a DNA helicase targeted by clinically relevant inactivating mutations. Proc Natl Acad Sci U S A. 2004 Feb 24; 101(8):2357-62.
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EMSY, a BRCA-2 partner in crime. Nat Med. 2004 Feb; 10(2):127-8.
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Association of BRCA1 with the inactive X chromosome and XIST RNA. Philos Trans R Soc Lond B Biol Sci. 2004 Jan 29; 359(1441):123-8.
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Trauma from tire and rim explosions: A retrospective analysis. J Oral Maxillofac Surg. 2004 Jan; 62(1):36-8.
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Novel consensus DNA-binding sequence for BRCA1 protein complexes. Mol Carcinog. 2003 Oct; 38(2):85-96.
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Active localization of the retinoblastoma protein in chromatin and its response to S phase DNA damage. Mol Cell. 2003 Sep; 12(3):735-46.
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MYC recruits the TIP60 histone acetyltransferase complex to chromatin. . 2003 Jun; 4(6):575-80.
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Polyubiquitination of p53 by a ubiquitin ligase activity of p300. Science. 2003 Apr 11; 300(5617):342-4.
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Delayed differentiation of HL-60 cells following exposure to hypoxia. J Surg Res. 2002 Dec; 108(2):243-9.
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BRCA1 supports XIST RNA concentration on the inactive X chromosome. Cell. 2002 Nov 01; 111(3):393-405.
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Distinct roles for CREB-binding protein and p300 in hematopoietic stem cell self-renewal. Proc Natl Acad Sci U S A. 2002 Nov 12; 99(23):14789-94.
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Two different E2F6 proteins generated by alternative splicing and internal translation initiation. Eur J Biochem. 2002 Oct; 269(20):5030-6.
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Homeotic transformations of the axial skeleton that accompany a targeted deletion of E2f6. . 2002 Jul; 3(7):695-700.
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Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX. Proc Natl Acad Sci U S A. 2002 Jun 11; 99(12):8173-8.
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A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells. Science. 2002 May 10; 296(5570):1132-6.
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Tumor suppression by a severely truncated species of retinoblastoma protein. Mol Cell Biol. 2002 May; 22(9):3103-10.
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Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha. Proc Natl Acad Sci U S A. 2002 Apr 16; 99(8):5367-72.
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Intrapancreatic bile duct injury: case report. J Trauma. 2002 Apr; 52(4):786-8.
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Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure. Genes Dev. 2002 Mar 01; 16(5):583-93.
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Induction of hypoxia-inducible factor-1alpha and activation of caspase-3 in hypoxia-reoxygenated bone marrow stroma is negatively regulated by the delayed production of substance P. J Immunol. 2001 Oct 15; 167(8):4600-8.
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Functional communication between endogenous BRCA1 and its partner, BARD1, during Xenopus laevis development. Proc Natl Acad Sci U S A. 2001 Oct 09; 98(21):12078-83.
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The p400 complex is an essential E1A transformation target. Cell. 2001 Aug 10; 106(3):297-307.
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Trauma inhibits erythroid burst-forming unit and granulocyte-monocyte colony-forming unit growth through the production of TGF-beta1 by bone marrow stroma. Ann Surg. 2001 Aug; 234(2):224-32.
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Self-excising retroviral vectors encoding the Cre recombinase overcome Cre-mediated cellular toxicity. Mol Cell. 2001 Jul; 8(1):233-43.
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Rescue of a telomere length defect of Nijmegen breakage syndrome cells requires NBS and telomerase catalytic subunit. Curr Biol. 2001 Jun 26; 11(12):962-6.
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Role of T-bet in commitment of TH1 cells before IL-12-dependent selection. Science. 2001 Jun 08; 292(5523):1907-10.
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BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function. Cell. 2001 Apr 06; 105(1):149-60.
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Cancer: Chromosome defects in the colon. Nature. 2001 Mar 29; 410(6828):536-7.
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p19ARF targets certain E2F species for degradation. Proc Natl Acad Sci U S A. 2001 Apr 10; 98(8):4455-60.
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Toward mechanism-based cancer care. JAMA. 2001 Feb 07; 285(5):588-93.
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E2F4 is exported from the nucleus in a CRM1-dependent manner. Mol Cell Biol. 2001 Feb; 21(4):1384-92.
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Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress. Genes Dev. 2000 Dec 01; 14(23):2989-3002.
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Suppression of tumor growth through disruption of hypoxia-inducible transcription. Nat Med. 2000 Dec; 6(12):1335-40.
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In search of the tumour-suppressor functions of BRCA1 and BRCA2. Nature. 2000 Nov 23; 408(6811):429-32.
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p300 interacts with the nuclear proto-oncoprotein SYT as part of the active control of cell adhesion. Cell. 2000 Sep 15; 102(6):839-48.
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E2F4 and E2F5 play an essential role in pocket protein-mediated G1 control. Mol Cell. 2000 Sep; 6(3):729-35.
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The impact of lagging strand replication mutations on the stability of CAG repeat tracts in yeast. Genetics. 2000 Aug; 155(4):1657-65.
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Independence of R/M/N focus formation and the presence of intact BRCA1. Science. 2000 Jul 07; 289(5476):11.
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ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response. Nature. 2000 May 25; 405(6785):477-82.
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Eleventh annual Pezcoller Symposium: molecular horizons in cancer therapeutics. Cancer Res. 2000 Feb 01; 60(3):768-73.
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Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP. Genes Dev. 2000 Feb 01; 14(3):272-7.
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Interactions of the Nijmegen breakage syndrome protein with ATM and BRCA1. Cold Spring Harb Symp Quant Biol. 2000; 65:535-45.
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Genetic analysis of BRCA1 function in a defined tumor cell line. Mol Cell. 1999 Dec; 4(6):1093-9.
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Molecular cloning and chromosomal localization of the human CITED2 gene encoding p35srj/Mrg1. Genomics. 1999 Nov 01; 61(3):307-13.
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A core activity associated with the N terminus of the yeast RAD52 protein is revealed by RAD51 overexpression suppression of C-terminal rad52 truncation alleles. Genetics. 1999 Oct; 153(2):681-92.
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The effect of DNA replication mutations on CAG tract stability in yeast. Genetics. 1999 Jul; 152(3):953-63.
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BRCA1, BRCA2, and Rad51 operate in a common DNA damage response pathway. Cancer Res. 1999 Apr 01; 59(7 Suppl):1752s-1756s.
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Regulation of endogenous E2F1 stability by the retinoblastoma family proteins. Proc Natl Acad Sci U S A. 1999 Mar 16; 96(6):2858-63.
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Localization of human BRCA1 and its loss in high-grade, non-inherited breast carcinomas. Nat Genet. 1999 Feb; 21(2):236-40.
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Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1. Genes Dev. 1999 Jan 01; 13(1):64-75.
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Endogenous E2F-1 promotes timely G0 exit of resting mouse embryo fibroblasts. Proc Natl Acad Sci U S A. 1998 Dec 22; 95(26):15583-6.
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p300/MDM2 complexes participate in MDM2-mediated p53 degradation. Mol Cell. 1998 Oct; 2(4):405-15.
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Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells. Mol Cell. 1998 Sep; 2(3):317-28.
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Unusual proliferation arrest and transcriptional control properties of a newly discovered E2F family member, E2F-6. Proc Natl Acad Sci U S A. 1998 Aug 04; 95(16):9190-5.
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Mapping the polarity of changes that occur in interrupted CAG repeat tracts in yeast. Mol Cell Biol. 1998 Aug; 18(8):4597-604.
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Distinct roles of the co-activators p300 and CBP in retinoic-acid-induced F9-cell differentiation. Nature. 1998 May 21; 393(6682):284-9.
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Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300. Cell. 1998 May 01; 93(3):361-72.
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A specific, nonproliferative role for E2F-5 in choroid plexus function revealed by gene targeting. Genes Dev. 1998 Apr 15; 12(8):1092-8.
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The effect of a suppressed rad52 mutation on the suppression of rad6 by srs2. Yeast. 1997 Sep 15; 13(11):1059-64.
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Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage. Cell. 1997 Aug 08; 90(3):425-35.
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Cold-sensitive rad52 alleles of yeast. Curr Genet. 1997 Aug; 32(2):100-7.
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Binding and modulation of p53 by p300/CBP coactivators. Nature. 1997 Jun 19; 387(6635):823-7.
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BRCA1 is a component of the RNA polymerase II holoenzyme. Proc Natl Acad Sci U S A. 1997 May 27; 94(11):5605-10.
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Genetics is coming to oncology. JAMA. 1997 May 14; 277(18):1476-7.
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The subcellular localization of E2F-4 is cell-cycle dependent. Proc Natl Acad Sci U S A. 1997 May 13; 94(10):5095-100.
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Cancer genetics and tumor suppressor genes. Sponsored by Cold Spring Harbor Laboratory--August 14-18, 1996. Biochim Biophys Acta. 1997 Apr 18; 1332(2):R25-31.
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Destabilization of CAG trinucleotide repeat tracts by mismatch repair mutations in yeast. Hum Mol Genet. 1997 Mar; 6(3):349-55.
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Severity and mortality of experimental pancreatitis are dependent on interleukin-1 converting enzyme (ICE). J Interferon Cytokine Res. 1997 Feb; 17(2):113-8.
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Erythropoietin gene regulation depends on heme-dependent oxygen sensing and assembly of interacting transcription factors. Kidney Int. 1997 Feb; 51(2):548-52.
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Association of BRCA1 with Rad51 in mitotic and meiotic cells. Cell. 1997 Jan 24; 88(2):265-75.
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p300 family members associate with the carboxyl terminus of simian virus 40 large tumor antigen. J Virol. 1997 Jan; 71(1):129-37.
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Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit. J Biol Chem. 1996 Dec 13; 271(50):32253-9.
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Orientation dependence of trinucleotide CAG repeat instability in Saccharomyces cerevisiae. Mol Cell Biol. 1996 Dec; 16(12):6617-22.
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The retinoblastoma gene product protects E2F-1 from degradation by the ubiquitin-proteasome pathway. Genes Dev. 1996 Dec 01; 10(23):2949-59.
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An essential role for p300/CBP in the cellular response to hypoxia. Proc Natl Acad Sci U S A. 1996 Nov 12; 93(23):12969-73.
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Interaction and functional collaboration of p300/CBP and bHLH proteins in muscle and B-cell differentiation. Genes Dev. 1996 Oct 01; 10(19):2478-90.
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The nuclear hormone receptor coactivator SRC-1 is a specific target of p300. Proc Natl Acad Sci U S A. 1996 Oct 01; 93(20):10626-31.
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Cooperation of Stat2 and p300/CBP in signalling induced by interferon-alpha. Nature. 1996 Sep 26; 383(6598):344-7.
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Association of p300 and CBP with simian virus 40 large T antigen. Mol Cell Biol. 1996 Jul; 16(7):3454-64.
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E2F-1 functions in mice to promote apoptosis and suppress proliferation. Cell. 1996 May 17; 85(4):549-61.
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Regulation of the retinoblastoma protein-related protein p107 by G1 cyclin-associated kinases. Proc Natl Acad Sci U S A. 1996 May 14; 93(10):4633-7.
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Location of BRCA1 in human breast and ovarian cancer cells. Science. 1996 Apr 05; 272(5258):123-6.
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Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit. Genes Dev. 1996 Apr 01; 10(7):851-61.
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Cancer genes: functional aspects. Meeting report. Biochim Biophys Acta. 1996 Mar 18; 1242(3):211-6.
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Cyclin A-kinase regulation of E2F-1 DNA binding function underlies suppression of an S phase checkpoint. Cell. 1995 Dec 29; 83(7):1149-58.
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Localization of human CREB-binding protein gene (CREBBP) to 16p13.2-p13.3 by fluorescence in situ hybridization. Genomics. 1995 Nov 20; 30(2):395-6.
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GSG1, a yeast gene required for sporulation. Yeast. 1995 Sep 30; 11(12):1147-55.
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The complexity of the interaction between RAD52 and SRS2. Genetics. 1995 Aug; 140(4):1441-2.
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Phosphorylation of the adenovirus E1A-associated 300 kDa protein in response to retinoic acid and E1A during the differentiation of F9 cells. EMBO J. 1995 Jul 17; 14(14):3496-509.
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Interaction between the retinoblastoma protein and the oncoprotein MDM2. Nature. 1995 Jun 22; 375(6533):694-8.
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Involvement of the cell-cycle inhibitor Cip1/WAF1 and the E1A-associated p300 protein in terminal differentiation. Proc Natl Acad Sci U S A. 1995 Jun 06; 92(12):5451-5.
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Relief of YY1 transcriptional repression by adenovirus E1A is mediated by E1A-associated protein p300. Genes Dev. 1995 May 15; 9(10):1188-98.
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Functional interaction between E2F-4 and p130: evidence for distinct mechanisms underlying growth suppression by different retinoblastoma protein family members. Genes Dev. 1995 Apr 01; 9(7):869-81.
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A family of transcriptional adaptor proteins targeted by the E1A oncoprotein. Nature. 1995 Mar 02; 374(6517):81-4.
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Multiple members of the E2F transcription factor family are the products of oncogenes. Proc Natl Acad Sci U S A. 1995 Feb 28; 92(5):1357-61.
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The transcription factor E2F-1 is a downstream target of RB action. Mol Cell Biol. 1995 Feb; 15(2):742-55.
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E2F-4, a new member of the E2F transcription factor family, interacts with p107. Genes Dev. 1994 Nov 15; 8(22):2665-79.
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Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis. Proc Natl Acad Sci U S A. 1994 Nov 08; 91(23):10918-22.
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Spinocerebellar ataxia type 5 in a family descended from the grandparents of President Lincoln maps to chromosome 11. Nat Genet. 1994 Nov; 8(3):280-4.
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Transrepression of RNA polymerase II promoters by the simian virus 40 small t antigen. J Virol. 1994 Oct; 68(10):6180-7.
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Saccharomyces cerevisiae RAD52 alleles temperature-sensitive for the repair of DNA double-strand breaks. Genetics. 1994 Aug; 137(4):933-44.
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Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase. Cell. 1994 Jul 15; 78(1):161-72.
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E1A-associated p300 and CREB-associated CBP belong to a conserved family of coactivators. Cell. 1994 Jun 17; 77(6):799-800.
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Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor. Genes Dev. 1994 Apr 15; 8(8):869-84.
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The adenovirus E1A-associated 300-kD protein exhibits properties of a transcriptional coactivator and belongs to an evolutionarily conserved family. Cold Spring Harb Symp Quant Biol. 1994; 59:85-95.
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Binding to DNA and the retinoblastoma gene product promoted by complex formation of different E2F family members. Science. 1993 Dec 03; 262(5139):1557-60.
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Cloning, sequencing, and expression of the Pseudomonas putida protocatechuate 3,4-dioxygenase genes. J Bacteriol. 1993 Oct; 175(19):6194-202.
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TGF beta inhibition of Cdk4 synthesis is linked to cell cycle arrest. Cell. 1993 Sep 24; 74(6):1009-20.
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Structural and functional contributions to the G1 blocking action of the retinoblastoma protein. (the 1992 Gordon Hamilton Fairley Memorial Lecture). Br J Cancer. 1993 Aug; 68(2):264-8.
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Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein. Genes Dev. 1993 Jul; 7(7A):1111-25.
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Cell cycle analysis of E2F in primary human T cells reveals novel E2F complexes and biochemically distinct forms of free E2F. Mol Cell Biol. 1993 Jul; 13(7):3975-83.
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Functional interactions of the retinoblastoma protein with mammalian D-type cyclins. Cell. 1993 May 07; 73(3):487-97.
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Specific enzymatic dephosphorylation of the retinoblastoma protein. Mol Cell Biol. 1993 Jan; 13(1):367-72.
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Identification of a growth suppression domain within the retinoblastoma gene product. Genes Dev. 1992 Jun; 6(6):953-64.
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Third annual Pezcoller symposium: tumor suppressor genes. Cancer Res. 1992 Jun 01; 52(11):3246-9.
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The retinoblastoma-susceptibility gene product becomes phosphorylated in multiple stages during cell cycle entry and progression. Proc Natl Acad Sci U S A. 1992 Mar 01; 89(5):1795-8.
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Saccharomyces cerevisiae elongation factor 2. Genetic cloning, characterization of expression, and G-domain modeling. J Biol Chem. 1992 Jan 15; 267(2):1190-7.
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The transcription factor E2F interacts with the retinoblastoma product and a p107-cyclin A complex in a cell cycle-regulated manner. Cell. 1992 Jan 10; 68(1):157-66.
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Interaction of p107 with cyclin A independent of complex formation with viral oncoproteins. Science. 1992 Jan 03; 255(5040):85-7.
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Interaction between human cyclin A and adenovirus E1A-associated p107 protein. Science. 1992 Jan 03; 255(5040):87-90.
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Functional analysis of the retinoblastoma gene product and of RB-SV40 T antigen complexes. Cancer Surv. 1992; 12:153-60.
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The T/t common region of simian virus 40 large T antigen contains a distinct transformation-governing sequence. J Virol. 1991 Oct; 65(10):5647-52.
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Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein. Cell. 1991 Sep 20; 66(6):1155-64.
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The T/E1A-binding domain of the retinoblastoma product can interact selectively with a sequence-specific DNA-binding protein. Cell. 1991 Jun 14; 65(6):1073-82.
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Effects of controlled RAD52 expression on repair and recombination in Saccharomyces cerevisiae. Mol Cell Biol. 1991 Apr; 11(4):2013-7.
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Lack of SV40 DNA in tumors from scientists working with SV40 virus. N Engl J Med. 1991 Feb 14; 324(7):494.
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Identification of cellular proteins that can interact specifically with the T/E1A-binding region of the retinoblastoma gene product. Cell. 1991 Feb 08; 64(3):521-32.
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Control of junB and extracellular matrix protein expression by transforming growth factor-beta 1 is independent of simian virus 40 T antigen-sensitive growth-sensitive growth-inhibitory events. Mol Cell Biol. 1991 Feb; 11(2):972-8.
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RB associates with an E2F-like, sequence-specific DNA-binding protein. Cold Spring Harb Symp Quant Biol. 1991; 56:187-95.
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Simian virus 40 small tumor antigen and an amino-terminal domain of large tumor antigen share a common transforming function. Proc Natl Acad Sci U S A. 1990 Oct; 87(19):7448-52.
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Growth inhibition by TGF-beta linked to suppression of retinoblastoma protein phosphorylation. Cell. 1990 Jul 13; 62(1):175-85.
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Definition of the minimal simian virus 40 large T antigen- and adenovirus E1A-binding domain in the retinoblastoma gene product. Mol Cell Biol. 1990 Jul; 10(7):3761-9.
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Expression and state of phosphorylation of the retinoblastoma susceptibility gene product in cycling and noncycling human hematopoietic cells. Proc Natl Acad Sci U S A. 1990 Apr; 87(7):2770-4.
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The retinoblastoma susceptibility gene product undergoes cell cycle-dependent dephosphorylation and binding to and release from SV40 large T. Cell. 1990 Feb 09; 60(3):387-96.
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The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element. Cell. 1989 Sep 22; 58(6):1085-95.
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An N-terminal transformation-governing sequence of SV40 large T antigen contributes to the binding of both p110Rb and a second cellular protein, p120. Cell. 1989 Jul 28; 58(2):257-67.
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SV40 large T antigen binds preferentially to an underphosphorylated member of the retinoblastoma susceptibility gene product family. Cell. 1989 Jan 13; 56(1):57-65.
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Does the product of the RB-1 locus have a cell cycle regulatory function? Princess Takamatsu Symp. 1989; 20:187-90.
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trans-activation of RNA polymerase II and III promoters by SV40 small t antigen. Cell. 1988 Dec 23; 55(6):1171-7.
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Expression of diphtheria toxin fragment A and hormone-toxin fusion proteins in toxin-resistant yeast mutants. Proc Natl Acad Sci U S A. 1988 Nov; 85(22):8386-90.
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Asparaginase II of Saccharomyces cerevisiae. Characterization of the ASP3 gene. J Biol Chem. 1988 Aug 25; 263(24):11948-53.
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Purification and functional properties of simian virus 40 large and small T antigens overproduced in insect cells. J Virol. 1988 Aug; 62(8):2951-9.
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SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene. Cell. 1988 Jul 15; 54(2):275-83.
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Effect of limited homology on gene conversion in a Saccharomyces cerevisiae plasmid recombination system. Mol Cell Biol. 1988 Jun; 8(6):2442-8.
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Stringent regulation of stably integrated chloramphenicol acetyl transferase genes by E. coli lac repressor in monkey cells. Cell. 1988 Mar 11; 52(5):713-22.
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Expression of abnormal von Willebrand factor by endothelial cells from a patient with type IIA von Willebrand disease. Proc Natl Acad Sci U S A. 1987 Sep; 84(18):6550-4.
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Molecular cloning of the human gene for von Willebrand factor and identification of the transcription initiation site. Proc Natl Acad Sci U S A. 1987 Jul; 84(13):4393-7.
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George Khoury (1943-1987). Cell. 1987 Jun 05; 49(5):577.
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lac repressor can regulate expression from a hybrid SV40 early promoter containing a lac operator in animal cells. Cell. 1987 Jun 05; 49(5):603-12.
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Consensus topography in the ATP binding site of the simian virus 40 and polyomavirus large tumor antigens. Proc Natl Acad Sci U S A. 1987 Jun; 84(12):4026-30.
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The simian virus 40 large T antigen. A lot packed into a little. Mol Biol Med. 1987 Apr; 4(2):63-80.
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SV40 small t antigen enhances the transformation activity of limiting concentrations of SV40 large T antigen. Cell. 1987 Jan 30; 48(2):321-30.
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Mitotic gene conversion lengths, coconversion patterns, and the incidence of reciprocal recombination in a Saccharomyces cerevisiae plasmid system. Mol Cell Biol. 1986 Nov; 6(11):3685-93.
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A recombinant murine retrovirus for simian virus 40 large T cDNA transforms mouse fibroblasts to anchorage-independent growth. J Virol. 1986 Oct; 60(1):290-3.
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Cellular proteins which can specifically associate with simian virus 40 small t antigen. J Virol. 1986 Sep; 59(3):692-702.
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Accumulation of single strand interruptions within the yeast 2 microns DNA plasmid during replication in a DNA ligase mutant. Mol Gen Genet. 1986 Jun; 203(3):406-9.
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The t-unique coding domain is important to the transformation maintenance function of the simian virus 40 small t antigen. Mol Cell Biol. 1986 Apr; 6(4):1172-8.
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Diphtheria toxin-resistant mutants of Saccharomyces cerevisiae. Mol Cell Biol. 1985 Dec; 5(12):3357-60.
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Formation of a cruciform structure at the simian virus 40 replication origin abolishes T-antigen binding to the origin in vitro. J Virol. 1985 Oct; 56(1):293-7.
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Molecular cloning of cDNA for human von Willebrand factor: authentication by a new method. Cell. 1985 May; 41(1):49-56.
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Specific in vitro adenylylation of the simian virus 40 large tumor antigen. Proc Natl Acad Sci U S A. 1984 Nov; 81(21):6574-8.
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Localization of the simian virus 40 small t antigen in the nucleus and cytoplasm of monkey and mouse cells. J Virol. 1984 May; 50(2):623-8.
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Subunit composition of oligomeric human von Willebrand factor. J Biol Chem. 1983 Nov 10; 258(21):12757-60.
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Effect of a stem-loop structure within the SV40 replication origin upon SV40 T antigen binding to origin region sequences. Cell. 1983 Sep; 34(2):629-39.
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Binding of simian virus 40 large T antigen from virus-infected monkey cells to wild-type and mutant viral replication origins. J Mol Biol. 1983 Aug 25; 168(4):791-808.
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Biosynthesis of the subunits of factor VIIIR by bovine aortic endothelial cells. Proc Natl Acad Sci U S A. 1983 May; 80(9):2738-42.
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Purification of biologically active simian virus 40 small tumor antigen. Proc Natl Acad Sci U S A. 1983 Feb; 80(4):906-10.
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A sequence of the yeast 2 micron DNA plasmid chromosome near the origin of replication is exposed to restriction endonuclease digestion. J Mol Biol. 1982 Sep 25; 160(3):397-410.
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Role of small t antigen in the acute transforming activity of SV40. Cell. 1982 Sep; 30(2):469-80.
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Binding of an analog of the simian virus 40 T antigen to wild-type and mutant viral replication origins. J Mol Biol. 1982 May 25; 157(3):473-92.
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Saccharomyces cerevisiae spheroplasts are sensitive to the action of diphtheria toxin. Mol Cell Biol. 1982 May; 2(5):588-92.
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Relationship of oligomerization to enzymatic and DNA-binding properties of the SV40 large T antigen. Cell. 1982 Jan; 28(1):125-34.
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T antigen repression of SV40 early transcription from two promoters. Cell. 1981 Dec; 27(3 Pt 2):603-13.
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Rapid and sensitive quantitative immunoassay for the large simian virus 40 T antigen. J Virol. 1981 May; 38(2):612-20.
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Cysteine auxotrophy of human leukemic lymphoblasts is associated with decreased amounts of intracellular cystathionase protein. Biochemistry. 1981 Mar 03; 20(5):1306-11.
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Characterization of the transmission during cytoductant formation of the 2 micrometers DNA plasmid from Saccharomyces. Mol Gen Genet. 1981; 183(1):59-65.
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Identification and initial characterization of a new low-molecular-weight virus-encoded T antigen in a line of simian virus 40-transformed cells. J Virol. 1980 Nov; 36(2):488-98.
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Mapping of SV40 DNA replication origin region binding sites for the SV40 T antigen by protection against exonuclease III digestion. Cell. 1980 Jun; 20(2):411-22.
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Intracellular neutralization of SV40 tumor antigens following microinjection of specific antibody. Cell. 1980 Mar; 19(3):627-35.
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Enzymatic activities associated with the SV40 large T antigen. Cold Spring Harb Symp Quant Biol. 1980; 44 Pt 1,:113-22.
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Synthesis of simian virus 40 t antigen in Escherichia coli. Proc Natl Acad Sci U S A. 1979 Nov; 76(11):5596-600.
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Protein kinase activity associated with simian virus 40 T antigen. Proc Natl Acad Sci U S A. 1979 Jun; 76(6):2610-4.
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Relationship between T-antigen and tumor-specific transplantation antigen in simian virus 40-transformed cells. J Virol. 1979 Jan; 29(1):69-75.
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Immunologic analyses of mouse cystathionase in normal and leukemic cells. Biochemistry. 1978 Nov 28; 17(24):5181-7.
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Phenotypic complementation of the SV40 tsA mutant defect in viral DNA synthesis following microinjection of SV40 T antigen. Cell. 1978 Aug; 14(4):983-94.
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Measurements of the molecular size of the simian virus 40 large T antigen. J Virol. 1978 Jul; 27(1):218-26.
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Characterization of a unique cell line (LAZ 221) from human acute lymphocytic ("null" cell) leukemia. Cancer Res. 1978 May; 38(5):1362-7.
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Purification and subunit structure of mouse liver cystathionase. Arch Biochem Biophys. 1978 Feb; 186(1):168-74.
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Interaction of Simian Virus 40 chromatin with Simian Virus 40 T-antigen. J Virol. 1977 Nov; 24(2):451-60.
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Cystine requirement of continuous human lymphoid cell lines of normal and leukemic origin. J Biol Chem. 1977 Oct 25; 252(20):7184-91.
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Control of Saccharomyces cerevisiae 2microN DNA replication by cell division cycle genes that control nuclear DNA replication. J Mol Biol. 1977 Oct 25; 116(2):249-60.
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Purification of simian virus 40 tumor antigen from a line of simian virus 40-transformed human cells. Proc Natl Acad Sci U S A. 1977 Sep; 74(9):3745-9.
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Inheritance of the 2 micrometer m DNA plasmid from Saccharomyces. Genetics. 1977 May; 86(1):73-84.
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Biological and biochemical studies of cells transformed by simian virus 40 temperature-sensitive gene A mutants and A mutant revertants. J Virol. 1977 Apr; 22(1):210-8.
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Nuclear preparations of SV40-transformed cells contain tumor-specific transplantation antigen activity. Virology. 1977 Jan; 76(1):420-5.
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Identification of regions of the SV40 genome which contain preferred SV40 T antigen-binding sites. Cell. 1976 Aug; 8(4):535-45.
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Identification of infectious virions which are vesicular stomatitis virus pseudotypes of murine type C virus. Virology. 1976 Apr; 70(2):432-9.
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Accumulation of cystine auxotrophic thymocytes accompanying type C viral leukemogenesis in the mouse. Cell. 1976 Jan; 7(1):41-7.
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Thermolabile T (tumor) antigen from cells transformed by a temperature-sensitive mutant of simian virus 40. Proc Natl Acad Sci U S A. 1975 Nov; 72(11):4351-5.
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Interaction of partially purified simian virus 40 T antigen with circular viral DNA molecules. Proc Natl Acad Sci U S A. 1975 May; 72(5):1960-4.
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Deoxyribonucleic acid polymerase III of Escherichia coli. Purification and properties. J Biol Chem. 1975 Jan 25; 250(2):461-9.
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SV40 T antigen: partial purification and properties. Cold Spring Harb Symp Quant Biol. 1975; 39 Pt 1:283-9.
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Studies on the type C viral replication defect in MSV-transformed rat nonproducer variant clones. Virology. 1974 Dec; 62(2):337-43.
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Partial purification and characterization of the SV40 T antigen. Cell. 1974 Sep; 3(1):65-70.
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Relationship between RNA-directed DNA polymerase (reverse transcriptase) from human acute leukemic blood cells and primate type-C viruses. Proc Natl Acad Sci U S A. 1974 Apr; 71(4):1309-13.
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Infectious C-type virus isolated from a baboon placenta. Nature. 1974 Mar 01; 248(5443):17-20.
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Characterization of a new murine cellular DNA polymerase. Proc Natl Acad Sci U S A. 1974 Jan; 71(1):57-62.
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Mammalian cells in culture frequently release type C viruses. Science. 1973 Oct 05; 182(4107):56-9.
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Infectious type C viruses released by normal cat embryo cells. Virology. 1973 Oct; 55(2):506-15.
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Superinduction of endogenous type C virus by 5-bromodeoxyuridine from transformed mouse clones. Science. 1973 Aug 03; 181(4098):443-4.
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Endogenous type C virus from a cat cell clone with properties distinct from previously described feline type C virus. Virology. 1973 May; 53(1):142-51.
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Radioimmunoassay of mammalian type C viral proteins. 3. Detection of viral antigen in normal murine cells and tissues. J Exp Med. 1973 Mar 01; 137(3):622-35.
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Murine sarcoma virus-transformed nonproducer rat cell lines resistant to type C-virus infection. Intervirology. 1973; 1(5-6):329-37.
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Detection of type C viruses in normal and transformed cells. Johns Hopkins Med J Suppl. 1973; 2:231-44.
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Affinity chromatography of avian type C viral reverse transcriptase: studies with Rous sarcoma virus transformed rat cells. Virology. 1972 Nov; 50(2):388-95.
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Radioimmunoassay of mammalian type C viral proteins. I. Species specific reactions of murine and feline viruses. J Immunol. 1972 Sep; 109(3):570-7.
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Affinity chromatography of RNA-dependent DNA polymerase from RNA tumor viruses on a solid phase immunoadsorbent. Proc Natl Acad Sci U S A. 1972 Feb; 69(2):393-7.
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Spectro-chemical probes for protein conformation and function. Cold Spring Harb Symp Quant Biol. 1972; 36:517-31.
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Protein biosynthesis: studies using synthetic and viral mRNAs. Cold Spring Harb Symp Quant Biol. 1969; 34:411-7.
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