Edward J. Benz Jr., MD

Edward J. Benz Jr., MD

Medical Oncology

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Edward J. Benz Jr., MD

Dr. Benz graduated from Harvard Medical School in 1973 and received his training at Brigham and Women's Hospital and the National Institutes of Health. He is president and CEO emeritus of Dana-Farber Cancer Institute, director emeritus and principal investigator of Dana-Farber/Harvard Cancer Center, and a member of the Governing Board of Dana-Farber/Children's Cancer Center. He is also a clinical hematologist and an active NIH-funded investigator.



President and CEO Emeritus, Dana-Farber Cancer Institute
Richard and Susan Smith Distinguished Professor of Medicine, Professor of Pediatrics, Professor of Genetics, Harvard Medical School

Board Certification

  • Hematology
  • Internal Medicine


  • Yale University, Hematology


  • Brigham and Women's Hospital, Internal Medicine

Medical School

  • Harvard Medical School

Recent Awards

  • President, American Association of Cancer Institutes 2005
  • Elected Fellow, American Association for the Advancement of Science 2004
  • Member, American Academy of Arts and Sciences 2004
  • Member, Institute of Medicine 2004


    The Molecular Pathology of Hemolytic Anemias

    Our laboratory continues to focus on the molecular pathology and physiology of red cell development, the molecular basis of inherited hemolytic anemias, and the use of the red cell homeostatic system as a model to study gene regulation and growth control in other tissues. During the past five years, we have focused on the structure, function, gene regulation, and molecular pathology of protein 4.1. This cytoskeletal protein, originally described in the red cell, forms a ternary complex with spectrin-actin, and attaches the spectrin latticework to membranes by binding to the cytoplasmic domains of key transmembrane proteins. Defects in this protein are associated with hereditary erythrocytosis. Our laboratory has shown that many isoforms of protein 4.1 arise from a single protein 4.1R gene by tissue-specific alternative mRNA splicing pathways, a number of which we have characterized. Our group has identified at least three target sequence areas and one putative splicing factor involved in tissue-specific regulation of red cell isoforms during erythroid differentiation. Isoforms of protein 4.1R are expressed in many tissues and exhibit complex patterns of intracellular localization. We have shown that some forms associate with NuMa, a key mitotic protein, and are components of the mitotic apparatus. Other domains of protein 4.1R participate in tight junction formation by binding the proteins ZO-2. Moreover, as cells approach the state of terminal differentiation, there is a clear shift from the intranuclear localization of protein 4.1R to peripheral localization. Current studies are pursuing the hypothesis that this complex shift in localization and association is indicative of a role for protein 4.1R in signaling terminal differentiation and initiating shutdown of cell proliferation and division.


      • Thalassemia. Hematol Oncol Clin North Am. 2023 04; 37(2):xiii-xv. View in: Pubmed

      • Introduction to the Thalassemia Syndromes: Molecular Medicine's Index Case. Hematol Oncol Clin North Am. 2023 04; 37(2):245-259. View in: Pubmed

      • Remembering the Contributions of Professor David J. Weatherall. Hematol Oncol Clin North Am. 2023 Apr; 37(2):xvii-xxi. View in: Pubmed

      • Multifunctional protein 4.1R regulates the asymmetric segregation of Numb during terminal erythroid maturation. J Biol Chem. 2021 09; 297(3):101051. View in: Pubmed

      • Progress in Cancer Research, Prevention, and Care. N Engl J Med. 2020 Sep 03; 383(10):897-900. View in: Pubmed

      • Value of Oncology Pharmacists in the Oncology Health Care Workforce-Reply. JAMA Oncol. 2020 07 01; 6(7):1121. View in: Pubmed

      • The Future of Cancer Care in the United States-Overcoming Workforce Capacity Limitations. JAMA Oncol. 2020 03 01; 6(3):327-328. View in: Pubmed

      • Epithelial-specific isoforms of protein 4.1R promote adherens junction assembly in maturing epithelia. J Biol Chem. 2020 01 03; 295(1):191-211. View in: Pubmed

      • Accelerating the Science of SCD Therapies-Is a Cure Possible? JAMA. 2019 Sep 10; 322(10):921-922. View in: Pubmed

      • Breakthrough Therapy Designation for New Drugs. JAMA. 2018 11 20; 320(19):2042. View in: Pubmed

      • Advancing the Science of Healthcare Service Delivery: The NHLBI Corporate Healthcare Leaders' Panel. Glob Heart. 2018 12; 13(4):339-345. View in: Pubmed

      • Protein 4.1R Exon 16 3' Splice Site Activation Requires Coordination among TIA1, Pcbp1, and RBM39 during Terminal Erythropoiesis. Mol Cell Biol. 2017 05 01; 37(9). View in: Pubmed

      • The Jeremiah Metzger Lecture Cancer in the Twenty-First Century: An Inside View from an Outsider. Trans Am Clin Climatol Assoc. 2017; 128:275-297. View in: Pubmed

      • Protein 4.1R Influences Myogenin Protein Stability and Skeletal Muscle Differentiation. J Biol Chem. 2016 Dec 02; 291(49):25591-25607. View in: Pubmed

      • Value, Access, and Cost of Cancer Care Delivery at Academic Cancer Centers. J Natl Compr Canc Netw. 2016 07; 14(7):837-47. View in: Pubmed

      • BERNARD GREGOIRE FORGET, MD: 1939 - 2015. Trans Am Clin Climatol Assoc. 2016; 127:lxxxviii-xci. View in: Pubmed

      • In Support of a Patient-Driven Initiative and Petition to Lower the High Price of Cancer Drugs. Mayo Clin Proc. 2015 Aug; 90(8):996-1000. View in: Pubmed

      • A tribute to Emil Frei III. J Clin Invest. 2013 Aug 1; 123(8):3188-9. View in: Pubmed

      • Presidential address: doing our part to ensure the future of academic medicine. Trans Am Clin Climatol Assoc. 2013; 124:1-13. View in: Pubmed

      • RBFOX2 promotes protein 4.1R exon 16 selection via U1 snRNP recruitment. Mol Cell Biol. 2012 Jan; 32(2):513-26. View in: Pubmed

      • Role of RBM25/LUC7L3 in abnormal cardiac sodium channel splicing regulation in human heart failure. Circulation. 2011 Sep 06; 124(10):1124-31. View in: Pubmed

      • Case records of the Massachusetts General Hospital. Case 25-2011. A 62-year-old woman with anemia and paraspinal masses. N Engl J Med. 2011 Aug 18; 365(7):648-58. View in: Pubmed

      • American Journal of Blood Research: Editorial Board (2011) e-Century Publishing Corporation. Am J Blood Res. 2011; 1(1):106-9. View in: Pubmed

      • Launching of american journal of blood research. Am J Blood Res. 2011; 1(1):i. View in: Pubmed

      • Newborn screening for a-thalassemia--keeping up with globalization. N Engl J Med. 2011 Feb 24; 364(8):770-1. View in: Pubmed

      • Learning about genomics and disease from the anucleate human red blood cell. J Clin Invest. 2010 Dec; 120(12):4204-6. View in: Pubmed

      • Ensuring quality cancer care through the oncology workforce. J Oncol Pract. 2010 Jan; 6(1):7-11. View in: Pubmed

      • Coupled transcription-splicing regulation of mutually exclusive splicing events at the 5' exons of protein 4.1R gene. Blood. 2009 Nov 05; 114(19):4233-42. View in: Pubmed

      • Commentary: troublesome words, linguistic precision, and medical oncology. Oncologist. 2009 Apr; 14(4):445-7. View in: Pubmed

      • Inhibition of protein 4.1 R and NuMA interaction by mutagenization of their binding-sites abrogates nuclear localization of 4.1 R. Clin Transl Sci. 2009 Apr; 2(2):102-11. View in: Pubmed

      • Novel splicing factor RBM25 modulates Bcl-x pre-mRNA 5' splice site selection. Mol Cell Biol. 2008 Oct; 28(19):5924-36. View in: Pubmed

      • Paroxysmal nocturnal hemoglobinuria (PNH): an historical perspective. Hematology Am Soc Hematol Educ Program. 2008; 92. View in: Pubmed

      • Targeting the cell death-survival equation. Clin Cancer Res. 2007 Dec 15; 13(24):7250-3. View in: Pubmed

      • Development of an integrated approach to cancer disparities: one cancer center's experience. Cancer Epidemiol Biomarkers Prev. 2007 Nov; 16(11):2186-92. View in: Pubmed

      • Regulated Fox-2 isoform expression mediates protein 4.1R splicing during erythroid differentiation. Blood. 2008 Jan 01; 111(1):392-401. View in: Pubmed

      • 2006 Association of American Physicians George M. Kober Medal. Introduction of David G. Nathan, MD. J Clin Invest. 2007 Apr; 117(4):1107-11. View in: Pubmed

      • Partnerships with patients. Trustee. 2006 Oct; 59(9):40, 56. View in: Pubmed

      • Restructuring the academic department of internal medicine. Am J Med. 2005 Dec; 118(12):1430-5. View in: Pubmed

      • Mitotic regulation of protein 4.1R involves phosphorylation by cdc2 kinase. Mol Biol Cell. 2005 Jan; 16(1):117-27. View in: Pubmed

      • An erythroid differentiation-specific splicing switch in protein 4.1R mediated by the interaction of SF2/ASF with an exonic splicing enhancer. Blood. 2005 Mar 01; 105(5):2146-53. View in: Pubmed

      • Genotypes and phenotypes--another lesson from the hemoglobinopathies. N Engl J Med. 2004 Oct 07; 351(15):1490-2. View in: Pubmed

      • Protein 4.1R, a microtubule-associated protein involved in microtubule aster assembly in mammalian mitotic extract. J Biol Chem. 2004 Aug 13; 279(33):34595-602. View in: Pubmed

      • A splicing alteration of 4.1R pre-mRNA generates 2 protein isoforms with distinct assembly to spindle poles in mitotic cells. Blood. 2002 Oct 01; 100(7):2629-36. View in: Pubmed

      • Multiple cis elements regulate an alternative splicing event at 4.1R pre-mRNA during erythroid differentiation. Blood. 2001 Dec 15; 98(13):3809-16. View in: Pubmed

      • Comprehensive cancer centres and the war on cancer. Nat Rev Cancer. 2001 Dec; 1(3):240-5. View in: Pubmed

      • Reassignment of the EPB4.1 gene to 1p36 and assessment of its involvement in neuroblastomas. Eur J Clin Invest. 2001 Oct; 31(10):907-14. View in: Pubmed

      • The prototypical 4.1R-10-kDa domain and the 4.1g-10-kDa paralog mediate fodrin-actin complex formation. J Biol Chem. 2001 Jun 08; 276(23):20679-87. View in: Pubmed

      • Translational regulation of Na-K-ATPase subunit mRNAs by glucocorticoids. Am J Physiol Renal Physiol. 2000 Dec; 279(6):F1132-8. View in: Pubmed

      • A nonerythroid isoform of protein 4.1R interacts with components of the contractile apparatus in skeletal myofibers. Mol Biol Cell. 2000 Nov; 11(11):3805-17. View in: Pubmed

      • Edward J. Benz, Jr, MD. J Investig Med. 2000 Nov; 48(6):381-4. View in: Pubmed

      • Characterization of the interaction between protein 4.1R and ZO-2. A possible link between the tight junction and the actin cytoskeleton. J Biol Chem. 2000 Sep 29; 275(39):30573-85. View in: Pubmed

      • Clonal variation, autoimmunity, and neoplasia: an ecology lesson from paroxysmal nocturnal hemoglobinuria. Ann Intern Med. 1999 Sep 21; 131(6):467-8. View in: Pubmed

      • A nonerythroid isoform of protein 4.1R interacts with the nuclear mitotic apparatus (NuMA) protein. J Cell Biol. 1999 Apr 05; 145(1):29-43. View in: Pubmed

      • Increasing academic internal medicine's investment in female faculty. Am J Med. 1998 Dec; 105(6):459-63. View in: Pubmed

      • The FERM domain: a unique module involved in the linkage of cytoplasmic proteins to the membrane. Trends Biochem Sci. 1998 Aug; 23(8):281-2. View in: Pubmed

      • Organization of the human protein 4.1 genomic locus: new insights into the tissue-specific alternative splicing of the pre-mRNA. Genomics. 1997 Feb 01; 39(3):289-302. View in: Pubmed

      • Role of tissue specific alternative pre-mRNA splicing in the differentiation of the erythrocyte membrane. Trans Am Clin Climatol Assoc. 1997; 108:78-95. View in: Pubmed

      • Asynchronous regulation of splicing events within protein 4.1 pre-mRNA during erythroid differentiation. Blood. 1996 May 01; 87(9):3934-41. View in: Pubmed

      • Na, K-ATPase isoform gene expression in normal and hypertrophied dog heart. Basic Res Cardiol. 1996 May-Jun; 91(3):256-66. View in: Pubmed

      • The thalassemia syndromes: lessons from molecular medicines index case. Trans Am Clin Climatol Assoc. 1996; 107:20-36; discussion 35-6. View in: Pubmed

      • Gene therapy in hematology. Rev Invest Clin. 1994 Apr; Suppl:143-6. View in: Pubmed

      • Molecular cloning and functional expression of the bumetanide-sensitive Na-K-Cl cotransporter. Proc Natl Acad Sci U S A. 1994 Mar 15; 91(6):2201-5. View in: Pubmed

      • Tissue-specific alternative splicing of protein 4.1 inserts an exon necessary for formation of the ternary complex with erythrocyte spectrin and F-actin. Blood. 1993 Oct 15; 82(8):2558-63. View in: Pubmed

      • Posttranscriptional regulation of colony-stimulating factor-1 (CSF-1) and CSF-1 receptor gene expression during inhibition of phorbol-ester-induced monocytic differentiation by dexamethasone and cyclosporin A: potential involvement of a destabilizing protein. Exp Hematol. 1993 Sep; 21(10):1328-34. View in: Pubmed

      • Expression of alpha isoforms of the Na,K-ATPase in human heart. Biochim Biophys Acta. 1993 Jul 04; 1149(2):189-94. View in: Pubmed

      • Genomic structure of the locus encoding protein 4.1. Structural basis for complex combinational patterns of tissue-specific alternative RNA splicing. J Biol Chem. 1993 Feb 15; 268(5):3758-66. View in: Pubmed

      • Prevalent skipping of an individual exon accounts for shortened protein 4.1 Presles. Blood. 1992 Dec 01; 80(11):2925-30. View in: Pubmed

      • Differential translation of the Na,K-ATPase subunit mRNAs. J Biol Chem. 1992 Nov 05; 267(31):22435-9. View in: Pubmed

      • Homozygous 4.1(-) hereditary elliptocytosis associated with a point mutation in the downstream initiation codon of protein 4.1 gene. J Clin Invest. 1992 Nov; 90(5):1713-7. View in: Pubmed

      • Presidential address to the American Society for Clinical Investigation, Baltimore, Maryland, 2-6 May 1992. J Clin Invest. 1992 Oct; 90(4):1177-9. View in: Pubmed

      • Changes in Na,K-ATPase gene expression during granulocytic differentiation of HL60 cells. Blood. 1992 Sep 15; 80(6):1559-64. View in: Pubmed

      • Deamidation of human erythrocyte protein 4.1: possible role in aging. Blood. 1992 Jun 15; 79(12):3355-61. View in: Pubmed

      • Lactoferrin gene promoter: structural integrity and nonexpression in HL60 cells. Blood. 1992 Jun 01; 79(11):2998-3006. View in: Pubmed

      • The A2 isoform of rat Na+,K(+)-adenosine triphosphatase is active and exhibits high ouabain affinity when expressed in transfected fibroblasts. FEBS Lett. 1992 Jun 01; 303(2-3):147-53. View in: Pubmed

      • Beta-globin nonsense mutation: deficient accumulation of mRNA occurs despite normal cytoplasmic stability. Proc Natl Acad Sci U S A. 1992 Apr 01; 89(7):2935-9. View in: Pubmed

      • The cardiac conduction system in the rat expresses the alpha 2 and alpha 3 isoforms of the Na+,K(+)-ATPase. Proc Natl Acad Sci U S A. 1992 Jan 01; 89(1):99-103. View in: Pubmed

      • Differential utilization of translation initiation sites in alternatively spliced mRNAs arising from the protein 4.1 gene. Trans Assoc Am Physicians. 1992; 105:165-71. View in: Pubmed

      • The stem cell mavens had a blast. Second International Symposium on the Molecular Biology of Hematopoiesis, Innsbruck, Austria, July 14-18, 1991. New Biol. 1992 Jan; 4(1):42-7. View in: Pubmed

      • Molecular analysis of hereditary elliptocytosis with reduced protein 4.1 in the French Northern Alps. Blood. 1991 Oct 15; 78(8):2113-9. View in: Pubmed

      • Cytoarchitectural relationships between [3H]ouabain binding and mRNA for isoforms of the sodium pump catalytic subunit in rat brain. Brain Res Mol Brain Res. 1991 May; 10(2):139-50. View in: Pubmed

      • Detection of the Na(+)-K(+)-ATPase alpha 3-isoform in multinucleated macrophages. Am J Physiol. 1991 May; 260(5 Pt 2):F704-9. View in: Pubmed

      • Gene expression during erythropoiesis. Int J Cell Cloning. 1991 Mar; 9(2):109-22. View in: Pubmed

      • Heterogeneity of mRNA and protein products arising from the protein 4.1 gene in erythroid and nonerythroid tissues. J Cell Biol. 1990 Mar; 110(3):617-24. View in: Pubmed

      • The molecular genetics of cancer. Introduction to principles of recombinant DNA technology. Cancer. 1990 Feb 01; 65(3 Suppl):731-41. View in: Pubmed

      • Sequence analysis of the gamma-globin gene locus from a patient with the deletion form of hereditary persistence of fetal hemoglobin. Blood. 1990 Jan 15; 75(2):499-504. View in: Pubmed

      • Metabolism of non-translatable globin mRNAs arising from premature translation termination codons. Ann N Y Acad Sci. 1990; 612:55-66. View in: Pubmed

      • Amplification of the phosphorylation site-ATP-binding site cDNA fragment of the Na+,K(+)-ATPase and the Ca2(+)-ATPase of Drosophila melanogaster by polymerase chain reaction. FEBS Lett. 1989 Dec 04; 258(2):203-7. View in: Pubmed

      • Expression of multiple Na+,K+-adenosine triphosphatase isoform genes in human hematopoietic cells. Behavior of the novel A3 isoform during induced maturation of HL60 cells. J Clin Invest. 1989 Jul; 84(1):347-51. View in: Pubmed

      • Characterization of the calmodulin-binding site of nonerythroid alpha-spectrin. Recombinant protein and model peptide studies. J Biol Chem. 1989 Apr 05; 264(10):5826-30. View in: Pubmed

      • Selective defect in myeloid cell lactoferrin gene expression in neutrophil specific granule deficiency. J Clin Invest. 1989 Feb; 83(2):514-9. View in: Pubmed

      • Selective expression of an erythroid-specific isoform of protein 4.1. Proc Natl Acad Sci U S A. 1988 Jun; 85(11):3713-7. View in: Pubmed

      • Nonsense mutations in the human beta-globin gene affect mRNA metabolism. Proc Natl Acad Sci U S A. 1988 Apr; 85(7):2056-60. View in: Pubmed

      • Chromosomal localization of human Na+, K+-ATPase alpha- and beta-subunit genes. Genomics. 1988 Feb; 2(2):128-38. View in: Pubmed

      • Molecular cloning and characterization of alpha-subunit isoforms of the Na,K-ATPase. Prog Clin Biol Res. 1988; 268B:119-26. View in: Pubmed

      • Antenatal diagnosis of the hemoglobinopathies. Hematol Pathol. 1988; 2(4):199-220. View in: Pubmed

      • Cellular factor affecting the stability of beta-globin mRNA. Gene. 1988; 62(1):65-74. View in: Pubmed

      • Expression of specific isoforms of protein 4.1 in erythroid and non-erythroid tissues. Adv Exp Med Biol. 1988; 241:81-95. View in: Pubmed

      • Comparison of nonerythroid alpha-spectrin genes reveals strict homology among diverse species. Mol Cell Biol. 1988 Jan; 8(1):1-9. View in: Pubmed

      • In vitro expression of the alpha and beta subunits of the Na,K-ATPase. Prog Clin Biol Res. 1988; 268B:71-6. View in: Pubmed

      • Molecular cloning of Na+,K+-ATPase alpha subunit gene using antibody probes. Methods Enzymol. 1988; 156:379-92. View in: Pubmed

      • Tissue specificity, localization in brain, and cell-free translation of mRNA encoding the A3 isoform of Na+,K+-ATPase. Proc Natl Acad Sci U S A. 1988 Jan; 85(1):284-8. View in: Pubmed

      • Isolation of lactoferrin cDNA from a human myeloid library and expression of mRNA during normal and leukemic myelopoiesis. Blood. 1987 Oct; 70(4):989-93. View in: Pubmed

      • Equal stabilities of normal beta globin and nontranslatable beta0 -39 thalassemic transcripts in cell-free extracts. Blood. 1987 Jul; 70(1):293-300. View in: Pubmed

      • Hospital cardiology, cardiac surgery program reported. Physician Exec. 1987 Mar-Apr; 13(2):28. View in: Pubmed

      • Expression of genes for the alpha and beta subunits of the Na,K-ATPase in normal and drug resistant cells. Blood Cells. 1987; 13(1-2):299-307. View in: Pubmed

      • c-myc gene inactivation during induced maturation of HL-60 cells. Transcriptional repression and loss of a specific DNAse I hypersensitive site. J Clin Invest. 1987 Jan; 79(1):93-9. View in: Pubmed

      • Rat-brain Na,K-ATPase beta-chain gene: primary structure, tissue-specific expression, and amplification in ouabain-resistant HeLa C+ cells. Mol Cell Biol. 1986 Nov; 6(11):3884-90. View in: Pubmed

      • Amino acid sequence of the plasma membrane ATPase of Neurospora crassa: deduction from genomic and cDNA sequences. Proc Natl Acad Sci U S A. 1986 Oct; 83(20):7693-7. View in: Pubmed

      • Amplification of DNA sequences coding for the Na,K-ATPase alpha-subunit in ouabain-resistant C+ cells. Mol Cell Biol. 1986 Jul; 6(7):2476-81. View in: Pubmed

      • Molecular cloning of rat brain Na,K-ATPase alpha-subunit cDNA. Proc Natl Acad Sci U S A. 1985 Sep; 82(18):6357-61. View in: Pubmed

      • Serous retinal detachments in thrombotic thrombocytopenic purpura. Arch Ophthalmol. 1985 Aug; 103(8):1172-4. View in: Pubmed

      • Polyadenylation of a human mitochondrial ribosomal RNA transcript detected by molecular cloning. Gene. 1985; 35(3):305-12. View in: Pubmed

      • Metabolism of structurally abnormal mRNAs resulting from beta-thalassemia mutations. Ann N Y Acad Sci. 1985; 445:57-67. View in: Pubmed

      • Analysis of gene expression during hematopoiesis: present and future applications. Crit Rev Oncol Hematol. 1985; 4(1):67-102. View in: Pubmed

      • Lactoferrin biosynthesis during granulocytopoiesis. Blood. 1984 Nov; 64(5):1103-9. View in: Pubmed

      • Intranuclear defect in beta-globin mRNA accumulation due to a premature translation termination codon. Blood. 1984 Jul; 64(1):13-22. View in: Pubmed

      • An immediate hemolytic transfusion reaction due to anti-C and a delayed hemolytic transfusion reaction due to anti-Ce+e: hemoglobinemia, hemoglobinuria and transient impaired renal function. Vox Sang. 1984; 47(5):348-53. View in: Pubmed

      • Molecular genetics of the sickling syndromes: evolution of new strategies for improved diagnosis. Am J Pediatr Hematol Oncol. 1984; 6(1):59-66. View in: Pubmed

      • Beta globin messenger RNA content of bone marrow erythroblasts in heterozygous beta-thalassemia. Am J Hematol. 1984 Jan; 16(1):33-45. View in: Pubmed

      • Isoniazid-induced pure red cell aplasia. Am J Med Sci. 1983 Jul-Aug; 286(1):2-9. View in: Pubmed

      • Clinical management of gene expression. N Engl J Med. 1982 Dec 09; 307(24):1515-6. View in: Pubmed

      • Constitutive expression of platelet glycoproteins by the human leukemia cell line K562. Blood. 1982 Sep; 60(3):785-9. View in: Pubmed

      • Differing responses of globin and glycophorin gene expression to hemin in the human leukemia cell line K562. Blood. 1982 Apr; 59(4):738-46. View in: Pubmed

      • Abnormally spliced messenger RNA in erythroid cells from patients with beta+ thalassemia and monkey cells expressing a cloned beta+-thalassemic gene. Cell. 1982 Mar; 28(3):585-93. View in: Pubmed

      • Globin mRNA metabolism and gene structure in beta +-thalassemia. Birth Defects Orig Artic Ser. 1982; 18(7):51-9. View in: Pubmed

      • The thalassemia syndromes: models for the molecular analysis of human disease. Annu Rev Med. 1982; 33:363-73. View in: Pubmed

      • Defective processing of beta mRNA in different forms of beta +-thalassemia. Trans Assoc Am Physicians. 1982; 95:325-33. View in: Pubmed

      • Posttranscriptional defects in beta-globin messenger RNA metabolism in beta-thalassemia: abnormal accumulation of beta-messenger RNA precursor sequences. J Clin Invest. 1981 Dec; 68(6):1529-38. View in: Pubmed

      • Molecular analysis of the beta-thalassemia phenotype associated with inheritance of hemoglobin E (alpha 2 beta2(26)Glu leads to Lys). J Clin Invest. 1981 Jul; 68(1):118-26. View in: Pubmed

      • beta-Thalassemia present in cis to a new beta-chain structural variant, Hb Vicksburg [beta 75 (E19)Leu leads to 0]. Proc Natl Acad Sci U S A. 1981 Jan; 78(1):469-73. View in: Pubmed

      • Embryonic-fetal erythroid characteristics of a human leukemic cell line. Proc Natl Acad Sci U S A. 1980 Jun; 77(6):3509-13. View in: Pubmed

      • Heterogeneity of messenger RNA defects in the thalassemia syndromes. Ann N Y Acad Sci. 1980; 344:101-12. View in: Pubmed

      • Pathogenesis of the thalassemia syndromes. Pathobiol Annu. 1980; 10:1-33. View in: Pubmed

      • Hemoglobin switching in animals. Tex Rep Biol Med. 1980-1981; 40:111-23. View in: Pubmed

      • Detection of early cardiac dysfunction in patients with severe beta-thalassemia and chronic iron overload. N Engl J Med. 1979 Nov 22; 301(21):1143-8. View in: Pubmed

      • Induction of erythropoietic colonies in a human chronic myelogenous leukemia cell line. Blood. 1979 Nov; 54(5):1182-7. View in: Pubmed

      • Hemoglobin switching in sheep. Synthesis, cloning, and characterization of DNA sequences coding for the beta B, beta C, and gamma-globin mRNAs. J Biol Chem. 1979 Aug 10; 254(15):6880-8. View in: Pubmed

      • Hemoglobin switching in sheep: only the gamma gene is in the active conformation in fetal liver but all the beta and gamma genes are in the active conformation in bone marrow. Proc Natl Acad Sci U S A. 1978 Dec; 75(12):5884-8. View in: Pubmed

      • Hemoglobin switching in sheep. Quantitation of betaA- and betaC-mRNA sequences in nuclear and cytoplasmic RNA during the HbA to HbC switch. J Biol Chem. 1978 Jul 25; 253(14):5025-32. View in: Pubmed

      • Hemoglobin switching in sheep: commitment of erythroid stem cells to expression of the betaC-globin gene and accumulation of betaC-globin mRNA. Cell. 1978 Jul; 14(3):733-40. View in: Pubmed

      • Variability in the amount of beta-globin mRNA in beta0 thalassemia. Cell. 1978 Jun; 14(2):299-312. View in: Pubmed

      • Studies of globin chain synthesis and globin mRNA content in a patient homozygous for hemoglobin Lepore. Hemoglobin. 1978; 2(2):117-28. View in: Pubmed

      • Regulation of hemoglobin synthesis during the development of the red cell (third of three parts). N Engl J Med. 1977 Dec 29; 297(26):1430-6. View in: Pubmed

      • Regulation of hemoglobin synthesis during the development of the red cell. (Second of three parts). N Engl J Med. 1977 Dec 22; 297(25):1371-81. View in: Pubmed

      • Regulation of hemoglobin synthesis during the development of the red cell (first of three parts). N Engl J Med. 1977 Dec 15; 297(24):1318-28. View in: Pubmed

      • Relative stability of alpha- and beta-globin messenger RNAs in homozygous beta+ thalassemia. Proc Natl Acad Sci U S A. 1977 Sep; 74(9):3960-4. View in: Pubmed

      • Stability of the individual globin genes during erythroid differentiation. Science. 1977 Jun 10; 196(4295):1213-4. View in: Pubmed

      • Hemoglobin switching in sheep and goats. Preparation and characterization of complementary DNAs specific for the alpha-, beta-, and gamma-globin messenger RNAs of sheep. J Biol Chem. 1977 Mar 25; 252(6):1908-16. View in: Pubmed

      • Synthesis of DNA complementary to separated human alpha and beta globin messenger RNAs. Proc Natl Acad Sci U S A. 1975 Mar; 72(3):984-8. View in: Pubmed

      • The molecular genetics of the thalassemia syndromes. Prog Hematol. 1975; 9:107-55. View in: Pubmed

      • Absence of functional messenger RNA activity for beta globin chain synthesis in beta 0-thalassemia. Blood. 1975 Jan; 45(1):1-10. View in: Pubmed

      • Use of globin cDNA as a hybridization probe for globin mRNA. Ann N Y Acad Sci. 1974 Nov 29; 241(0):280-9. View in: Pubmed

      • The biosynthesis of hemoglobin. Semin Hematol. 1974 Oct; 11(4):463-523. View in: Pubmed

      • Absence of messenger RNA for beta globin chain in beta(0) thalassaemia. Nature. 1974 Feb 08; 247(5440):379-81. View in: Pubmed

      • Globin messenger RNA in the thalassemia syndromes. Ann N Y Acad Sci. 1974; 232(0):76-87. View in: Pubmed

      • Globin messenger RNA in hemoglobin H disease. Blood. 1973 Dec; 42(6):825-33. View in: Pubmed

      • Quantitative deficiency of chain-specific globin messenger ribonucleic acids in the thalassemia syndromes. Proc Natl Acad Sci U S A. 1973 Jun; 70(6):1809-13. View in: Pubmed

      • Family and community medicine in a general hospital. Putting principles to work. JAMA. 1972 Jul 03; 221(1):54-7. View in: Pubmed

      • Defect in messenger RNA for human hemoglobin synthesis in beta thalassemia. J Clin Invest. 1971 Dec; 50(12):2755-60. View in: Pubmed

      • Hyperproduction and purification of nicotinamide deamidase, a microconstitutive enzyme of Escherichia coli. J Biol Chem. 1971 Nov 25; 246(22):6792-6. View in: Pubmed

      • Gonadal dysgenesis with male chromatin pattern: testicular feminization syndrome. Clinical and pathological findings in two cases in siblings. JAMA. 1962 Aug 04; 181:375-9. View in: Pubmed

      • Serum adenosine deaminase: methodology and clinical applications. Clin Chem. 1962 Apr; 8:133-40. View in: Pubmed

      • The concept of organizing pneumonia. Arch Pathol. 1961 Dec; 72:607-19. View in: Pubmed

      • Focal cirrhosis of the liver: its relation to the so-called hamartoma (adenoma, benign hepatoma). Cancer. 1953 Jul; 6(4):743-55. View in: Pubmed

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