Molecular mechanisms of metabolic disease and dysfunction
Our research focuses on deciphering the molecular mechanisms of metabolic disease and dysfunction, and using this information to develop targeted therapeutic strategies.
As we age the form and function of our cells is diminished, leading to decreased quality of life and increased risk of death. Dysfunction in a particular cellular locale – the mitochondrion – is implicated in much of this pathology.
We apply mass spectrometry and biochemical approaches to identify mitochondrial metabolic pathways that control the protective and pathological cascades initiated by this organelle.
Our work to date has focused on elucidating these mechanisms of damage and protection in pre-clinical models of cardiovascular and metabolic disease.