Hajime Uno, PhD

Hajime Uno, PhD

Contact Information

Office Phone Number






On This Page



Assistant Professor, Harvard Medical School


    Research Abstract

    Dr. Hajime Uno is biostatistician devoted to collaborative clinical and methodological research to promote improved understanding of human disease.  His statistical methodological research focuses on evaluating prediction models for clinical outcomes based on standard clinical parameter and biomarkers.


      • Discussions About Goals of Care and Advance Care Planning Among Adolescents and Young Adults With Cancer Approaching the End of Life. J Clin Oncol. 2023 Aug 25; JCO2300641. View in: Pubmed

      • PREMM5 distinguishes sporadic from Lynch syndrome-associated MMR-deficient/MSI-high colorectal cancer. Fam Cancer. 2023 Oct; 22(4):459-465. View in: Pubmed

      • Vascular injury markers associated with cognitive impairment in people with HIV on suppressive antiretroviral therapy. AIDS. 2023 Jul 28. View in: Pubmed

      • Vascular injury markers associated with cognitive impairment in people with HIV on suppressive antiretroviral therapy. medRxiv. 2023 Jul 24. View in: Pubmed

      • Marital status, frailty, and survival in older adults with blood cancer. J Geriatr Oncol. 2023 Jul 13; 101589. View in: Pubmed

      • Direct Oral Anticoagulants vs Low-Molecular-Weight Heparin and Recurrent VTE in Patients With Cancer: A Randomized Clinical Trial. JAMA. 2023 06 13; 329(22):1924-1933. View in: Pubmed

      • Obesity Risk of Pediatric Central Nervous System Tumor Survivors: A Cross-Sectional Study. Nutrients. 2023 May 11; 15(10). View in: Pubmed

      • Improving Cognitive Function Through High-Intensity Interval Training in Breast Cancer Patients Undergoing Chemotherapy: Protocol for a Randomized Controlled Trial. JMIR Res Protoc. 2023 Apr 07; 12:e39740. View in: Pubmed

      • Elucidating Analytic Bias Due to Informative Cohort Entry in Cancer Clinico-genomic Datasets. Cancer Epidemiol Biomarkers Prev. 2023 03 06; 32(3):344-352. View in: Pubmed

      • Clinical factors associated with skin neoplasms in individuals with Lynch syndrome in a longitudinal observational cohort. J Am Acad Dermatol. 2023 06; 88(6):1282-1290. View in: Pubmed

      • Combining Breast Cancer Risk Prediction Models. Cancers (Basel). 2023 Feb 08; 15(4). View in: Pubmed

      • On assessing survival benefit of immunotherapy using long-term restricted mean survival time. Stat Med. 2023 04 15; 42(8):1139-1155. View in: Pubmed

      • Ratio and difference of average hazard with survival weight: New measures to quantify survival benefit of new therapy. Stat Med. 2023 03 30; 42(7):936-952. View in: Pubmed

      • Change in the Parent-Clinician Relationship Throughout the First Year of Treatment in Pediatric Oncology. JAMA Netw Open. 2022 09 01; 5(9):e2230503. View in: Pubmed

      • Association of Oncologist Participation in Medicare's Oncology Care Model With Patient Receipt of Novel Cancer Therapies. JAMA Netw Open. 2022 09 01; 5(9):e2234161. View in: Pubmed

      • A validation of models for prediction of pathogenic variants in mismatch repair genes. Genet Med. 2022 10; 24(10):2155-2166. View in: Pubmed

      • Development and Validation of the PREMMplus Model for Multigene Hereditary Cancer Risk Assessment. J Clin Oncol. 2022 12 10; 40(35):4083-4094. View in: Pubmed

      • Regional Disparities in the Use and Delivery of Adjuvant Radiation Therapy after Lumpectomy for Breast Cancer in the Medicare Population. Adv Radiat Oncol. 2022 Nov-Dec; 7(6):101017. View in: Pubmed

      • Quantifying Treatment Effects in Trials with Multiple Event-Time Outcomes. NEJM Evid. 2022 Oct; 1(10). View in: Pubmed

      • Semi-supervised approach to event time annotation using longitudinal electronic health records. Lifetime Data Anal. 2022 07; 28(3):428-491. View in: Pubmed

      • Targeting Adiposity and Inflammation With Movement to Improve Prognosis in Breast Cancer Survivors (The AIM Trial): Rationale, Design, and Methods. Front Oncol. 2022; 12:896995. View in: Pubmed

      • Implementation of patient-reported outcomes for symptom management in oncology practice through the SIMPRO research consortium: a protocol for a pragmatic type II hybrid effectiveness-implementation multi-center cluster-randomized stepped wedge trial. Trials. 2022 Jun 16; 23(1):506. View in: Pubmed

      • Reducing Metabolic Dysregulation in Obese Latina and/or Hispanic Breast Cancer Survivors Using Physical Activity (ROSA) Trial: A Study Protocol. Front Oncol. 2022; 12:864844. View in: Pubmed

      • Randomized controlled trial of geriatric consultation versus standard care in older adults with hematologic malignancies. Haematologica. 2022 05 01; 107(5):1172-1180. View in: Pubmed

      • Geospatial Disparities in the Treatment of Curable Breast Cancer Across the US. JAMA Oncol. 2022 Mar 01; 8(3):445-449. View in: Pubmed

      • Predictors of Transition to Frailty in Middle-Aged and Older People With HIV: A Prospective Cohort Study. J Acquir Immune Defic Syndr. 2021 12 15; 88(5):518-527. View in: Pubmed

      • Multimorbidity networks associated with frailty among middle-aged and older people with HIV. AIDS. 2021 12 01; 35(15):2451-2461. View in: Pubmed

      • Moving beyond conventional stratified analysis to assess the treatment effect in a comparative oncology study. J Immunother Cancer. 2021 11; 9(11). View in: Pubmed

      • Parent and Clinician Perspectives on Challenging Parent-Clinician Relationships in Pediatric Oncology. JAMA Netw Open. 2021 11 01; 4(11):e2132138. View in: Pubmed

      • Novel Models of Genetic Education and Testing for Pancreatic Cancer Interception: Preliminary Results from the GENERATE Study. Cancer Prev Res (Phila). 2021 11; 14(11):1021-1032. View in: Pubmed

      • Patterns of Medical Care Cost by Service Type for Patients With Recurrent and De Novo Advanced Cancer. Value Health. 2022 01; 25(1):69-76. View in: Pubmed

      • Regarding the Utility of Unstructured Data and Natural Language Processing for Identification of Breast Cancer Recurrence. JCO Clin Cancer Inform. 2021 09; 5:1024-1025. View in: Pubmed

      • OptBand: optimization-based confidence bands for functions to characterize time-to-event distributions. Lifetime Data Anal. 2021 07; 27(3):481-498. View in: Pubmed

      • Familial Burden and Other Clinical Factors Associated With Various Types of Cancer in Individuals With Lynch Syndrome. Gastroenterology. 2021 07; 161(1):143-150.e4. View in: Pubmed

      • Implementing Systematic Genetic Counseling and Multigene Germline Testing for Individuals With Pancreatic Cancer. JCO Oncol Pract. 2021 02; 17(2):e236-e247. View in: Pubmed

      • Acrolein and other toxicant exposures in relation to cardiovascular disease among marijuana and tobacco smokers in a longitudinal cohort of HIV-positive and negative adults. EClinicalMedicine. 2021 Jan; 31:100697. View in: Pubmed

      • Erratum to "ROC curves for clinical prediction models part 1. ROC plots showed no added value above the AUC when evaluating the performance of clinical prediction models" [J Clin Epidemiol. 126C(2020):207-16]. J Clin Epidemiol. 2021 Feb; 130:171-173. View in: Pubmed

      • Comparison of Colorectal and Endometrial Microsatellite Instability Tumor Analysis and Premm5 Risk Assessment for Predicting Pathogenic Germline Variants on Multigene Panel Testing. J Clin Oncol. 2020 12 01; 38(34):4086-4094. View in: Pubmed

      • Empirical power comparison of statistical tests in contemporary phase III randomized controlled trials with time-to-event outcomes in oncology. Clin Trials. 2020 12; 17(6):597-606. View in: Pubmed

      • The Effect of Disclosing Life Expectancy Information on Patients' Prognostic Understanding: Secondary Outcomes From a Multicenter Randomized Trial of a Palliative Chemotherapy Educational Intervention. J Pain Symptom Manage. 2021 01; 61(1):1-11.e3. View in: Pubmed

      • Characterizing germline APC and MUTYH variants in Ashkenazi Jews compared to other individuals. Fam Cancer. 2021 04; 20(2):111-116. View in: Pubmed

      • Effectiveness of a Multimedia Educational Intervention to Improve Understanding of the Risks and Benefits of Palliative Chemotherapy in Patients With Advanced Cancer: A Randomized Clinical Trial. JAMA Oncol. 2020 08 01; 6(8):1265-1270. View in: Pubmed

      • ROC curves for clinical prediction models part 1. ROC plots showed no added value above the AUC when evaluating the performance of clinical prediction models. J Clin Epidemiol. 2020 10; 126:207-216. View in: Pubmed

      • Assessment of Temporal Selection Bias in Genomic Testing in a Cohort of Patients With Cancer. JAMA Netw Open. 2020 06 01; 3(6):e206976. View in: Pubmed

      • Patterns and predictors of cancer-related fatigue in ovarian and endometrial cancers: 1-year longitudinal study. Cancer. 2020 08 01; 126(15):3526-3533. View in: Pubmed

      • On permutation tests for comparing restricted mean survival time with small sample from randomized trials. Stat Med. 2020 09 10; 39(20):2655-2670. View in: Pubmed

      • Racial and Ethnic Differences in Communication and Care for Children With Advanced Cancer. J Pain Symptom Manage. 2020 10; 60(4):782-789. View in: Pubmed

      • Is the Log-Rank and Hazard Ratio Test/Estimation the Best Approach for Primary Analysis for All Trials? J Clin Oncol. 2020 06 10; 38(17):2000-2001. View in: Pubmed

      • Loss of tetherin antagonism by Nef impairs SIV replication during acute infection of rhesus macaques. PLoS Pathog. 2020 04; 16(4):e1008487. View in: Pubmed

      • On the empirical choice of the time window for restricted mean survival time. Biometrics. 2020 12; 76(4):1157-1166. View in: Pubmed

      • Statistical Test/Estimation Methods Used in Contemporary Phase III Cancer Randomized Controlled Trials with Time-to-Event Outcomes. Oncologist. 2020 02; 25(2):91-93. View in: Pubmed

      • Statistical Test/Estimation Methods Used in Contemporary Phase III Cancer Randomized Controlled Trials with Time-to-Event Outcomes. Oncologist. 2019 Nov 19. View in: Pubmed

      • Clinical Factors Associated with Urinary Tract Cancer in Individuals with Lynch Syndrome. Cancer Epidemiol Biomarkers Prev. 2020 01; 29(1):193-199. View in: Pubmed

      • Goals of care discussions for patients with blood cancers: Association of person, place, and time with end-of-life care utilization. Cancer. 2020 02 01; 126(3):515-522. View in: Pubmed

      • Unrealistic parental expectations for cure in poor-prognosis childhood cancer. Cancer. 2020 01 15; 126(2):416-424. View in: Pubmed

      • Patient-preferred outcomes measurement after post-mastectomy radiation therapy and immediate reconstruction. Breast J. 2020 02; 26(2):319-321. View in: Pubmed

      • Assessing Clinical Equivalence in Oncology Biosimilar Trials With Time-to-Event Outcomes. JNCI Cancer Spectr. 2019 Dec; 3(4):pkz058. View in: Pubmed

      • Spending for Advanced Cancer Diagnoses: Comparing Recurrent Versus De Novo Stage IV Disease. J Oncol Pract. 2019 07; 15(7):e616-e627. View in: Pubmed

      • Unifying Design and Analysis for Superiority and Noninferiority Trials With Appropriate End Point. JAMA Surg. 2019 05 01; 154(5):466-467. View in: Pubmed

      • Hospitalization Risk During Chemotherapy for Advanced Cancer: Development and Validation of Risk Stratification Models Using Real-World Data. JCO Clin Cancer Inform. 2019 04; 3:1-10. View in: Pubmed

      • Performance of Cancer Recurrence Algorithms After Coding Scheme Switch From International Classification of Diseases 9th Revision to International Classification of Diseases 10th Revision. JCO Clin Cancer Inform. 2019 03; 3:1-9. View in: Pubmed

      • Increased risk of anal squamous cell carcinoma in HIV-positive men with prior hepatitis B virus infection. AIDS. 2019 01 27; 33(1):145-152. View in: Pubmed

      • Effect of marijuana smoking on pulmonary disease in HIV-infected and uninfected men: a longitudinal cohort study. EClinicalMedicine. 2019 Jan; 7:55-64. View in: Pubmed

      • Determining the Time of Cancer Recurrence Using Claims or Electronic Medical Record Data. JCO Clin Cancer Inform. 2018 12; 2:1-10. View in: Pubmed

      • Moving beyond the conventional stratified analysis to estimate an overall treatment efficacy with the data from a comparative randomized clinical study. Stat Med. 2019 03 15; 38(6):917-932. View in: Pubmed

      • Low T-cell subsets prior to development of virus-associated cancer in HIV-seronegative men who have sex with men. Cancer Causes Control. 2018 Nov; 29(11):1131-1142. View in: Pubmed

      • Hospitalization and Survival of Medicare Patients Treated With Carboplatin Plus Paclitaxel or Pemetrexed for Metastatic, Nonsquamous, Non-Small Cell Lung Cancer. JAMA Netw Open. 2018 10 05; 1(6):e183023. View in: Pubmed

      • Commentary: PREMM5 threshold of 2.5% is recommended to improve identification of PMS2 carriers. Fam Cancer. 2018 10; 17(4):567. View in: Pubmed

      • Impact of Antiretroviral Regimens on Cerebrospinal Fluid Viral Escape in a Prospective Multicohort Study of Antiretroviral Therapy-Experienced Human Immunodeficiency Virus-1-Infected Adults in the United States. Clin Infect Dis. 2018 09 28; 67(8):1182-1190. View in: Pubmed

      • How Do the Accrual Pattern and Follow-Up Duration Affect the Hazard Ratio Estimate When the Proportional Hazards Assumption Is Violated? Oncologist. 2019 07; 24(7):867-871. View in: Pubmed

      • Interpreting the Association of First-in-Class Immune Checkpoint Inhibition and Targeted Therapy With Survival in Patients With Stage IV Melanoma. JAMA Oncol. 2018 08 01; 4(8):1135-1136. View in: Pubmed

      • Estimating and Interpreting the Overall Survival Benefit of Checkpoint Inhibitors via Meta-analysis. JAMA Oncol. 2018 08 01; 4(8):1137-1138. View in: Pubmed

      • Medical Care Costs for Recurrent versus De Novo Stage IV Cancer by Age at Diagnosis. Health Serv Res. 2018 12; 53(6):5106-5128. View in: Pubmed

      • Comparing Survival After Recurrent vs De Novo Stage IV Advanced Breast, Lung, and Colorectal Cancer. JNCI Cancer Spectr. 2018 Apr; 2(2):pky024. View in: Pubmed

      • Estrogen-receptor status and risk of contralateral breast cancer following DCIS. Breast Cancer Res Treat. 2018 Oct; 171(3):777-781. View in: Pubmed

      • Quantification of Long-term Survival Benefit in a Comparative Oncology Clinical Study. JAMA Oncol. 2018 06 01; 4(6):881-882. View in: Pubmed

      • Interactive or static reports to guide clinical interpretation of cancer genomics. J Am Med Inform Assoc. 2018 05 01; 25(5):458-464. View in: Pubmed

      • Assessing Metronomic Chemotherapy for Progressive Pediatric Solid Malignant Tumors. JAMA Oncol. 2018 05 01; 4(5):743. View in: Pubmed

      • Adding a new analytical procedure with clinical interpretation in the tool box of survival analysis. Ann Oncol. 2018 05 01; 29(5):1092-1094. View in: Pubmed

      • A flexible and coherent test/estimation procedure based on restricted mean survival times for censored time-to-event data in randomized clinical trials. Stat Med. 2018 07 10; 37(15):2307-2320. View in: Pubmed

      • Zoledronic Acid Dosing in Patients With Metastatic Breast Cancer. JAMA Oncol. 2018 04 01; 4(4):585. View in: Pubmed

      • Development, Validation, and Dissemination of a Breast Cancer Recurrence Detection and Timing Informatics Algorithm. J Natl Cancer Inst. 2018 03 01; 110(3):273-281. View in: Pubmed

      • Evaluating Noninferiority With Clinically Interpretable Statistics for the PROSELICA Study to Assess Treatment Efficacy of a Reduced Dose of Cabazitaxel for Treating Metastatic Prostate Cancer. J Clin Oncol. 2018 03 10; 36(8):825-826. View in: Pubmed

      • Axillary vs Sentinel Lymph Node Dissection in Women With Invasive Breast Cancer. JAMA. 2018 01 16; 319(3):306. View in: Pubmed

      • Patients With Advanced Melanoma Who Discontinued Treatment With Nivolumab and Ipilimumab as a Result of Adverse Events Lived Significantly Longer Than Patients Who Continued Treatment. J Clin Oncol. 2018 03 01; 36(7):720-721. View in: Pubmed

      • Detecting Lung and Colorectal Cancer Recurrence Using Structured Clinical/Administrative Data to Enable Outcomes Research and Population Health Management. Med Care. 2017 12; 55(12):e88-e98. View in: Pubmed

      • Interpretability of Cancer Clinical Trial Results Using Restricted Mean Survival Time as an Alternative to the Hazard Ratio. JAMA Oncol. 2017 12 01; 3(12):1692-1696. View in: Pubmed

      • Poor performance of clinical prediction models: the harm of commonly applied methods. J Clin Epidemiol. 2018 06; 98:133-143. View in: Pubmed

      • Restricted Mean Survival Time as a Measure to Interpret Clinical Trial Results. JAMA Cardiol. 2017 11 01; 2(11):1179-1180. View in: Pubmed

      • Efficiency of two sample tests via the restricted mean survival time for analyzing event time observations. Biometrics. 2018 06; 74(2):694-702. View in: Pubmed

      • Decision on performing interim analysis for comparative clinical trials. Contemp Clin Trials Commun. 2017 Sep; 7:224-230. View in: Pubmed

      • Marijuana Use Impacts Midlife Cardiovascular Events in HIV-Infected Men. Clin Infect Dis. 2017 Aug 15; 65(4):626-635. View in: Pubmed

      • Overall Survival in the Randomized Phase II Study Investigating Pazopanib Versus Weekly Paclitaxel in Relapsed or Progressive Urothelial Cancer. J Clin Oncol. 2017 10 10; 35(29):3373. View in: Pubmed

      • KIR3DL01 upregulation on gut natural killer cells in response to SIV infection of KIR- and MHC class I-defined rhesus macaques. PLoS Pathog. 2017 Jul; 13(7):e1006506. View in: Pubmed

      • Survival after recurrence of stage I-III breast, colorectal, or lung cancer. Cancer Epidemiol. 2017 08; 49:186-194. View in: Pubmed

      • Long-term nitrite inhalant exposure and cancer risk in MSM. AIDS. 2017 05 15; 31(8):1169-1180. View in: Pubmed

      • Development and Validation of the PREMM5 Model for Comprehensive Risk Assessment of Lynch Syndrome. J Clin Oncol. 2017 Jul 01; 35(19):2165-2172. View in: Pubmed

      • Racial differences in prostate cancer risk in young HIV-positive and HIV-negative men: a prospective cohort study. Cancer Causes Control. 2017 Jul; 28(7):767-777. View in: Pubmed

      • Long-term nitrite inhalant exposure and cancer risk in men who have sex with men: a prospective cohort study. AIDS. 2017 Mar 18. View in: Pubmed

      • Cancer Susceptibility Gene Mutations in Individuals With Colorectal Cancer. J Clin Oncol. 2017 Apr 01; 35(10):1086-1095. View in: Pubmed

      • Tumor aneuploidy correlates with markers of immune evasion and with reduced response to immunotherapy. Science. 2017 01 20; 355(6322). View in: Pubmed

      • Association of Regional Intensity of Ductal Carcinoma In Situ Treatment With Likelihood of Breast Preservation. JAMA Oncol. 2017 Jan 01; 3(1):101-104. View in: Pubmed

      • How to Summarize the Safety Profile of Epoetin Alfa Versus Best Standard of Care in Anemic Patients With Metastatic Breast Cancer Receiving Standard Chemotherapy? J Clin Oncol. 2016 11 01; 34(31):3818. View in: Pubmed

      • Safety Study of Salmeterol in Asthma in Adults. N Engl J Med. 2016 09 15; 375(11):1097. View in: Pubmed

      • Reply to comparative effectiveness of stereotactic radiosurgery versus whole-brain radiation therapy for patients with brain metastases from breast or non-small cell lung cancer. Cancer. 2016 10 15; 122(20):3244-3245. View in: Pubmed

      • Neratinib after trastuzumab in patients with HER2-positive breast cancer. Lancet Oncol. 2016 05; 17(5):e176. View in: Pubmed

      • Comparative effectiveness of stereotactic radiosurgery versus whole-brain radiation therapy for patients with brain metastases from breast or non-small cell lung cancer. Cancer. 2016 Jul 01; 122(13):2091-100. View in: Pubmed

      • Influence of patient and provider characteristics on quality of care for the myelodysplastic syndromes. Br J Haematol. 2016 06; 173(5):713-21. View in: Pubmed

      • Nivolumab in Nonsquamous Non-Small-Cell Lung Cancer. N Engl J Med. 2016 02 04; 374(5):492-3. View in: Pubmed

      • Detection and prognostic value of pulmonary congestion by lung ultrasound in ambulatory heart failure patients. Eur Heart J. 2016 Apr 14; 37(15):1244-51. View in: Pubmed

      • Intensity of Medical Interventions between Diagnosis and Death in Patients with Advanced Lung and Colorectal Cancer: A CanCORS Analysis. J Palliat Med. 2016 Jan; 19(1):42-50. View in: Pubmed

      • On the restricted mean survival time curve in survival analysis. Biometrics. 2016 Mar; 72(1):215-21. View in: Pubmed

      • Detecting Lung and Colorectal Cancer Recurrence Using Structured Clinical/Administrative Data to Enable Outcomes Research and Population Health Management. Med Care. 2015 Jul 29. View in: Pubmed

      • Alternatives to Hazard Ratios for Comparing the Efficacy or Safety of Therapies in Noninferiority Studies. Ann Intern Med. 2015 Jul 21; 163(2):127-34. View in: Pubmed

      • A versatile test for equality of two survival functions based on weighted differences of Kaplan-Meier curves. Stat Med. 2015 Dec 10; 34(28):3680-95. View in: Pubmed

      • Biological Subtype Predicts Risk of Locoregional Recurrence After Mastectomy and Impact of Postmastectomy Radiation in a Large National Database. Int J Radiat Oncol Biol Phys. 2015 Nov 01; 93(3):622-30. View in: Pubmed

      • Adverse Outcomes After Palliative Radiation Therapy for Uncomplicated Spine Metastases: Role of Spinal Instability and Single-Fraction Radiation Therapy. Int J Radiat Oncol Biol Phys. 2015 Oct 01; 93(2):373-81. View in: Pubmed

      • Clinician assessment of potentially avoidable hospitalization in patients with cancer. J Clin Oncol. 2014 Oct 20; 32(30_suppl):4. View in: Pubmed

      • Acute hospital care is the chief driver of regional spending variation in Medicare patients with advanced cancer. Health Aff (Millwood). 2014 Oct; 33(10):1793-800. View in: Pubmed

      • Derivation and validation of the SEER-Medicare myelodysplastic syndromes risk score (SMMRS). Leuk Res. 2014 Dec; 38(12):1420-4. View in: Pubmed

      • Financial hardship and the intensity of medical care received near death. Psychooncology. 2015 May; 24(5):572-8. View in: Pubmed

      • Interinstitutional variation in management decisions for treatment of 4 common types of cancer: A multi-institutional cohort study. Ann Intern Med. 2014 Jul 01; 161(1):20-30. View in: Pubmed

      • Moving beyond the hazard ratio in quantifying the between-group difference in survival analysis. J Clin Oncol. 2014 Aug 01; 32(22):2380-5. View in: Pubmed

      • Effects of bracing in adolescents with idiopathic scoliosis. N Engl J Med. 2014 02 13; 370(7):680. View in: Pubmed

      • Identification of potentially avoidable hospitalizations in patients with GI cancer. J Clin Oncol. 2014 Feb 20; 32(6):496-503. View in: Pubmed

      • Hemoglobin stability in patients with anemia, CKD, and type 2 diabetes: an analysis of the TREAT (Trial to Reduce Cardiovascular Events With Aranesp Therapy) placebo arm. Am J Kidney Dis. 2013 Feb; 61(2):238-46. View in: Pubmed

      • A unified inference procedure for a class of measures to assess improvement in risk prediction systems with survival data. Stat Med. 2013 Jun 30; 32(14):2430-42. View in: Pubmed

      • Utilizing the integrated difference of two survival functions to quantify the treatment contrast for designing, monitoring, and analyzing a comparative clinical study. Clin Trials. 2012 Oct; 9(5):570-7. View in: Pubmed

      • Monocyte activation markers in cerebrospinal fluid associated with impaired neurocognitive testing in advanced HIV infection. J Acquir Immune Defic Syndr. 2012 Jul 01; 60(3):234-43. View in: Pubmed

      • Mortality rates in trials of subjects with type 2 diabetes. J Am Heart Assoc. 2012 Feb; 1(1):8-15. View in: Pubmed

      • Functional pathway analysis in acute myeloid leukemia using single cell network profiling assay: effect of specimen source (bone marrow or peripheral blood) on assay readouts. Cytometry B Clin Cytom. 2012 May; 82(3):158-72. View in: Pubmed

      • Stroke in patients with type 2 diabetes mellitus, chronic kidney disease, and anemia treated with Darbepoetin Alfa: the trial to reduce cardiovascular events with Aranesp therapy (TREAT) experience. Circulation. 2011 Dec 20; 124(25):2903-8. View in: Pubmed

      • Predictors of fatal and nonfatal cardiovascular events in patients with type 2 diabetes mellitus, chronic kidney disease, and anemia: an analysis of the Trial to Reduce cardiovascular Events with Aranesp (darbepoetin-alfa) Therapy (TREAT). Am Heart J. 2011 Oct; 162(4):748-755.e3. View in: Pubmed

      • Impact of high-risk classification by FISH: an eastern cooperative oncology group (ECOG) study E4A03. Br J Haematol. 2011 Nov; 155(3):340-8. View in: Pubmed

      • Impact of gene expression profiling-based risk stratification in patients with myeloma receiving initial therapy with lenalidomide and dexamethasone. Blood. 2011 Oct 20; 118(16):4359-62. View in: Pubmed

      • Plasma sCD14 is a biomarker associated with impaired neurocognitive test performance in attention and learning domains in HIV infection. J Acquir Immune Defic Syndr. 2011 Aug 15; 57(5):371-9. View in: Pubmed

      • Prognostic assessment of estimated glomerular filtration rate by the new Chronic Kidney Disease Epidemiology Collaboration equation in comparison with the Modification of Diet in Renal Disease Study equation. Am Heart J. 2011 Sep; 162(3):548-54. View in: Pubmed

      • Association between cardiac biomarkers and the development of ESRD in patients with type 2 diabetes mellitus, anemia, and CKD. Am J Kidney Dis. 2011 Nov; 58(5):717-28. View in: Pubmed

      • Suppression of aldosterone mediates regression of left ventricular hypertrophy in patients with hypertension. J Renin Angiotensin Aldosterone Syst. 2011 Dec; 12(4):483-90. View in: Pubmed

      • Relationship between improvement in left ventricular dyssynchrony and contractile function and clinical outcome with cardiac resynchronization therapy: the MADIT-CRT trial. Eur Heart J. 2011 Jul; 32(14):1720-9. View in: Pubmed

      • Circumstances and outcomes of sudden unexpected death in patients with high-risk myocardial infarction: implications for prevention. Circulation. 2011 Jun 14; 123(23):2674-80. View in: Pubmed

      • Dyssynchrony, contractile function, and response to cardiac resynchronization therapy. Circ Heart Fail. 2011 Jul; 4(4):433-40. View in: Pubmed

      • Survival outcomes in elderly patients with plasma cell myeloma: The three-decade Eastern Cooperative Oncology Group (ECOG) experience. J Clin Oncol. 2011 May 20; 29(15_suppl):8021. View in: Pubmed

      • Graphical procedures for evaluating overall and subject-specific incremental values from new predictors with censored event time data. Biometrics. 2011 Dec; 67(4):1389-96. View in: Pubmed

      • Opposing effects of ß blockers and angiotensin-converting enzyme inhibitors on development of new-onset diabetes mellitus in patients with stable coronary artery disease. Am J Cardiol. 2011 Jun 15; 107(12):1705-9. View in: Pubmed

      • Outcome prediction in sepsis combined use of genetic polymorphisms - A study in Japanese population. Cytokine. 2011 Apr; 54(1):79-84. View in: Pubmed

      • On the C-statistics for evaluating overall adequacy of risk prediction procedures with censored survival data. Stat Med. 2011 May 10; 30(10):1105-17. View in: Pubmed

      • Darbepoetin alfa impact on health status in diabetes patients with kidney disease: a randomized trial. Clin J Am Soc Nephrol. 2011 Apr; 6(4):845-55. View in: Pubmed

      • Longitudinal and circumferential strain rate, left ventricular remodeling, and prognosis after myocardial infarction. J Am Coll Cardiol. 2010 Nov 23; 56(22):1812-22. View in: Pubmed

      • The inter-relationship of diabetes and left ventricular systolic function on outcome after high-risk myocardial infarction. Eur J Heart Fail. 2010 Nov; 12(11):1229-37. View in: Pubmed

      • Erythropoietic response and outcomes in kidney disease and type 2 diabetes. N Engl J Med. 2010 Sep 16; 363(12):1146-55. View in: Pubmed

      • Zosuquidar, a novel modulator of P-glycoprotein, does not improve the outcome of older patients with newly diagnosed acute myeloid leukemia: a randomized, placebo-controlled trial of the Eastern Cooperative Oncology Group 3999. Blood. 2010 Nov 18; 116(20):4077-85. View in: Pubmed

      • Pathogenesis of sudden unexpected death in a clinical trial of patients with myocardial infarction and left ventricular dysfunction, heart failure, or both. Circulation. 2010 Aug 10; 122(6):597-602. View in: Pubmed

      • Clinical consequences of road traffic injuries among the elderly in Japan. BMC Public Health. 2010 Jun 28; 10:375. View in: Pubmed

      • Calibrating parametric subject-specific risk estimation. Biometrika. 2010 Jun; 97(2):389-404. View in: Pubmed

      • Mechanical dyssynchrony after myocardial infarction in patients with left ventricular dysfunction, heart failure, or both. Circulation. 2010 Mar 09; 121(9):1096-103. View in: Pubmed

      • Defibrotide for the treatment of severe hepatic veno-occlusive disease and multiorgan failure after stem cell transplantation: a multicenter, randomized, dose-finding trial. Biol Blood Marrow Transplant. 2010 Jul; 16(7):1005-17. View in: Pubmed

      • Predicted Interval Plots (PIPS): A Graphical Tool for Data Monitoring of Clinical Trials. Stat Biopharm Res. 2009 Nov 01; 1(4):348-355. View in: Pubmed

      • Clinical value of minor responses after 4 doses of rituximab in Waldenström macroglobulinaemia: a follow-up of the Eastern Cooperative Oncology Group E3A98 trial. Br J Haematol. 2009 Dec; 147(5):677-80. View in: Pubmed

      • Baseline characteristics in the Trial to Reduce Cardiovascular Events With Aranesp Therapy (TREAT). Am J Kidney Dis. 2009 Jul; 54(1):59-69. View in: Pubmed

      • Long-lasting responses after four doses of rituximab in Waldenström's macroglobulinemia: Clinical value of minor responses: A follow-up of the Eastern Cooperative Oncology Group E3A98 trial. J Clin Oncol. 2009 May 20; 27(15_suppl):8513. View in: Pubmed

      • Left atrial remodelling in patients with myocardial infarction complicated by heart failure, left ventricular dysfunction, or both: the VALIANT Echo study. Eur Heart J. 2009 Jan; 30(1):56-65. View in: Pubmed

      • The short treatment with the angiotensin receptor blocker candesartan surveyed by telemedicine (STAR CAST) study: rationale and study design. Hypertens Res. 2008 Oct; 31(10):1843-9. View in: Pubmed

      • Diagnostic performance of PET/CT in differentiation of malignant and benign non-solid solitary pulmonary nodules. Ann Nucl Med. 2008 Aug; 22(7):571-7. View in: Pubmed

      • Development and verification of a prediction model using serum tumor markers to predict the response to chemotherapy of patients with metastatic or recurrent breast cancer. J Cancer Res Clin Oncol. 2008 Nov; 134(11):1199-206. View in: Pubmed

      • Which factors will make the duration short between last palliative chemotherapy and death? J Clin Oncol. 2008 May 20; 26(15_suppl):20575. View in: Pubmed

      • Development and validation of diagnostic prediction model for solitary pulmonary nodules. Respirology. 2007 Nov; 12(6):856-62. View in: Pubmed

      • Prediction of response and prognostic factors for Ewing family of tumors in a low incidence population. J Cancer Res Clin Oncol. 2008 Mar; 134(3):389-95. View in: Pubmed

      • Solitary pulmonary granuloma caused by Mycobacterium avium-intracellulare complex. Int J Tuberc Lung Dis. 2007 Feb; 11(2):215-21. View in: Pubmed

      • Genomic characterization of multiple clinical phenotypes of cancer using multivariate linear regression models. Bioinformatics. 2007 Mar 15; 23(6):732-8. View in: Pubmed

      • Prediction of response to repeat utilization of anthracycline in recurrent breast cancer patients previously administered anthracycline-containing chemotherapeutic regimens as neoadjuvant or adjuvant chemotherapy. Breast Cancer Res Treat. 2007 Jul; 103(3):313-8. View in: Pubmed

      • Diagnostic accuracy of CT-guided percutaneous cutting needle biopsy for thymic tumours. Clin Radiol. 2006 Sep; 61(9):771-5. View in: Pubmed

      • Prediction of lung adenocarcinoma without vessel invasion: a CT scan volumetric analysis. Chest. 2005 Nov; 128(5):3276-83. View in: Pubmed

      • Efficacy of weekly paclitaxel in patients with docetaxel-resistant metastatic breast cancer. Breast Cancer Res Treat. 2005 Feb; 89(3):237-41. View in: Pubmed

      • Risk factors for endometriosis in the rhesus monkey (Macaca mulatta): a case-control study. Hum Reprod Update. 1997 Mar-Apr; 3(2):109-15. View in: Pubmed

      • Action of topical minoxidil in the bald stump-tailed macaque. J Am Acad Dermatol. 1987 Mar; 16(3 Pt 2):657-68. View in: Pubmed


      Location Avtar

      Dana-Farber Cancer Institute

      450 Brookline Avenue Dana 1112 Boston, MA 02215
      Get Directions

      Dana-Farber Cancer Institute

      Location Avtar

      Dana-Farber Cancer Institute

      450 Brookline Avenue Dana 1112 Boston, MA 02215
      Get Direction
      42.3374, -71.1082

      Discovery and Insights