James A. DeCaprio, MD

James A. DeCaprio, MD

Medical Oncology

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James A. DeCaprio, MD

Dr. DeCaprio received his MD in 1984 from the University at Buffalo School of Medicine and Biomedical Sciences. He completed his internal medicine residency at the University of Chicago, and his medical oncology fellowship at DFCI. In 1992, he joined the faculty of DFCI, where his laboratory has focused on mechanisms of cellular transformation and oncogenesis.



Professor of Medicine, Harvard Medical School


Clinical Interests

Viral oncology


  • Dana-Farber Cancer Institute, Medical Oncology


  • University of Chicago, Internal Medicine

Medical School

  • University at Buffalo School of Medicine and Biomedical Sciences

Recent Awards

  • American Society for Clinical Investigation 1997
  • Scholar, Leukemia Society of America 1997
  • Stohlman Scholar, Leukemia & Lymphoma Society 2002
  • Biological and Biochemical Sciences HMS Award in Teaching 2000
  • Association of American Physicians 2004
  • Harvard University GSAS Everett Mendelsohn Excellence in Mentoring Award 2004


    Mechanisms of Cellular Transformation and Oncogenesis

    Viral oncology

    Our laboratory examines how viruses can cause human cancer. In particular, we study the family of small DNA tumor viruses that include human papilloma virus (HPV) and polyomavirus. HPV can cause cervical cancer and oropharyngeal cancer. The Merkel cell polyomavirus can cause Merkel cell carcinoma, a highly lethal form of skin cancer.  Our laboratory studies how these viruses infect normal human cells and the consequences of the subsequent interactions between the viral oncogenes and the cellular DNA, genes and proteins.

    Cell Cycle

    One hallmark of cancer is rapid and uncontrolled proliferation. A cancer cell retains the ability to replicate its DNA and undergo cell division similar to a normal cell. However, a cancer cell has lost important checkpoints that regulate entry into the cell cycle, resulting in continuous and inappropriate cell proliferation. Our laboratory has focused on transcription factors that regulate entry into and progression through the cell cycle. In addition, we study how a cell and a tumor can stop proliferating by exiting the cell cycle and entering into a state of cellular quiescence or senescence and tumor dormancy.


      • Tumor cell-intrinsic PD-1 promotes Merkel cell carcinoma growth by activating downstream mTOR-mitochondrial ROS signaling. Sci Adv. 2024 Jan 19; 10(3):eadi2012. View in: Pubmed

      • Author Correction: Liquid biopsy epigenomic profiling for cancer subtyping. Nat Med. 2023 Dec 04. View in: Pubmed

      • Integrative analysis reveals therapeutic potential of pyrvinium pamoate in Merkel cell carcinoma. bioRxiv. 2023 Nov 04. View in: Pubmed

      • Liquid biopsy epigenomic profiling for cancer subtyping. Nat Med. 2023 Nov; 29(11):2737-2741. View in: Pubmed

      • YAP1 and WWTR1 expression inversely correlates with neuroendocrine markers in Merkel cell carcinoma. J Clin Invest. 2023 03 01; 133(5). View in: Pubmed

      • Virology under the Microscope-a Call for Rational Discourse. mBio. 2023 02 28; 14(1):e0018823. View in: Pubmed

      • Virology under the Microscope-a Call for Rational Discourse. mSphere. 2023 04 20; 8(2):e0003423. View in: Pubmed

      • Virology under the Microscope-a Call for Rational Discourse. J Virol. 2023 02 28; 97(2):e0008923. View in: Pubmed

      • An international report on bacterial communities in esophageal squamous cell carcinoma. Int J Cancer. 2022 Dec 01; 151(11):1947-1959. View in: Pubmed

      • Distinct Radiation Responses in Virus-Positive and Virus-Negative Merkel Cell Carcinoma. J Invest Dermatol. 2023 01; 143(1):166-169.e5. View in: Pubmed

      • Disrupting the DREAM complex enables proliferation of adult human pancreatic ß cells. J Clin Invest. 2022 08 01; 132(15). View in: Pubmed

      • Coordinating gene expression during the cell cycle. Trends Biochem Sci. 2022 Dec; 47(12):1009-1022. View in: Pubmed

      • Milademetan is a highly potent MDM2 inhibitor in Merkel cell carcinoma. JCI Insight. 2022 07 08; 7(13). View in: Pubmed

      • Reversal of viral and epigenetic HLA class I repression in Merkel cell carcinoma. J Clin Invest. 2022 07 01; 132(13). View in: Pubmed

      • Addiction of Merkel cell carcinoma to MUC1-C identifies a potential new target for treatment. Oncogene. 2022 07; 41(27):3511-3523. View in: Pubmed

      • Merkel cell polyomavirus large T antigen binding to pRb promotes skin hyperplasia and tumor development. PLoS Pathog. 2022 05; 18(5):e1010551. View in: Pubmed

      • CDC7-independent G1/S transition revealed by targeted protein degradation. Nature. 2022 05; 605(7909):357-365. View in: Pubmed

      • Long-read sequencing reveals complex patterns of wraparound transcription in polyomaviruses. PLoS Pathog. 2022 04; 18(4):e1010401. View in: Pubmed

      • TargetGeneReg 2.0: a comprehensive web-atlas for p53, p63, and cell cycle-dependent gene regulation. NAR Cancer. 2022 Mar; 4(1):zcac009. View in: Pubmed

      • Merkel Cell Carcinoma Sensitivity to EZH2 Inhibition Is Mediated by SIX1 Derepression. J Invest Dermatol. 2022 10; 142(10):2783-2792.e15. View in: Pubmed

      • Merkel Cell Polyomavirus: Oncogenesis in a Stable Genome. Viruses. 2021 12 30; 14(1). View in: Pubmed

      • David M. Livingston 1941-2021. Nat Cancer. 2021 12; 2(12):1276-1277. View in: Pubmed

      • Simultaneous expression of MMB-FOXM1 complex components enables efficient bypass of senescence. Sci Rep. 2021 11 02; 11(1):21506. View in: Pubmed

      • Subtype heterogeneity and epigenetic convergence in neuroendocrine prostate cancer. Nat Commun. 2021 10 01; 12(1):5775. View in: Pubmed

      • Preparing Live Cells for Immunization. Cold Spring Harb Protoc. 2021 08 02; 2021(8). View in: Pubmed

      • An analysis of the use of targeted therapies in patients with advanced Merkel cell carcinoma and an evaluation of genomic correlates of response. Cancer Med. 2021 09; 10(17):5889-5896. View in: Pubmed

      • MMB-FOXM1-driven premature mitosis is required for CHK1 inhibitor sensitivity. Cell Rep. 2021 03 02; 34(9):108808. View in: Pubmed

      • The Merkel Cell Polyomavirus T Antigens Function as Tumor Promoters in Murine Skin. Cancers (Basel). 2021 Jan 09; 13(2). View in: Pubmed

      • Pervasive generation of non-canonical subgenomic RNAs by SARS-CoV-2. Genome Med. 2020 12 01; 12(1):108. View in: Pubmed

      • Predictors of immunotherapy benefit in Merkel cell carcinoma. Oncotarget. 2020 Nov 24; 11(47):4401-4410. View in: Pubmed

      • Molecular Pathogenesis of Merkel Cell Carcinoma. Annu Rev Pathol. 2021 01 24; 16:69-91. View in: Pubmed

      • Association between treatment center experience and survival after diagnosis of stage I to III Merkel cell carcinoma treated with surgery with or without postoperative radiation therapy. J Am Acad Dermatol. 2021 Mar; 84(3):875-877. View in: Pubmed

      • Immunoprecipitation. Cold Spring Harb Protoc. 2020 11 02; 2020(11). View in: Pubmed

      • CHK1 Inhibitor Blocks Phosphorylation of FAM122A and Promotes Replication Stress. Mol Cell. 2020 11 05; 80(3):410-422.e6. View in: Pubmed

      • Real-world outcomes treating patients with advanced cutaneous squamous cell carcinoma with immune checkpoint inhibitors (CPI). Br J Cancer. 2020 11; 123(10):1535-1542. View in: Pubmed

      • Association of Programmed Death 1 Protein Ligand (PD-L1) Expression With Prognosis in Merkel Cell Carcinoma. Front Med (Lausanne). 2020; 7:198. View in: Pubmed

      • Author Correction: Merkel cell polyomavirus activates LSD1-mediated blockade of non-canonical BAF to regulate transformation and tumorigenesis. Nat Cell Biol. 2020 06; 22(6):752. View in: Pubmed

      • Merkel cell polyomavirus activates LSD1-mediated blockade of non-canonical BAF to regulate transformation and tumorigenesis. Nat Cell Biol. 2020 05; 22(5):603-615. View in: Pubmed

      • Comprehensive metagenomic analysis of blastic plasmacytoid dendritic cell neoplasm. Blood Adv. 2020 03 24; 4(6):1006-1011. View in: Pubmed

      • Clinical and molecular characterization of virus-positive and virus-negative Merkel cell carcinoma. Genome Med. 2020 03 18; 12(1):30. View in: Pubmed

      • ViroPanel: Hybrid Capture and Massively Parallel Sequencing for Simultaneous Detection and Profiling of Oncogenic Virus Infection and Tumor Genome. J Mol Diagn. 2020 04; 22(4):476-487. View in: Pubmed

      • Denaturing Lysis of Cells for Immunoprecipitation. Cold Spring Harb Protoc. 2020 02 03; 2020(2):098616. View in: Pubmed

      • STRIPAK directs PP2A activity toward MAP4K4 to promote oncogenic transformation of human cells. Elife. 2020 Jan 08; 9. View in: Pubmed

      • Preparing Protein Antigens from Sodium Dodecyl Sulfate-Polyacrylamide Gels for Immunization. Cold Spring Harb Protoc. 2019 12 02; 2019(12). View in: Pubmed

      • RB, p130 and p107 differentially repress G1/S and G2/M genes after p53 activation. Nucleic Acids Res. 2019 12 02; 47(21):11197-11208. View in: Pubmed

      • The Genomic Landscape of Merkel Cell Carcinoma and Clinicogenomic Biomarkers of Response to Immune Checkpoint Inhibitor Therapy. Clin Cancer Res. 2019 10 01; 25(19):5961-5971. View in: Pubmed

      • Cyclin D-CDK4 relieves cooperative repression of proliferation and cell cycle gene expression by DREAM and RB. Oncogene. 2019 06; 38(25):4962-4976. View in: Pubmed

      • Transfected Dendritic Cell Immunizations. Cold Spring Harb Protoc. 2019 03 01; 2019(3). View in: Pubmed

      • DYRK1A regulates the recruitment of 53BP1 to the sites of DNA damage in part through interaction with RNF169. Cell Cycle. 2019 03; 18(5):531-551. View in: Pubmed

      • A Murine Model of Chronic Lymphocytic Leukemia Based on B Cell-Restricted Expression of Sf3b1 Mutation and Atm Deletion. Cancer Cell. 2019 02 11; 35(2):283-296.e5. View in: Pubmed

      • Merkel Cell Carcinoma in the HIV-1/AIDS Patient. Cancer Treat Res. 2019; 177:211-229. View in: Pubmed

      • Dual inhibition of MDM2 and MDM4 in virus-positive Merkel cell carcinoma enhances the p53 response. Proc Natl Acad Sci U S A. 2019 01 15; 116(3):1027-1032. View in: Pubmed

      • SPOP Promotes Nanog Destruction to Suppress Stem Cell Traits and Prostate Cancer Progression. Dev Cell. 2019 02 11; 48(3):329-344.e5. View in: Pubmed

      • Contribution of DNA Replication to the FAM111A-Mediated Simian Virus 40 Host Range Phenotype. J Virol. 2019 01 01; 93(1). View in: Pubmed

      • The biology and treatment of Merkel cell carcinoma: current understanding and research priorities. Nat Rev Clin Oncol. 2018 12; 15(12):763-776. View in: Pubmed

      • Metabolic Labeling of Protein Antigens with [32P]Orthophosphate. Cold Spring Harb Protoc. 2018 09 04; 2018(9). View in: Pubmed

      • Cabozantinib in Patients with Advanced Merkel Cell Carcinoma. Oncologist. 2018 07; 23(7):814-821. View in: Pubmed

      • Epidemiology, biology and therapy of Merkel cell carcinoma: conclusions from the EU project IMMOMEC. Cancer Immunol Immunother. 2018 03; 67(3):341-351. View in: Pubmed

      • Merkel cell carcinoma. Nat Rev Dis Primers. 2017 Oct 26; 3:17077. View in: Pubmed

      • Merkel cell polyomavirus and Merkel cell carcinoma. Philos Trans R Soc Lond B Biol Sci. 2017 Oct 19; 372(1732). View in: Pubmed

      • Merkel cell polyomavirus recruits MYCL to the EP400 complex to promote oncogenesis. PLoS Pathog. 2017 Oct; 13(10):e1006668. View in: Pubmed

      • Transcriptional landscape of the human cell cycle. Proc Natl Acad Sci U S A. 2017 03 28; 114(13):3473-3478. View in: Pubmed

      • Merkel Cell Polyomavirus Exhibits Dominant Control of the Tumor Genome and Transcriptome in Virus-Associated Merkel Cell Carcinoma. mBio. 2017 01 03; 8(1). View in: Pubmed

      • Merkel Cell Polyomavirus Small T Antigen Promotes Pro-Glycolytic Metabolic Perturbations Required for Transformation. PLoS Pathog. 2016 Nov; 12(11):e1006020. View in: Pubmed

      • Proteomic Landscape of Tissue-Specific Cyclin E Functions in Vivo. PLoS Genet. 2016 Nov; 12(11):e1006429. View in: Pubmed

      • Merkel Cell Carcinoma: A Population Analysis on Survival. J Natl Compr Canc Netw. 2016 10; 14(10):1247-1257. View in: Pubmed

      • APC/C and SCF(cyclin F) Constitute a Reciprocal Feedback Circuit Controlling S-Phase Entry. Cell Rep. 2016 09 20; 16(12):3359-3372. View in: Pubmed

      • Integration of TP53, DREAM, MMB-FOXM1 and RB-E2F target gene analyses identifies cell cycle gene regulatory networks. Nucleic Acids Res. 2016 Jul 27; 44(13):6070-86. View in: Pubmed

      • Inhibition of Rb Phosphorylation Leads to mTORC2-Mediated Activation of Akt. Mol Cell. 2016 06 16; 62(6):929-942. View in: Pubmed

      • Does Arabidopsis thaliana DREAM of cell cycle control? EMBO J. 2015 Aug 04; 34(15):1987-9. View in: Pubmed

      • Tumorigenic activity of merkel cell polyomavirus T antigens expressed in the stratified epithelium of mice. Cancer Res. 2015 Mar 15; 75(6):1068-79. View in: Pubmed

      • Malawi polyomavirus is a prevalent human virus that interacts with known tumor suppressors. J Virol. 2015 Jan; 89(1):857-62. View in: Pubmed

      • SMCX and components of the TIP60 complex contribute to E2 regulation of the HPV E6/E7 promoter. Virology. 2014 Nov; 468-470:311-321. View in: Pubmed

      • The DREAM complex in antitumor activity of imatinib mesylate in gastrointestinal stromal tumors. Curr Opin Oncol. 2014 Jul; 26(4):415-21. View in: Pubmed

      • PP2A-mediated regulation of Ras signaling in G2 is essential for stable quiescence and normal G1 length. Mol Cell. 2014 Jun 19; 54(6):932-945. View in: Pubmed

      • Loss of the mammalian DREAM complex deregulates chondrocyte proliferation. Mol Cell Biol. 2014 Jun; 34(12):2221-34. View in: Pubmed

      • Nuclear interferon-inducible protein 16 promotes silencing of herpesviral and transfected DNA. Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):E4492-501. View in: Pubmed

      • Human papillomavirus type 16 E7 perturbs DREAM to promote cellular proliferation and mitotic gene expression. Oncogene. 2014 Jul 31; 33(31):4036-8. View in: Pubmed

      • The DNA damage and the DNA replication checkpoints converge at the MBF transcription factor. Mol Biol Cell. 2013 Nov; 24(21):3350-7. View in: Pubmed

      • The DREAM complex: master coordinator of cell cycle-dependent gene expression. Nat Rev Cancer. 2013 08; 13(8):585-95. View in: Pubmed

      • The DREAM complex mediates GIST cell quiescence and is a novel therapeutic target to enhance imatinib-induced apoptosis. Cancer Res. 2013 Aug 15; 73(16):5120-9. View in: Pubmed

      • Merkel cell polyomavirus large T antigen has growth-promoting and inhibitory activities. J Virol. 2013 Jun; 87(11):6118-26. View in: Pubmed

      • A cornucopia of human polyomaviruses. Nat Rev Microbiol. 2013 Apr; 11(4):264-76. View in: Pubmed

      • Improved detection suggests all Merkel cell carcinomas harbor Merkel polyomavirus. J Clin Invest. 2012 Dec; 122(12):4645-53. View in: Pubmed

      • Identification of FAM111A as an SV40 host range restriction and adenovirus helper factor. PLoS Pathog. 2012; 8(10):e1002949. View in: Pubmed

      • Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins. Nature. 2012 Jul 26; 487(7408):491-5. View in: Pubmed

      • Viral perturbations of host networks reflect disease etiology. PLoS Comput Biol. 2012; 8(6):e1002531. View in: Pubmed

      • Structure of a glomulin-RBX1-CUL1 complex: inhibition of a RING E3 ligase through masking of its E2-binding surface. Mol Cell. 2012 Aug 10; 47(3):371-82. View in: Pubmed

      • Negative regulation of the stability and tumor suppressor function of Fbw7 by the Pin1 prolyl isomerase. Mol Cell. 2012 Jun 29; 46(6):771-83. View in: Pubmed

      • The glomuvenous malformation protein Glomulin binds Rbx1 and regulates cullin RING ligase-mediated turnover of Fbw7. Mol Cell. 2012 Apr 13; 46(1):67-78. View in: Pubmed

      • The MuvB complex sequentially recruits B-Myb and FoxM1 to promote mitotic gene expression. Genes Dev. 2012 Mar 01; 26(5):474-89. View in: Pubmed

      • The CHR promoter element controls cell cycle-dependent gene transcription and binds the DREAM and MMB complexes. Nucleic Acids Res. 2012 Feb; 40(4):1561-78. View in: Pubmed

      • DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly. Genes Dev. 2011 Apr 15; 25(8):801-13. View in: Pubmed

      • A kinase shRNA screen links LATS2 and the pRB tumor suppressor. Genes Dev. 2011 Apr 15; 25(8):814-30. View in: Pubmed

      • Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction. Mol Cell. 2010 Sep 10; 39(5):797-808. View in: Pubmed

      • Does detection of Merkel cell polyomavirus in Merkel cell carcinoma provide prognostic information? J Natl Cancer Inst. 2009 Jul 01; 101(13):905-7. View in: Pubmed

      • A compendium of potential biomarkers of pancreatic cancer. PLoS Med. 2009 Apr 07; 6(4):e1000046. View in: Pubmed

      • Cellular transformation by Simian Virus 40 and Murine Polyoma Virus T antigens. Semin Cancer Biol. 2009 Aug; 19(4):218-28. View in: Pubmed

      • How the Rb tumor suppressor structure and function was revealed by the study of Adenovirus and SV40. Virology. 2009 Feb 20; 384(2):274-84. View in: Pubmed

      • Plakophilin3 downregulation leads to a decrease in cell adhesion and promotes metastasis. Int J Cancer. 2008 Nov 15; 123(10):2303-14. View in: Pubmed

      • Does a new polyomavirus contribute to Merkel cell carcinoma? Genome Biol. 2008; 9(6):228. View in: Pubmed

      • AMP-activated protein kinase is essential for survival in chronic hypoxia. Biochem Biophys Res Commun. 2008 May 30; 370(2):230-4. View in: Pubmed

      • Disruption of the Fbxw8 gene results in pre- and postnatal growth retardation in mice. Mol Cell Biol. 2008 Jan; 28(2):743-51. View in: Pubmed

      • The tumor suppressor PP2A Abeta regulates the RalA GTPase. Cell. 2007 Jun 01; 129(5):969-82. View in: Pubmed

      • Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence. Mol Cell. 2007 May 25; 26(4):539-51. View in: Pubmed

      • PARC and CUL7 form atypical cullin RING ligase complexes. Cancer Res. 2007 Mar 01; 67(5):2006-14. View in: Pubmed

      • Inhibition of Simian virus 40 large T antigen helicase activity by fluoroquinolones. Antivir Ther. 2007; 12(1):1-6. View in: Pubmed

      • Is there a role for SV40 in human cancer? J Clin Oncol. 2006 Sep 10; 24(26):4356-65. View in: Pubmed

      • A novel p53-binding domain in CUL7. Biochem Biophys Res Commun. 2006 Sep 15; 348(1):132-8. View in: Pubmed

      • Targeting of p300/CREB binding protein coactivators by simian virus 40 is mediated through p53. J Virol. 2006 May; 80(9):4292-303. View in: Pubmed

      • The carboxyl-terminal domain of large T antigen rescues SV40 host range activity in trans independent of acetylation. Virology. 2006 May 25; 349(1):212-21. View in: Pubmed

      • Simian virus 40 large T antigen's association with the CUL7 SCF complex contributes to cellular transformation. J Virol. 2005 Sep; 79(18):11685-92. View in: Pubmed

      • Dimerization of CUL7 and PARC is not required for all CUL7 functions and mouse development. Mol Cell Biol. 2005 Jul; 25(13):5579-89. View in: Pubmed

      • Glycogen synthase kinase 3 phosphorylates RBL2/p130 during quiescence. Mol Cell Biol. 2004 Oct; 24(20):8970-80. View in: Pubmed

      • p53 targets simian virus 40 large T antigen for acetylation by CBP. J Virol. 2004 Aug; 78(15):8245-53. View in: Pubmed

      • Activation of a DNA damage checkpoint response in a TAF1-defective cell line. Mol Cell Biol. 2004 Jun; 24(12):5332-9. View in: Pubmed

      • 14-3-3 family members act coordinately to regulate mitotic progression. Cell Cycle. 2004 May; 3(5):672-7. View in: Pubmed

      • Cul7/p185/p193 binding to simian virus 40 large T antigen has a role in cellular transformation. J Virol. 2004 Mar; 78(6):2749-57. View in: Pubmed

      • Molecular cloning and characterization of the von Hippel-Lindau-like protein. Mol Cancer Res. 2004 Jan; 2(1):43-52. View in: Pubmed

      • Proteomics-based target identification: bengamides as a new class of methionine aminopeptidase inhibitors. J Biol Chem. 2003 Dec 26; 278(52):52964-71. View in: Pubmed

      • SV40 large T antigen promotes dephosphorylation of p130. J Biol Chem. 2003 Nov 21; 278(47):46482-7. View in: Pubmed

      • Targeted disruption of p185/Cul7 gene results in abnormal vascular morphogenesis. Proc Natl Acad Sci U S A. 2003 Aug 19; 100(17):9855-60. View in: Pubmed

      • Telomerase maintains telomere structure in normal human cells. Cell. 2003 Jul 25; 114(2):241-53. View in: Pubmed

      • Fludarabine-induced apoptosis of B chronic lymphocytic leukemia cells includes early cleavage of p27kip1 by caspases. Leukemia. 2003 Jun; 17(6):1104-11. View in: Pubmed

      • Structure of the replicative helicase of the oncoprotein SV40 large tumour antigen. Nature. 2003 May 29; 423(6939):512-8. View in: Pubmed

      • Processing, localization, and requirement of human separase for normal anaphase progression. Proc Natl Acad Sci U S A. 2003 Apr 15; 100(8):4574-9. View in: Pubmed

      • Western blot screening for monoclonal antibodies against human separase. J Immunol Methods. 2003 Mar 01; 274(1-2):105-13. View in: Pubmed

      • NFATc2-mediated repression of cyclin-dependent kinase 4 expression. Mol Cell. 2002 Nov; 10(5):1071-81. View in: Pubmed

      • Enumeration of the simian virus 40 early region elements necessary for human cell transformation. Mol Cell Biol. 2002 Apr; 22(7):2111-23. View in: Pubmed

      • 14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport. J Cell Biol. 2002 Mar 04; 156(5):817-28. View in: Pubmed

      • Nucleocytoplasmic shuttling of p130/RBL2: novel regulatory mechanism. Mol Cell Biol. 2002 Jan; 22(2):453-68. View in: Pubmed

      • Feedback regulation of the MBF transcription factor by cyclin Cig2. Nat Cell Biol. 2001 Dec; 3(12):1043-50. View in: Pubmed

      • HIRA, the human homologue of yeast Hir1p and Hir2p, is a novel cyclin-cdk2 substrate whose expression blocks S-phase progression. Mol Cell Biol. 2001 Mar; 21(5):1854-65. View in: Pubmed

      • Cellular transformation by SV40 large T antigen: interaction with host proteins. Semin Cancer Biol. 2001 Feb; 11(1):15-23. View in: Pubmed

      • Binding of SV40 large T antigen to the retinoblastoma susceptibility gene product and related proteins. Methods Mol Biol. 2001; 165:213-8. View in: Pubmed

      • Cells degrade a novel inhibitor of differentiation with E1A-like properties upon exiting the cell cycle. Mol Cell Biol. 2000 Dec; 20(23):8889-902. View in: Pubmed

      • Phosphorylation of the retinoblastoma-related protein p130 in growth-arrested cells. Oncogene. 2000 Oct 19; 19(44):5116-22. View in: Pubmed

      • Loss of p19(ARF) eliminates the requirement for the pRB-binding motif in simian virus 40 large T antigen-mediated transformation. Mol Cell Biol. 2000 Oct; 20(20):7624-33. View in: Pubmed

      • Bcl-2 retards cell cycle entry through p27(Kip1), pRB relative p130, and altered E2F regulation. Mol Cell Biol. 2000 Jul; 20(13):4745-53. View in: Pubmed

      • Calcineurin regulation of the mammalian G0/G1 checkpoint element, cyclin dependent kinase 4. Oncogene. 2000 Jun 01; 19(24):2820-7. View in: Pubmed

      • pRB-dependent, J domain-independent function of simian virus 40 large T antigen in override of p53 growth suppression. J Virol. 2000 Jan; 74(2):864-74. View in: Pubmed

      • RBP1 recruits both histone deacetylase-dependent and -independent repression activities to retinoblastoma family proteins. Mol Cell Biol. 1999 Oct; 19(10):6632-41. View in: Pubmed

      • Discrimination between sialic acid-containing receptors and pseudoreceptors regulates polyomavirus spread in the mouse. J Virol. 1999 Jul; 73(7):5826-32. View in: Pubmed

      • Cytoplasmic localization of human cdc25C during interphase requires an intact 14-3-3 binding site. Mol Cell Biol. 1999 Jun; 19(6):4465-79. View in: Pubmed

      • Functional interaction between retinoblastoma protein and stress-activated protein kinase in multiple myeloma cells. Cancer Res. 1999 Mar 15; 59(6):1192-5. View in: Pubmed

      • The role of the J domain of SV40 large T in cellular transformation. Biologicals. 1999 Mar; 27(1):23-8. View in: Pubmed

      • Segregation of steroid receptor coactivator-1 from steroid receptors in mammary epithelium. Proc Natl Acad Sci U S A. 1999 Jan 05; 96(1):208-13. View in: Pubmed

      • Viral oncoproteins discriminate between p53 and the p53 homolog p73. Mol Cell Biol. 1998 Nov; 18(11):6316-24. View in: Pubmed

      • Inhibition of cellular proliferation by the Wilms tumor suppressor WT1 requires association with the inducible chaperone Hsp70. Genes Dev. 1998 Apr 15; 12(8):1108-20. View in: Pubmed

      • The J domain of simian virus 40 large T antigen is required to functionally inactivate RB family proteins. Mol Cell Biol. 1998 Mar; 18(3):1408-15. View in: Pubmed

      • SV40 as an oncogenic virus and possible human pathogen. Dev Biol Stand. 1998; 94:355-60, 369-82. View in: Pubmed

      • The DnaJ domain of polyomavirus large T antigen is required to regulate Rb family tumor suppressor function. J Virol. 1997 Dec; 71(12):9410-6. View in: Pubmed

      • p16INK4A promotes differentiation and inhibits apoptosis of JKB acute lymphoblastic leukemia cells. Blood. 1997 Nov 15; 90(10):4106-15. View in: Pubmed

      • Characterization of p16(INK4A) expression in multiple myeloma and plasma cell leukemia. Clin Cancer Res. 1997 Nov; 3(11):2173-9. View in: Pubmed

      • The fission yeast protein p73res2 is an essential component of the mitotic MBF complex and a master regulator of meiosis. Mol Cell Biol. 1997 Nov; 17(11):6246-54. View in: Pubmed

      • Role of CDK4 and p16INK4A in interleukin-6-mediated growth of multiple myeloma. Leukemia. 1997 Nov; 11(11):1957-63. View in: Pubmed

      • Inactivation of pRB-related proteins p130 and p107 mediated by the J domain of simian virus 40 large T antigen. Mol Cell Biol. 1997 Sep; 17(9):4979-90. View in: Pubmed

      • MDM2 protein overexpression promotes proliferation and survival of multiple myeloma cells. Blood. 1997 Sep 01; 90(5):1982-92. View in: Pubmed

      • Binding and modulation of p53 by p300/CBP coactivators. Nature. 1997 Jun 19; 387(6635):823-7. View in: Pubmed

      • Mitogenic stimulation of resting T cells causes rapid phosphorylation of the transcription factor LSF and increased DNA-binding activity. Genes Dev. 1997 Jun 01; 11(11):1435-46. View in: Pubmed

      • DnaJ/hsp40 chaperone domain of SV40 large T antigen promotes efficient viral DNA replication. Genes Dev. 1997 May 01; 11(9):1098-110. View in: Pubmed

      • Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein. Nature. 1997 Mar 13; 386(6621):177-81. View in: Pubmed

      • Cyclin E, a redundant cyclin in breast cancer. Proc Natl Acad Sci U S A. 1996 Dec 24; 93(26):15215-20. View in: Pubmed

      • A novel pre-B acute lymphoblastic leukemia cell line with chromosomal translocation between p16(INK4A)/p15(INK4B) tumor suppressor and immunoglobulin heavy chain genes: TGFbeta/IL-7 inhibitory signaling mechanism. Leukemia. 1996 Oct; 10(10):1576-83. View in: Pubmed

      • Interleukin-6 promotes multiple myeloma cell growth via phosphorylation of retinoblastoma protein. Blood. 1996 Sep 15; 88(6):2219-27. View in: Pubmed

      • A maize cDNA encoding a member of the retinoblastoma protein family: involvement in endoreduplication. Proc Natl Acad Sci U S A. 1996 Aug 20; 93(17):8962-7. View in: Pubmed

      • Association of p300 and CBP with simian virus 40 large T antigen. Mol Cell Biol. 1996 Jul; 16(7):3454-64. View in: Pubmed

      • Simian virus 40 large T antigen alters the phosphorylation state of the RB-related proteins p130 and p107. J Virol. 1996 May; 70(5):2781-8. View in: Pubmed

      • Role of pRb-related proteins in simian virus 40 large-T-antigen-mediated transformation. Mol Cell Biol. 1995 Oct; 15(10):5800-10. View in: Pubmed

      • Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B and C. Science. 1995 Sep 08; 269(5229):1444-6. View in: Pubmed

      • The Schizosaccharomyces pombe MBF complex requires heterodimerization for entry into S phase. Mol Cell Biol. 1995 May; 15(5):2589-99. View in: Pubmed

      • Cell synchronization. Methods Enzymol. 1995; 254:114-24. View in: Pubmed

      • E2F-4, a new member of the E2F transcription factor family, interacts with p107. Genes Dev. 1994 Nov 15; 8(22):2665-79. View in: Pubmed

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