Skip Navigation

James M. Cleary, MD, PhD

Medical Oncology

Make an Appointment
Watch Video


  • Senior Physician
  • Instructor in Medicine, Harvard Medical School

Clinical Interests

  • Gastrointestinal malignancies
  • Phase 1 clinical trials

Contact Information

  • Appointments617-632-5829
  • Office Phone Number617-632-6073
  • Fax617-632-5370

Board Certification:

  • Internal Medicine, 2006
  • Medical Oncology, 2008


  • Dana-Farber Cancer Institute, Medical Oncology


  • Massachusetts General Hospital, Internal Medicine

Medical School:

  • Albert Einstein Medical School


Early Drug Development, Gastrointestinal Malignancies, Translational Research

My career is focused on phase 1 and proof-of-mechanism clinical trials that are testing new targeted therapies and novel therapeutic strategies. While I conduct trials appropriate for a broad range of solid tumors, I am particularly interested in new drug development for gastrointestinal malignancies. Currently, I am developing several protocols appropriate for specific molecularly defined patient cohorts, including those whose tumors are dependent on EGFR, mutant K-Ras and mutant B-Raf, respectively. I also interact with Dana-Farber translational researchers to understand and develop predictors of sensitivity and resistance to targeted agents that can be incorporated into patient selection for trials.


Dana-Farber Cancer Institute
450 Brookline Avenue
Boston, MA 02215
Get Directions