Leonard I. Zon, MD

Leonard I. Zon, MD

Pediatric Hematology/Oncology

Contact Information

Office Phone Number

617-919-2069

Fax

(617) 355-7262

Appointments

617-919-2069

Biography

Leonard I. Zon, MD

Leonard Zon received his MD degree from Thomas Jefferson University. He completed an internship and residency at New England Deaconess Hospital and a fellowship at Dana-Farber Cancer Institute. Dr. Zon is a Howard Hughes Medical Institute Investigator.

Researcher

Physician

Director, Stem Cell Research Program, Boston Children's Hospital
Senior Physician
Grousbeck Professor of Pediatrics, Harvard Medical School

Clinical Interests

Oncology

Research

    Leonard Zon's laboratory focuses on the use of the zebrafish model for research into hematopoiesis and as a screen for oncogenic genes and proteins. Dr. Zon chose the zebrafish because the zebrafish embryo is completely clear, providing a "real-time" view of all organs and systems as they develop. In addition, the species is extremely fecund - each mother lays 200-300 eggs weekly - and thrifty - a large number of animals can be kept in a relatively small space.

    Finally, zebrafish have several naturally occurring mutants that mirror human anemias. The Zon laboratory has spearheaded the successful effort to sequence the zebrafish genome; isolated and cloned a gene responsible for congenital anemia; identified a gene - cdx4 - which, in concert with hox, is pivotal in hematopoiesis; and found a chemical that increases blood stem cells and creates screens for genetic mutations affecting cell proliferation and cancer susceptibility in the zebrafish and for small molecule suppressors of the cancer-susceptible crb cell cycle mutant.

    Research Departments

    Publications

      • Colorimetric Barcoding to Track, Isolate, and Analyze Hematopoietic Stem Cell Clones. Methods Mol Biol. 2024; 2707:265-277. View in: Pubmed

      • Structural basis for inactivation of PRC2 by G-quadruplex RNA. Science. 2023 09 22; 381(6664):1331-1337. View in: Pubmed

      • Transcription factors interact with RNA to regulate genes. Mol Cell. 2023 07 20; 83(14):2449-2463.e13. View in: Pubmed

      • Microenvironmental control of hematopoietic stem cell fate via CXCL8 and protein kinase C. Cell Rep. 2023 05 30; 42(5):112528. View in: Pubmed

      • PGE2 alters chromatin through H2A.Z-variant enhancer nucleosome modification to promote hematopoietic stem cell fate. Proc Natl Acad Sci U S A. 2023 05 09; 120(19):e2220613120. View in: Pubmed

      • Transcription factor induction of vascular blood stem cell niches in vivo. Dev Cell. 2023 06 19; 58(12):1037-1051.e4. View in: Pubmed

      • Oncogenic CDK13 mutations impede nuclear RNA surveillance. Science. 2023 04 21; 380(6642):eabn7625. View in: Pubmed

      • Identification of unique a4 chain structure and conserved antiangiogenic activity of a3NC1 type IV collagen in zebrafish. Dev Dyn. 2023 07; 252(7):1046-1060. View in: Pubmed

      • Transplantation-based screen identifies inducers of muscle progenitor cell engraftment across vertebrate species. Cell Rep. 2023 Apr 25; 42(4):112365. View in: Pubmed

      • Clonal hematopoiesis and inflammation - the perpetual cycle. Trends Cell Biol. 2023 Aug; 33(8):695-707. View in: Pubmed

      • The effects of intensive feeding on reproductive performance in laboratory zebrafish (Danio rerio). PLoS One. 2022; 17(11):e0278302. View in: Pubmed

      • Cellular barcoding to decipher clonal dynamics in disease. Science. 2022 10 14; 378(6616):eabm5874. View in: Pubmed

      • Loss of NECTIN1 triggers melanoma dissemination upon local IGF1 depletion. Nat Genet. 2022 12; 54(12):1839-1852. View in: Pubmed

      • Quality assurance of hematopoietic stem cells by macrophages determines stem cell clonality. Science. 2022 09 23; 377(6613):1413-1419. View in: Pubmed

      • Single-cell analyses reveal early thymic progenitors and pre-B cells in zebrafish. J Exp Med. 2022 09 05; 219(9). View in: Pubmed

      • Modeling Spitz melanoma in zebrafish using sequential mutagenesis. Dis Model Mech. 2022 08 01; 15(8). View in: Pubmed

      • External signals regulate continuous transcriptional states in hematopoietic stem cells. Elife. 2021 12 23; 10. View in: Pubmed

      • Resistance to inflammation underlies enhanced fitness in clonal hematopoiesis. Science. 2021 Nov 05; 374(6568):768-772. View in: Pubmed

      • Dissecting melanocytes to predict melanoma. Nat Cell Biol. 2021 09; 23(9):930-931. View in: Pubmed

      • In memory of Paul Sylvain Frenette, a pioneering explorer of the hematopoietic stem cell niche who left far too early. Exp Hematol. 2021 Aug 14. View in: Pubmed

      • Telomerase RNA recruits RNA polymerase II to target gene promoters to enhance myelopoiesis. Proc Natl Acad Sci U S A. 2021 08 10; 118(32). View in: Pubmed

      • Synergistic melanoma cell death mediated by inhibition of both MCL1 and BCL2 in high-risk tumors driven by NF1/PTEN loss. Oncogene. 2021 09; 40(38):5718-5729. View in: Pubmed

      • Nucleotide stress responses in neural crest cell fate and melanoma. Cell Cycle. 2021 08; 20(15):1455-1467. View in: Pubmed

      • Single-cell ATAC-seq reveals GATA2-dependent priming defect in myeloid and a maturation bottleneck in lymphoid lineages. Blood Adv. 2021 07 13; 5(13):2673-2686. View in: Pubmed

      • NNT mediates redox-dependent pigmentation via a UVB- and MITF-independent mechanism. Cell. 2021 08 05; 184(16):4268-4283.e20. View in: Pubmed

      • Zebrafish disease models in drug discovery: from preclinical modelling to clinical trials. Nat Rev Drug Discov. 2021 08; 20(8):611-628. View in: Pubmed

      • From development toward therapeutics, a collaborative effort on blood progenitors. Stem Cell Reports. 2021 07 13; 16(7):1674-1685. View in: Pubmed

      • A phase II trial of all-trans retinoic acid (ATRA) in advanced adenoid cystic carcinoma. Oral Oncol. 2021 08; 119:105366. View in: Pubmed

      • Mitochondrial function in development and disease. Dis Model Mech. 2021 06 01; 14(6). View in: Pubmed

      • Cell-specific transcriptional control of mitochondrial metabolism by TIF1? drives erythropoiesis. Science. 2021 05 14; 372(6543):716-721. View in: Pubmed

      • Identification of Basp1 as a novel angiogenesis-regulating gene by multi-model system studies. FASEB J. 2021 05; 35(5):e21404. View in: Pubmed

      • 'Enhancing' red cell fate through epigenetic mechanisms. Curr Opin Hematol. 2021 05 01; 28(3):129-137. View in: Pubmed

      • A uniform format for manuscript submission. Cell. 2021 04 01; 184(7):1654-1656. View in: Pubmed

      • SPRED1 deletion confers resistance to MAPK inhibition in melanoma. J Exp Med. 2021 03 01; 218(3). View in: Pubmed

      • Melanoma models for the next generation of therapies. Cancer Cell. 2021 05 10; 39(5):610-631. View in: Pubmed

      • SATB2 induction of a neural crest mesenchyme-like program drives melanoma invasion and drug resistance. Elife. 2021 02 02; 10. View in: Pubmed

      • Blood in the water: recent uses of zebrafish to study myeloid biology. Curr Opin Hematol. 2021 01; 28(1):43-49. View in: Pubmed

      • Common variants in signaling transcription-factor-binding sites drive phenotypic variability in red blood cell traits. Nat Genet. 2020 12; 52(12):1333-1345. View in: Pubmed

      • Recurrent co-alteration of HDGF and SETDB1 on chromosome 1q drives cutaneous melanoma progression and poor prognosis. Pigment Cell Melanoma Res. 2021 05; 34(3):641-647. View in: Pubmed

      • Calmodulin inhibitors improve erythropoiesis in Diamond-Blackfan anemia. Sci Transl Med. 2020 10 21; 12(566). View in: Pubmed

      • Impact of COVID-19 Pandemic on Cancer Research. Cancer Cell. 2020 11 09; 38(5):591-593. View in: Pubmed

      • CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiation. Proc Natl Acad Sci U S A. 2020 09 22; 117(38):23626-23635. View in: Pubmed

      • Cross-species analysis of enhancer logic using deep learning. Genome Res. 2020 12; 30(12):1815-1834. View in: Pubmed

      • A Transgenic System for Rapid Magnetic Enrichment of Rare Embryonic Cells. Zebrafish. 2020 10; 17(5):354-357. View in: Pubmed

      • An evolutionarily ancient mechanism for regulation of hemoglobin expression in vertebrate red cells. Blood. 2020 07 16; 136(3):269-278. View in: Pubmed

      • PRL3-DDX21 Transcriptional Control of Endolysosomal Genes Restricts Melanocyte Stem Cell Differentiation. Dev Cell. 2020 08 10; 54(3):317-332.e9. View in: Pubmed

      • Long-Range Optogenetic Control of Axon Guidance Overcomes Developmental Boundaries and Defects. Dev Cell. 2020 06 08; 53(5):577-588.e7. View in: Pubmed

      • Massively parallel reporter assays of melanoma risk variants identify MX2 as a gene promoting melanoma. Nat Commun. 2020 06 01; 11(1):2718. View in: Pubmed

      • Transcriptome Dynamics of Hematopoietic Stem Cell Formation Revealed Using a Combinatorial Runx1 and Ly6a Reporter System. Stem Cell Reports. 2020 05 12; 14(5):956-971. View in: Pubmed

      • Difference in biophysical properties of cancer-initiating cells in melanoma mutated zebrafish. J Mech Behav Biomed Mater. 2020 07; 107:103746. View in: Pubmed

      • Gain-of-Function Genetic Alterations of G9a Drive Oncogenesis. Cancer Discov. 2020 07; 10(7):980-997. View in: Pubmed

      • Zebrafish patient avatars in cancer biology and precision cancer therapy. Nat Rev Cancer. 2020 05; 20(5):263-273. View in: Pubmed

      • RNA helicase DDX21 mediates nucleotide stress responses in neural crest and melanoma cells. Nat Cell Biol. 2020 04; 22(4):372-379. View in: Pubmed

      • Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells. Nature. 2020 01; 577(7792):676-681. View in: Pubmed

      • From blood development to disease: a paradigm for clinical translation. Dis Model Mech. 2020 01 09; 13(1). View in: Pubmed

      • The Paf1 complex and P-TEFb have reciprocal and antagonist roles in maintaining multipotent neural crest progenitors. Development. 2019 12 16; 146(24). View in: Pubmed

      • Use of Zebrafish in Drug Discovery Toxicology. Chem Res Toxicol. 2020 01 21; 33(1):95-118. View in: Pubmed

      • Slow phosphorylation of a tyrosine residue in LAT optimizes T cell ligand discrimination. Nat Immunol. 2019 11; 20(11):1481-1493. View in: Pubmed

      • Zebrafish modeling reveals that SPINT1 regulates the aggressiveness of skin cutaneous melanoma and its crosstalk with tumor immune microenvironment. J Exp Clin Cancer Res. 2019 Sep 13; 38(1):405. View in: Pubmed

      • Tumor-Derived Extracellular Vesicles Breach the Intact Blood-Brain Barrier via Transcytosis. ACS Nano. 2019 12 24; 13(12):13853-13865. View in: Pubmed

      • Author Correction: Epoxyeicosatrienoic acids enhance embryonic haematopoiesis and adult marrow engraftment. Nature. 2019 Sep; 573(7772):E1. View in: Pubmed

      • Inflammasome Regulates Hematopoiesis through Cleavage of the Master Erythroid Transcription Factor GATA1. Immunity. 2019 07 16; 51(1):50-63.e5. View in: Pubmed

      • Modeling Cancer with Flies and Fish. Dev Cell. 2019 05 06; 49(3):317-324. View in: Pubmed

      • AIBP-mediated cholesterol efflux instructs hematopoietic stem and progenitor cell fate. Science. 2019 03 08; 363(6431):1085-1088. View in: Pubmed

      • Improving the visibility of developmental biology: time for induction and specification. Development. 2019 01 16; 146(2). View in: Pubmed

      • Estrogen Activation of G-Protein-Coupled Estrogen Receptor 1 Regulates Phosphoinositide 3-Kinase and mTOR Signaling to Promote Liver Growth in Zebrafish and Proliferation of Human Hepatocytes. Gastroenterology. 2019 05; 156(6):1788-1804.e13. View in: Pubmed

      • Nfe2 is dispensable for early but required for adult thrombocyte formation and function in zebrafish. Blood Adv. 2018 12 11; 2(23):3418-3427. View in: Pubmed

      • Stem cell safe harbor: the hematopoietic stem cell niche in zebrafish. Blood Adv. 2018 11 13; 2(21):3063-3069. View in: Pubmed

      • Generation of mouse-zebrafish hematopoietic tissue chimeric embryos for hematopoiesis and host-pathogen interaction studies. Dis Model Mech. 2018 11 05; 11(11). View in: Pubmed

      • Human tumor genomics and zebrafish modeling identify SPRED1 loss as a driver of mucosal melanoma. Science. 2018 11 30; 362(6418):1055-1060. View in: Pubmed

      • FAM210B is an erythropoietin target and regulates erythroid heme synthesis by controlling mitochondrial iron import and ferrochelatase activity. J Biol Chem. 2018 12 21; 293(51):19797-19811. View in: Pubmed

      • Stu Orkin is a superhero. J Clin Invest. 2018 10 01; 128(10):4213-4217. View in: Pubmed

      • Zebrafish blastomere screen identifies retinoic acid suppression of MYB in adenoid cystic carcinoma. J Exp Med. 2018 10 01; 215(10):2673-2685. View in: Pubmed

      • Specific oxylipins enhance vertebrate hematopoiesis via the receptor GPR132. Proc Natl Acad Sci U S A. 2018 09 11; 115(37):9252-9257. View in: Pubmed

      • Making HSCs in vitro: don't forget the hemogenic endothelium. Blood. 2018 09 27; 132(13):1372-1378. View in: Pubmed

      • JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemia. J Exp Med. 2018 07 02; 215(7):1929-1945. View in: Pubmed

      • Protection from UV light is an evolutionarily conserved feature of the haematopoietic niche. Nature. 2018 06; 558(7710):445-448. View in: Pubmed

      • Neural crest state activation in NRAS driven melanoma, but not in NRAS-driven melanocyte expansion. Dev Biol. 2019 05 15; 449(2):107-114. View in: Pubmed

      • NOTCH signaling specifies arterial-type definitive hemogenic endothelium from human pluripotent stem cells. Nat Commun. 2018 05 08; 9(1):1828. View in: Pubmed

      • Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma. Cancer Cell. 2018 04 09; 33(4):785. View in: Pubmed

      • RNA helicase, DDX27 regulates skeletal muscle growth and regeneration by modulation of translational processes. PLoS Genet. 2018 03; 14(3):e1007226. View in: Pubmed

      • Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma. Cancer Cell. 2018 02 12; 33(2):322-336.e8. View in: Pubmed

      • The histone demethylase Jmjd3 regulates zebrafish myeloid development by promoting spi1 expression. Biochim Biophys Acta Gene Regul Mech. 2018 Feb; 1861(2):106-116. View in: Pubmed

      • Purification of zebrafish erythrocytes as a means of identifying a novel regulator of haematopoiesis. Br J Haematol. 2018 02; 180(3):420-431. View in: Pubmed

      • PD-L1 genetic overexpression or pharmacological restoration in hematopoietic stem and progenitor cells reverses autoimmune diabetes. Sci Transl Med. 2017 Nov 15; 9(416). View in: Pubmed

      • Cancer immunotherapy: The dark side of PD-1 receptor inhibition. Nature. 2017 12 07; 552(7683):41-42. View in: Pubmed

      • Toddler signaling regulates mesodermal cell migration downstream of Nodal signaling. Elife. 2017 11 09; 6. View in: Pubmed

      • Loci associated with skin pigmentation identified in African populations. Science. 2017 11 17; 358(6365). View in: Pubmed

      • KIT Suppresses BRAFV600E-Mutant Melanoma by Attenuating Oncogenic RAS/MAPK Signaling. Cancer Res. 2017 11 01; 77(21):5820-5830. View in: Pubmed

      • Fishing for answers in precision cancer medicine. Proc Natl Acad Sci U S A. 2017 09 26; 114(39):10306-10308. View in: Pubmed

      • A chemical screen in zebrafish embryonic cells establishes that Akt activation is required for neural crest development. Elife. 2017 08 23; 6. View in: Pubmed

      • Efforts to enhance blood stem cell engraftment: Recent insights from zebrafish hematopoiesis. J Exp Med. 2017 Oct 02; 214(10):2817-2827. View in: Pubmed

      • PGE2 pulsing of murine bone marrow cells reduces migration of daughter monocytes/macrophages in vitro and in vivo. Exp Hematol. 2017 12; 56:64-68. View in: Pubmed

      • Blood on the tracks: hematopoietic stem cell-endothelial cell interactions in homing and engraftment. J Mol Med (Berl). 2017 08; 95(8):809-819. View in: Pubmed

      • Identification of Padi2 as a novel angiogenesis-regulating gene by genome association studies in mice. PLoS Genet. 2017 Jun; 13(6):e1006848. View in: Pubmed

      • From fish bowl to bedside: The power of zebrafish to unravel melanoma pathogenesis and discover new therapeutics. Pigment Cell Melanoma Res. 2017 07; 30(4):402-412. View in: Pubmed

      • Using Zebrafish to Study Pathways that Regulate Hematopoietic Stem Cell Self-Renewal and Migration. Stem Cell Reports. 2017 06 06; 8(6):1465-1471. View in: Pubmed

      • Efficient Transduction of Zebrafish Melanoma Cell Lines and Embryos Using Lentiviral Vectors. Zebrafish. 2017 08; 14(4):379-382. View in: Pubmed

      • Distinct Roles for Matrix Metalloproteinases 2 and 9 in Embryonic Hematopoietic Stem Cell Emergence, Migration, and Niche Colonization. Stem Cell Reports. 2017 05 09; 8(5):1226-1241. View in: Pubmed

      • Evolution of the hypoxia-sensitive cells involved in amniote respiratory reflexes. Elife. 2017 04 07; 6. View in: Pubmed

      • CXCR1 remodels the vascular niche to promote hematopoietic stem and progenitor cell engraftment. J Exp Med. 2017 04 03; 214(4):1011-1027. View in: Pubmed

      • Drug discovery for Diamond-Blackfan anemia using reprogrammed hematopoietic progenitors. Sci Transl Med. 2017 02 08; 9(376). View in: Pubmed

      • EXTL3 mutations cause skeletal dysplasia, immune deficiency, and developmental delay. J Exp Med. 2017 03 06; 214(3):623-637. View in: Pubmed

      • Corrigendum: Clonal fate mapping quantifies the number of haematopoietic stem cells that arise during development. Nat Cell Biol. 2017 01 31; 19(2):142. View in: Pubmed

      • Sorting zebrafish thrombocyte lineage cells with a Cd41 monoclonal antibody enriches hematopoietic stem cell activity. Blood. 2017 03 09; 129(10):1394-1397. View in: Pubmed

      • Chemical screening in zebrafish for novel biological and therapeutic discovery. Methods Cell Biol. 2017; 138:651-679. View in: Pubmed

      • Genome-wide Trans-ethnic Meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for RBPMS in Erythropoiesis. Am J Hum Genet. 2017 Jan 05; 100(1):51-63. View in: Pubmed

      • Aging Hematopoietic Stem Cells Make Their History. Dev Cell. 2016 11 21; 39(4):390-391. View in: Pubmed

      • Clonal fate mapping quantifies the number of haematopoietic stem cells that arise during development. Nat Cell Biol. 2017 Jan; 19(1):17-27. View in: Pubmed

      • Development: For cloche the Bell Tolls. Curr Biol. 2016 10 10; 26(19):R890-R892. View in: Pubmed

      • Understanding the regulation of vertebrate hematopoiesis and blood disorders - big lessons from a small fish. FEBS Lett. 2016 Nov; 590(22):4016-4033. View in: Pubmed

      • Transplantation in zebrafish. Methods Cell Biol. 2017; 138:629-647. View in: Pubmed

      • MED12 Regulates HSC-Specific Enhancers Independently of Mediator Kinase Activity to Control Hematopoiesis. Cell Stem Cell. 2016 12 01; 19(6):784-799. View in: Pubmed

      • Identification of novel regulators of developmental hematopoiesis using Endoglin regulatory elements as molecular probes. Blood. 2016 10 13; 128(15):1928-1939. View in: Pubmed

      • Loss-of-function mutations in the C9ORF72 mouse ortholog cause fatal autoimmune disease. Sci Transl Med. 2016 07 13; 8(347):347ra93. View in: Pubmed

      • CAT7 and cat7l Long Non-coding RNAs Tune Polycomb Repressive Complex 1 Function during Human and Zebrafish Development. J Biol Chem. 2016 09 09; 291(37):19558-72. View in: Pubmed

      • Chromatin immunoprecipitation and an open chromatin assay in zebrafish erythrocytes. Methods Cell Biol. 2016; 135:387-412. View in: Pubmed

      • c-myb hyperactivity leads to myeloid and lymphoid malignancies in zebrafish. Leukemia. 2017 01; 31(1):222-233. View in: Pubmed

      • Generation of Parabiotic Zebrafish Embryos by Surgical Fusion of Developing Blastulae. J Vis Exp. 2016 06 11; (112). View in: Pubmed

      • Engineering Hematopoietic Stem Cells: Lessons from Development. Cell Stem Cell. 2016 06 02; 18(6):707-720. View in: Pubmed

      • Modeling human diseases: an education in interactions and interdisciplinary approaches. Dis Model Mech. 2016 06 01; 9(6):597-600. View in: Pubmed

      • Long-term drug administration in the adult zebrafish using oral gavage for cancer preclinical studies. Dis Model Mech. 2016 07 01; 9(7):811-20. View in: Pubmed

      • Ex vivo tools for the clonal analysis of zebrafish hematopoiesis. Nat Protoc. 2016 May; 11(5):1007-20. View in: Pubmed

      • Tissue-specific gene targeting using CRISPR/Cas9. Methods Cell Biol. 2016; 135:189-202. View in: Pubmed

      • Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma. Mol Cell. 2016 Apr 07; 62(1):34-46. View in: Pubmed

      • Insight into GATA1 transcriptional activity through interrogation of cis elements disrupted in human erythroid disorders. Proc Natl Acad Sci U S A. 2016 Apr 19; 113(16):4434-9. View in: Pubmed

      • A Tribute to George Stamatoyannopoulos. Hum Gene Ther. 2016 Apr; 27(4):280-6. View in: Pubmed

      • Fish to Learn: Insights into Blood Development and Blood Disorders from Zebrafish Hematopoiesis. Hum Gene Ther. 2016 Apr; 27(4):287-94. View in: Pubmed

      • Embryonic cell culture in zebrafish. Methods Cell Biol. 2016; 133:1-10. View in: Pubmed

      • The Red Light District and Its Effects on Zebrafish Reproduction. Zebrafish. 2016 06; 13(3):226-9. View in: Pubmed

      • GATA Factor-G-Protein-Coupled Receptor Circuit Suppresses Hematopoiesis. Stem Cell Reports. 2016 Mar 08; 6(3):368-82. View in: Pubmed

      • A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation. Science. 2016 Jan 29; 351(6272):aad2197. View in: Pubmed

      • Dynamic Control of Enhancer Repertoires Drives Lineage and Stage-Specific Transcription during Hematopoiesis. Dev Cell. 2016 Jan 11; 36(1):9-23. View in: Pubmed

      • Identifying Novel Cancer Therapies Using Chemical Genetics and Zebrafish. Adv Exp Med Biol. 2016; 916:103-24. View in: Pubmed

      • Targeted Application of Human Genetic Variation Can Improve Red Blood Cell Production from Stem Cells. Cell Stem Cell. 2016 Jan 07; 18(1):73-78. View in: Pubmed

      • Hematopoietic stem cells develop in the absence of endothelial cadherin 5 expression. Blood. 2015 Dec 24; 126(26):2811-20. View in: Pubmed

      • Generating and evaluating a ranked candidate gene list for potential vertebrate heart field regulators. Genom Data. 2015 Dec; 6:199-201. View in: Pubmed

      • Chamber identity programs drive early functional partitioning of the heart. Nat Commun. 2015 Aug 26; 6:8146. View in: Pubmed

      • A Quantitative System for Studying Metastasis Using Transparent Zebrafish. Cancer Res. 2015 10 15; 75(20):4272-4282. View in: Pubmed

      • Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells. Nat Cell Biol. 2015 Aug; 17(8):994-1003. View in: Pubmed

      • Epoxyeicosatrienoic acids enhance embryonic haematopoiesis and adult marrow engraftment. Nature. 2015 Jul 23; 523(7561):468-71. View in: Pubmed

      • Mutation of kri1l causes definitive hematopoiesis failure via PERK-dependent excessive autophagy induction. Cell Res. 2015 Aug; 25(8):946-62. View in: Pubmed

      • TopBP1 Governs Hematopoietic Stem/Progenitor Cells Survival in Zebrafish Definitive Hematopoiesis. PLoS Genet. 2015 Jul; 11(7):e1005346. View in: Pubmed

      • A point mutation of zebrafish c-cbl gene in the ring finger domain produces a phenotype mimicking human myeloproliferative disease. Leukemia. 2015 Dec; 29(12):2355-65. View in: Pubmed

      • Screening for melanoma resistance genes in vivo. Pigment Cell Melanoma Res. 2015 Jul; 28(4):375-6. View in: Pubmed

      • Adenosine signaling promotes hematopoietic stem and progenitor cell emergence. J Exp Med. 2015 May 04; 212(5):649-63. View in: Pubmed

      • Flow-induced protein kinase A-CREB pathway acts via BMP signaling to promote HSC emergence. J Exp Med. 2015 May 04; 212(5):633-48. View in: Pubmed

      • A CRISPR/Cas9 vector system for tissue-specific gene disruption in zebrafish. Dev Cell. 2015 Mar 23; 32(6):756-64. View in: Pubmed

      • Angiopoietin-like proteins stimulate HSPC development through interaction with notch receptor signaling. Elife. 2015 Feb 25; 4. View in: Pubmed

      • DNA methyltransferase 1 functions through C/ebpa to maintain hematopoietic stem and progenitor cells in zebrafish. J Hematol Oncol. 2015 Feb 22; 8:15. View in: Pubmed

      • Hematopoietic stem cell arrival triggers dynamic remodeling of the perivascular niche. Cell. 2015 Jan 15; 160(1-2):241-52. View in: Pubmed

      • Notch1 acts via Foxc2 to promote definitive hematopoiesis via effects on hemogenic endothelium. Blood. 2015 Feb 26; 125(9):1418-26. View in: Pubmed

      • A zebrafish model of myelodysplastic syndrome produced through tet2 genomic editing. Mol Cell Biol. 2015 Mar; 35(5):789-804. View in: Pubmed

      • A comparison of non-integrating reprogramming methods. Nat Biotechnol. 2015 Jan; 33(1):58-63. View in: Pubmed

      • Selective microRNA uridylation by Zcchc6 (TUT7) and Zcchc11 (TUT4). Nucleic Acids Res. 2014 Oct; 42(18):11777-91. View in: Pubmed

      • Getting more for your marrow: boosting hematopoietic stem cell numbers with PGE2. Exp Cell Res. 2014 Dec 10; 329(2):220-6. View in: Pubmed

      • Intrinsic expression of a multiexon type 3 deiodinase gene controls zebrafish embryo size. Endocrinology. 2014 Oct; 155(10):4069-80. View in: Pubmed

      • From fish tank to bedside in cancer therapy: an interview with Leonard Zon. Dis Model Mech. 2014 Jul; 7(7):735-8. View in: Pubmed

      • Dissection of vertebrate hematopoiesis using zebrafish thrombopoietin. Blood. 2014 Jul 10; 124(2):220-8. View in: Pubmed

      • Whole-exome sequencing and functional studies identify RPS29 as a novel gene mutated in multicase Diamond-Blackfan anemia families. Blood. 2014 Jul 03; 124(1):24-32. View in: Pubmed

      • Neural crest development and craniofacial morphogenesis is coordinated by nitric oxide and histone acetylation. Chem Biol. 2014 Apr 24; 21(4):488-501. View in: Pubmed

      • Mutations in QARS, encoding glutaminyl-tRNA synthetase, cause progressive microcephaly, cerebral-cerebellar atrophy, and intractable seizures. Am J Hum Genet. 2014 Apr 03; 94(4):547-58. View in: Pubmed

      • Unexpectedly uneven: posttransplant skeletal distribution of hematopoietic stem cell clones. J Exp Med. 2014 Mar 10; 211(3):384-5. View in: Pubmed

      • Translational research: the path for bringing discovery to patients. Cell Stem Cell. 2014 Feb 06; 14(2):146-8. View in: Pubmed

      • Tissue specific roles for the ribosome biogenesis factor Wdr43 in zebrafish development. PLoS Genet. 2014 Jan; 10(1):e1004074. View in: Pubmed

      • A non-canonical function of telomerase RNA in the regulation of developmental myelopoiesis in zebrafish. Nat Commun. 2014; 5:3228. View in: Pubmed

      • Novel cardiovascular gene functions revealed via systematic phenotype prediction in zebrafish. Development. 2014 Jan; 141(1):224-35. View in: Pubmed

      • Of fish and men: using zebrafish to fight human diseases. Trends Cell Biol. 2013 Dec; 23(12):584-6. View in: Pubmed

      • A network of epigenetic regulators guides developmental haematopoiesis in vivo. Nat Cell Biol. 2013 Dec; 15(12):1516-25. View in: Pubmed

      • A Cdx4-Sall4 regulatory module controls the transition from mesoderm formation to embryonic hematopoiesis. Stem Cell Reports. 2013; 1(5):425-36. View in: Pubmed

      • A zebrafish embryo culture system defines factors that promote vertebrate myogenesis across species. Cell. 2013 Nov 07; 155(4):909-921. View in: Pubmed

      • zebraflash transgenic lines for in vivo bioluminescence imaging of stem cells and regeneration in adult zebrafish. Development. 2013 Dec; 140(24):4988-97. View in: Pubmed

      • The zebrafish granulocyte colony-stimulating factors (Gcsfs): 2 paralogous cytokines and their roles in hematopoietic development and maintenance. Blood. 2013 Dec 05; 122(24):3918-28. View in: Pubmed

      • Induction of multipotential hematopoietic progenitors from human pluripotent stem cells via respecification of lineage-restricted precursors. Cell Stem Cell. 2013 Oct 03; 13(4):459-70. View in: Pubmed

      • Zebrafish cancer: the state of the art and the path forward. Nat Rev Cancer. 2013 Sep; 13(9):624-36. View in: Pubmed

      • Prostaglandin-modulated umbilical cord blood hematopoietic stem cell transplantation. Blood. 2013 Oct 24; 122(17):3074-81. View in: Pubmed

      • Assaying hematopoiesis using zebrafish. Blood Cells Mol Dis. 2013 Dec; 51(4):271-6. View in: Pubmed

      • Site-directed zebrafish transgenesis into single landing sites with the phiC31 integrase system. Dev Dyn. 2013 Aug; 242(8):949-963. View in: Pubmed

      • Zebrafish rhabdomyosarcoma reflects the developmental stage of oncogene expression during myogenesis. Development. 2013 Jul; 140(14):3040-50. View in: Pubmed

      • Hematopoiesis. Development. 2013 Jun; 140(12):2463-7. View in: Pubmed

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