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Dr. Sicinski received his MD and PhD from the Warsaw Medical School in Poland. He spent two years as a visiting scientist at the Medical Research Council in Cambridge, England, before becoming a postdoctoral fellow with Dr. Robert A. Weinberg at Massachusetts Institute of Technology. In 1997, Dr. Sicinski joined the faculty of Harvard and Dana-Farber Cancer Institute, where his research focuses on genes in the cell cycle machinery involved in normal cell development and cancer.
The cell cycle machinery is the ultimate recipient of oncogenic and mitogenic signals.Our laboratory studies the function of the cell cycle machinery at a molecular, cellular and organismal levels. We generated several knock-out and knock-in mouse strains which allow us to dissect the function of cell cycle proteins in normal development and in cancer formation or progression. We are also developing novel strains of mice that allow proteomic approaches to study the functions of cell cycle proteins (including cell cycle-independent functions) in various tissues of the living animal. The broad goal of these new directions is to combine the techniques of mouse germline manipulation with the new methods of proteome- and genome-wide analyses. We are also focusing on the functioning of the cell cycle machinery in various stem cell compartments.An important direction of our studies is to analyze the molecular functions of cell cycle proteins in human cancers.
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