Ramesh A. Shivdasani, MD, PhD

Ramesh A. Shivdasani, MD, PhD

Medical Oncology

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Ramesh A. Shivdasani, MD, PhD

Dr. Shivdasani received his medical and graduate degrees from The University of Michigan School in 1989. He completed his residency in Internal Medicine at Brigham and Women's Hospital, his fellowship in Medical Oncology at the Dana-Farber Cancer Institute, and post-doctoral research training at The Howard Hughes Medical Institute and Childrens Hospital Boston. In 1996, he joined the staff of Dana-Farber and Brigham and Women's Hospital, where he is a medical oncologist and laboratory investigator in the Gastrointestinal Cancer Center. Dr. Shivdasani's research focuses on normal mechanisms of development and cell differentiation in the gastrointestinal tract and new targets for treatment of intestinal tumors.

Board Certification

  • Medical Oncology, 1995


  • Dana-Farber Cancer Institute, Medical Oncology


  • Brigham and Women's Hospital, Internal Medicine

Medical School

  • University of Michigan School of Medicine

Recent Awards

  • Association of American Physicians 2009
  • American Society for Clinical Investigation 2005
  • Harvard Medical School Class of 2007 teaching award, Best Tutor of the Year 2004
  • Brian ODell Memorial Research Award (Leukemia & Lymphoma Society) 2003


    Development and differentiation of the gastrointestinal epithelium; targeted molecular therapies.

    Dr. Shivdasanis laboratory studies mechanisms of cell differentiation in the gastrointestinal epithelium. The research combines methods in molecular and cell biology with generation and analysis of genetically engineered mouse lines. The laboratory aims to elucidate and characterize genetic pathways that control differentiation of fetal and adult gastrointestinal epithelium. Present efforts include characterizing specific functions of the Wnt, Hedgehog and Notch signaling pathways and how these pathways intersect with tissue-restricted transcription factors.Dr. Shivdasani also directs a Translational Research laboratory that unites several Dana-Farber efforts in gastrointestinal cancers under a single umbrella. To acquire and exploit new molecular insights for biologically targeted cancer therapy, this laboratory investigates clinically annotated samples of gastric, colorectal and GI neuroendocrine tumors for polymorphisms, mutations and phenotypic alterations.


      • Graded BMP signaling within intestinal crypt architecture directs self-organization of the Wnt-secreting stem cell niche. Cell Stem Cell. 2023 04 06; 30(4):433-449.e8. View in: Pubmed

      • Smooth muscle contributes to the development and function of a layered intestinal stem cell niche. Dev Cell. 2023 04 10; 58(7):550-564.e6. View in: Pubmed

      • Defining the structure, signals, and cellular elements of the gastric mesenchymal niche. bioRxiv. 2023 Feb 24. View in: Pubmed

      • Cell and chromatin transitions in intestinal stem cell regeneration. Genes Dev. 2022 06 01; 36(11-12):684-698. View in: Pubmed

      • The hens guarding epithelial cancer fox-houses. Cell Res. 2022 03; 32(3):225-226. View in: Pubmed

      • Transcription factor-mediated intestinal metaplasia and the role of a shadow enhancer. Genes Dev. 2022 01 01; 36(1-2):38-52. View in: Pubmed

      • Stem cell responses to stretch and strain. Trends Cell Biol. 2022 01; 32(1):4-7. View in: Pubmed

      • SATB2 preserves colon stem cell identity and mediates ileum-colon conversion via enhancer remodeling. Cell Stem Cell. 2022 01 06; 29(1):101-115.e10. View in: Pubmed

      • Race to the bottom: Darwinian competition in early intestinal tumorigenesis. Cell Stem Cell. 2021 08 05; 28(8):1340-1342. View in: Pubmed

      • Hybrid Stomach-Intestinal Chromatin States Underlie Human Barrett's Metaplasia. Gastroenterology. 2021 09; 161(3):924-939.e11. View in: Pubmed

      • Creb5 establishes the competence for Prg4 expression in articular cartilage. Commun Biol. 2021 03 12; 4(1):332. View in: Pubmed

      • Adaptation of pancreatic cancer cells to nutrient deprivation is reversible and requires glutamine synthetase stabilization by mTORC1. Proc Natl Acad Sci U S A. 2021 03 09; 118(10). View in: Pubmed

      • Tissue regeneration: Reserve or reverse? Science. 2021 Feb 19; 371(6531):784-786. View in: Pubmed

      • Progastrin production transitions from Bmi1+/Prox1+ to Lgr5high cells during early intestinal tumorigenesis. Transl Oncol. 2021 Feb; 14(2):101001. View in: Pubmed

      • Epigenetic Signatures and Plasticity of Intestinal and Other Stem Cells. Annu Rev Physiol. 2021 02 10; 83:405-427. View in: Pubmed

      • Cellular and molecular architecture of the intestinal stem cell niche. Nat Cell Biol. 2020 09; 22(9):1033-1041. View in: Pubmed

      • Epigenetic regulation of intestinal stem cell differentiation. Am J Physiol Gastrointest Liver Physiol. 2020 08 01; 319(2):G189-G196. View in: Pubmed

      • Hedgehog-Activated Fat4 and PCP Pathways Mediate Mesenchymal Cell Clustering and Villus Formation in Gut Development. Dev Cell. 2020 03 09; 52(5):647-658.e6. View in: Pubmed

      • Ascl2-Dependent Cell Dedifferentiation Drives Regeneration of Ablated Intestinal Stem Cells. Cell Stem Cell. 2020 03 05; 26(3):377-390.e6. View in: Pubmed

      • Distinct Mesenchymal Cell Populations Generate the Essential Intestinal BMP Signaling Gradient. Cell Stem Cell. 2020 03 05; 26(3):391-402.e5. View in: Pubmed

      • Replicational Dilution of H3K27me3 in Mammalian Cells and the Role of Poised Promoters. Mol Cell. 2020 04 02; 78(1):141-151.e5. View in: Pubmed

      • Krüppel-like Factor 5 Regulates Stemness, Lineage Specification, and Regeneration of Intestinal Epithelial Stem Cells. Cell Mol Gastroenterol Hepatol. 2020; 9(4):587-609. View in: Pubmed

      • Publisher Correction: Enhancer signatures stratify and predict outcomes of non-functional pancreatic neuroendocrine tumors. Nat Med. 2019 Oct; 25(10):1627. View in: Pubmed

      • Enhancer signatures stratify and predict outcomes of non-functional pancreatic neuroendocrine tumors. Nat Med. 2019 08; 25(8):1260-1265. View in: Pubmed

      • Extensive Recovery of Embryonic Enhancer and Gene Memory Stored in Hypomethylated Enhancer DNA. Mol Cell. 2019 05 02; 74(3):542-554.e5. View in: Pubmed

      • The lineage-specific transcription factor CDX2 navigates dynamic chromatin to control distinct stages of intestine development. Development. 2019 03 01; 146(5). View in: Pubmed

      • Dissecting Cell Lineages: From Microscope to Kaleidoscope. Cell. 2019 02 21; 176(5):949-951. View in: Pubmed

      • TRPS1 Is a Lineage-Specific Transcriptional Dependency in Breast Cancer. Cell Rep. 2018 10 30; 25(5):1255-1267.e5. View in: Pubmed

      • Enhancer, transcriptional, and cell fate plasticity precedes intestinal determination during endoderm development. Genes Dev. 2018 11 01; 32(21-22):1430-1442. View in: Pubmed

      • Limited gut cell repertoire for multiple hormones. Nat Cell Biol. 2018 08; 20(8):865-867. View in: Pubmed

      • RORa-expressing T regulatory cells restrain allergic skin inflammation. Sci Immunol. 2018 03 02; 3(21). View in: Pubmed

      • Transcription factor-dependent 'anti-repressive' mammalian enhancers exclude H3K27me3 from extended genomic domains. Genes Dev. 2017 12 01; 31(23-24):2391-2404. View in: Pubmed

      • Dynamic Reorganization of Chromatin Accessibility Signatures during Dedifferentiation of Secretory Precursors into Lgr5+ Intestinal Stem Cells. Cell Stem Cell. 2017 07 06; 21(1):65-77.e5. View in: Pubmed

      • A Summary of the 2016 James W. Freston Conference of the American Gastroenterological Association: Intestinal Metaplasia in the Esophagus and Stomach: Origins, Differences, Similarities and Significance. Gastroenterology. 2017 Jul; 153(1):e6-e13. View in: Pubmed

      • Challenges and emerging directions in single-cell analysis. Genome Biol. 2017 05 08; 18(1):84. View in: Pubmed

      • Somatic copy number alterations in gastric adenocarcinomas among Asian and Western patients. PLoS One. 2017; 12(4):e0176045. View in: Pubmed

      • ARID1A loss impairs enhancer-mediated gene regulation and drives colon cancer in mice. Nat Genet. 2017 Feb; 49(2):296-302. View in: Pubmed

      • Transcriptional Regulator CNOT3 Defines an Aggressive Colorectal Cancer Subtype. Cancer Res. 2017 02 01; 77(3):766-779. View in: Pubmed

      • Natural Selection, Crypt Fitness, and Pol III Dependency in the Intestine. Cell Mol Gastroenterol Hepatol. 2016 Nov; 2(6):714-715. View in: Pubmed

      • Single-Cell Transcript Profiles Reveal Multilineage Priming in Early Progenitors Derived from Lgr5(+) Intestinal Stem Cells. Cell Rep. 2016 08 23; 16(8):2053-2060. View in: Pubmed

      • Sox2 Suppresses Gastric Tumorigenesis in Mice. Cell Rep. 2016 08 16; 16(7):1929-41. View in: Pubmed

      • NF-E2, FLI1 and RUNX1 collaborate at areas of dynamic chromatin to activate transcription in mature mouse megakaryocytes. Sci Rep. 2016 07 26; 6:30255. View in: Pubmed

      • Acquired Tissue-Specific Promoter Bivalency Is a Basis for PRC2 Necessity in Adult Cells. Cell. 2016 Jun 02; 165(6):1389-1400. View in: Pubmed

      • Chromatin immunoprecipitation from fixed clinical tissues reveals tumor-specific enhancer profiles. Nat Med. 2016 06; 22(6):685-91. View in: Pubmed

      • Reprogrammed Stomach Tissue as a Renewable Source of Functional ß Cells for Blood Glucose Regulation. Cell Stem Cell. 2016 Mar 03; 18(3):410-21. View in: Pubmed

      • Stomach development, stem cells and disease. Development. 2016 Feb 15; 143(4):554-65. View in: Pubmed

      • Co-culture of Gastric Organoids and Immortalized Stomach Mesenchymal Cells. Methods Mol Biol. 2016; 1422:23-31. View in: Pubmed

      • Survival Benefit of Exercise Differs by Tumor IRS1 Expression Status in Colorectal Cancer. Ann Surg Oncol. 2016 Mar; 23(3):908-17. View in: Pubmed

      • SOX15 governs transcription in human stratified epithelia and a subset of esophageal adenocarcinomas. Cell Mol Gastroenterol Hepatol. 2015 Nov 01; 1(6):598-609.e6. View in: Pubmed

      • Distinct Processes and Transcriptional Targets Underlie CDX2 Requirements in Intestinal Stem Cells and Differentiated Villus Cells. Stem Cell Reports. 2015 Nov 10; 5(5):673-681. View in: Pubmed

      • The androgen receptor cistrome is extensively reprogrammed in human prostate tumorigenesis. Nat Genet. 2015 Nov; 47(11):1346-51. View in: Pubmed

      • Control of stomach smooth muscle development and intestinal rotation by transcription factor BARX1. Dev Biol. 2015 Sep 01; 405(1):21-32. View in: Pubmed

      • The use of murine-derived fundic organoids in studies of gastric physiology. J Physiol. 2015 Apr 15; 593(8):1809-27. View in: Pubmed

      • Erratum for Verzi et al., Intestinal Master Transcription Factor CDX2 Controls Chromatin Access for Partner Transcription Factor Binding. Mol Cell Biol. 2015 Jan 15; 35(2):496. View in: Pubmed

      • Transcription factors GATA4 and HNF4A control distinct aspects of intestinal homeostasis in conjunction with transcription factor CDX2. J Biol Chem. 2015 Jan 16; 290(3):1850-60. View in: Pubmed

      • Active enhancers are delineated de novo during hematopoiesis, with limited lineage fidelity among specified primary blood cells. Genes Dev. 2014 Aug 15; 28(16):1827-39. View in: Pubmed

      • Dissecting engineered cell types and enhancing cell fate conversion via CellNet. Cell. 2014 Aug 14; 158(4):889-902. View in: Pubmed

      • Indian Hedgehog mediates gastrin-induced proliferation in stomach of adult mice. Gastroenterology. 2014 Sep; 147(3):655-666.e9. View in: Pubmed

      • Radiation redux: reserve intestinal stem cells miss the call to duty. Cell Stem Cell. 2014 Feb 06; 14(2):135-6. View in: Pubmed

      • Wnt secretion from epithelial cells and subepithelial myofibroblasts is not required in the mouse intestinal stem cell niche in vivo. Stem Cell Reports. 2014 Feb 11; 2(2):127-34. View in: Pubmed

      • Broadly permissive intestinal chromatin underlies lateral inhibition and cell plasticity. Nature. 2014 Feb 27; 506(7489):511-5. View in: Pubmed

      • An integrative analysis reveals functional targets of GATA6 transcriptional regulation in gastric cancer. Oncogene. 2014 Dec 04; 33(49):5637-48. View in: Pubmed

      • Somatic mutation of CDKN1B in small intestine neuroendocrine tumors. Nat Genet. 2013 Dec; 45(12):1483-6. View in: Pubmed

      • p63-expressing cells are the stem cells of developing prostate, bladder, and colorectal epithelia. Proc Natl Acad Sci U S A. 2013 May 14; 110(20):8105-10. View in: Pubmed

      • DOT1L-mediated H3K79 methylation in chromatin is dispensable for Wnt pathway-specific and other intestinal epithelial functions. Mol Cell Biol. 2013 May; 33(9):1735-45. View in: Pubmed

      • Genetics and diet regulate vitamin A production via the homeobox transcription factor ISX. J Biol Chem. 2013 Mar 29; 288(13):9017-27. View in: Pubmed

      • Intestinal master transcription factor CDX2 controls chromatin access for partner transcription factor binding. Mol Cell Biol. 2013 Jan; 33(2):281-92. View in: Pubmed

      • Targeted disruption of the BCL9/ß-catenin complex inhibits oncogenic Wnt signaling. Sci Transl Med. 2012 Aug 22; 4(148):148ra117. View in: Pubmed

      • Stem cell niches: famished Paneth cells, gluttonous stem cells. Curr Biol. 2012 Jul 24; 22(14):R579-80. View in: Pubmed

      • Gastrointestinal adenocarcinomas of the esophagus, stomach, and colon exhibit distinct patterns of genome instability and oncogenesis. Cancer Res. 2012 Sep 01; 72(17):4383-93. View in: Pubmed

      • GEFs on the RhoAd to a colossal nucleus. Dev Cell. 2012 Mar 13; 22(3):471-2. View in: Pubmed

      • Intact function of Lgr5 receptor-expressing intestinal stem cells in the absence of Paneth cells. Proc Natl Acad Sci U S A. 2012 Mar 06; 109(10):3932-7. View in: Pubmed

      • Differential WNT activity in colorectal cancer confers limited tumorigenic potential and is regulated by MAPK signaling. Cancer Res. 2012 Mar 15; 72(6):1547-56. View in: Pubmed

      • The Stem Cell Discovery Engine: an integrated repository and analysis system for cancer stem cell comparisons. Nucleic Acids Res. 2012 Jan; 40(Database issue):D984-91. View in: Pubmed

      • Genomic analysis identifies association of Fusobacterium with colorectal carcinoma. Genome Res. 2012 Feb; 22(2):292-8. View in: Pubmed

      • Activation of ERBB2 signaling causes resistance to the EGFR-directed therapeutic antibody cetuximab. Sci Transl Med. 2011 Sep 07; 3(99):99ra86. View in: Pubmed

      • Endodermal Hedgehog signals modulate Notch pathway activity in the developing digestive tract mesenchyme. Development. 2011 Aug; 138(15):3225-33. View in: Pubmed

      • Boundaries, junctions and transitions in the gastrointestinal tract. Exp Cell Res. 2011 Nov 15; 317(19):2711-8. View in: Pubmed

      • Barx1-mediated inhibition of Wnt signaling in the mouse thoracic foregut controls tracheo-esophageal septation and epithelial differentiation. PLoS One. 2011; 6(7):e22493. View in: Pubmed

      • Targeting PI3K signaling as a therapeutic approach for colorectal cancer. Gastroenterology. 2011 Jul; 141(1):50-61. View in: Pubmed

      • Notch signaling in stomach epithelial stem cell homeostasis. J Exp Med. 2011 Apr 11; 208(4):677-88. View in: Pubmed

      • Essential and redundant functions of caudal family proteins in activating adult intestinal genes. Mol Cell Biol. 2011 May; 31(10):2026-39. View in: Pubmed

      • Regulation of mouse stomach development and Barx1 expression by specific microRNAs. Development. 2011 Mar; 138(6):1081-6. View in: Pubmed

      • Genetic evidence that intestinal Notch functions vary regionally and operate through a common mechanism of Math1 repression. J Biol Chem. 2011 Apr 01; 286(13):11427-33. View in: Pubmed

      • Gastric epithelial stem cells. Gastroenterology. 2011 Feb; 140(2):412-24. View in: Pubmed

      • Differentiation-specific histone modifications reveal dynamic chromatin interactions and partners for the intestinal transcription factor CDX2. Dev Cell. 2010 Nov 16; 19(5):713-26. View in: Pubmed

      • Stem cells: The intestinal-crypt casino. Nature. 2010 Oct 28; 467(7319):1055-6. View in: Pubmed

      • Requirement of the epithelium-specific Ets transcription factor Spdef for mucous gland cell function in the gastric antrum. J Biol Chem. 2010 Nov 05; 285(45):35047-55. View in: Pubmed

      • TCF4 and CDX2, major transcription factors for intestinal function, converge on the same cis-regulatory regions. Proc Natl Acad Sci U S A. 2010 Aug 24; 107(34):15157-62. View in: Pubmed

      • Hedgehog signaling controls mesenchymal growth in the developing mammalian digestive tract. Development. 2010 May; 137(10):1721-9. View in: Pubmed

      • Platelets contribute to postnatal occlusion of the ductus arteriosus. Nat Med. 2010 Jan; 16(1):75-82. View in: Pubmed

      • Profiling critical cancer gene mutations in clinical tumor samples. PLoS One. 2009 Nov 18; 4(11):e7887. View in: Pubmed

      • SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas. Nat Genet. 2009 Nov; 41(11):1238-42. View in: Pubmed

      • The microtubule modulator RanBP10 plays a critical role in regulation of platelet discoid shape and degranulation. Blood. 2009 Dec 24; 114(27):5532-40. View in: Pubmed

      • Prognostic and predictive value of common mutations for treatment response and survival in patients with metastatic colorectal cancer. Br J Cancer. 2009 Aug 04; 101(3):465-72. View in: Pubmed

      • Relationship of CDX2 loss with molecular features and prognosis in colorectal cancer. Clin Cancer Res. 2009 Jul 15; 15(14):4665-73. View in: Pubmed

      • Regulation of platelet biogenesis: insights from the May-Hegglin anomaly and other MYH9-related disorders. J Thromb Haemost. 2009 Jul; 7 Suppl 1:272-6. View in: Pubmed

      • The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer. Nat Genet. 2009 Aug; 41(8):882-4. View in: Pubmed

      • Prominin1 (CD133) as an intestinal stem cell marker: promise and nuance. Gastroenterology. 2009 Jun; 136(7):2051-4. View in: Pubmed

      • Role of the homeodomain transcription factor Bapx1 in mouse distal stomach development. Gastroenterology. 2009 May; 136(5):1701-10. View in: Pubmed

      • Trps1, a regulator of chondrocyte proliferation and differentiation, interacts with the activator form of Gli3. Dev Biol. 2009 Apr 01; 328(1):40-53. View in: Pubmed

      • Cell-type selective chromatin remodeling defines the active subset of FOXA1-bound enhancers. Genome Res. 2009 Mar; 19(3):372-80. View in: Pubmed

      • Tricho-rhino-phalangeal syndrome with supernumerary teeth. J Dent Res. 2008 Nov; 87(11):1027-31. View in: Pubmed

      • CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity. Nature. 2008 Sep 25; 455(7212):547-51. View in: Pubmed

      • High-resolution analysis of genetic alterations in small bowel carcinoid tumors reveals areas of recurrent amplification and loss. Genes Chromosomes Cancer. 2008 Jul; 47(7):591-603. View in: Pubmed

      • Expression and function of Nkx6.3 in vertebrate hindbrain. Brain Res. 2008 Jul 30; 1222:42-50. View in: Pubmed

      • Transcription factor foxq1 controls mucin gene expression and granule content in mouse stomach surface mucous cells. Gastroenterology. 2008 Aug; 135(2):591-600. View in: Pubmed

      • Uncoupling of chondrocyte differentiation and perichondrial mineralization underlies the skeletal dysplasia in tricho-rhino-phalangeal syndrome. Hum Mol Genet. 2008 Jul 15; 17(14):2244-54. View in: Pubmed

      • Wnt signaling in gut organogenesis. Organogenesis. 2008 Apr; 4(2):87-91. View in: Pubmed

      • Requirement of the tissue-restricted homeodomain transcription factor Nkx6.3 in differentiation of gastrin-producing G cells in the stomach antrum. Mol Cell Biol. 2008 May; 28(10):3208-18. View in: Pubmed

      • RanBP10 is a cytoplasmic guanine nucleotide exchange factor that modulates noncentrosomal microtubules. J Biol Chem. 2008 May 16; 283(20):14109-19. View in: Pubmed

      • Visualization of microtubule growth in living platelets reveals a dynamic marginal band with multiple microtubules. Blood. 2008 May 01; 111(9):4605-16. View in: Pubmed

      • High-resolution analysis of genetic alterations in small bowel carcinoid tumors reveals areas of recurrent amplification and loss. Genes Chrom Cancer. 2008; 47:591-603. View in: Pubmed

      • PU.1 is a major downstream target of AML1 (RUNX1) in adult mouse hematopoiesis. Nat Genet. 2008 Jan; 40(1):51-60. View in: Pubmed

      • Loss of the PlagL2 transcription factor affects lacteal uptake of chylomicrons. Cell Metab. 2007 Nov; 6(5):406-13. View in: Pubmed

      • Dynamic visualization of thrombopoiesis within bone marrow. Science. 2007 Sep 21; 317(5845):1767-70. View in: Pubmed

      • Independent functions and mechanisms for homeobox gene Barx1 in patterning mouse stomach and spleen. Development. 2007 Oct; 134(20):3603-13. View in: Pubmed

      • Phases of canonical Wnt signaling during the development of mouse intestinal epithelium. Gastroenterology. 2007 Aug; 133(2):529-38. View in: Pubmed

      • The May-Hegglin anomaly gene MYH9 is a negative regulator of platelet biogenesis modulated by the Rho-ROCK pathway. Blood. 2007 Jul 01; 110(1):171-9. View in: Pubmed

      • Expression analysis of primary mouse megakaryocyte differentiation and its application in identifying stage-specific molecular markers and a novel transcriptional target of NF-E2. Blood. 2007 Feb 15; 109(4):1451-9. View in: Pubmed

      • A dynamic expression survey identifies transcription factors relevant in mouse digestive tract development. Development. 2006 Oct; 133(20):4119-29. View in: Pubmed

      • MicroRNAs: regulators of gene expression and cell differentiation. Blood. 2006 Dec 01; 108(12):3646-53. View in: Pubmed

      • Characterization of the megakaryocyte demarcation membrane system and its role in thrombopoiesis. Blood. 2006 May 15; 107(10):3868-75. View in: Pubmed

      • Overlapping gene expression in fetal mouse intestine development and human colorectal cancer. Cancer Res. 2005 Oct 01; 65(19):8715-22. View in: Pubmed

      • Mechanisms of organelle transport and capture along proplatelets during platelet production. Blood. 2005 Dec 15; 106(13):4066-75. View in: Pubmed

      • Differential roles of microtubule assembly and sliding in proplatelet formation by megakaryocytes. Blood. 2005 Dec 15; 106(13):4076-85. View in: Pubmed

      • Mechanisms of thrombopoiesis. J Thromb Haemost. 2005 Aug; 3(8):1717-24. View in: Pubmed

      • Culture, expansion, and differentiation of murine megakaryocytes. Curr Protoc Immunol. 2005 Jul; Chapter 22:Unit 22F.6. View in: Pubmed

      • The stomach mesenchymal transcription factor Barx1 specifies gastric epithelial identity through inhibition of transient Wnt signaling. Dev Cell. 2005 Apr; 8(4):611-22. View in: Pubmed

      • Hic-5 regulates an epithelial program mediated by PPARgamma. Genes Dev. 2005 Feb 01; 19(3):362-75. View in: Pubmed

      • A Fli in the ointment. Blood. 2005; 105:9-10. View in: Pubmed

      • Culture and in vitro differentiation of murine megakaryocytes. In: Coligan JE, Bierer BE, Margulies DH, Shevach EM, Strober W, editors. Current protocols in immunology. 2005; Chapter 22F:6.1-6.13. View in: Pubmed

      • Insights into developmental mechanisms and cancers in the mammalian intestine derived from serial analysis of gene expression and study of the hepatoma-derived growth factor (HDGF). Development. 2005 Jan; 132(2):415-27. View in: Pubmed

      • Interactions between the megakaryocyte/platelet-specific beta1 tubulin and the secretory leukocyte protease inhibitor SLPI suggest a role for regulated proteolysis in platelet functions. Blood. 2004 Dec 15; 104(13):3949-57. View in: Pubmed

      • Molecular mechanisms of megakaryocyte differentiation. Semin Thromb Hemost. 2004 Aug; 30(4):389-98. View in: Pubmed

      • Lonely in Paris: when one gene copy isn't enough. J Clin Invest. 2004 Jul; 114(1):17-9. View in: Pubmed

      • Complexity of CNC transcription factors as revealed by gene targeting of the Nrf3 locus. Mol Cell Biol. 2004 Apr; 24(8):3286-94. View in: Pubmed

      • Regulation of mammalian epithelial differentiation and intestine development by class I histone deacetylases. Mol Cell Biol. 2004 Apr; 24(8):3132-9. View in: Pubmed

      • Molecular mechanisms of megakaryocyte differentiation and platelet production. Sem Thromb Hemost. 2004; 30:389-98. View in: Pubmed

      • Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex. Cancer Cell. 2004 Jan; 5(1):91-102. View in: Pubmed

      • Megakaryocyte-osteoblast interaction revealed in mice deficient in transcription factors GATA-1 and NF-E2. J Bone Miner Res. 2004 Apr; 19(4):652-60. View in: Pubmed

      • A role for Rab27b in NF-E2-dependent pathways of platelet formation. Blood. 2003 Dec 01; 102(12):3970-9. View in: Pubmed

      • Megakaryocytes and beyond: the birth of platelets. J Thromb Haemost. 2003 Jun; 1(6):1174-82. View in: Pubmed

      • Mechanisms and implications of platelet discoid shape. Blood. 2003 Jun 15; 101(12):4789-96. View in: Pubmed

      • Management of extragonadal germ cell tumors. In: Raghavan D, editor. American Cancer Society Atlas of Clinical Oncology - Germ Cell Tumors. 2003; 243-64. View in: Pubmed

      • Deletion of the GATA domain of TRPS1 causes an absence of facial hair and provides new insights into the bone disorder in inherited tricho-rhino-phalangeal syndromes. Mol Cell Biol. 2002 Dec; 22(24):8592-600. View in: Pubmed

      • Characterization of a novel mammalian Groucho isoform and its role in transcriptional regulation. J Biol Chem. 2002 Dec 06; 277(49):47732-40. View in: Pubmed

      • Molecular regulation of vertebrate early endoderm development. Dev Biol. 2002 Sep 15; 249(2):191-203. View in: Pubmed

      • A phase II study of troglitazone, an activator of the PPARgamma receptor, in patients with chemotherapy-resistant metastatic colorectal cancer. Cancer J. 2002 Sep-Oct; 8(5):395-9. View in: Pubmed

      • An animal model for myelofibrosis. Blood. 2002 Aug 15; 100(4):1109. View in: Pubmed

      • A Phase II study of gemcitabine and docetaxel in patients with metastatic pancreatic carcinoma. Cancer. 2002 Jan 01; 94(1):97-103. View in: Pubmed

      • Structure of a human Tcf4-beta-catenin complex. Nat Struct Biol. 2001 Dec; 8(12):1053-7. View in: Pubmed

      • A lineage-restricted and divergent beta-tubulin isoform is essential for the biogenesis, structure and function of blood platelets. Curr Biol. 2001 Apr 17; 11(8):579-86. View in: Pubmed

      • Transcriptional repression and developmental functions of the atypical vertebrate GATA protein TRPS1. EMBO J. 2001 Apr 02; 20(7):1715-25. View in: Pubmed

      • Toward mechanism-based cancer care. JAMA. 2001 Feb 07; 285(5):588-93. View in: Pubmed

      • Molecular and transcriptional regulation of megakaryocyte differentiation. Stem Cells. 2001; 19(5):397-407. View in: Pubmed

      • Regulation of megakaryocyte and erythroid differentiation by NF-E2. In: Licht J, Ravid K, editors. Trancription factors: Normal and malignant development of blood cells. 2001; 13-29. View in: Pubmed

      • p45(NFE2) is a negative regulator of erythroid proliferation which contributes to the progression of Friend virus-induced erythroleukemias. Mol Cell Biol. 2001 Jan; 21(1):73-80. View in: Pubmed

      • Downregulation of Hedgehog signaling is required for organogenesis of the small intestine in Xenopus. Dev Biol. 2001 Jan 01; 229(1):188-202. View in: Pubmed

      • Hematopoietic-specific beta 1 tubulin participates in a pathway of platelet biogenesis dependent on the transcription factor NF-E2. Blood. 2000 Aug 15; 96(4):1366-73. View in: Pubmed

      • Structure and expression of a novel frizzled gene isolated from the developing mouse gut. Biochem J. 2000 Aug 01; 349 Pt 3:829-34. View in: Pubmed

      • Action of the Caenorhabditis elegans GATA factor END-1 in Xenopus suggests that similar mechanisms initiate endoderm development in ecdysozoa and vertebrates. Proc Natl Acad Sci U S A. 2000 Apr 11; 97(8):4076-81. View in: Pubmed

      • Blood platelets are assembled principally at the ends of proplatelet processes produced by differentiated megakaryocytes. J Cell Biol. 1999 Dec 13; 147(6):1299-312. View in: Pubmed

      • Pathophysiology of thrombocytopenia and anemia in mice lacking transcription factor NF-E2. Blood. 1999 Nov 01; 94(9):3037-47. View in: Pubmed

      • Consequences of GATA-1 deficiency in megakaryocytes and platelets. Blood. 1999 May 01; 93(9):2867-75. View in: Pubmed

      • A possible role for the high mobility group box transcription factor Tcf-4 in vertebrate gut epithelial cell differentiation. J Biol Chem. 1999 Jan 15; 274(3):1566-72. View in: Pubmed

      • Mice lacking transcription factor NF-E2 provide in vivo validation of the proplatelet model of thrombocytopoiesis and show a platelet production defect that is intrinsic to megakaryocytes. Blood. 1998 Sep 01; 92(5):1608-16. View in: Pubmed

      • Regulation of megakaryocytopoiesis and platelet production: lessons from animal models. J Lab Clin Med. 1998 Jun; 131(6):496-501. View in: Pubmed

      • Erythroid maturation and globin gene expression in mice with combined deficiency of NF-E2 and nrf-2. Blood. 1998 May 01; 91(9):3459-66. View in: Pubmed

      • Characterization of the hematopoietic transcription factor NF-E2 in primary murine megakaryocytes. J Biol Chem. 1998 Mar 27; 273(13):7572-8. View in: Pubmed

      • Cellular and molecular biology of megakaryocyte differentiation in the absence of lineage-restricted transcription factors. Stem Cells. 1998; 16 Suppl 2:91-5. View in: Pubmed

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