Ramesh A. Shivdasani, MD, PhD

Graded BMP signaling within intestinal crypt architecture directs self-organization of the Wnt-secreting stem cell niche. Cell Stem Cell. 2023 04 06; 30(4):433-449.e8. View in: Pubmed

Smooth muscle contributes to the development and function of a layered intestinal stem cell niche. Dev Cell. 2023 04 10; 58(7):550-564.e6. View in: Pubmed

Defining the structure, signals, and cellular elements of the gastric mesenchymal niche. bioRxiv. 2023 Feb 24. View in: Pubmed

Cell and chromatin transitions in intestinal stem cell regeneration. Genes Dev. 2022 06 01; 36(11-12):684-698. View in: Pubmed

The hens guarding epithelial cancer fox-houses. Cell Res. 2022 03; 32(3):225-226. View in: Pubmed

Transcription factor-mediated intestinal metaplasia and the role of a shadow enhancer. Genes Dev. 2022 01 01; 36(1-2):38-52. View in: Pubmed

Stem cell responses to stretch and strain. Trends Cell Biol. 2022 01; 32(1):4-7. View in: Pubmed

SATB2 preserves colon stem cell identity and mediates ileum-colon conversion via enhancer remodeling. Cell Stem Cell. 2022 01 06; 29(1):101-115.e10. View in: Pubmed

Race to the bottom: Darwinian competition in early intestinal tumorigenesis. Cell Stem Cell. 2021 08 05; 28(8):1340-1342. View in: Pubmed

Hybrid Stomach-Intestinal Chromatin States Underlie Human Barrett's Metaplasia. Gastroenterology. 2021 09; 161(3):924-939.e11. View in: Pubmed

Creb5 establishes the competence for Prg4 expression in articular cartilage. Commun Biol. 2021 03 12; 4(1):332. View in: Pubmed

Adaptation of pancreatic cancer cells to nutrient deprivation is reversible and requires glutamine synthetase stabilization by mTORC1. Proc Natl Acad Sci U S A. 2021 03 09; 118(10). View in: Pubmed

Tissue regeneration: Reserve or reverse? Science. 2021 Feb 19; 371(6531):784-786. View in: Pubmed

Progastrin production transitions from Bmi1+/Prox1+ to Lgr5high cells during early intestinal tumorigenesis. Transl Oncol. 2021 Feb; 14(2):101001. View in: Pubmed

Epigenetic Signatures and Plasticity of Intestinal and Other Stem Cells. Annu Rev Physiol. 2021 02 10; 83:405-427. View in: Pubmed

Cellular and molecular architecture of the intestinal stem cell niche. Nat Cell Biol. 2020 09; 22(9):1033-1041. View in: Pubmed

Epigenetic regulation of intestinal stem cell differentiation. Am J Physiol Gastrointest Liver Physiol. 2020 08 01; 319(2):G189-G196. View in: Pubmed

Hedgehog-Activated Fat4 and PCP Pathways Mediate Mesenchymal Cell Clustering and Villus Formation in Gut Development. Dev Cell. 2020 03 09; 52(5):647-658.e6. View in: Pubmed

Ascl2-Dependent Cell Dedifferentiation Drives Regeneration of Ablated Intestinal Stem Cells. Cell Stem Cell. 2020 03 05; 26(3):377-390.e6. View in: Pubmed

Distinct Mesenchymal Cell Populations Generate the Essential Intestinal BMP Signaling Gradient. Cell Stem Cell. 2020 03 05; 26(3):391-402.e5. View in: Pubmed

Replicational Dilution of H3K27me3 in Mammalian Cells and the Role of Poised Promoters. Mol Cell. 2020 04 02; 78(1):141-151.e5. View in: Pubmed

Krüppel-like Factor 5 Regulates Stemness, Lineage Specification, and Regeneration of Intestinal Epithelial Stem Cells. Cell Mol Gastroenterol Hepatol. 2020; 9(4):587-609. View in: Pubmed

Publisher Correction: Enhancer signatures stratify and predict outcomes of non-functional pancreatic neuroendocrine tumors. Nat Med. 2019 Oct; 25(10):1627. View in: Pubmed

Enhancer signatures stratify and predict outcomes of non-functional pancreatic neuroendocrine tumors. Nat Med. 2019 08; 25(8):1260-1265. View in: Pubmed

Extensive Recovery of Embryonic Enhancer and Gene Memory Stored in Hypomethylated Enhancer DNA. Mol Cell. 2019 05 02; 74(3):542-554.e5. View in: Pubmed

The lineage-specific transcription factor CDX2 navigates dynamic chromatin to control distinct stages of intestine development. Development. 2019 03 01; 146(5). View in: Pubmed

Dissecting Cell Lineages: From Microscope to Kaleidoscope. Cell. 2019 02 21; 176(5):949-951. View in: Pubmed

TRPS1 Is a Lineage-Specific Transcriptional Dependency in Breast Cancer. Cell Rep. 2018 10 30; 25(5):1255-1267.e5. View in: Pubmed

Enhancer, transcriptional, and cell fate plasticity precedes intestinal determination during endoderm development. Genes Dev. 2018 11 01; 32(21-22):1430-1442. View in: Pubmed

Limited gut cell repertoire for multiple hormones. Nat Cell Biol. 2018 08; 20(8):865-867. View in: Pubmed

RORa-expressing T regulatory cells restrain allergic skin inflammation. Sci Immunol. 2018 03 02; 3(21). View in: Pubmed

Transcription factor-dependent 'anti-repressive' mammalian enhancers exclude H3K27me3 from extended genomic domains. Genes Dev. 2017 12 01; 31(23-24):2391-2404. View in: Pubmed

Dynamic Reorganization of Chromatin Accessibility Signatures during Dedifferentiation of Secretory Precursors into Lgr5+ Intestinal Stem Cells. Cell Stem Cell. 2017 07 06; 21(1):65-77.e5. View in: Pubmed

A Summary of the 2016 James W. Freston Conference of the American Gastroenterological Association: Intestinal Metaplasia in the Esophagus and Stomach: Origins, Differences, Similarities and Significance. Gastroenterology. 2017 Jul; 153(1):e6-e13. View in: Pubmed

Challenges and emerging directions in single-cell analysis. Genome Biol. 2017 05 08; 18(1):84. View in: Pubmed

Somatic copy number alterations in gastric adenocarcinomas among Asian and Western patients. PLoS One. 2017; 12(4):e0176045. View in: Pubmed

ARID1A loss impairs enhancer-mediated gene regulation and drives colon cancer in mice. Nat Genet. 2017 Feb; 49(2):296-302. View in: Pubmed

Transcriptional Regulator CNOT3 Defines an Aggressive Colorectal Cancer Subtype. Cancer Res. 2017 02 01; 77(3):766-779. View in: Pubmed

Natural Selection, Crypt Fitness, and Pol III Dependency in the Intestine. Cell Mol Gastroenterol Hepatol. 2016 Nov; 2(6):714-715. View in: Pubmed

Single-Cell Transcript Profiles Reveal Multilineage Priming in Early Progenitors Derived from Lgr5(+) Intestinal Stem Cells. Cell Rep. 2016 08 23; 16(8):2053-2060. View in: Pubmed

Sox2 Suppresses Gastric Tumorigenesis in Mice. Cell Rep. 2016 08 16; 16(7):1929-41. View in: Pubmed

NF-E2, FLI1 and RUNX1 collaborate at areas of dynamic chromatin to activate transcription in mature mouse megakaryocytes. Sci Rep. 2016 07 26; 6:30255. View in: Pubmed

Acquired Tissue-Specific Promoter Bivalency Is a Basis for PRC2 Necessity in Adult Cells. Cell. 2016 Jun 02; 165(6):1389-1400. View in: Pubmed

Chromatin immunoprecipitation from fixed clinical tissues reveals tumor-specific enhancer profiles. Nat Med. 2016 06; 22(6):685-91. View in: Pubmed

Reprogrammed Stomach Tissue as a Renewable Source of Functional ß Cells for Blood Glucose Regulation. Cell Stem Cell. 2016 Mar 03; 18(3):410-21. View in: Pubmed

Stomach development, stem cells and disease. Development. 2016 Feb 15; 143(4):554-65. View in: Pubmed

Co-culture of Gastric Organoids and Immortalized Stomach Mesenchymal Cells. Methods Mol Biol. 2016; 1422:23-31. View in: Pubmed

Survival Benefit of Exercise Differs by Tumor IRS1 Expression Status in Colorectal Cancer. Ann Surg Oncol. 2016 Mar; 23(3):908-17. View in: Pubmed

SOX15 governs transcription in human stratified epithelia and a subset of esophageal adenocarcinomas. Cell Mol Gastroenterol Hepatol. 2015 Nov 01; 1(6):598-609.e6. View in: Pubmed

Distinct Processes and Transcriptional Targets Underlie CDX2 Requirements in Intestinal Stem Cells and Differentiated Villus Cells. Stem Cell Reports. 2015 Nov 10; 5(5):673-681. View in: Pubmed

The androgen receptor cistrome is extensively reprogrammed in human prostate tumorigenesis. Nat Genet. 2015 Nov; 47(11):1346-51. View in: Pubmed

Control of stomach smooth muscle development and intestinal rotation by transcription factor BARX1. Dev Biol. 2015 Sep 01; 405(1):21-32. View in: Pubmed

The use of murine-derived fundic organoids in studies of gastric physiology. J Physiol. 2015 Apr 15; 593(8):1809-27. View in: Pubmed

Erratum for Verzi et al., Intestinal Master Transcription Factor CDX2 Controls Chromatin Access for Partner Transcription Factor Binding. Mol Cell Biol. 2015 Jan 15; 35(2):496. View in: Pubmed

Transcription factors GATA4 and HNF4A control distinct aspects of intestinal homeostasis in conjunction with transcription factor CDX2. J Biol Chem. 2015 Jan 16; 290(3):1850-60. View in: Pubmed

Active enhancers are delineated de novo during hematopoiesis, with limited lineage fidelity among specified primary blood cells. Genes Dev. 2014 Aug 15; 28(16):1827-39. View in: Pubmed

Dissecting engineered cell types and enhancing cell fate conversion via CellNet. Cell. 2014 Aug 14; 158(4):889-902. View in: Pubmed

Indian Hedgehog mediates gastrin-induced proliferation in stomach of adult mice. Gastroenterology. 2014 Sep; 147(3):655-666.e9. View in: Pubmed

Radiation redux: reserve intestinal stem cells miss the call to duty. Cell Stem Cell. 2014 Feb 06; 14(2):135-6. View in: Pubmed

Wnt secretion from epithelial cells and subepithelial myofibroblasts is not required in the mouse intestinal stem cell niche in vivo. Stem Cell Reports. 2014 Feb 11; 2(2):127-34. View in: Pubmed

Broadly permissive intestinal chromatin underlies lateral inhibition and cell plasticity. Nature. 2014 Feb 27; 506(7489):511-5. View in: Pubmed

An integrative analysis reveals functional targets of GATA6 transcriptional regulation in gastric cancer. Oncogene. 2014 Dec 04; 33(49):5637-48. View in: Pubmed

Somatic mutation of CDKN1B in small intestine neuroendocrine tumors. Nat Genet. 2013 Dec; 45(12):1483-6. View in: Pubmed

p63-expressing cells are the stem cells of developing prostate, bladder, and colorectal epithelia. Proc Natl Acad Sci U S A. 2013 May 14; 110(20):8105-10. View in: Pubmed

DOT1L-mediated H3K79 methylation in chromatin is dispensable for Wnt pathway-specific and other intestinal epithelial functions. Mol Cell Biol. 2013 May; 33(9):1735-45. View in: Pubmed

Genetics and diet regulate vitamin A production via the homeobox transcription factor ISX. J Biol Chem. 2013 Mar 29; 288(13):9017-27. View in: Pubmed

Intestinal master transcription factor CDX2 controls chromatin access for partner transcription factor binding. Mol Cell Biol. 2013 Jan; 33(2):281-92. View in: Pubmed

Targeted disruption of the BCL9/ß-catenin complex inhibits oncogenic Wnt signaling. Sci Transl Med. 2012 Aug 22; 4(148):148ra117. View in: Pubmed

Stem cell niches: famished Paneth cells, gluttonous stem cells. Curr Biol. 2012 Jul 24; 22(14):R579-80. View in: Pubmed

Gastrointestinal adenocarcinomas of the esophagus, stomach, and colon exhibit distinct patterns of genome instability and oncogenesis. Cancer Res. 2012 Sep 01; 72(17):4383-93. View in: Pubmed

GEFs on the RhoAd to a colossal nucleus. Dev Cell. 2012 Mar 13; 22(3):471-2. View in: Pubmed

Intact function of Lgr5 receptor-expressing intestinal stem cells in the absence of Paneth cells. Proc Natl Acad Sci U S A. 2012 Mar 06; 109(10):3932-7. View in: Pubmed

Differential WNT activity in colorectal cancer confers limited tumorigenic potential and is regulated by MAPK signaling. Cancer Res. 2012 Mar 15; 72(6):1547-56. View in: Pubmed

The Stem Cell Discovery Engine: an integrated repository and analysis system for cancer stem cell comparisons. Nucleic Acids Res. 2012 Jan; 40(Database issue):D984-91. View in: Pubmed

Genomic analysis identifies association of Fusobacterium with colorectal carcinoma. Genome Res. 2012 Feb; 22(2):292-8. View in: Pubmed

Activation of ERBB2 signaling causes resistance to the EGFR-directed therapeutic antibody cetuximab. Sci Transl Med. 2011 Sep 07; 3(99):99ra86. View in: Pubmed

Endodermal Hedgehog signals modulate Notch pathway activity in the developing digestive tract mesenchyme. Development. 2011 Aug; 138(15):3225-33. View in: Pubmed

Boundaries, junctions and transitions in the gastrointestinal tract. Exp Cell Res. 2011 Nov 15; 317(19):2711-8. View in: Pubmed

Barx1-mediated inhibition of Wnt signaling in the mouse thoracic foregut controls tracheo-esophageal septation and epithelial differentiation. PLoS One. 2011; 6(7):e22493. View in: Pubmed

Targeting PI3K signaling as a therapeutic approach for colorectal cancer. Gastroenterology. 2011 Jul; 141(1):50-61. View in: Pubmed

Notch signaling in stomach epithelial stem cell homeostasis. J Exp Med. 2011 Apr 11; 208(4):677-88. View in: Pubmed

Essential and redundant functions of caudal family proteins in activating adult intestinal genes. Mol Cell Biol. 2011 May; 31(10):2026-39. View in: Pubmed

Regulation of mouse stomach development and Barx1 expression by specific microRNAs. Development. 2011 Mar; 138(6):1081-6. View in: Pubmed

Genetic evidence that intestinal Notch functions vary regionally and operate through a common mechanism of Math1 repression. J Biol Chem. 2011 Apr 01; 286(13):11427-33. View in: Pubmed

Gastric epithelial stem cells. Gastroenterology. 2011 Feb; 140(2):412-24. View in: Pubmed

Differentiation-specific histone modifications reveal dynamic chromatin interactions and partners for the intestinal transcription factor CDX2. Dev Cell. 2010 Nov 16; 19(5):713-26. View in: Pubmed

Stem cells: The intestinal-crypt casino. Nature. 2010 Oct 28; 467(7319):1055-6. View in: Pubmed

Requirement of the epithelium-specific Ets transcription factor Spdef for mucous gland cell function in the gastric antrum. J Biol Chem. 2010 Nov 05; 285(45):35047-55. View in: Pubmed

TCF4 and CDX2, major transcription factors for intestinal function, converge on the same cis-regulatory regions. Proc Natl Acad Sci U S A. 2010 Aug 24; 107(34):15157-62. View in: Pubmed

Hedgehog signaling controls mesenchymal growth in the developing mammalian digestive tract. Development. 2010 May; 137(10):1721-9. View in: Pubmed

Platelets contribute to postnatal occlusion of the ductus arteriosus. Nat Med. 2010 Jan; 16(1):75-82. View in: Pubmed

Profiling critical cancer gene mutations in clinical tumor samples. PLoS One. 2009 Nov 18; 4(11):e7887. View in: Pubmed

SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas. Nat Genet. 2009 Nov; 41(11):1238-42. View in: Pubmed

The microtubule modulator RanBP10 plays a critical role in regulation of platelet discoid shape and degranulation. Blood. 2009 Dec 24; 114(27):5532-40. View in: Pubmed

Prognostic and predictive value of common mutations for treatment response and survival in patients with metastatic colorectal cancer. Br J Cancer. 2009 Aug 04; 101(3):465-72. View in: Pubmed

Relationship of CDX2 loss with molecular features and prognosis in colorectal cancer. Clin Cancer Res. 2009 Jul 15; 15(14):4665-73. View in: Pubmed

Regulation of platelet biogenesis: insights from the May-Hegglin anomaly and other MYH9-related disorders. J Thromb Haemost. 2009 Jul; 7 Suppl 1:272-6. View in: Pubmed

The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer. Nat Genet. 2009 Aug; 41(8):882-4. View in: Pubmed

Prominin1 (CD133) as an intestinal stem cell marker: promise and nuance. Gastroenterology. 2009 Jun; 136(7):2051-4. View in: Pubmed

Role of the homeodomain transcription factor Bapx1 in mouse distal stomach development. Gastroenterology. 2009 May; 136(5):1701-10. View in: Pubmed

Trps1, a regulator of chondrocyte proliferation and differentiation, interacts with the activator form of Gli3. Dev Biol. 2009 Apr 01; 328(1):40-53. View in: Pubmed

Cell-type selective chromatin remodeling defines the active subset of FOXA1-bound enhancers. Genome Res. 2009 Mar; 19(3):372-80. View in: Pubmed

Tricho-rhino-phalangeal syndrome with supernumerary teeth. J Dent Res. 2008 Nov; 87(11):1027-31. View in: Pubmed

CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity. Nature. 2008 Sep 25; 455(7212):547-51. View in: Pubmed

High-resolution analysis of genetic alterations in small bowel carcinoid tumors reveals areas of recurrent amplification and loss. Genes Chromosomes Cancer. 2008 Jul; 47(7):591-603. View in: Pubmed

Expression and function of Nkx6.3 in vertebrate hindbrain. Brain Res. 2008 Jul 30; 1222:42-50. View in: Pubmed

Transcription factor foxq1 controls mucin gene expression and granule content in mouse stomach surface mucous cells. Gastroenterology. 2008 Aug; 135(2):591-600. View in: Pubmed

Uncoupling of chondrocyte differentiation and perichondrial mineralization underlies the skeletal dysplasia in tricho-rhino-phalangeal syndrome. Hum Mol Genet. 2008 Jul 15; 17(14):2244-54. View in: Pubmed

Wnt signaling in gut organogenesis. Organogenesis. 2008 Apr; 4(2):87-91. View in: Pubmed

Requirement of the tissue-restricted homeodomain transcription factor Nkx6.3 in differentiation of gastrin-producing G cells in the stomach antrum. Mol Cell Biol. 2008 May; 28(10):3208-18. View in: Pubmed

RanBP10 is a cytoplasmic guanine nucleotide exchange factor that modulates noncentrosomal microtubules. J Biol Chem. 2008 May 16; 283(20):14109-19. View in: Pubmed

Visualization of microtubule growth in living platelets reveals a dynamic marginal band with multiple microtubules. Blood. 2008 May 01; 111(9):4605-16. View in: Pubmed

High-resolution analysis of genetic alterations in small bowel carcinoid tumors reveals areas of recurrent amplification and loss. Genes Chrom Cancer. 2008; 47:591-603. View in: Pubmed

PU.1 is a major downstream target of AML1 (RUNX1) in adult mouse hematopoiesis. Nat Genet. 2008 Jan; 40(1):51-60. View in: Pubmed

Loss of the PlagL2 transcription factor affects lacteal uptake of chylomicrons. Cell Metab. 2007 Nov; 6(5):406-13. View in: Pubmed

Dynamic visualization of thrombopoiesis within bone marrow. Science. 2007 Sep 21; 317(5845):1767-70. View in: Pubmed

Independent functions and mechanisms for homeobox gene Barx1 in patterning mouse stomach and spleen. Development. 2007 Oct; 134(20):3603-13. View in: Pubmed

Phases of canonical Wnt signaling during the development of mouse intestinal epithelium. Gastroenterology. 2007 Aug; 133(2):529-38. View in: Pubmed

The May-Hegglin anomaly gene MYH9 is a negative regulator of platelet biogenesis modulated by the Rho-ROCK pathway. Blood. 2007 Jul 01; 110(1):171-9. View in: Pubmed

Expression analysis of primary mouse megakaryocyte differentiation and its application in identifying stage-specific molecular markers and a novel transcriptional target of NF-E2. Blood. 2007 Feb 15; 109(4):1451-9. View in: Pubmed

A dynamic expression survey identifies transcription factors relevant in mouse digestive tract development. Development. 2006 Oct; 133(20):4119-29. View in: Pubmed

MicroRNAs: regulators of gene expression and cell differentiation. Blood. 2006 Dec 01; 108(12):3646-53. View in: Pubmed

Characterization of the megakaryocyte demarcation membrane system and its role in thrombopoiesis. Blood. 2006 May 15; 107(10):3868-75. View in: Pubmed

Overlapping gene expression in fetal mouse intestine development and human colorectal cancer. Cancer Res. 2005 Oct 01; 65(19):8715-22. View in: Pubmed

Mechanisms of organelle transport and capture along proplatelets during platelet production. Blood. 2005 Dec 15; 106(13):4066-75. View in: Pubmed

Differential roles of microtubule assembly and sliding in proplatelet formation by megakaryocytes. Blood. 2005 Dec 15; 106(13):4076-85. View in: Pubmed

Mechanisms of thrombopoiesis. J Thromb Haemost. 2005 Aug; 3(8):1717-24. View in: Pubmed

Culture, expansion, and differentiation of murine megakaryocytes. Curr Protoc Immunol. 2005 Jul; Chapter 22:Unit 22F.6. View in: Pubmed

The stomach mesenchymal transcription factor Barx1 specifies gastric epithelial identity through inhibition of transient Wnt signaling. Dev Cell. 2005 Apr; 8(4):611-22. View in: Pubmed

Hic-5 regulates an epithelial program mediated by PPARgamma. Genes Dev. 2005 Feb 01; 19(3):362-75. View in: Pubmed

A Fli in the ointment. Blood. 2005; 105:9-10. View in: Pubmed

Culture and in vitro differentiation of murine megakaryocytes. In: Coligan JE, Bierer BE, Margulies DH, Shevach EM, Strober W, editors. Current protocols in immunology. 2005; Chapter 22F:6.1-6.13. View in: Pubmed

Insights into developmental mechanisms and cancers in the mammalian intestine derived from serial analysis of gene expression and study of the hepatoma-derived growth factor (HDGF). Development. 2005 Jan; 132(2):415-27. View in: Pubmed

Interactions between the megakaryocyte/platelet-specific beta1 tubulin and the secretory leukocyte protease inhibitor SLPI suggest a role for regulated proteolysis in platelet functions. Blood. 2004 Dec 15; 104(13):3949-57. View in: Pubmed

Molecular mechanisms of megakaryocyte differentiation. Semin Thromb Hemost. 2004 Aug; 30(4):389-98. View in: Pubmed

Lonely in Paris: when one gene copy isn't enough. J Clin Invest. 2004 Jul; 114(1):17-9. View in: Pubmed

Complexity of CNC transcription factors as revealed by gene targeting of the Nrf3 locus. Mol Cell Biol. 2004 Apr; 24(8):3286-94. View in: Pubmed

Regulation of mammalian epithelial differentiation and intestine development by class I histone deacetylases. Mol Cell Biol. 2004 Apr; 24(8):3132-9. View in: Pubmed

Molecular mechanisms of megakaryocyte differentiation and platelet production. Sem Thromb Hemost. 2004; 30:389-98. View in: Pubmed

Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex. Cancer Cell. 2004 Jan; 5(1):91-102. View in: Pubmed

Megakaryocyte-osteoblast interaction revealed in mice deficient in transcription factors GATA-1 and NF-E2. J Bone Miner Res. 2004 Apr; 19(4):652-60. View in: Pubmed

A role for Rab27b in NF-E2-dependent pathways of platelet formation. Blood. 2003 Dec 01; 102(12):3970-9. View in: Pubmed

Megakaryocytes and beyond: the birth of platelets. J Thromb Haemost. 2003 Jun; 1(6):1174-82. View in: Pubmed

Mechanisms and implications of platelet discoid shape. Blood. 2003 Jun 15; 101(12):4789-96. View in: Pubmed

Management of extragonadal germ cell tumors. In: Raghavan D, editor. American Cancer Society Atlas of Clinical Oncology - Germ Cell Tumors. 2003; 243-64. View in: Pubmed

Deletion of the GATA domain of TRPS1 causes an absence of facial hair and provides new insights into the bone disorder in inherited tricho-rhino-phalangeal syndromes. Mol Cell Biol. 2002 Dec; 22(24):8592-600. View in: Pubmed

Characterization of a novel mammalian Groucho isoform and its role in transcriptional regulation. J Biol Chem. 2002 Dec 06; 277(49):47732-40. View in: Pubmed

Molecular regulation of vertebrate early endoderm development. Dev Biol. 2002 Sep 15; 249(2):191-203. View in: Pubmed

A phase II study of troglitazone, an activator of the PPARgamma receptor, in patients with chemotherapy-resistant metastatic colorectal cancer. Cancer J. 2002 Sep-Oct; 8(5):395-9. View in: Pubmed

An animal model for myelofibrosis. Blood. 2002 Aug 15; 100(4):1109. View in: Pubmed

A Phase II study of gemcitabine and docetaxel in patients with metastatic pancreatic carcinoma. Cancer. 2002 Jan 01; 94(1):97-103. View in: Pubmed

Structure of a human Tcf4-beta-catenin complex. Nat Struct Biol. 2001 Dec; 8(12):1053-7. View in: Pubmed

A lineage-restricted and divergent beta-tubulin isoform is essential for the biogenesis, structure and function of blood platelets. Curr Biol. 2001 Apr 17; 11(8):579-86. View in: Pubmed

Transcriptional repression and developmental functions of the atypical vertebrate GATA protein TRPS1. EMBO J. 2001 Apr 02; 20(7):1715-25. View in: Pubmed

Toward mechanism-based cancer care. JAMA. 2001 Feb 07; 285(5):588-93. View in: Pubmed

Molecular and transcriptional regulation of megakaryocyte differentiation. Stem Cells. 2001; 19(5):397-407. View in: Pubmed

Regulation of megakaryocyte and erythroid differentiation by NF-E2. In: Licht J, Ravid K, editors. Trancription factors: Normal and malignant development of blood cells. 2001; 13-29. View in: Pubmed

p45(NFE2) is a negative regulator of erythroid proliferation which contributes to the progression of Friend virus-induced erythroleukemias. Mol Cell Biol. 2001 Jan; 21(1):73-80. View in: Pubmed

Downregulation of Hedgehog signaling is required for organogenesis of the small intestine in Xenopus. Dev Biol. 2001 Jan 01; 229(1):188-202. View in: Pubmed

Hematopoietic-specific beta 1 tubulin participates in a pathway of platelet biogenesis dependent on the transcription factor NF-E2. Blood. 2000 Aug 15; 96(4):1366-73. View in: Pubmed

Structure and expression of a novel frizzled gene isolated from the developing mouse gut. Biochem J. 2000 Aug 01; 349 Pt 3:829-34. View in: Pubmed

Action of the Caenorhabditis elegans GATA factor END-1 in Xenopus suggests that similar mechanisms initiate endoderm development in ecdysozoa and vertebrates. Proc Natl Acad Sci U S A. 2000 Apr 11; 97(8):4076-81. View in: Pubmed

Blood platelets are assembled principally at the ends of proplatelet processes produced by differentiated megakaryocytes. J Cell Biol. 1999 Dec 13; 147(6):1299-312. View in: Pubmed

Pathophysiology of thrombocytopenia and anemia in mice lacking transcription factor NF-E2. Blood. 1999 Nov 01; 94(9):3037-47. View in: Pubmed

Consequences of GATA-1 deficiency in megakaryocytes and platelets. Blood. 1999 May 01; 93(9):2867-75. View in: Pubmed

A possible role for the high mobility group box transcription factor Tcf-4 in vertebrate gut epithelial cell differentiation. J Biol Chem. 1999 Jan 15; 274(3):1566-72. View in: Pubmed

Mice lacking transcription factor NF-E2 provide in vivo validation of the proplatelet model of thrombocytopoiesis and show a platelet production defect that is intrinsic to megakaryocytes. Blood. 1998 Sep 01; 92(5):1608-16. View in: Pubmed

Regulation of megakaryocytopoiesis and platelet production: lessons from animal models. J Lab Clin Med. 1998 Jun; 131(6):496-501. View in: Pubmed

Erythroid maturation and globin gene expression in mice with combined deficiency of NF-E2 and nrf-2. Blood. 1998 May 01; 91(9):3459-66. View in: Pubmed

Characterization of the hematopoietic transcription factor NF-E2 in primary murine megakaryocytes. J Biol Chem. 1998 Mar 27; 273(13):7572-8. View in: Pubmed

Cellular and molecular biology of megakaryocyte differentiation in the absence of lineage-restricted transcription factors. Stem Cells. 1998; 16 Suppl 2:91-5. View in: Pubmed

Transcription factor GATA-1 in megakaryocyte development. Stem Cells. 1998; 16 Suppl 2:79-83. View in: Pubmed

Stem cell transcription factors. Hematol Oncol Clin North Am. 1997 Dec; 11(6):1199-206. View in: Pubmed

p45 NF-E2 regulates expression of thromboxane synthase in megakaryocytes. EMBO J. 1997 Sep 15; 16(18):5654-61. View in: Pubmed

Regulation of the serum concentration of thrombopoietin in thrombocytopenic NF-E2 knockout mice. Blood. 1997 Sep 01; 90(5):1821-7. View in: Pubmed

An upstream, DNase I hypersensitive region of the hematopoietic-expressed transcription factor GATA-1 gene confers developmental specificity in transgenic mice. Proc Natl Acad Sci U S A. 1997 Jul 22; 94(15):7976-81. View in: Pubmed

A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development. EMBO J. 1997 Jul 01; 16(13):3965-73. View in: Pubmed

A "knockdown" mutation created by cis-element gene targeting reveals the dependence of erythroid cell maturation on the level of transcription factor GATA-1. Proc Natl Acad Sci U S A. 1997 Jun 24; 94(13):6781-5. View in: Pubmed

Characterization of adult alpha- and beta-globin genes in the zebrafish. Blood. 1997 Jan 15; 89(2):688-700. View in: Pubmed

Transcription factors in megakaryocyte differentiation and gene expression. In: Hunt P, Kuter D, Sheridan W, Zucker-Franklin D, editors. Thrombopoiesis and thrombopoietins. 1997; 189-202. View in: Pubmed

Anion exchanger 1 (band 3) is required to prevent erythrocyte membrane surface loss but not to form the membrane skeleton. Cell. 1996 Sep 20; 86(6):917-27. View in: Pubmed

The transcriptional control of hematopoiesis. Blood. 1996 May 15; 87(10):4025-39. View in: Pubmed

The role of transcription factor NF-E2 in megakaryocyte maturation and platelet production. Stem Cells. 1996; 14 Suppl 1:112-5. View in: Pubmed

Extragonadal germ cell tumors. In: Raghavan D, Scher HI, Leibel SA, Lange P, editors. Principles and practice of genitourinary oncology. 1996; 751-64. View in: Pubmed

Erythropoiesis and globin gene expression in mice lacking the transcription factor NF-E2. Proc Natl Acad Sci U S A. 1995 Sep 12; 92(19):8690-4. View in: Pubmed

Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocyte development. Cell. 1995 Jun 02; 81(5):695-704. View in: Pubmed

Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL. Nature. 1995 Feb 02; 373(6513):432-4. View in: Pubmed

Transfusion-associated graft-versus-host disease. In: Petz LD, Swisher S, Kleinman S, Spence R, Strauss R, editors. Clinical practice of transfusion medicine. 1995; 931-46. View in: Pubmed

HLA homozygosity and shared HLA haplotypes in the development of transfusion-associated graft-versus-host disease. Leuk Lymphoma. 1994 Oct; 15(3-4):227-34. View in: Pubmed

The role of methotrexate in the management of steriod-dependent asthma. Chest. 1994; 105:117-21. View in: Pubmed

Transfusion-associated graft-versus-host disease: scratching the surface. Transfusion. 1993 Sep; 33(9):696-7. View in: Pubmed

Intermediate lymphocytic lymphoma: clinical and pathologic features of a recently characterized subtype of non-Hodgkin's lymphoma. J Clin Oncol. 1993 Apr; 11(4):802-111. View in: Pubmed

Brief report: graft-versus-host disease associated with transfusion of blood from unrelated HLA-homozygous donors. N Engl J Med. 1993 Mar 18; 328(11):766-70. View in: Pubmed

Regulation of gene expression with double-stranded phosphorothioate oligonucleotides. Science. 1990 Nov 16; 250(4983):997-1000. View in: Pubmed

Monoclonal antibodies define the characteristics and cellular distribution of an Ia-associated protein. Hybridoma. 1990 Feb; 9(1):17-30. View in: Pubmed

Science, another culture: an essay after C. P. Snow. Pharos Alpha Omega Alpha Honor Med Soc. 1989; 52(4):21-4. View in: Pubmed

Molecular associations of IA antigens after T-B cell interactions. I. Identification of new molecular associations. J Immunol. 1988 Aug 15; 141(4):1252-60. View in: Pubmed

Antigen recognition by T lymphocytes: Three cases for two receptors. In: Sercarz E, Berzofsky J, editors. Immunogenicity of protein antigen: Repertoire and regulation. 1987; 67-73. View in: Pubmed

Two roles for Ia in antigen-specific T lymphocyte activation. J Immunol. 1986 Dec 01; 137(11):3393-400. View in: Pubmed