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Dr. Shivdasani received his medical and graduate degrees from The University of Michigan School in 1989. He completed his residency in Internal Medicine at Brigham and Women's Hospital, his fellowship in Medical Oncology at the Dana-Farber Cancer Institute, and post-doctoral research training at The Howard Hughes Medical Institute and Childrens Hospital Boston. In 1996, he joined the staff of Dana-Farber and Brigham and Women's Hospital, where he is a medical oncologist and laboratory investigator in the Gastrointestinal Cancer Center. Dr. Shivdasani's research focuses on normal mechanisms of development and cell differentiation in the gastrointestinal tract and new targets for treatment of intestinal tumors.
Dr. Shivdasanis laboratory studies mechanisms of cell differentiation in the gastrointestinal epithelium. The research combines methods in molecular and cell biology with generation and analysis of genetically engineered mouse lines. The laboratory aims to elucidate and characterize genetic pathways that control differentiation of fetal and adult gastrointestinal epithelium. Present efforts include characterizing specific functions of the Wnt, Hedgehog and Notch signaling pathways and how these pathways intersect with tissue-restricted transcription factors.Dr. Shivdasani also directs a Translational Research laboratory that unites several Dana-Farber efforts in gastrointestinal cancers under a single umbrella. To acquire and exploit new molecular insights for biologically targeted cancer therapy, this laboratory investigates clinically annotated samples of gastric, colorectal and GI neuroendocrine tumors for polymorphisms, mutations and phenotypic alterations.
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