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Ramesh A. Shivdasani, MD, PhD


Medical Oncology

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Physician

  • Physician
  • Professor of Medicine, Harvard Medical School

Centers/Programs

Clinical Interests

  • Gastrointestinal cancers

Contact Information

  • Appointments617-632-4955
  • Office Phone Number617-632-5746
  • Fax617-582-7198

Bio

Dr. Shivdasani received his medical and graduate degrees from The University of Michigan School in 1989. He completed his residency in Internal Medicine at Brigham and Women's Hospital, his fellowship in Medical Oncology at the Dana-Farber Cancer Institute, and post-doctoral research training at The Howard Hughes Medical Institute and Childrens Hospital Boston. In 1996, he joined the staff of Dana-Farber and Brigham and Women's Hospital, where he is a medical oncologist and laboratory investigator in the Gastrointestinal Cancer Center. Dr. Shivdasani's research focuses on normal mechanisms of development and cell differentiation in the gastrointestinal tract and new targets for treatment of intestinal tumors.

Board Certification:

  • Medical Oncology, 1995

Fellowship:

  • Dana-Farber Cancer Institute, Medical Oncology

Residency:

  • Brigham and Women's Hospital, Internal Medicine

Medical School:

  • University of Michigan School of Medicine

Recent Awards:

  • Association of American Physicians 2009
  • American Society for Clinical Investigation 2005
  • Harvard Medical School Class of 2007 teaching award, Best Tutor of the Year 2004
  • Brian ODell Memorial Research Award (Leukemia & Lymphoma Society) 2003

Research

Development and differentiation of the gastrointestinal epithelium; targeted molecular therapies.

Dr. Shivdasanis laboratory studies mechanisms of cell differentiation in the gastrointestinal epithelium. The research combines methods in molecular and cell biology with generation and analysis of genetically engineered mouse lines. The laboratory aims to elucidate and characterize genetic pathways that control differentiation of fetal and adult gastrointestinal epithelium. Present efforts include characterizing specific functions of the Wnt, Hedgehog and Notch signaling pathways and how these pathways intersect with tissue-restricted transcription factors.Dr. Shivdasani also directs a Translational Research laboratory that unites several Dana-Farber efforts in gastrointestinal cancers under a single umbrella. To acquire and exploit new molecular insights for biologically targeted cancer therapy, this laboratory investigates clinically annotated samples of gastric, colorectal and GI neuroendocrine tumors for polymorphisms, mutations and phenotypic alterations.

Hybrid stomach-intestinal chromatin states underlie human Barrett's metaplasia. Gastroenterology. 2021 Jun 03.
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Creb5 establishes the competence for Prg4 expression in articular cartilage. Commun Biol. 2021 Mar 12; 4(1):332.
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Adaptation of pancreatic cancer cells to nutrient deprivation is reversible and requires glutamine synthetase stabilization by mTORC1. Proc Natl Acad Sci U S A. 2021 Mar 09; 118(10).
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Tissue regeneration: Reserve or reverse? Science. 2021 Feb 19; 371(6531):784-786.
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Progastrin production transitions from Bmi1+/Prox1+ to Lgr5high cells during early intestinal tumorigenesis. Transl Oncol. 2021 Feb; 14(2):101001.
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Epigenetic Signatures and Plasticity of Intestinal and Other Stem Cells. Annu Rev Physiol. 2021 02 10; 83:405-427.
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Cellular and molecular architecture of the intestinal stem cell niche. Nat Cell Biol. 2020 09; 22(9):1033-1041.
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Epigenetic regulation of intestinal stem cell differentiation. Am J Physiol Gastrointest Liver Physiol. 2020 08 01; 319(2):G189-G196.
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Hedgehog-Activated Fat4 and PCP Pathways Mediate Mesenchymal Cell Clustering and Villus Formation in Gut Development. Dev Cell. 2020 03 09; 52(5):647-658.e6.
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Ascl2-Dependent Cell Dedifferentiation Drives Regeneration of Ablated Intestinal Stem Cells. Cell Stem Cell. 2020 03 05; 26(3):377-390.e6.
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Distinct Mesenchymal Cell Populations Generate the Essential Intestinal BMP Signaling Gradient. Cell Stem Cell. 2020 03 05; 26(3):391-402.e5.
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Replicational Dilution of H3K27me3 in Mammalian Cells and the Role of Poised Promoters. Mol Cell. 2020 04 02; 78(1):141-151.e5.
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Krüppel-like Factor 5 Regulates Stemness, Lineage Specification, and Regeneration of Intestinal Epithelial Stem Cells. Cell Mol Gastroenterol Hepatol. 2020; 9(4):587-609.
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Publisher Correction: Enhancer signatures stratify and predict outcomes of non-functional pancreatic neuroendocrine tumors. Nat Med. 2019 Oct; 25(10):1627.
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Enhancer signatures stratify and predict outcomes of non-functional pancreatic neuroendocrine tumors. Nat Med. 2019 08; 25(8):1260-1265.
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Extensive Recovery of Embryonic Enhancer and Gene Memory Stored in Hypomethylated Enhancer DNA. Mol Cell. 2019 05 02; 74(3):542-554.e5.
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The lineage-specific transcription factor CDX2 navigates dynamic chromatin to control distinct stages of intestine development. Development. 2019 03 01; 146(5).
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Dissecting Cell Lineages: From Microscope to Kaleidoscope. Cell. 2019 02 21; 176(5):949-951.
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TRPS1 Is a Lineage-Specific Transcriptional Dependency in Breast Cancer. Cell Rep. 2018 10 30; 25(5):1255-1267.e5.
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Enhancer, transcriptional, and cell fate plasticity precedes intestinal determination during endoderm development. Genes Dev. 2018 11 01; 32(21-22):1430-1442.
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Limited gut cell repertoire for multiple hormones. Nat Cell Biol. 2018 08; 20(8):865-867.
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RORa-expressing T regulatory cells restrain allergic skin inflammation. Sci Immunol. 2018 03 02; 3(21).
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Transcription factor-dependent 'anti-repressive' mammalian enhancers exclude H3K27me3 from extended genomic domains. Genes Dev. 2017 12 01; 31(23-24):2391-2404.
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Dynamic Reorganization of Chromatin Accessibility Signatures during Dedifferentiation of Secretory Precursors into Lgr5+ Intestinal Stem Cells. Cell Stem Cell. 2017 07 06; 21(1):65-77.e5.
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A Summary of the 2016 James W. Freston Conference of the American Gastroenterological Association: Intestinal Metaplasia in the Esophagus and Stomach: Origins, Differences, Similarities and Significance. Gastroenterology. 2017 Jul; 153(1):e6-e13.
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Challenges and emerging directions in single-cell analysis. Genome Biol. 2017 05 08; 18(1):84.
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Somatic copy number alterations in gastric adenocarcinomas among Asian and Western patients. PLoS One. 2017; 12(4):e0176045.
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ARID1A loss impairs enhancer-mediated gene regulation and drives colon cancer in mice. Nat Genet. 2017 Feb; 49(2):296-302.
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Transcriptional Regulator CNOT3 Defines an Aggressive Colorectal Cancer Subtype. Cancer Res. 2017 02 01; 77(3):766-779.
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Natural Selection, Crypt Fitness, and Pol III Dependency in the Intestine. Cell Mol Gastroenterol Hepatol. 2016 Nov; 2(6):714-715.
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Single-Cell Transcript Profiles Reveal Multilineage Priming in Early Progenitors Derived from Lgr5(+) Intestinal Stem Cells. Cell Rep. 2016 08 23; 16(8):2053-2060.
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Sox2 Suppresses Gastric Tumorigenesis in Mice. Cell Rep. 2016 08 16; 16(7):1929-41.
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NF-E2, FLI1 and RUNX1 collaborate at areas of dynamic chromatin to activate transcription in mature mouse megakaryocytes. Sci Rep. 2016 07 26; 6:30255.
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Acquired Tissue-Specific Promoter Bivalency Is a Basis for PRC2 Necessity in Adult Cells. Cell. 2016 Jun 02; 165(6):1389-1400.
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Chromatin immunoprecipitation from fixed clinical tissues reveals tumor-specific enhancer profiles. Nat Med. 2016 06; 22(6):685-91.
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Reprogrammed Stomach Tissue as a Renewable Source of Functional ß Cells for Blood Glucose Regulation. Cell Stem Cell. 2016 Mar 03; 18(3):410-21.
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Stomach development, stem cells and disease. Development. 2016 Feb 15; 143(4):554-65.
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Co-culture of Gastric Organoids and Immortalized Stomach Mesenchymal Cells. Methods Mol Biol. 2016; 1422:23-31.
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Survival Benefit of Exercise Differs by Tumor IRS1 Expression Status in Colorectal Cancer. Ann Surg Oncol. 2016 Mar; 23(3):908-17.
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SOX15 governs transcription in human stratified epithelia and a subset of esophageal adenocarcinomas. Cell Mol Gastroenterol Hepatol. 2015 Nov 01; 1(6):598-609.e6.
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Distinct Processes and Transcriptional Targets Underlie CDX2 Requirements in Intestinal Stem Cells and Differentiated Villus Cells. Stem Cell Reports. 2015 Nov 10; 5(5):673-681.
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The androgen receptor cistrome is extensively reprogrammed in human prostate tumorigenesis. Nat Genet. 2015 Nov; 47(11):1346-51.
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Control of stomach smooth muscle development and intestinal rotation by transcription factor BARX1. Dev Biol. 2015 Sep 01; 405(1):21-32.
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The use of murine-derived fundic organoids in studies of gastric physiology. J Physiol. 2015 Apr 15; 593(8):1809-27.
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Erratum for Verzi et al., Intestinal Master Transcription Factor CDX2 Controls Chromatin Access for Partner Transcription Factor Binding. Mol Cell Biol. 2015 Jan 15; 35(2):496.
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Transcription factors GATA4 and HNF4A control distinct aspects of intestinal homeostasis in conjunction with transcription factor CDX2. J Biol Chem. 2015 Jan 16; 290(3):1850-60.
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Active enhancers are delineated de novo during hematopoiesis, with limited lineage fidelity among specified primary blood cells. Genes Dev. 2014 Aug 15; 28(16):1827-39.
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Dissecting engineered cell types and enhancing cell fate conversion via CellNet. Cell. 2014 Aug 14; 158(4):889-902.
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Indian Hedgehog mediates gastrin-induced proliferation in stomach of adult mice. Gastroenterology. 2014 Sep; 147(3):655-666.e9.
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Radiation redux: reserve intestinal stem cells miss the call to duty. Cell Stem Cell. 2014 Feb 06; 14(2):135-6.
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Wnt secretion from epithelial cells and subepithelial myofibroblasts is not required in the mouse intestinal stem cell niche in vivo. Stem Cell Reports. 2014 Feb 11; 2(2):127-34.
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Broadly permissive intestinal chromatin underlies lateral inhibition and cell plasticity. Nature. 2014 Feb 27; 506(7489):511-5.
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An integrative analysis reveals functional targets of GATA6 transcriptional regulation in gastric cancer. Oncogene. 2014 Dec 04; 33(49):5637-48.
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Somatic mutation of CDKN1B in small intestine neuroendocrine tumors. Nat Genet. 2013 Dec; 45(12):1483-6.
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p63-expressing cells are the stem cells of developing prostate, bladder, and colorectal epithelia. Proc Natl Acad Sci U S A. 2013 May 14; 110(20):8105-10.
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DOT1L-mediated H3K79 methylation in chromatin is dispensable for Wnt pathway-specific and other intestinal epithelial functions. Mol Cell Biol. 2013 May; 33(9):1735-45.
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Genetics and diet regulate vitamin A production via the homeobox transcription factor ISX. J Biol Chem. 2013 Mar 29; 288(13):9017-27.
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Intestinal master transcription factor CDX2 controls chromatin access for partner transcription factor binding. Mol Cell Biol. 2013 Jan; 33(2):281-92.
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Targeted disruption of the BCL9/ß-catenin complex inhibits oncogenic Wnt signaling. Sci Transl Med. 2012 Aug 22; 4(148):148ra117.
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Stem cell niches: famished Paneth cells, gluttonous stem cells. Curr Biol. 2012 Jul 24; 22(14):R579-80.
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Gastrointestinal adenocarcinomas of the esophagus, stomach, and colon exhibit distinct patterns of genome instability and oncogenesis. Cancer Res. 2012 Sep 01; 72(17):4383-93.
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GEFs on the RhoAd to a colossal nucleus. Dev Cell. 2012 Mar 13; 22(3):471-2.
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Intact function of Lgr5 receptor-expressing intestinal stem cells in the absence of Paneth cells. Proc Natl Acad Sci U S A. 2012 Mar 06; 109(10):3932-7.
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Differential WNT activity in colorectal cancer confers limited tumorigenic potential and is regulated by MAPK signaling. Cancer Res. 2012 Mar 15; 72(6):1547-56.
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The Stem Cell Discovery Engine: an integrated repository and analysis system for cancer stem cell comparisons. Nucleic Acids Res. 2012 Jan; 40(Database issue):D984-91.
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Genomic analysis identifies association of Fusobacterium with colorectal carcinoma. Genome Res. 2012 Feb; 22(2):292-8.
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Activation of ERBB2 signaling causes resistance to the EGFR-directed therapeutic antibody cetuximab. Sci Transl Med. 2011 Sep 07; 3(99):99ra86.
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Endodermal Hedgehog signals modulate Notch pathway activity in the developing digestive tract mesenchyme. Development. 2011 Aug; 138(15):3225-33.
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Boundaries, junctions and transitions in the gastrointestinal tract. Exp Cell Res. 2011 Nov 15; 317(19):2711-8.
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Barx1-mediated inhibition of Wnt signaling in the mouse thoracic foregut controls tracheo-esophageal septation and epithelial differentiation. PLoS One. 2011; 6(7):e22493.
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Targeting PI3K signaling as a therapeutic approach for colorectal cancer. Gastroenterology. 2011 Jul; 141(1):50-61.
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Notch signaling in stomach epithelial stem cell homeostasis. J Exp Med. 2011 Apr 11; 208(4):677-88.
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Essential and redundant functions of caudal family proteins in activating adult intestinal genes. Mol Cell Biol. 2011 May; 31(10):2026-39.
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Regulation of mouse stomach development and Barx1 expression by specific microRNAs. Development. 2011 Mar; 138(6):1081-6.
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Genetic evidence that intestinal Notch functions vary regionally and operate through a common mechanism of Math1 repression. J Biol Chem. 2011 Apr 01; 286(13):11427-33.
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Gastric epithelial stem cells. Gastroenterology. 2011 Feb; 140(2):412-24.
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Differentiation-specific histone modifications reveal dynamic chromatin interactions and partners for the intestinal transcription factor CDX2. Dev Cell. 2010 Nov 16; 19(5):713-26.
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Stem cells: The intestinal-crypt casino. Nature. 2010 Oct 28; 467(7319):1055-6.
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Requirement of the epithelium-specific Ets transcription factor Spdef for mucous gland cell function in the gastric antrum. J Biol Chem. 2010 Nov 05; 285(45):35047-55.
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TCF4 and CDX2, major transcription factors for intestinal function, converge on the same cis-regulatory regions. Proc Natl Acad Sci U S A. 2010 Aug 24; 107(34):15157-62.
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Hedgehog signaling controls mesenchymal growth in the developing mammalian digestive tract. Development. 2010 May; 137(10):1721-9.
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Platelets contribute to postnatal occlusion of the ductus arteriosus. Nat Med. 2010 Jan; 16(1):75-82.
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Profiling critical cancer gene mutations in clinical tumor samples. PLoS One. 2009 Nov 18; 4(11):e7887.
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SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas. Nat Genet. 2009 Nov; 41(11):1238-42.
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The microtubule modulator RanBP10 plays a critical role in regulation of platelet discoid shape and degranulation. Blood. 2009 Dec 24; 114(27):5532-40.
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Prognostic and predictive value of common mutations for treatment response and survival in patients with metastatic colorectal cancer. Br J Cancer. 2009 Aug 04; 101(3):465-72.
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Relationship of CDX2 loss with molecular features and prognosis in colorectal cancer. Clin Cancer Res. 2009 Jul 15; 15(14):4665-73.
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Regulation of platelet biogenesis: insights from the May-Hegglin anomaly and other MYH9-related disorders. J Thromb Haemost. 2009 Jul; 7 Suppl 1:272-6.
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The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer. Nat Genet. 2009 Aug; 41(8):882-4.
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Prominin1 (CD133) as an intestinal stem cell marker: promise and nuance. Gastroenterology. 2009 Jun; 136(7):2051-4.
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Role of the homeodomain transcription factor Bapx1 in mouse distal stomach development. Gastroenterology. 2009 May; 136(5):1701-10.
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Trps1, a regulator of chondrocyte proliferation and differentiation, interacts with the activator form of Gli3. Dev Biol. 2009 Apr 01; 328(1):40-53.
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Cell-type selective chromatin remodeling defines the active subset of FOXA1-bound enhancers. Genome Res. 2009 Mar; 19(3):372-80.
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Tricho-rhino-phalangeal syndrome with supernumerary teeth. J Dent Res. 2008 Nov; 87(11):1027-31.
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CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity. Nature. 2008 Sep 25; 455(7212):547-51.
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High-resolution analysis of genetic alterations in small bowel carcinoid tumors reveals areas of recurrent amplification and loss. Genes Chromosomes Cancer. 2008 Jul; 47(7):591-603.
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Expression and function of Nkx6.3 in vertebrate hindbrain. Brain Res. 2008 Jul 30; 1222:42-50.
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Transcription factor foxq1 controls mucin gene expression and granule content in mouse stomach surface mucous cells. Gastroenterology. 2008 Aug; 135(2):591-600.
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Uncoupling of chondrocyte differentiation and perichondrial mineralization underlies the skeletal dysplasia in tricho-rhino-phalangeal syndrome. Hum Mol Genet. 2008 Jul 15; 17(14):2244-54.
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Wnt signaling in gut organogenesis. Organogenesis. 2008 Apr; 4(2):87-91.
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Requirement of the tissue-restricted homeodomain transcription factor Nkx6.3 in differentiation of gastrin-producing G cells in the stomach antrum. Mol Cell Biol. 2008 May; 28(10):3208-18.
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RanBP10 is a cytoplasmic guanine nucleotide exchange factor that modulates noncentrosomal microtubules. J Biol Chem. 2008 May 16; 283(20):14109-19.
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Visualization of microtubule growth in living platelets reveals a dynamic marginal band with multiple microtubules. Blood. 2008 May 01; 111(9):4605-16.
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High-resolution analysis of genetic alterations in small bowel carcinoid tumors reveals areas of recurrent amplification and loss. Genes Chrom Cancer. 2008; 47:591-603.

PU.1 is a major downstream target of AML1 (RUNX1) in adult mouse hematopoiesis. Nat Genet. 2008 Jan; 40(1):51-60.
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Loss of the PlagL2 transcription factor affects lacteal uptake of chylomicrons. Cell Metab. 2007 Nov; 6(5):406-13.
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Dynamic visualization of thrombopoiesis within bone marrow. Science. 2007 Sep 21; 317(5845):1767-70.
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Independent functions and mechanisms for homeobox gene Barx1 in patterning mouse stomach and spleen. Development. 2007 Oct; 134(20):3603-13.
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Phases of canonical Wnt signaling during the development of mouse intestinal epithelium. Gastroenterology. 2007 Aug; 133(2):529-38.
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The May-Hegglin anomaly gene MYH9 is a negative regulator of platelet biogenesis modulated by the Rho-ROCK pathway. Blood. 2007 Jul 01; 110(1):171-9.
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Expression analysis of primary mouse megakaryocyte differentiation and its application in identifying stage-specific molecular markers and a novel transcriptional target of NF-E2. Blood. 2007 Feb 15; 109(4):1451-9.
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A dynamic expression survey identifies transcription factors relevant in mouse digestive tract development. Development. 2006 Oct; 133(20):4119-29.
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MicroRNAs: regulators of gene expression and cell differentiation. Blood. 2006 Dec 01; 108(12):3646-53.
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Characterization of the megakaryocyte demarcation membrane system and its role in thrombopoiesis. Blood. 2006 May 15; 107(10):3868-75.
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Overlapping gene expression in fetal mouse intestine development and human colorectal cancer. Cancer Res. 2005 Oct 01; 65(19):8715-22.
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Mechanisms of organelle transport and capture along proplatelets during platelet production. Blood. 2005 Dec 15; 106(13):4066-75.
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Differential roles of microtubule assembly and sliding in proplatelet formation by megakaryocytes. Blood. 2005 Dec 15; 106(13):4076-85.
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Mechanisms of thrombopoiesis. J Thromb Haemost. 2005 Aug; 3(8):1717-24.
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Culture, expansion, and differentiation of murine megakaryocytes. Curr Protoc Immunol. 2005 Jul; Chapter 22:Unit 22F.6.
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The stomach mesenchymal transcription factor Barx1 specifies gastric epithelial identity through inhibition of transient Wnt signaling. Dev Cell. 2005 Apr; 8(4):611-22.
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Hic-5 regulates an epithelial program mediated by PPARgamma. Genes Dev. 2005 Feb 01; 19(3):362-75.
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A Fli in the ointment. Blood. 2005; 105:9-10.

Culture and in vitro differentiation of murine megakaryocytes. In: Coligan JE, Bierer BE, Margulies DH, Shevach EM, Strober W, editors. Current protocols in immunology. 2005; Chapter 22F:6.1-6.13.

Insights into developmental mechanisms and cancers in the mammalian intestine derived from serial analysis of gene expression and study of the hepatoma-derived growth factor (HDGF). Development. 2005 Jan; 132(2):415-27.
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Interactions between the megakaryocyte/platelet-specific beta1 tubulin and the secretory leukocyte protease inhibitor SLPI suggest a role for regulated proteolysis in platelet functions. Blood. 2004 Dec 15; 104(13):3949-57.
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Molecular mechanisms of megakaryocyte differentiation. Semin Thromb Hemost. 2004 Aug; 30(4):389-98.
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Lonely in Paris: when one gene copy isn't enough. J Clin Invest. 2004 Jul; 114(1):17-9.
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Complexity of CNC transcription factors as revealed by gene targeting of the Nrf3 locus. Mol Cell Biol. 2004 Apr; 24(8):3286-94.
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Regulation of mammalian epithelial differentiation and intestine development by class I histone deacetylases. Mol Cell Biol. 2004 Apr; 24(8):3132-9.
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Molecular mechanisms of megakaryocyte differentiation and platelet production. Sem Thromb Hemost. 2004; 30:389-98.

Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex. Cancer Cell. 2004 Jan; 5(1):91-102.
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Megakaryocyte-osteoblast interaction revealed in mice deficient in transcription factors GATA-1 and NF-E2. J Bone Miner Res. 2004 Apr; 19(4):652-60.
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A role for Rab27b in NF-E2-dependent pathways of platelet formation. Blood. 2003 Dec 01; 102(12):3970-9.
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Megakaryocytes and beyond: the birth of platelets. J Thromb Haemost. 2003 Jun; 1(6):1174-82.
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Mechanisms and implications of platelet discoid shape. Blood. 2003 Jun 15; 101(12):4789-96.
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Management of extragonadal germ cell tumors. In: Raghavan D, editor. American Cancer Society Atlas of Clinical Oncology - Germ Cell Tumors. 2003; 243-64.

Deletion of the GATA domain of TRPS1 causes an absence of facial hair and provides new insights into the bone disorder in inherited tricho-rhino-phalangeal syndromes. Mol Cell Biol. 2002 Dec; 22(24):8592-600.
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Characterization of a novel mammalian Groucho isoform and its role in transcriptional regulation. J Biol Chem. 2002 Dec 06; 277(49):47732-40.
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Molecular regulation of vertebrate early endoderm development. Dev Biol. 2002 Sep 15; 249(2):191-203.
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A phase II study of troglitazone, an activator of the PPARgamma receptor, in patients with chemotherapy-resistant metastatic colorectal cancer. Cancer J. 2002 Sep-Oct; 8(5):395-9.
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An animal model for myelofibrosis. Blood. 2002 Aug 15; 100(4):1109.
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A Phase II study of gemcitabine and docetaxel in patients with metastatic pancreatic carcinoma. Cancer. 2002 Jan 01; 94(1):97-103.
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Structure of a human Tcf4-beta-catenin complex. Nat Struct Biol. 2001 Dec; 8(12):1053-7.
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A lineage-restricted and divergent beta-tubulin isoform is essential for the biogenesis, structure and function of blood platelets. Curr Biol. 2001 Apr 17; 11(8):579-86.
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Transcriptional repression and developmental functions of the atypical vertebrate GATA protein TRPS1. EMBO J. 2001 Apr 02; 20(7):1715-25.
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Toward mechanism-based cancer care. JAMA. 2001 Feb 07; 285(5):588-93.
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Molecular and transcriptional regulation of megakaryocyte differentiation. Stem Cells. 2001; 19(5):397-407.
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Regulation of megakaryocyte and erythroid differentiation by NF-E2. In: Licht J, Ravid K, editors. Trancription factors: Normal and malignant development of blood cells. 2001; 13-29.

p45(NFE2) is a negative regulator of erythroid proliferation which contributes to the progression of Friend virus-induced erythroleukemias. Mol Cell Biol. 2001 Jan; 21(1):73-80.
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Downregulation of Hedgehog signaling is required for organogenesis of the small intestine in Xenopus. Dev Biol. 2001 Jan 01; 229(1):188-202.
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Hematopoietic-specific beta 1 tubulin participates in a pathway of platelet biogenesis dependent on the transcription factor NF-E2. Blood. 2000 Aug 15; 96(4):1366-73.
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Structure and expression of a novel frizzled gene isolated from the developing mouse gut. Biochem J. 2000 Aug 01; 349 Pt 3:829-34.
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Action of the Caenorhabditis elegans GATA factor END-1 in Xenopus suggests that similar mechanisms initiate endoderm development in ecdysozoa and vertebrates. Proc Natl Acad Sci U S A. 2000 Apr 11; 97(8):4076-81.
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Blood platelets are assembled principally at the ends of proplatelet processes produced by differentiated megakaryocytes. J Cell Biol. 1999 Dec 13; 147(6):1299-312.
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Pathophysiology of thrombocytopenia and anemia in mice lacking transcription factor NF-E2. Blood. 1999 Nov 01; 94(9):3037-47.
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Consequences of GATA-1 deficiency in megakaryocytes and platelets. Blood. 1999 May 01; 93(9):2867-75.
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A possible role for the high mobility group box transcription factor Tcf-4 in vertebrate gut epithelial cell differentiation. J Biol Chem. 1999 Jan 15; 274(3):1566-72.
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Mice lacking transcription factor NF-E2 provide in vivo validation of the proplatelet model of thrombocytopoiesis and show a platelet production defect that is intrinsic to megakaryocytes. Blood. 1998 Sep 01; 92(5):1608-16.
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Regulation of megakaryocytopoiesis and platelet production: lessons from animal models. J Lab Clin Med. 1998 Jun; 131(6):496-501.
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Erythroid maturation and globin gene expression in mice with combined deficiency of NF-E2 and nrf-2. Blood. 1998 May 01; 91(9):3459-66.
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Characterization of the hematopoietic transcription factor NF-E2 in primary murine megakaryocytes. J Biol Chem. 1998 Mar 27; 273(13):7572-8.
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Cellular and molecular biology of megakaryocyte differentiation in the absence of lineage-restricted transcription factors. Stem Cells. 1998; 16 Suppl 2:91-5.
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Transcription factor GATA-1 in megakaryocyte development. Stem Cells. 1998; 16 Suppl 2:79-83.
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Stem cell transcription factors. Hematol Oncol Clin North Am. 1997 Dec; 11(6):1199-206.
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p45 NF-E2 regulates expression of thromboxane synthase in megakaryocytes. EMBO J. 1997 Sep 15; 16(18):5654-61.
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Regulation of the serum concentration of thrombopoietin in thrombocytopenic NF-E2 knockout mice. Blood. 1997 Sep 01; 90(5):1821-7.
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An upstream, DNase I hypersensitive region of the hematopoietic-expressed transcription factor GATA-1 gene confers developmental specificity in transgenic mice. Proc Natl Acad Sci U S A. 1997 Jul 22; 94(15):7976-81.
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A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development. EMBO J. 1997 Jul 01; 16(13):3965-73.
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A "knockdown" mutation created by cis-element gene targeting reveals the dependence of erythroid cell maturation on the level of transcription factor GATA-1. Proc Natl Acad Sci U S A. 1997 Jun 24; 94(13):6781-5.
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Characterization of adult alpha- and beta-globin genes in the zebrafish. Blood. 1997 Jan 15; 89(2):688-700.
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Transcription factors in megakaryocyte differentiation and gene expression. In: Hunt P, Kuter D, Sheridan W, Zucker-Franklin D, editors. Thrombopoiesis and thrombopoietins. 1997; 189-202.

Anion exchanger 1 (band 3) is required to prevent erythrocyte membrane surface loss but not to form the membrane skeleton. Cell. 1996 Sep 20; 86(6):917-27.
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The transcriptional control of hematopoiesis. Blood. 1996 May 15; 87(10):4025-39.
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