Rebecca S. Gelman, PhD
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Appointments
Biography
Rebecca S. Gelman, PhD
Dr. Gelman received her PhD in statistics from the State University of New York, Buffalo, in 1978. In the same year, she joined the Department of Biostatistics at Harvard School of Public Health and DFCI, and in 1990, the Department of Radiation Oncology at Harvard Medical School. She is associate director of the Biostatistics Core of the Dana-Farber/Harvard Cancer Center, principal investigator of the Biostatistics Core of the Harvard Center for AIDS Research, and chief statistician for the National Institute of Allergy and Infectious Diseases (NIAID) Division of AIDS Immunology Laboratory Quality Assessment Program. She is the only statistician member of the Flow Advisory Committee to the NIAID.
Researcher
Physician
Research
Biostatistics in Clinical Cancer Studies and AIDS Research
Our research involves two main areas: collaboration on cancer and HIV studies and the statistical problems arising from them. Our work is focused primarily on studies of breast cancer (both laboratory and clinical), radiation oncology, immunology, and evaluation of new immunology assays, particularly those involving flow cytometry. Recent research activities in cancer include (1) modeling the effects of screening and therapy on breast cancer mortality in the United States (with the NIH CISNET group), (2) designing xenograft growth experiments to assess the cancer-promotion abilities of various stromal and fibroblast cells, (3) assessing longitudinal circulating tumor markers in breast cancer, (4) designing breast cancer prevention pilot studies, and (5) analyzing long-term follow-up on several randomized breast cancer therapy trials. Recent research activities in HIV disease include (1) modeling changes in the distributions of percents and counts of various lymphocyte subsets in healthy children from birth to age 18 (for use as controls in pediatric HIV and cancer studies), (2) quantitating the co-localization of CD8 cells and JC virus (JCV)-infected glial cells in brain biopsies from patients with progressive multifocal leukoencephalopathy (PML) disease, (3) analyzing the effect of various immune maneuvers on the effectiveness of vaccines against simian-human immunodeficiency viruses (SHIV), and (4) designing and analyzing studies that compare the within-laboratory and between-laboratory variability in CD4 counts using either current methods or several cheaper and simpler methods being developed for use in the third world. Our statistical interests include methods (1) to analyze nonindependent competing risks, (2) to assess the surrogate value of longitudinal markers in cancer and HIV disease (particularly methods that incorporate external information on within-laboratory and between-laboratory variation in assessing these markers), and (3) to assess the heterogeneity of distributions of various types of cells in pathology specimens or high-definition imaging techniques.
Research Departments
Publications
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Pretest Video Education Versus Genetic Counseling for Patients With Prostate Cancer: ProGen, A Multisite Randomized Controlled Trial. JCO Oncol Pract. 2023 Sep 21; OP2300007. View in: Pubmed
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Impact of Genetic Counseling on Patient-Reported Electronic Cancer Family History Collection. J Natl Compr Canc Netw. 2022 08; 20(8):898-905.e2. View in: Pubmed
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Phase II trial of veliparib and temozolomide in metastatic breast cancer patients with and without BRCA1/2 mutations. Breast Cancer Res Treat. 2021 Oct; 189(3):641-651. View in: Pubmed
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Phase II trial of carboplatin and bevacizumab in patients with breast cancer brain metastases. Breast Cancer Res. 2020 11 30; 22(1):131. View in: Pubmed
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The Incidence of Adjacent Synchronous Invasive Carcinoma and/or Ductal Carcinoma In Situ in Patients with Intraductal Papilloma without Atypia on Core Biopsy: Results from a Prospective Multi-Institutional Registry (TBCRC 034). Ann Surg Oncol. 2021 May; 28(5):2573-2578. View in: Pubmed
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Pre- and Postoperative Neratinib for HER2-Positive Breast Cancer Brain Metastases: Translational Breast Cancer Research Consortium 022. Clin Breast Cancer. 2020 04; 20(2):145-151.e2. View in: Pubmed
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TBCRC 022: A Phase II Trial of Neratinib and Capecitabine for Patients With Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer and Brain Metastases. J Clin Oncol. 2019 05 01; 37(13):1081-1089. View in: Pubmed
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Induction of Tier 1 HIV Neutralizing Antibodies by Envelope Trimers Incorporated into a Replication Competent Vesicular Stomatitis Virus Vector. Viruses. 2019 02 15; 11(2). View in: Pubmed
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BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1a activation. Proc Natl Acad Sci U S A. 2018 10 09; 115(41):E9600-E9609. View in: Pubmed
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Differences in TP53 Mutation Carrier Phenotypes Emerge From Panel-Based Testing. J Natl Cancer Inst. 2018 08 01; 110(8):863-870. View in: Pubmed
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Phase II study of ruxolitinib, a selective JAK1/2 inhibitor, in patients with metastatic triple-negative breast cancer. NPJ Breast Cancer. 2018; 4:10. View in: Pubmed
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Brief Report: High Sensitivity and Specificity of the Cepheid Xpert HIV-1 Qualitative Point-of-Care Test Among Newborns in Botswana. J Acquir Immune Defic Syndr. 2017 08 15; 75(5):e128-e131. View in: Pubmed
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HIV Testing Among Black and Hispanic Immigrants in the United States. AIDS Patient Care STDS. 2016 07; 30(7):307-14. View in: Pubmed
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BRCA1/FANCD2/BRG1-Driven DNA Repair Stabilizes the Differentiation State of Human Mammary Epithelial Cells. Mol Cell. 2016 07 21; 63(2):277-292. View in: Pubmed
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Translational Breast Cancer Research Consortium (TBCRC) 022: A Phase II Trial of Neratinib for Patients With Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer and Brain Metastases. J Clin Oncol. 2016 Mar 20; 34(9):945-52. View in: Pubmed
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Incidence of Adjacent Synchronous Invasive Carcinoma and/or Ductal Carcinoma In-situ in Patients with Lobular Neoplasia on Core Biopsy: Results from a Prospective Multi-Institutional Registry (TBCRC 020). Ann Surg Oncol. 2016 Mar; 23(3):722-8. View in: Pubmed
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Broad-spectrum antibodies against self-antigens and cytokines in RAG deficiency. J Clin Invest. 2015 Nov 02; 125(11):4135-48. View in: Pubmed
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Inhibitory Effect of Individual or Combinations of Broadly Neutralizing Antibodies and Antiviral Reagents against Cell-Free and Cell-to-Cell HIV-1 Transmission. J Virol. 2015 Aug; 89(15):7813-28. View in: Pubmed
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Control lymphocyte subsets: can one country's values serve for another's? J Allergy Clin Immunol. 2014 Sep; 134(3):759-761.e8. View in: Pubmed
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Eight-year update of a prospective study of wide excision alone for small low- or intermediate-grade ductal carcinoma in situ (DCIS). Breast Cancer Res Treat. 2014 Jan; 143(2):343-50. View in: Pubmed
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A phase I study of lapatinib with whole brain radiotherapy in patients with Human Epidermal Growth Factor Receptor 2 (HER2)-positive breast cancer brain metastases. Breast Cancer Res Treat. 2013 Nov; 142(2):405-14. View in: Pubmed
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Personalized medicine in breast cancer: tamoxifen, endoxifen, and CYP2D6 in clinical practice. Breast Cancer Res Treat. 2013 Oct; 141(3):421-7. View in: Pubmed
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Treatment of high-grade anal dysplasia in high-risk patients: outcome at an urban community health centre. Int J STD AIDS. 2013 Feb; 24(2):134-8. View in: Pubmed
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A phase II study of bevacizumab in combination with vinorelbine and trastuzumab in HER2-positive metastatic breast cancer. Breast Cancer Res Treat. 2013 Jun; 139(2):403-10. View in: Pubmed
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Prevalence of germline TP53 mutations in HER2+ breast cancer patients. Breast Cancer Res Treat. 2013 May; 139(1):193-8. View in: Pubmed
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Combination antiangiogenic therapy in advanced breast cancer: a phase 1 trial of vandetanib, a VEGFR inhibitor, and metronomic chemotherapy, with correlative platelet proteomics. Breast Cancer Res Treat. 2012 Nov; 136(1):169-78. View in: Pubmed
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Respiratory virus detection in immunocompromised patients with FilmArray respiratory panel compared to conventional methods. J Clin Microbiol. 2012 Oct; 50(10):3216-21. View in: Pubmed
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Association of activating KIR copy number variation of NK cells with containment of SIV replication in rhesus monkeys. PLoS Pathog. 2011 Dec; 7(12):e1002436. View in: Pubmed
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A phase II study of sagopilone (ZK 219477; ZK-EPO) in patients with breast cancer and brain metastases. Clin Breast Cancer. 2011 Dec; 11(6):376-83. View in: Pubmed
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TBCRC 003: Phase II trial of trastuzumab (T) and lapatinib (L) in patients (pts) with HER2+ metastatic breast cancer (MBC). J Clin Oncol. 2011 May 20; 29(15_suppl):527. View in: Pubmed
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Immune and Genetic Correlates of Vaccine Protection Against Mucosal Infection by SIV in Monkeys. Sci Transl Med. 2011 May 04; 3(81):81ra36. View in: Pubmed
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Characteristics of lymphocyte subsets in HIV-infected, long-term nonprogressor, and healthy Asian children through 12 years of age. J Allergy Clin Immunol. 2010 Dec; 126(6):1294-301.e10. View in: Pubmed
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Optimization of storage and shipment of cryopreserved peripheral blood mononuclear cells from HIV-infected and uninfected individuals for ELISPOT assays. J Immunol Methods. 2010 Dec 15; 363(1):42-50. View in: Pubmed
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Does neoadjuvant bevacizumab increase surgical complications in breast surgery? Ann Surg Oncol. 2011 Mar; 18(3):733-7. View in: Pubmed
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Contributions of Mamu-A*01 status and TRIM5 allele expression, but not CCL3L copy number variation, to the control of SIVmac251 replication in Indian-origin rhesus monkeys. PLoS Genet. 2010 Jun 24; 6(6):e1000997. View in: Pubmed
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PIK3CA mutations in in situ and invasive breast carcinomas. Cancer Res. 2010 Jul 15; 70(14):5674-8. View in: Pubmed
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Patient-reported acute gastrointestinal symptoms during concurrent chemoradiation treatment for rectal cancer. Cancer. 2010 Apr 15; 116(8):1879-86. View in: Pubmed
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Estrogen receptor positive breast cancers in BRCA1 mutation carriers: clinical risk factors and pathologic features. Breast Cancer Res. 2010; 12(1):R12. View in: Pubmed
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Heterogeneity for stem cell-related markers according to tumor subtype and histologic stage in breast cancer. Clin Cancer Res. 2010 Feb 01; 16(3):876-87. View in: Pubmed
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Efficacy of neoadjuvant Cisplatin in triple-negative breast cancer. J Clin Oncol. 2010 Mar 01; 28(7):1145-53. View in: Pubmed
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Tolerability and efficacy of 500 mg fulvestrant in postmenopausal women with estrogen receptor (ER)+ advanced breast cancer. J Clin Oncol. 2009 May 20; 27(15_suppl):1050. View in: Pubmed
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Determination of factors predicting for estrogen receptor positive (ER+) breast cancers in BRCA1 mutation carriers. J Clin Oncol. 2009 May 20; 27(15_suppl):11045. View in: Pubmed
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Neoadjuvant cisplatin and bevacizumab in triple negative breast cancer (TNBC): Safety and efficacy. J Clin Oncol. 2009 May 20; 27(15_suppl):551. View in: Pubmed
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Tolerability of and adherence to combination oral therapy with gefitinib and capecitabine in metastatic breast cancer. Breast Cancer Res Treat. 2009 Oct; 117(3):615-23. View in: Pubmed
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Role of COX-2 in epithelial-stromal cell interactions and progression of ductal carcinoma in situ of the breast. Proc Natl Acad Sci U S A. 2009 Mar 03; 106(9):3372-7. View in: Pubmed
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VEGF as a marker for outcome among advanced breast cancer patients receiving anti-VEGF therapy with bevacizumab and vinorelbine chemotherapy. Clin Cancer Res. 2008 Dec 01; 14(23):7871-7. View in: Pubmed
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Cell type-specific DNA methylation patterns in the human breast. Proc Natl Acad Sci U S A. 2008 Sep 16; 105(37):14076-81. View in: Pubmed
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Potent simian immunodeficiency virus-specific cellular immune responses in the breast milk of simian immunodeficiency virus-infected, lactating rhesus monkeys. J Immunol. 2008 Sep 01; 181(5):3643-50. View in: Pubmed
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Epithelial and stromal cathepsin K and CXCL14 expression in breast tumor progression. Clin Cancer Res. 2008 Sep 01; 14(17):5357-67. View in: Pubmed
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The impact of sharing results of a randomized breast cancer clinical trial with study participants. Breast Cancer Res Treat. 2009 May; 115(1):123-9. View in: Pubmed
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Regulation of in situ to invasive breast carcinoma transition. Cancer Cell. 2008 May; 13(5):394-406. View in: Pubmed
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Phase II trial of lapatinib for brain metastases in patients with human epidermal growth factor receptor 2-positive breast cancer. J Clin Oncol. 2008 Apr 20; 26(12):1993-9. View in: Pubmed
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A North American multilaboratory study of CD4 counts using flow cytometric panLeukogating (PLG): a NIAID-DAIDS Immunology Quality Assessment Program Study. Cytometry B Clin Cytom. 2008; 74 Suppl 1:S52-64. View in: Pubmed
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Incidence of major corrective surgery after post-mastectomy breast reconstruction and radiation therapy. Breast J. 2008 Jan-Feb; 14(1):49-54. View in: Pubmed
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Network modeling links breast cancer susceptibility and centrosome dysfunction. Nat Genet. 2007 Nov; 39(11):1338-49. View in: Pubmed
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Trastuzumab plus vinorelbine or taxane chemotherapy for HER2-overexpressing metastatic breast cancer: the trastuzumab and vinorelbine or taxane study. Cancer. 2007 Sep 01; 110(5):965-72. View in: Pubmed
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The virologic, immunologic, and clinical effects of interleukin 2 with potent antiretroviral therapy in patients with moderately advanced human immunodeficiency virus infection: a randomized controlled clinical trial--AIDS Clinical Trials Group 328. Arch Intern Med. 2007 Mar 26; 167(6):597-605. View in: Pubmed
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Further evidence for BRCA1 communication with the inactive X chromosome. Cell. 2007 Mar 09; 128(5):991-1002. View in: Pubmed
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Phase II study of CT-2103 as first- or second-line chemotherapy in patients with metastatic breast cancer: unexpected incidence of hypersensitivity reactions. Invest New Drugs. 2007 Aug; 25(4):369-75. View in: Pubmed
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Molecular definition of breast tumor heterogeneity. Cancer Cell. 2007 Mar; 11(3):259-73. View in: Pubmed
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Predictors of resistance to preoperative trastuzumab and vinorelbine for HER2-positive early breast cancer. Clin Cancer Res. 2007 Feb 15; 13(4):1198-207. View in: Pubmed
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Variability among breast radiation oncologists in delineation of the postsurgical lumpectomy cavity. Int J Radiat Oncol Biol Phys. 2007 Apr 01; 67(5):1299-308. View in: Pubmed
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Rebeccamycin analog for refractory breast cancer: a randomized phase II trial of dosing schedules. Invest New Drugs. 2007 Apr; 25(2):161-4. View in: Pubmed
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Germinal center function in the spleen during simian HIV infection in rhesus monkeys. J Immunol. 2006 Jul 15; 177(2):1108-19. View in: Pubmed
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Combination therapy with gefitinib and capecitabine in metastatic breast cancer (MBC): A phase I trial. J Clin Oncol. 2006 Jun 20; 24(18_suppl):10564. View in: Pubmed
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Trastuzumab and vinorelbine or taxane chemotherapy for HER2+ metastatic breast cancer: The TRAVIOTA study. J Clin Oncol. 2006 Jun 20; 24(18_suppl):650. View in: Pubmed
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A prospective study of conservative surgery without radiation therapy in select patients with Stage I breast cancer. Int J Radiat Oncol Biol Phys. 2006 Jul 15; 65(4):1149-54. View in: Pubmed
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Combined cDNA array comparative genomic hybridization and serial analysis of gene expression analysis of breast tumor progression. Cancer Res. 2006 Apr 15; 66(8):4065-78. View in: Pubmed
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Characterization of lymphocytic infiltrates in progressive multifocal leukoencephalopathy: co-localization of CD8(+) T cells with JCV-infected glial cells. J Neurovirol. 2006 Apr; 12(2):116-28. View in: Pubmed
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Prospective study of wide excision alone for ductal carcinoma in situ of the breast. J Clin Oncol. 2006 Mar 01; 24(7):1031-6. View in: Pubmed
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A putative role for psoriasin in breast tumor progression. Cancer Res. 2005 Dec 15; 65(24):11326-34. View in: Pubmed
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Dose density in breast cancer: a simple message? J Natl Cancer Inst. 2005 Dec 07; 97(23):1712-4. View in: Pubmed
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Quality of life in a clinical trial of highly active antiretroviral therapy alone or with intravenous or subcutaneous interleukin-2 administration. J Acquir Immune Defic Syndr. 2005 Dec 01; 40(4):428-33. View in: Pubmed
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Efficacy of pegfilgrastim and darbepoetin alfa as hematopoietic support for dose-dense every-2-week adjuvant breast cancer chemotherapy. J Clin Oncol. 2005 Nov 20; 23(33):8340-7. View in: Pubmed
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HIN-1, an inhibitor of cell growth, invasion, and AKT activation. Cancer Res. 2005 Nov 01; 65(21):9659-69. View in: Pubmed
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Prospective evaluation of concurrent paclitaxel and radiation therapy after adjuvant doxorubicin and cyclophosphamide chemotherapy for Stage II or III breast cancer. Int J Radiat Oncol Biol Phys. 2006 Feb 01; 64(2):496-504. View in: Pubmed
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Effect of CD8+ lymphocyte depletion on virus containment after simian immunodeficiency virus SIVmac251 challenge of live attenuated SIVmac239delta3-vaccinated rhesus macaques. J Virol. 2005 Jul; 79(13):8131-41. View in: Pubmed
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Antigen-specific T-cell memory is preserved in children treated for acute lymphoblastic leukemia. Blood. 2005 Sep 01; 106(5):1749-54. View in: Pubmed
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Vaccine-elicited memory cytotoxic T lymphocytes contribute to Mamu-A*01-associated control of simian/human immunodeficiency virus 89.6P replication in rhesus monkeys. J Virol. 2005 Apr; 79(8):4580-8. View in: Pubmed
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Sequencing of chemotherapy and radiation therapy in early-stage breast cancer: updated results of a prospective randomized trial. J Clin Oncol. 2005 Mar 20; 23(9):1934-40. View in: Pubmed
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Offering participants results of a clinical trial: sharing results of a negative study. Lancet. 2005 Mar 12-18; 365(9463):963-4. View in: Pubmed
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Prognosis after local recurrence after conservative surgery and radiation for early-stage breast cancer. Int J Radiat Oncol Biol Phys. 2005 Feb 01; 61(2):348-57. View in: Pubmed
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Serum levels of matrix extracellular phosphoglycoprotein (MEPE) in normal humans correlate with serum phosphorus, parathyroid hormone and bone mineral density. J Clin Endocrinol Metab. 2004 Aug; 89(8):4158-61. View in: Pubmed
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Recombinant poxvirus boosting of DNA-primed rhesus monkeys augments peak but not memory T lymphocyte responses. Proc Natl Acad Sci U S A. 2004 Jul 27; 101(30):11088-93. View in: Pubmed
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Rebeccamycin analog for refractory breast cancer: a randomized phase II trial. J Clin Oncol. 2004 Jul 15; 22(14_suppl):547. View in: Pubmed
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Heterologous envelope immunogens contribute to AIDS vaccine protection in rhesus monkeys. J Virol. 2004 Jul; 78(14):7490-7. View in: Pubmed
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Outcome after breast-conserving therapy for patients with stage I or II mucinous, medullary, or tubular breast carcinoma. Int J Radiat Oncol Biol Phys. 2004 May 01; 59(1):152-9. View in: Pubmed
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Daily low-dose subcutaneous interleukin-2 added to single- or dual-nucleoside therapy in HIV infection does not protect against CD4+ T-cell decline or improve other indices of immune function: results of a randomized controlled clinical trial (ACTG 248). J Acquir Immune Defic Syndr. 2004 May 01; 36(1):576-87. View in: Pubmed
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Oncology physician and nurse practices and attitudes regarding offering clinical trial results to study participants. J Natl Cancer Inst. 2004 Apr 21; 96(8):629-32. View in: Pubmed
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A prospective study of concurrent cyclophosphamide/methotrexate/5-fluorouracil and reduced-dose radiotherapy in patients with early-stage breast carcinoma. Cancer. 2004 Apr 01; 100(7):1358-64. View in: Pubmed
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Lymphocyte subsets in healthy children from birth through 18 years of age: the Pediatric AIDS Clinical Trials Group P1009 study. J Allergy Clin Immunol. 2003 Nov; 112(5):973-80. View in: Pubmed
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A neural survival factor is a candidate oncogene in breast cancer. Proc Natl Acad Sci U S A. 2003 Sep 16; 100(19):10931-6. View in: Pubmed
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Trastuzumab and vinorelbine as first-line therapy for HER2-overexpressing metastatic breast cancer: multicenter phase II trial with clinical outcomes, analysis of serum tumor markers as predictive factors, and cardiac surveillance algorithm. J Clin Oncol. 2003 Aug 01; 21(15):2889-95. View in: Pubmed
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Central nervous system metastases in women who receive trastuzumab-based therapy for metastatic breast carcinoma. Cancer. 2003 Jun 15; 97(12):2972-7. View in: Pubmed
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Lack of HIN-1 methylation in BRCA1-linked and "BRCA1-like" breast tumors. Cancer Res. 2003 May 01; 63(9):2024-7. View in: Pubmed
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Complementary medicine use among women enrolled in a genetic testing program. Cancer Epidemiol Biomarkers Prev. 2003 Apr; 12(4):321-6. View in: Pubmed
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Do patients participating in clinical trials want to know study results? J Natl Cancer Inst. 2003 Mar 19; 95(6):491-2. View in: Pubmed
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Molecular markers in ductal carcinoma in situ of the breast. Mol Cancer Res. 2003 Mar; 1(5):362-75. View in: Pubmed
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Effect of humoral immune responses on controlling viremia during primary infection of rhesus monkeys with simian immunodeficiency virus. J Virol. 2003 Feb; 77(3):2165-73. View in: Pubmed
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Preoperative therapy with trastuzumab and paclitaxel followed by sequential adjuvant doxorubicin/cyclophosphamide for HER2 overexpressing stage II or III breast cancer: a pilot study. J Clin Oncol. 2003 Jan 01; 21(1):46-53. View in: Pubmed
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BRCA1/2 genetic testing in the community setting. J Clin Oncol. 2002 Nov 15; 20(22):4485-92. View in: Pubmed
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Effect of etanercept (Enbrel) on interleukin 6, tumor necrosis factor alpha, and markers of immune activation in HIV-infected subjects receiving interleukin 2. AIDS Res Hum Retroviruses. 2002 Jun 10; 18(9):661-5. View in: Pubmed
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Understanding the basis of CD4(+) T-cell depletion in macaques infected by a simian-human immunodeficiency virus. Vaccine. 2002 May 06; 20(15):1934-7. View in: Pubmed
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Use of CD45 gating in three and four-color flow cytometric immunophenotyping: guideline from the National Institute of Allergy and Infectious Diseases, Division of AIDS. Cytometry. 2002 Apr 15; 50(2):46-52. View in: Pubmed
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Second nonbreast malignancies after conservative surgery and radiation therapy for early-stage breast cancer. Int J Radiat Oncol Biol Phys. 2002 Feb 01; 52(2):406-14. View in: Pubmed
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Respiratory maneuvers decrease irradiated cardiac volume in patients with left-sided breast cancer. J Cardiovasc Magn Reson. 2002; 4(2):265-71. View in: Pubmed
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Membrane-fusing capacity of the human immunodeficiency virus envelope proteins determines the efficiency of CD+ T-cell depletion in macaques infected by a simian-human immunodeficiency virus. J Virol. 2001 Jun; 75(12):5646-55. View in: Pubmed
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Clinical activity of trastuzumab and vinorelbine in women with HER2-overexpressing metastatic breast cancer. J Clin Oncol. 2001 May 15; 19(10):2722-30. View in: Pubmed
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Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination. Science. 2000 Oct 20; 290(5491):486-92. View in: Pubmed
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Is radiation alone adequate treatment to the axilla for patients with limited axillary surgery? Implications for treatment after a positive sentinel node biopsy. Int J Radiat Oncol Biol Phys. 2000 Aug 01; 48(1):125-32. View in: Pubmed
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Domain specificity and variability in cognitive development. Child Dev. 2000 Jul-Aug; 71(4):854-6; discussion 860-1. View in: Pubmed
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Multisite comparison of methods for the quantitation of the surface expression of CD38 on CD8(+) T lymphocytes. The ACTG Advanced Flow Cytometry Focus Group. Cytometry. 2000 Jun 15; 42(3):174-9. View in: Pubmed
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Outcome at 8 years after breast-conserving surgery and radiation therapy for invasive breast cancer: influence of margin status and systemic therapy on local recurrence. J Clin Oncol. 2000 Apr; 18(8):1668-75. View in: Pubmed
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Analyses of quality assessment studies using CD45 for gating lymphocytes for CD3(+)4(+)%. Cytometry. 2000 Feb 15; 42(1):1-4. View in: Pubmed
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Prevalence of germline truncating mutations in ATM in women with a second breast cancer after radiation therapy for a contralateral tumor. Genes Chromosomes Cancer. 2000 Feb; 27(2):124-9. View in: Pubmed
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The significance of extracapsular extension of axillary lymph node metastases in early-stage breast cancer. Int J Radiat Oncol Biol Phys. 2000 Jan 01; 46(1):31-4. View in: Pubmed
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The influence of infiltrating lobular carcinoma on the outcome of patients treated with breast-conserving surgery and radiation therapy. Breast Cancer Res Treat. 2000 Jan; 59(1):49-54. View in: Pubmed
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Factors associated with regional nodal failure in patients with early stage breast cancer with 0-3 positive axillary nodes following tangential irradiation alone. Int J Radiat Oncol Biol Phys. 1999 Dec 01; 45(5):1157-66. View in: Pubmed
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Concurrent CMF and radiation therapy for early stage breast cancer: results of a pilot study. Int J Radiat Oncol Biol Phys. 1999 Nov 01; 45(4):877-84. View in: Pubmed
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Treatment-related toxicity from a randomized trial of the sequencing of doxorubicin and radiation therapy in patients treated for early stage breast cancer. Int J Radiat Oncol Biol Phys. 1999 Aug 01; 45(1):69-72. View in: Pubmed
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Effect of complement consumption by cobra venom factor on the course of primary infection with simian immunodeficiency virus in rhesus monkeys. AIDS Res Hum Retroviruses. 1999 Jan 20; 15(2):195-202. View in: Pubmed
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Predictors of local recurrence following excision alone for ductal carcinoma in situ. Cancer. 1999 Jan 15; 85(2):427-31. View in: Pubmed
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Monitoring therapeutic response in skeletal metastases using dual-energy x-ray absorptiometry: a prospective feasibility study in breast cancer patients. Cancer Invest. 1999; 17(8):566-74. View in: Pubmed
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Editorial comment on "the link between local recurrence and distant metastasis in human breast cancer" by Serge Koscielny and Maurice Tubiana. Int J Radiat Oncol Biol Phys. 1999 Jan 01; 43(1):7-9. View in: Pubmed
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Cardiac effects of adjuvant doxorubicin and radiation therapy in breast cancer patients. J Clin Oncol. 1998 Nov; 16(11):3493-501. View in: Pubmed
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The envelope glycoprotein ectodomains determine the efficiency of CD4+ T lymphocyte depletion in simian-human immunodeficiency virus-infected macaques. J Exp Med. 1998 Sep 21; 188(6):1159-71. View in: Pubmed
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Expression of the CD8alpha beta-heterodimer on CD8(+) T lymphocytes in peripheral blood lymphocytes of human immunodeficiency virus- and human immunodeficiency virus+ individuals. Blood. 1998 Jul 01; 92(1):198-206. View in: Pubmed
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Family history and treatment outcome in young women after breast-conserving surgery and radiation therapy for early-stage breast cancer. J Clin Oncol. 1998 Jun; 16(6):2045-51. View in: Pubmed
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A putative gene causes variability in lifespan among genotypically identical mice. Nat Genet. 1998 Jun; 19(2):114-6. View in: Pubmed
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Eastern Cooperative Oncology Group randomized trials of observation versus maintenance therapy for patients with metastatic breast cancer in complete remission following induction treatment. J Clin Oncol. 1998 May; 16(5):1669-76. View in: Pubmed
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No long-term increase in cardiac-related mortality after breast-conserving surgery and radiation therapy using modern techniques. J Clin Oncol. 1998 Apr; 16(4):1374-9. View in: Pubmed
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Variations in measurement of the iliac angle of the fetal pelvis in Down syndrome. Radiology. 1998 Mar; 206(3):846-7. View in: Pubmed
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Induction chemotherapy of dibromodulcitol, Adriamycin, vincristine, tamoxifen, and Halotestin with methotrexate in metastatic breast cancer: an Eastern Cooperative Oncology Group Study (E1181). Am J Clin Oncol. 1998 Feb; 21(1):99-104. View in: Pubmed
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Impact of respiratory maneuvers on cardiac volume within left-breast radiation portals. Circulation. 1997 Nov 18; 96(10):3269-72. View in: Pubmed
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Prediction of response to antiestrogen therapy in advanced breast cancer patients by pretreatment circulating levels of extracellular domain of the HER-2/c-neu protein. J Clin Oncol. 1997 Jul; 15(7):2518-25. View in: Pubmed
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Breast-conserving therapy for stage I-II synchronous bilateral breast carcinoma. Cancer. 1997 Apr 01; 79(7):1362-9. View in: Pubmed
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Inter- and intrainstitutional evaluation of automated volumetric capillary cytometry for the quantitation of CD4- and CD8-positive T lymphocytes in the peripheral blood of persons infected with human immunodeficiency virus. Site Investigators and the NIAID New CD4 Technologies Focus Group. Clin Diagn Lab Immunol. 1997 Mar; 4(2):173-9. View in: Pubmed
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Repetitive cycles of cyclophosphamide, thiotepa, and carboplatin intensification with peripheral-blood progenitor cells and filgrastim in advanced breast cancer patients. J Clin Oncol. 1997 Feb; 15(2):674-83. View in: Pubmed
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Pathologic margin involvement and the risk of recurrence in patients treated with breast-conserving therapy. Cancer. 1996 Nov 01; 78(9):1921-8. View in: Pubmed
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Relationship of tumor grade to other pathologic features and to treatment outcome of patients with early stage breast carcinoma treated with breast-conserving therapy. Cancer. 1996 Oct 01; 78(7):1426-31. View in: Pubmed
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The sequencing of chemotherapy and radiation therapy after conservative surgery for early-stage breast cancer. N Engl J Med. 1996 May 23; 334(21):1356-61. View in: Pubmed
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A prospective study of conservative surgery alone in the treatment of selected patients with stage I breast cancer. Cancer. 1996 Mar 15; 77(6):1094-100. View in: Pubmed
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Analysis of prostate and seminal vesicle motion: implications for treatment planning. Int J Radiat Oncol Biol Phys. 1996 Jan 15; 34(2):451-8. View in: Pubmed
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Long-term outcome following breast-conserving surgery and radiation therapy. Int J Radiat Oncol Biol Phys. 1995 Sep 30; 33(2):245-51. View in: Pubmed
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