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Shuji Ogino, MD, PhD, MS


Oncologic Pathology

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Physician

  • Professor of Pathology, Harvard Medical School
  • Professor, Department of Epidemiology, Harvard T.H. Chan School of Public Health
  • Chief, Program of Molecular Pathological Epidemiology, Brigham and Women’s Hospital
  • Associate Member, Broad Institute of MIT and Harvard

Centers/Programs

Clinical Interests

  • Molecular diagnostics

Contact Information

  • Appointments877-332-4294
  • Office Phone Number617-632-1985
  • Fax617-582-8558

Bio

Dr. Ogino received his MD in 1993 and his PhD in 2001 from the University of Tokyo, Japan. He completed his residency in anatomic pathology and clinical pathology at Case Western Reserve University and University Hospitals Case Medical Center in 1999, and a molecular pathology fellowship in 2000 at the University of Pennsylvania. He joined Dana-Farber Cancer Institute as an Instructor in 2001. In 2015, Dr. Ogino was promoted to Professor of Pathology at Dana-Farber Cancer Institute, Brigham and Women’s Hospital (BWH), and Harvard Medical School; and Professor in the Department of Epidemiology at the Harvard T.H. Chan School of Public Health. In 2016, Dr. Ogino became the first Chief of the Division of Molecular Pathological Epidemiology (MPE) at BWH. Dr. Ogino has been serving as the Chairperson for the International Molecular Pathological Epidemiology (MPE) Meeting Series since 2013. Dr. Ogino has received a number of awards and honors, particularly in recognition of his pioneering effort of establishing the interdisciplinary and integrative field of MPE. These recognitions include the Ramzi Cotran Young Investigator Award from the United States and Canadian Academy of Pathology (USCAP) in 2011; Executive Officer’s Award (2004) and Meritorious Service Award (2012) from the Association for Molecular Pathology (AMP); Elected Membership of American Society for Clinical Investigation (since 2014); recognition as the Most Influential Scientific Minds (2014), and High Cited Researcher (2015) by Thomson Reuters; and a 7-year grant, NCI R35 Outstanding Investigator Award (2015-2022) from the National Institute of Health.

Board Certification:

  • Anatomic Pathology and Clinical Pathology, 2000
  • Molecular Genetic Pathology, 2003

Fellowship:

  • University of Pennsylvania, Molecular Pathology

Residency:

  • Case Western Reserve University, Anatomic Pathology and Clinical Pathology

Medical School:

  • Harvard School of Public Health (MS in Epidemiology)
  • University of Tokyo
  • University of Tokyo Graduate School of Medicine (PhD)

Recent Awards:

  • Highly Cited Researcher (Clarivate Analytics), 2017
  • Highly Cited Researcher (Clarivate Analytics), 2016
  • Highly Cited Researcher (Thomson Reuters), 2015
  • Recipient of R35 Outstanding Investigator Award from National Cancer Institute, 2015 to present
  • Elected Membership of American Society for Clinical Investigation (ASCI), 2014
  • The Most Influential Scientific Minds (Thomson Reuters), 2014
  • Meritorious Service Award, from Association for Molecular Pathology (AMP) October 2012
  • Ramzi Cotran Young Investigator Award, from United States and Canadian Academy of Pathology (USCAP) March 2011

Research

The Molecular Pathological Epidemiology Laboratory (The MPE Laboratory)

The relationship between exposures and tumor molecular changes has been examined (eg, smoking -> KRAS mutation), under the umbrella of "molecular epidemiology".  However, this type of analysis needs a consideration of disease heterogeneity (eg, KRAS mutation present vs. absent), which necessitates a paradigm shift from conventional epidemiology, which is based on the premise that individuals with a given disease (by name) are homogeneous and can be lumped together to analyze the associations with exposures.

Considering this paradigm shift, “Molecular Pathological Epidemiology (MPE)” (or Molecular Pathologic Epidemiology) has been coined for integrative science to analyze inherent disease heterogeneity in epidemiology research (Ogino et al. JNCI 2010; Gut 2011; Nat Rev Clin Oncol 2011).  The power and promise of MPE has been well attested by our recent study (Liao et al. NEJM 2012) which discovered an interactive effect of aspirin use and colorectal cancer PIK3CA mutation.  MPE encompasses ALL HUMAN DISEASES (Ogino et al. Mod Pathol 2013).  MPE is based on the "Unique Tumor Principle" (Ogino et al. Expert Rev Mol Diagn 2012) and more broadly, the “Unique Disease Principle” (Ogino et al. Mod Pathol 2013).  MPE design can be used as the next step of genome-wide association study (“GWAS-MPE Approach”; Ogino et al. Gut 2011; Garcia-Albeniz et al. Carcinogenesis 2013).  Other new concepts related to MPE include "Colorectal Continuum Paradigm / Theory / Hypothesis" (Yamauchi, et al. Gut 2012), which underscores the importance of interplay of gut microbiota, microbiome, host factors and carcinogenesis. 

We have been utilizing two large U.S. nationwide prospective cohort studies, the Nurses’ Health Study, and the Health Professionals Follow-up Study, as well as CALGB trials.  Our discoveries by the MPE approach include (to mention just several); influence of the tumor microenvironment on tumor phenotype (Straussman et al. Nature 2012); YAP1 in colorectal cancer (Barry et al. Nature 2013); interactions between aspirin use and tumor PTGS2 (cyclooxygenase-2) expression (Chan et al. NEJM 2007; JAMA 2009); interactions between obesity (host energetics) and tumor FASN expression (Ogino et al. J Clin Oncol 2008; Kuchiba et al. JNCI 2012); interactions between host energetics and tumor CTNNB1 (b-catenin) (Morikawa et al. JAMA 2011; Cancer Res 2013); LINE-1 hypomethylation and colon cancer aggression and family history (Ogino et al. JNCI 2008; JNCI 2013).

(For full description, please visit http://www.hsph.harvard.edu/shuji-ogino/ )

Long-Term Colorectal Cancer Incidence and Mortality After Colonoscopy Screening According to Individuals' Risk Profiles. J Natl Cancer Inst. 2021 Mar 18.
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Interindividual immunogenic variants: Susceptibility to coronavirus, respiratory syncytial virus and influenza virus. Rev Med Virol. 2021 Mar 16; e2189.
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Response to Li and Hopper. Am J Hum Genet. 2021 03 04; 108(3):527-529.
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Aspirin Use and Risk of Colorectal Cancer Among Older Adults. JAMA Oncol. 2021 Mar 01; 7(3):428-435.
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Association of Fusobacterium nucleatum with Specific T Cell Subsets in the Colorectal Carcinoma Microenvironment. Clin Cancer Res. 2021 Feb 25.
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Genetic architectures of proximal and distal colorectal cancer are partly distinct. Gut. 2021 Feb 25.
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Preexisting Type 2 Diabetes and Survival among Patients with Colorectal Cancer. Cancer Epidemiol Biomarkers Prev. 2021 Feb 02.
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Healthy lifestyle, endoscopic screening, and colorectal cancer incidence and mortality in the United States: A nationwide cohort study. PLoS Med. 2021 Feb; 18(2):e1003522.
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Plasma sex hormones and risk of conventional and serrated precursors of colorectal cancer in postmenopausal women. BMC Med. 2021 Jan 28; 19(1):18.
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Reflection on modern methods: causal inference considerations for heterogeneous disease etiology. Int J Epidemiol. 2021 Jan 23.
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Opinion: Standardizing gene product nomenclature-a call to action. Proc Natl Acad Sci U S A. 2021 Jan 19; 118(3).
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Dairy intake during adolescence and risk of colorectal adenoma later in life. Br J Cancer. 2021 Mar; 124(6):1160-1168.
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Association of Body Mass Index With Colorectal Cancer Risk by Genome-Wide Variants. J Natl Cancer Inst. 2021 Jan 04; 113(1):38-47.
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Dietary intake of branched-chain amino acids and survival after colorectal cancer diagnosis. Int J Cancer. 2020 Dec 19.
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Adiposity, metabolites, and colorectal cancer risk: Mendelian randomization study. BMC Med. 2020 12 17; 18(1):396.
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Depressed Colorectal Cancer: A New Paradigm in Early Colorectal Cancer. Clin Transl Gastroenterol. 2020 12; 11(12):e00269.
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Composition, Spatial Characteristics, and Prognostic Significance of Myeloid Cell Infiltration in Pancreatic Cancer. Clin Cancer Res. 2021 Feb 15; 27(4):1069-1081.
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Rising incidence of early-onset colorectal cancer - a call to action. Nat Rev Clin Oncol. 2020 Nov 20.
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The microbiome, genetics, and gastrointestinal neoplasms: the evolving field of molecular pathological epidemiology to analyze the tumor-immune-microbiome interaction. Hum Genet. 2020 Nov 12.
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Comprehensive Assessment of Diet Quality and Risk of Precursors of Early-Onset Colorectal Cancer. J Natl Cancer Inst. 2020 Nov 02.
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Emerging Standards and the Hybrid Model for Organizing Scientific Events During and After The COVID-19 Pandemic. Disaster Med Public Health Prep. 2020 Oct 26; 1-17.
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A Modified Tumor-Node-Metastasis Classification for Primary Operable Colorectal Cancer. JNCI Cancer Spectr. 2021 Feb; 5(1):pkaa093.
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Risk Factors and Incidence of Colorectal Cancer According to Major Molecular Subtypes. JNCI Cancer Spectr. 2021 Feb; 5(1):pkaa089.
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The Prognostic Role of Macrophage Polarization in the Colorectal Cancer Microenvironment. Cancer Immunol Res. 2021 Jan; 9(1):8-19.
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Genetic Variants in the Regulatory T cell-Related Pathway and Colorectal Cancer Prognosis. Cancer Epidemiol Biomarkers Prev. 2020 Dec; 29(12):2719-2728.
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Extracorporeal high-pressure therapy (EHPT) for malignant melanoma consisting of simultaneous tumor eradication and autologous dermal substitute preparation. Regen Ther. 2020 Dec; 15:187-194.
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Prediagnostic Circulating Concentrations of Vitamin D Binding Protein and Survival among Patients with Colorectal Cancer. Cancer Epidemiol Biomarkers Prev. 2020 Nov; 29(11):2323-2331.
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Coffee Intake and Colorectal Cancer Incidence According to T-Cell Response. JNCI Cancer Spectr. 2020 Dec; 4(6):pkaa068.
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Circulating bilirubin levels and risk of colorectal cancer: serological and Mendelian randomization analyses. BMC Med. 2020 09 03; 18(1):229.
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Consumption of Fish and ?-3 Fatty Acids and Cancer Risk: An Umbrella Review of Meta-Analyses of Observational Studies. Adv Nutr. 2020 09 01; 11(5):1134-1149.
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Intake of Dietary Fruit, Vegetables, and Fiber and Risk of Colorectal Cancer According to Molecular Subtypes: A Pooled Analysis of 9 Studies. Cancer Res. 2020 10 15; 80(20):4578-4590.
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Genome-wide Modeling of Polygenic Risk Score in Colorectal Cancer Risk. Am J Hum Genet. 2020 09 03; 107(3):432-444.
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A prospective study of erythrocyte polyunsaturated fatty acids and risk of colorectal serrated polyps and conventional adenomas. Int J Cancer. 2021 Jan 01; 148(1):57-66.
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Periodontal Disease, Tooth Loss, and Risk of Serrated Polyps and Conventional Adenomas. Cancer Prev Res (Phila). 2020 08; 13(8):699-706.
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Landscape of somatic single nucleotide variants and indels in colorectal cancer and impact on survival. Nat Commun. 2020 07 20; 11(1):3644.
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Periodontal disease, tooth loss, and risk of oesophageal and gastric adenocarcinoma: a prospective study. Gut. 2021 Mar; 70(3):620-621.
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Tumour budding, poorly differentiated clusters, and T-cell response in colorectal cancer. EBioMedicine. 2020 Jul; 57:102860.
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Acid-suppressive medications and risk of colorectal cancer: results from three large prospective cohort studies. Br J Cancer. 2020 09; 123(5):844-851.
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Association between yogurt consumption and plasma soluble CD14 in two prospective cohorts of US adults. Eur J Nutr. 2021 Mar; 60(2):929-938.
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Influence of KRAS mutations, persistent organic pollutants, and trace elements on survival from pancreatic ductal adenocarcinoma. Environ Res. 2020 11; 190:109781.
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Insulin-Like Growth Factor-1 Receptor Expression and Disease Recurrence and Survival in Patients with Resected Pancreatic Ductal Adenocarcinoma. Cancer Epidemiol Biomarkers Prev. 2020 Aug; 29(8):1586-1595.
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Prognostic Significance of Immune Cell Populations Identified by Machine Learning in Colorectal Cancer Using Routine Hematoxylin and Eosin-Stained Sections. Clin Cancer Res. 2020 08 15; 26(16):4326-4338.
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Postmenopausal Hormone Therapy and Colorectal Cancer Risk by Molecularly Defined Subtypes and Tumor Location. JNCI Cancer Spectr. 2020 Aug; 4(5):pkaa042.
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The urgent need for integrated science to fight COVID-19 pandemic and beyond. J Transl Med. 2020 05 19; 18(1):205.
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Smoking Status at Diagnosis and Colorectal Cancer Prognosis According to Tumor Lymphocytic Reaction. JNCI Cancer Spectr. 2020 Aug; 4(5):pkaa040.
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Characterizing diversity in the tumor-immune microenvironment of distinct subclasses of gastroesophageal adenocarcinomas. Ann Oncol. 2020 08; 31(8):1011-1020.
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Risk Factor Profiles Differ for Cancers of Different Regions of the Colorectum. Gastroenterology. 2020 07; 159(1):241-256.e13.
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A novel calibration framework for survival analysis when a binary covariate is measured at sparse time points. Biostatistics. 2020 04 01; 21(2):e148-e163.
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Body fatness over the life course and risk of serrated polyps and conventional adenomas. Int J Cancer. 2020 Oct 01; 147(7):1831-1844.
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Functional informed genome-wide interaction analysis of body mass index, diabetes and colorectal cancer risk. Cancer Med. 2020 05; 9(10):3563-3573.
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Genetic Predictors of Circulating 25-Hydroxyvitamin D and Prognosis after Colorectal Cancer. Cancer Epidemiol Biomarkers Prev. 2020 06; 29(6):1128-1134.
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Metabolic Profiling of Formalin-Fixed Paraffin-Embedded Tissues Discriminates Normal Colon from Colorectal Cancer. Mol Cancer Res. 2020 06; 18(6):883-890.
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An integrated analysis of lymphocytic reaction, tumour molecular characteristics and patient survival in colorectal cancer. Br J Cancer. 2020 04; 122(9):1367-1377.
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Association Between Molecular Subtypes of Colorectal Tumors and Patient Survival, Based on Pooled Analysis of 7 International Studies. Gastroenterology. 2020 06; 158(8):2158-2168.e4.
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Response to the letter by Lai et al. regarding our manuscript "Statin use and pancreatic cancer risk in two prospective cohort studies". J Gastroenterol. 2020 04; 55(4):473-474.
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No Association Between Vitamin D Supplementation and Risk of Colorectal Adenomas or Serrated Polyps in a Randomized Trial. Clin Gastroenterol Hepatol. 2021 Jan; 19(1):128-135.e6.
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Association of autophagy status with amount of Fusobacterium nucleatum in colorectal cancer. J Pathol. 2020 04; 250(4):397-408.
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Corrigendum to: Colorectal cancer susceptibility variants and risk of conventional adenomas and serrated polyps: results from three cohort studies. Int J Epidemiol. 2020 02 01; 49(1):352.
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Colorectal cancer susceptibility variants and risk of conventional adenomas and serrated polyps: results from three cohort studies. Int J Epidemiol. 2020 02 01; 49(1):259-269.
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Association Between Sulfur-Metabolizing Bacterial Communities in Stool and Risk of Distal Colorectal Cancer in Men. Gastroenterology. 2020 04; 158(5):1313-1325.
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Pre-diagnostic leukocyte mitochondrial DNA copy number and colorectal cancer risk. Carcinogenesis. 2019 12 31; 40(12):1462-1468.
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Circulating Levels of Insulin-like Growth Factor 1 and Insulin-like Growth Factor Binding Protein 3 Associate With Risk of Colorectal Cancer Based on Serologic and Mendelian Randomization Analyses. Gastroenterology. 2020 04; 158(5):1300-1312.e20.
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Effect of Supplementation With Marine ?-3 Fatty Acid on Risk of Colorectal Adenomas and Serrated Polyps in the US General Population: A Prespecified Ancillary Study of a Randomized Clinical Trial. JAMA Oncol. 2019 Nov 21.
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Mucosal cancer-associated microbes and anastomotic leakage after resection of colorectal carcinoma. Surg Oncol. 2020 Mar; 32:63-68.
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Dietary Intake of Branched-Chain Amino Acids and Risk of Colorectal Cancer. Cancer Prev Res (Phila). 2020 01; 13(1):65-72.
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Hyperprogressive Disease during Anti-PD-1 (PDCD1) / PD-L1 (CD274) Therapy: A Systematic Review and Meta-Analysis. Cancers (Basel). 2019 Nov 01; 11(11).
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Night-Shift Work Duration and Risk of Colorectal Cancer According to IRS1 and IRS2 Expression. Cancer Epidemiol Biomarkers Prev. 2020 01; 29(1):133-140.
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Prediagnostic Leukocyte Telomere Length and Pancreatic Cancer Survival. Cancer Epidemiol Biomarkers Prev. 2019 11; 28(11):1868-1875.
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Plasma Biomarkers of Insulin and the Insulin-like Growth Factor Axis, and Risk of Colorectal Adenoma and Serrated Polyp. JNCI Cancer Spectr. 2019 Sep; 3(3):pkz056.
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Long-term status of predicted body fat percentage, body mass index and other anthropometric factors with risk of colorectal carcinoma: Two large prospective cohort studies in the US. Int J Cancer. 2020 05 01; 146(9):2383-2393.
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Long-term Risk of Colorectal Cancer After Removal of Conventional Adenomas and Serrated Polyps. Gastroenterology. 2020 03; 158(4):852-861.e4.
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DNA repair and cancer in colon and rectum: Novel players in genetic susceptibility. Int J Cancer. 2020 01 15; 146(2):363-372.
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Intrinsic Resistance to Immune Checkpoint Blockade in a Mismatch Repair-Deficient Colorectal Cancer. Cancer Immunol Res. 2019 08; 7(8):1230-1236.
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Yogurt consumption and risk of conventional and serrated precursors of colorectal cancer. Gut. 2020 05; 69(5):970-972.
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Meta-analysis of 16 studies of the association of alcohol with colorectal cancer. Int J Cancer. 2020 02 01; 146(3):861-873.
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Mendelian randomization analysis of C-reactive protein on colorectal cancer risk. Int J Epidemiol. 2019 06 01; 48(3):767-780.
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Physical activity during adolescence and risk of colorectal adenoma later in life: results from the Nurses' Health Study II. Br J Cancer. 2019 07; 121(1):86-94.
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Dietary intake of fiber, whole grains and risk of colorectal cancer: An updated analysis according to food sources, tumor location and molecular subtypes in two large US cohorts. Int J Cancer. 2019 12 01; 145(11):3040-3051.
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Proceedings of the fourth international molecular pathological epidemiology (MPE) meeting. Cancer Causes Control. 2019 Aug; 30(8):799-811.
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Correction: Gene Regulatory Network Analysis Identifies Sex-Linked Differences in Colon Cancer Drug Metabolism. Cancer Res. 2019 Apr 15; 79(8):2084.
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Calcium intake and colon cancer risk subtypes by tumor molecular characteristics. Cancer Causes Control. 2019 Jun; 30(6):637-649.
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Integrative Genome-Scale DNA Methylation Analysis of a Large and Unselected Cohort Reveals 5 Distinct Subtypes of Colorectal Adenocarcinomas. Cell Mol Gastroenterol Hepatol. 2019; 8(2):269-290.
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Family history of cancer, Ashkenazi Jewish ancestry, and pancreatic cancer risk. Br J Cancer. 2019 04; 120(8):848-854.
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Prognostic association of PTGS2 (COX-2) over-expression according to BRAF mutation status in colorectal cancer: Results from two prospective cohorts and CALGB 89803 (Alliance) trial. Eur J Cancer. 2019 04; 111:82-93.
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Integration of microbiology, molecular pathology, and epidemiology: a new paradigm to explore the pathogenesis of microbiome-driven neoplasms. J Pathol. 2019 04; 247(5):615-628.
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Calcium Intake and Risk of Colorectal Cancer According to Tumor-infiltrating T Cells. Cancer Prev Res (Phila). 2019 05; 12(5):283-294.
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Dietary Insulin Load and Cancer Recurrence and Survival in Patients With Stage III Colon Cancer: Findings From CALGB 89803 (Alliance). J Natl Cancer Inst. 2019 02 01; 111(2):170-179.
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Low-Carbohydrate Diet Score and Macronutrient Intake in Relation to Survival After Colorectal Cancer Diagnosis. JNCI Cancer Spectr. 2018 Nov; 2(4):pky077.
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Sedentary Behaviors, TV Viewing Time, and Risk of Young-Onset Colorectal Cancer. JNCI Cancer Spectr. 2018 Nov; 2(4):pky073.
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Physical Activity and Colorectal Cancer Prognosis According to Tumor-Infiltrating T Cells. JNCI Cancer Spectr. 2018 Oct; 2(4):pky058.
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Smoking and Risk of Colorectal Cancer Sub-Classified by Tumor-Infiltrating T Cells. J Natl Cancer Inst. 2019 01 01; 111(1):42-51.
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Association of Obesity With Risk of Early-Onset Colorectal Cancer Among Women. JAMA Oncol. 2019 01 01; 5(1):37-44.
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SMAD4 Loss in Colorectal Cancer Patients Correlates with Recurrence, Loss of Immune Infiltrate, and Chemoresistance. Clin Cancer Res. 2019 03 15; 25(6):1948-1956.
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Calcium Intake and Survival after Colorectal Cancer Diagnosis. Clin Cancer Res. 2019 03 15; 25(6):1980-1988.
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Discovery of common and rare genetic risk variants for colorectal cancer. Nat Genet. 2019 01; 51(1):76-87.
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Association Between Intake of Red and Processed Meat and Survival in Patients With Colorectal Cancer in a Pooled Analysis. Clin Gastroenterol Hepatol. 2019 07; 17(8):1561-1570.e3.
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Type 2 diabetes and risk of colorectal cancer in two large U.S. prospective cohorts. Br J Cancer. 2018 11; 119(11):1436-1442.
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Gene Regulatory Network Analysis Identifies Sex-Linked Differences in Colon Cancer Drug Metabolism. Cancer Res. 2018 10 01; 78(19):5538-5547.
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Characterization of the Neuroendocrine Tumor Immune Microenvironment. Pancreas. 2018 10; 47(9):1123-1129.
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Dysbiosis of the gut microbiota and colorectal cancer: the key target of molecular pathological epidemiology. J Lab Precis Med. 2018 Sep; 3.
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Continuity of transcriptomes among colorectal cancer subtypes based on meta-analysis. Genome Biol. 2018 09 25; 19(1):142.
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The Amount of Bifidobacterium Genus in Colorectal Carcinoma Tissue in Relation to Tumor Characteristics and Clinical Outcome. Am J Pathol. 2018 12; 188(12):2839-2852.
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Fusobacterium nucleatum in Colorectal Cancer Relates to Immune Response Differentially by Tumor Microsatellite Instability Status. Cancer Immunol Res. 2018 11; 6(11):1327-1336.
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Vitamin D status after colorectal cancer diagnosis and patient survival according to immune response to tumour. Eur J Cancer. 2018 11; 103:98-107.
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Insights into Pathogenic Interactions Among Environment, Host, and Tumor at the Crossroads of Molecular Pathology and Epidemiology. Annu Rev Pathol. 2019 01 24; 14:83-103.
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Dietary Fat Intake after Colon Cancer Diagnosis in Relation to Cancer Recurrence and Survival: CALGB 89803 (Alliance). Cancer Epidemiol Biomarkers Prev. 2018 10; 27(10):1227-1230.
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Associations of artificially sweetened beverage intake with disease recurrence and mortality in stage III colon cancer: Results from CALGB 89803 (Alliance). PLoS One. 2018; 13(7):e0199244.
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Germline cancer susceptibility gene variants, somatic second hits, and survival outcomes in patients with resected pancreatic cancer. Genet Med. 2019 01; 21(1):213-223.
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Ancient Thali Diet: Gut Microbiota, Immunity, and Health. Yale J Biol Med. 2018 06; 91(2):177-184.
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Association of Survival With Adherence to the American Cancer Society Nutrition and Physical Activity Guidelines for Cancer Survivors After Colon Cancer Diagnosis: The CALGB 89803/Alliance Trial. JAMA Oncol. 2018 06 01; 4(6):783-790.
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Grain Intake and Clinical Outcome in Stage III Colon Cancer: Results From CALGB 89803 (Alliance). JNCI Cancer Spectr. 2018 Feb; 2(2):pky017.
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Immunoscore for (colorectal) cancer precision medicine. Lancet. 2018 05 26; 391(10135):2084-2086.
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Diets That Promote Colon Inflammation Associate With Risk of Colorectal Carcinomas That Contain Fusobacterium nucleatum. Clin Gastroenterol Hepatol. 2018 10; 16(10):1622-1631.e3.
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Association Between Risk Factors for Colorectal Cancer and Risk of Serrated Polyps and Conventional Adenomas. Gastroenterology. 2018 08; 155(2):355-373.e18.
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TIME (Tumor Immunity in the MicroEnvironment) classification based on tumor CD274 (PD-L1) expression status and tumor-infiltrating lymphocytes in colorectal carcinomas. Oncoimmunology. 2018; 7(7):e1442999.
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Association of Alterations in Main Driver Genes With Outcomes of Patients With Resected Pancreatic Ductal Adenocarcinoma. JAMA Oncol. 2018 Mar 08; 4(3):e173420.
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Genetic Mechanisms of Immune Evasion in Colorectal Cancer. Cancer Discov. 2018 06; 8(6):730-749.
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Association of Dietary Inflammatory Potential With Colorectal Cancer Risk in Men and Women. JAMA Oncol. 2018 Mar 01; 4(3):366-373.
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Nut Consumption and Survival in Patients With Stage III Colon Cancer: Results From CALGB 89803 (Alliance). J Clin Oncol. 2018 04 10; 36(11):1112-1120.
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Inherited DNA-Repair Defects in Colorectal Cancer. Am J Hum Genet. 2018 03 01; 102(3):401-414.
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Prediagnosis Use of Statins Associates With Increased Survival Times of Patients With Pancreatic Cancer. Clin Gastroenterol Hepatol. 2018 08; 16(8):1300-1306.e3.
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Integrative analysis of exogenous, endogenous, tumour and immune factors for precision medicine. Gut. 2018 06; 67(6):1168-1180.
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Statin use and pancreatic cancer risk in two prospective cohort studies. J Gastroenterol. 2018 Aug; 53(8):959-966.
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Marine ?-3 Polyunsaturated Fatty Acid and Fish Intake after Colon Cancer Diagnosis and Survival: CALGB 89803 (Alliance). Cancer Epidemiol Biomarkers Prev. 2018 04; 27(4):438-445.
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Fiber Intake and Survival After Colorectal Cancer Diagnosis. JAMA Oncol. 2018 Jan 01; 4(1):71-79.
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Utility of inverse probability weighting in molecular pathological epidemiology. Eur J Epidemiol. 2018 04; 33(4):381-392.
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Regular Use of Aspirin or Non-Aspirin Nonsteroidal Anti-Inflammatory Drugs Is Not Associated With Risk of Incident Pancreatic Cancer in Two Large Cohort Studies. Gastroenterology. 2018 04; 154(5):1380-1390.e5.
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Integration of pharmacology, molecular pathology, and population data science to support precision gastrointestinal oncology. NPJ Precis Oncol. 2017; 1.
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Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer. Science. 2017 12 15; 358(6369):1443-1448.
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Association Between Coffee Intake After Diagnosis of Colorectal Cancer and Reduced Mortality. Gastroenterology. 2018 03; 154(4):916-926.e9.
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Cell Cycle Protein Expression in Neuroendocrine Tumors: Association of CDK4/CDK6, CCND1, and Phosphorylated Retinoblastoma Protein With Proliferative Index. Pancreas. 2017 Nov/Dec; 46(10):1347-1353.
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Tumor PDCD1LG2 (PD-L2) Expression and the Lymphocytic Reaction to Colorectal Cancer. Cancer Immunol Res. 2017 11; 5(11):1046-1055.
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Lymph node metastases in resected pancreatic ductal adenocarcinoma: predictors of disease recurrence and survival. Br J Cancer. 2017 Dec 05; 117(12):1874-1882.
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Tumor expression of calcium sensing receptor and colorectal cancer survival: Results from the nurses' health study and health professionals follow-up study. Int J Cancer. 2017 12 15; 141(12):2471-2479.
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Aspirin exerts high anti-cancer activity in PIK3CA-mutant colon cancer cells. Oncotarget. 2017 Oct 20; 8(50):87379-87389.
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Aspirin in the era of immunotherapy. Oncotarget. 2017 Sep 26; 8(43):73370-73371.
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Association Between Inflammatory Diet Pattern and Risk of Colorectal Carcinoma Subtypes Classified by Immune Responses to Tumor. Gastroenterology. 2017 12; 153(6):1517-1530.e14.
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The competing risks Cox model with auxiliary case covariates under weaker missing-at-random cause of failure. Lifetime Data Anal. 2018 07; 24(3):425-442.
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The role of intestinal bacteria in the development and progression of gastrointestinal tract neoplasms. Surg Oncol. 2017 Dec; 26(4):368-376.
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Tumor-associated macrophages and response to 5-fluorouracil adjuvant therapy in stage III colorectal cancer. Oncoimmunology. 2017; 6(12):e1342918.
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Calcium intake and risk of colorectal cancer according to expression status of calcium-sensing receptor (CASR). Gut. 2018 08; 67(8):1475-1483.
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Association of Dietary Patterns With Risk of Colorectal Cancer Subtypes Classified by Fusobacterium nucleatum in Tumor Tissue. JAMA Oncol. 2017 Jul 01; 3(7):921-927.
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Biomarker correlation network in colorectal carcinoma by tumor anatomic location. BMC Bioinformatics. 2017 Jun 17; 18(1):304.
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Predicted vitamin D status and colon cancer recurrence and mortality in CALGB 89803 (Alliance). Ann Oncol. 2017 Jun 01; 28(6):1359-1367.
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