Steven J. Mentzer, MD

Steven J. Mentzer, MD

Surgical Oncology

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Steven J. Mentzer, MD

Dr. Mentzer received his MD in 1981 from the University of Minnesota. He completed his general surgery training at Brigham and Women's Hospital and his cardiothoracic surgery fellowship at the University of Toronto. He also completed a research fellowship at DFCI, where he investigated the molecular mechanisms involved in the regulation of T lymphocyte function. He is board certified in general surgery, cardiothoracic surgery, and surgical critical care.



Professor of Surgery, Harvard Medical School

Clinical Interests

Esophageal cancer, Hyperhidrosis and neurogenic tumors, Lung and pleural cancer, Lung transplantation, Mediastinal tumors, Minimally invasive and robotic thoracic surgery

Board Certification

  • Surgery, 1989
  • Surgical Critical Care, 1994
  • Thoracic Surgery, 1991


  • Toronto General Hospital, Thoracic Surgery


  • Brigham and Women's Hospital, General Surgery

Medical School

  • University of Minnesota, Minneapolis School of Medicine


    Mechanisms of Lymphocyte Recirculation and Recruitment

    In the mammalian immune system, cell migration plays an important role in the host defense against a variety of antigenic challenges. Cell migration is the process that delivers lymphocytes to virally infected tissues, organ allografts, or growing tumors. Understanding the mechanism of lymphocyte homing to the site of antigen challenge offers the potential for regulating this process clinically. For example, it would be desirable to enhance lymphocyte migration into virally infected tissues and malignant tumors, but suppress lymphocyte migration into organ allografts.In recent years, attempts to define the mechanism of lymphocyte homing to the site of inflammation have focused on cell adhesion molecules. These molecules are expressed on the cell surface and appear to regulate the interaction of lymphocytes with the endothelial cells that line the vessel wall. Our approach was to study the function of these molecules under physiologic conditions both in vitro and in vivo. Using a video microscopy chamber to simulate flow conditions in the inflammatory microcirculation, we studied the contribution of these cell adhesion molecules to lymphocyte movement, adhesion, and locomotion. The regulation of lymphocyte migration can be clarified by selectively inhibiting or augmenting the function of these cell adhesion molecules.Cell migration to the site of antigen challenge is a process that involves not only lymphocytes and endothelial cells, but complex microhemodynamic forces as well. The forces at the vessel wall appear to be important determinants of whether cells exit the microcirculation or remain in the flow stream. For example, during lymphocytic inflammation, microhemodynamic forces can vary widely as the microcirculation undergoes dramatic structural adaptation. It is possible that these structural changes facilitate lymphocyte transmigration. To study the effect of microhemodynamic forces on lymphocyte migration, we tracked migrating lymphocytes from the efferent lymph to the antigen-stimulated microcirculation. Using fluorescence and dark-field intravital video microscopy, we directly observed the movements of cells in the microcirculation. Defining the molecular and physiologic mechanisms of lymphocyte migration into the inflammatory tissue has led to new approaches to the inhibition and augmentation of cell migration in vivo.


      • Vascularization of the adult mouse lung grafted onto the chick chorioallantoic membrane. Microvasc Res. 2024 Jan; 151:104596. View in: Pubmed

      • Stochastic simulations of self-organized elastogenesis in the developing lung. PLoS Comput Biol. 2023 06; 19(6):e1011219. View in: Pubmed

      • Geometric and network organization of visceral organ epithelium. Front Netw Physiol. 2023; 3:1144186. View in: Pubmed

      • Biomechanics of a Plant-Derived Sealant for Corneal Injuries. Transl Vis Sci Technol. 2023 05 01; 12(5):20. View in: Pubmed

      • Bioadhesive patch as a parenchymal sparing treatment of acute traumatic pulmonary air leaks. J Trauma Acute Care Surg. 2023 11 01; 95(5):679-684. View in: Pubmed

      • 3D stimulated Raman spectral imaging of water dynamics associated with pectin-glycocalyceal entanglement. Biomed Opt Express. 2023 Apr 01; 14(4):1460-1471. View in: Pubmed

      • Pectin based biologic Velcro effectively seals traumatic solid organ and small bowel injuries. J Trauma Acute Care Surg. 2023 07 01; 95(1):55-61. View in: Pubmed

      • Active Loading of Pectin Hydrogels for Targeted Drug Delivery. Polymers (Basel). 2022 Dec 26; 15(1). View in: Pubmed

      • Topography of pleural epithelial structure enabled by en face isolation and machine learning. J Cell Physiol. 2023 01; 238(1):274-284. View in: Pubmed

      • Inflammation and vascular remodeling in COVID-19 hearts. Angiogenesis. 2023 05; 26(2):233-248. View in: Pubmed

      • The fatal trajectory of pulmonary COVID-19 is driven by lobular ischemia and fibrotic remodelling. EBioMedicine. 2022 Nov; 85:104296. View in: Pubmed

      • Endothelialitis, Microischemia, and Intussusceptive Angiogenesis in COVID-19. Cold Spring Harb Perspect Med. 2022 10 03; 12(10). View in: Pubmed

      • Kinetics of Pectin Biopolymer Facial Erosion Characterized by Fluorescent Tracer Microfluidics. Polymers (Basel). 2022 Sep 19; 14(18). View in: Pubmed

      • Reply to Bush et al. and to Persson. Am J Respir Crit Care Med. 2022 07 15; 206(2):229-230. View in: Pubmed

      • Optical and Mechanical Properties of Self-Repairing Pectin Biopolymers. Polymers (Basel). 2022 Mar 26; 14(7). View in: Pubmed

      • Interstitial lung disease in infancy and early childhood: a clinicopathological primer. Eur Respir Rev. 2022 Mar 31; 31(163). View in: Pubmed

      • The Bronchial Circulation in COVID-19 Pneumonia. Am J Respir Crit Care Med. 2022 01 01; 205(1):121-125. View in: Pubmed

      • Noninvasive Method and Metric for Monitoring Lung Condition. Annu Int Conf IEEE Eng Med Biol Soc. 2021 11; 2021:6841-6844. View in: Pubmed

      • Functional Adhesion of Pectin Biopolymers to the Lung Visceral Pleura. Polymers (Basel). 2021 Sep 02; 13(17). View in: Pubmed

      • Biomaterial-Assisted Anastomotic Healing: Serosal Adhesion of Pectin Films. Polymers (Basel). 2021 Aug 21; 13(16). View in: Pubmed

      • COVID-19 is a systemic vascular hemopathy: insight for mechanistic and clinical aspects. Angiogenesis. 2021 11; 24(4):755-788. View in: Pubmed

      • Visualization of SARS-CoV-2 in the Lung. Reply. N Engl J Med. 2020 12 31; 383(27):2689-2690. View in: Pubmed

      • Outcomes of superior segmentectomy versus lower lobectomy for superior segment Stage I non-small-cell lung cancer are equivalent: An analysis of 196 patients at a single, high volume institution. J Surg Oncol. 2021 Feb; 123(2):570-578. View in: Pubmed

      • Adjuvant therapy following induction therapy and surgery improves survival in N2-positive non-small cell lung cancer. J Surg Oncol. 2021 Feb; 123(2):579-586. View in: Pubmed

      • Inflammation and intussusceptive angiogenesis in COVID-19: everything in and out of flow. Eur Respir J. 2020 11; 56(5). View in: Pubmed

      • Impact of Neoadjuvant Chemoradiation on Adverse Events After Bronchial Sleeve Resection. Ann Thorac Surg. 2021 09; 112(3):890-896. View in: Pubmed

      • Improved outcomes utilizing a novel pectin-based pleural sealant following acute lung injury. J Trauma Acute Care Surg. 2020 11; 89(5):915-919. View in: Pubmed

      • Mesopolysaccharides: The extracellular surface layer of visceral organs. PLoS One. 2020; 15(9):e0238798. View in: Pubmed

      • Pulmonary Vascular Pathology in Covid-19. Reply. N Engl J Med. 2020 08 27; 383(9):888-889. View in: Pubmed

      • Visualizing pectin polymer-polymer entanglement produced by interfacial water movement. Carbohydr Polym. 2020 Oct 15; 246:116618. View in: Pubmed

      • Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19. N Engl J Med. 2020 07 09; 383(2):120-128. View in: Pubmed

      • Water-Dependent Blending of Pectin Films: The Mechanics of Conjoined Biopolymers. Molecules. 2020 Apr 30; 25(9). View in: Pubmed

      • Single-Cell Transcriptional Profiling of Cells Derived From Regenerating Alveolar Ducts. Front Med (Lausanne). 2020; 7:112. View in: Pubmed

      • Morphomolecular motifs of pulmonary neoangiogenesis in interstitial lung diseases. Eur Respir J. 2020 03; 55(3). View in: Pubmed

      • Completion pneumonectomy is safe and effective in select patients with recurrent non-small cell lung cancer. J Thorac Dis. 2020 Mar; 12(3):217-222. View in: Pubmed

      • The Effect of Calcium on the Cohesive Strength and Flexural Properties of Low-Methoxyl Pectin Biopolymers. Molecules. 2019 Dec 24; 25(1). View in: Pubmed

      • Pectin biopolymer mechanics and microstructure associated with polysaccharide phase transitions. J Biomed Mater Res A. 2020 02; 108(2):246-253. View in: Pubmed

      • Analysis of pectin biopolymer phase states using acoustic emissions. Carbohydr Polym. 2020 Jan 01; 227:115282. View in: Pubmed

      • Why do myofibroblasts preferentially accumulate on the convex surface of the remodeling lung after pneumonectomy? J Theor Biol. 2019 10 21; 479:90-96. View in: Pubmed

      • Structural heteropolysaccharides as air-tight sealants of the human pleura. J Biomed Mater Res B Appl Biomater. 2019 04; 107(3):799-806. View in: Pubmed

      • Pressure-decay testing of pleural air leaks in intact murine lungs: evidence for peripheral airway regulation. Physiol Rep. 2018 05; 6(10):e13712. View in: Pubmed

      • Free-Floating Mesothelial Cells in Pleural Fluid After Lung Surgery. Front Med (Lausanne). 2018; 5:89. View in: Pubmed

      • The puzzling mechanism of compensatory lung growth. Stem Cell Investig. 2018; 5:8. View in: Pubmed

      • Functional Mechanics of a Pectin-Based Pleural Sealant after Lung Injury. Tissue Eng Part A. 2018 05; 24(9-10):695-702. View in: Pubmed

      • Pleural mechanics and the pathophysiology of air leaks. J Thorac Cardiovasc Surg. 2018 05; 155(5):2182-2189. View in: Pubmed

      • Structural and functional evidence for the scaffolding effect of alveolar blood vessels. Exp Lung Res. 2017 Nov - Dec; 43(9-10):337-346. View in: Pubmed

      • Pneumonectomy is safe and effective for non-small cell lung cancer following induction therapy. J Thorac Dis. 2017 Nov; 9(11):4447-4453. View in: Pubmed

      • Plexiform Vasculopathy in Chronic Thromboembolic Pulmonary Hypertension. Am J Respir Crit Care Med. 2017 10 15; 196(8):e48-e51. View in: Pubmed

      • Utility and reproducibility of 3-dimensional printed models in pre-operative planning of complex thoracic tumors. J Surg Oncol. 2017 Sep; 116(3):407-415. View in: Pubmed

      • Structural Heteropolysaccharide Adhesion to the Glycocalyx of Visceral Mesothelium. Tissue Eng Part A. 2018 02; 24(3-4):199-206. View in: Pubmed

      • Evidence for pleural epithelial-mesenchymal transition in murine compensatory lung growth. PLoS One. 2017; 12(5):e0177921. View in: Pubmed

      • Extracellular Assembly of the Elastin Cable Line Element in the Developing Lung. Anat Rec (Hoboken). 2017 Sep; 300(9):1670-1679. View in: Pubmed

      • Alveolar septal patterning during compensatory lung growth: Part II the effect of parenchymal pressure gradients. J Theor Biol. 2017 05 21; 421:168-178. View in: Pubmed

      • Effects of nintedanib on the microvascular architecture in a lung fibrosis model. Angiogenesis. 2017 Aug; 20(3):359-372. View in: Pubmed

      • Pulmonary microvascular architecture in hereditary haemorrhagic telangiectasia. Thorax. 2017 09; 72(9):861-863. View in: Pubmed

      • Deformation-induced transitional myofibroblasts contribute to compensatory lung growth. Am J Physiol Lung Cell Mol Physiol. 2017 Jan 01; 312(1):L79-L88. View in: Pubmed

      • Neoadjuvant irinotecan, cisplatin, and concurrent radiation therapy with celecoxib for patients with locally advanced esophageal cancer. BMC Cancer. 2016 07 13; 16:468. View in: Pubmed

      • Interstitial fluid flow of alveolar primary septa after pneumonectomy. J Theor Biol. 2016 07 07; 400:118-28. View in: Pubmed

      • Elastin Cables Define the Axial Connective Tissue System in the Murine Lung. Anat Rec (Hoboken). 2015 Nov; 298(11):1960-8. View in: Pubmed

      • Three-dimensional image analytical detection of intussusceptive pillars in murine lung. J Microsc. 2015 Dec; 260(3):326-37. View in: Pubmed

      • Remodeling of alveolar septa after murine pneumonectomy. Am J Physiol Lung Cell Mol Physiol. 2015 Jun 15; 308(12):L1237-44. View in: Pubmed

      • Laser microdissection of the alveolar duct enables single-cell genomic analysis. Front Oncol. 2014; 4:260. View in: Pubmed

      • Stretch-induced intussuceptive and sprouting angiogenesis in the chick chorioallantoic membrane. Microvasc Res. 2014 Sep; 95:60-7. View in: Pubmed

      • Intussusceptive angiogenesis: expansion and remodeling of microvascular networks. Angiogenesis. 2014 Jul; 17(3):499-509. View in: Pubmed

      • Relationship between margin distance and local recurrence among patients undergoing wedge resection for small (=2 cm) non-small cell lung cancer. J Thorac Cardiovasc Surg. 2014 Apr; 147(4):1169-75; discussion 1175-7. View in: Pubmed

      • Sprouting and intussusceptive angiogenesis in postpneumonectomy lung growth: mechanisms of alveolar neovascularization. Angiogenesis. 2014 Jul; 17(3):541-51. View in: Pubmed

      • Mapping cyclic stretch in the postpneumonectomy murine lung. J Appl Physiol (1985). 2013 Nov 01; 115(9):1370-8. View in: Pubmed

      • Effect of unilateral diaphragmatic paralysis on postpneumonectomy lung growth. Am J Physiol Lung Cell Mol Physiol. 2013 Sep 15; 305(6):L439-45. View in: Pubmed

      • Postoperative antibacterial prophylaxis for the prevention of infectious complications associated with tube thoracostomy in patients undergoing elective general thoracic surgery: a double-blind, placebo-controlled, randomized trial. JAMA Surg. 2013 May; 148(5):440-6. View in: Pubmed

      • Alveolar epithelial dynamics in postpneumonectomy lung growth. Anat Rec (Hoboken). 2013 Mar; 296(3):495-503. View in: Pubmed

      • Intussusceptive remodeling of vascular branch angles in chemically-induced murine colitis. Microvasc Res. 2013 May; 87:75-82. View in: Pubmed

      • Migration of CD11b+ accessory cells during murine lung regeneration. Stem Cell Res. 2013 May; 10(3):267-77. View in: Pubmed

      • Detection of murine post-pneumonectomy lung regeneration by 18FDG PET imaging. EJNMMI Res. 2012 Sep 21; 2(1):48. View in: Pubmed

      • Computational analysis of lung deformation after murine pneumonectomy. [corrected]. Comput Methods Biomech Biomed Engin. 2014; 17(8):838-44. View in: Pubmed

      • Alveolar macrophage dynamics in murine lung regeneration. J Cell Physiol. 2012 Sep; 227(9):3208-15. View in: Pubmed

      • Mechanostructural adaptations preceding postpneumonectomy lung growth. Exp Lung Res. 2012 Oct; 38(8):396-405. View in: Pubmed

      • Evidence for adult lung growth in humans. N Engl J Med. 2012 Jul 19; 367(3):244-7. View in: Pubmed

      • Cross-circulation and cell distribution kinetics in parabiotic mice. J Cell Physiol. 2012 Feb; 227(2):821-8. View in: Pubmed

      • Lobectomy versus sublobar resection for small (2 cm or less) non-small cell lung cancers. Ann Thorac Surg. 2011 Nov; 92(5):1819-23; discussion 1824-5. View in: Pubmed

      • Spatial dependence of alveolar angiogenesis in post-pneumonectomy lung growth. Angiogenesis. 2012 Mar; 15(1):23-32. View in: Pubmed

      • A morphometric study of mechanotransductively induced dermal neovascularization. Plast Reconstr Surg. 2011 Oct; 128(4):288e-299e. View in: Pubmed

      • CD34+ progenitor to endothelial cell transition in post-pneumonectomy angiogenesis. Am J Respir Cell Mol Biol. 2012 Mar; 46(3):283-9. View in: Pubmed

      • A framework for analytical characterization of monoclonal antibodies based on reactivity profiles in different tissues. Bioinformatics. 2011 Oct 01; 27(19):2746-53. View in: Pubmed

      • Angiogenesis gene expression in murine endothelial cells during post-pneumonectomy lung growth. Respir Res. 2011 Jul 27; 12:98. View in: Pubmed

      • Dynamic determination of oxygenation and lung compliance in murine pneumonectomy. Exp Lung Res. 2011 Jun; 37(5):301-9. View in: Pubmed

      • Intravascular pillars and pruning in the extraembryonic vessels of chick embryos. Dev Dyn. 2011 Jun; 240(6):1335-43. View in: Pubmed

      • Angiogenesis in wounds treated by microdeformational wound therapy. Ann Surg. 2011 Feb; 253(2):402-9. View in: Pubmed

      • Blood flow shapes intravascular pillar geometry in the chick chorioallantoic membrane. J Angiogenes Res. 2010 Jul 07; 2:11. View in: Pubmed

      • Inflammation-induced intussusceptive angiogenesis in murine colitis. Anat Rec (Hoboken). 2010 May; 293(5):849-57. View in: Pubmed

      • Outcomes of patients with stage III nonsmall cell lung cancer treated with chemotherapy and radiation with and without surgery. Cancer. 2009 Sep 15; 115(18):4156-66. View in: Pubmed

      • Hierarchical clustering of monoclonal antibody reactivity patterns in nonhuman species. Cytometry A. 2009 Sep; 75(9):734-42. View in: Pubmed

      • Computational flow dynamics in a geometric model of intussusceptive angiogenesis. Microvasc Res. 2009 Dec; 78(3):286-93. View in: Pubmed

      • Blood flow patterns spatially associated with platelet aggregates in murine colitis. Anat Rec (Hoboken). 2009 Aug; 292(8):1143-53. View in: Pubmed

      • The role of extrapleural pneumonectomy in the management of pleural cancers. J Clin Oncol. 2009 May 20; 27(15_suppl):7577. View in: Pubmed

      • Vascular microarchitecture of murine colitis-associated lymphoid angiogenesis. Anat Rec (Hoboken). 2009 May; 292(5):621-32. View in: Pubmed

      • Spatial calibration of structured illumination fluorescence microscopy using capillary tissue phantoms. Microsc Res Tech. 2009 Feb; 72(2):85-92. View in: Pubmed

      • Bimodal oscillation frequencies of blood flow in the inflammatory colon microcirculation. Anat Rec (Hoboken). 2009 Jan; 292(1):65-72. View in: Pubmed

      • Effect of intraluminal pillars on particle motion in bifurcated microchannels. In Vitro Cell Dev Biol Anim. 2008 Nov-Dec; 44(10):426-33. View in: Pubmed

      • Pneumonectomy after chemoradiation: the Dana-Farber Cancer Institute/Brigham and Women's Hospital experience. Cancer. 2008 Mar 01; 112(5):1106-13. View in: Pubmed

      • Bridging mucosal vessels associated with rhythmically oscillating blood flow in murine colitis. Anat Rec (Hoboken). 2008 Jan; 291(1):74-82. View in: Pubmed

      • Unresectable adenoid cystic carcinoma of the trachea treated with chemoradiation. J Clin Oncol. 2007 Dec 01; 25(34):5521-3. View in: Pubmed

      • Tensile forces stimulate vascular remodeling and epidermal cell proliferation in living skin. Ann Surg. 2007 Nov; 246(5):896-902. View in: Pubmed

      • Interactions of blood cell constituents: experimental investigation and computational modeling by discrete particle dynamics algorithm. Microvasc Res. 2008 Mar; 75(2):279-84. View in: Pubmed

      • Biological and optical properties of fluorescent nanoparticles developed for intravascular imaging. Microsc Res Tech. 2007 Sep; 70(9):776-81. View in: Pubmed

      • Osteomalacia associated with a fibroblast growth factor-23 secreting chest wall tumor. J Thorac Cardiovasc Surg. 2007 Sep; 134(3):803-5. View in: Pubmed

      • Factors predicting poor survival after resection of stage IA non-small cell lung cancer. J Thorac Cardiovasc Surg. 2007 Oct; 134(4):850-6. View in: Pubmed

      • Murine microvideo endoscopy of the colonic microcirculation. J Surg Res. 2007 Sep; 142(1):97-103. View in: Pubmed

      • Sources of graft restriction after single lung transplantation for emphysema. J Thorac Cardiovasc Surg. 2007 Jul; 134(1):204-9. View in: Pubmed

      • Insulin receptor activation in solitary fibrous tumours. J Pathol. 2007 Apr; 211(5):550-554. View in: Pubmed

      • Modified T-tube repair of delayed esophageal perforation results in a low mortality rate similar to that seen with acute perforations. Ann Thorac Surg. 2007 Mar; 83(3):1129-33. View in: Pubmed

      • The murine bronchopulmonary microcirculation in hapten-induced inflammation. J Thorac Cardiovasc Surg. 2007 Jan; 133(1):97-103. View in: Pubmed

      • Optimizing the selection of surgical candidates for lung volume reduction surgery. Semin Thorac Cardiovasc Surg. 2007; 19(2):151-6. View in: Pubmed

      • Inflammation-responsive focal constrictors in the mouse ear microcirculation. J Anat. 2006 Dec; 209(6):807-16. View in: Pubmed

      • A phase 1/2 trial of arginine butyrate and ganciclovir in patients with Epstein-Barr virus-associated lymphoid malignancies. Blood. 2007 Mar 15; 109(6):2571-8. View in: Pubmed

      • Structural adaptations in the murine colon microcirculation associated with hapten-induced inflammation. Gut. 2007 Apr; 56(4):518-23. View in: Pubmed

      • Multiframe particle tracking in intravital imaging: defining Lagrangian coordinates in the microcirculation. Biotechniques. 2006 Nov; 41(5):597-601. View in: Pubmed

      • Multi-image particle tracking velocimetry of the microcirculation using fluorescent nanoparticles. Microvasc Res. 2006 Jul-Sep; 72(1-2):27-33. View in: Pubmed

      • Feature-guided clustering of multi-dimensional flow cytometry datasets. J Biomed Inform. 2007 Jun; 40(3):325-31. View in: Pubmed

      • Phase I/II trial of Arginine Butyrate and ganciclovir in Epstein-Barr virus-associated lymphoid malignancies. J Clin Oncol. 2006 Jun 20; 24(18_suppl):7542. View in: Pubmed

      • Structural mapping of immunoglobulin subclasses using multiplexed bead flow cytometry. Hybridoma (Larchmt). 2006 Jun; 25(3):133-8. View in: Pubmed

      • Melittin-induced membrane permeability: a nonosmotic mechanism of cell death. In Vitro Cell Dev Biol Anim. 2005 Nov-Dec; 41(10):349-55. View in: Pubmed

      • Vessel painting of the microcirculation using fluorescent lipophilic tracers. Microvasc Res. 2005 Jul; 70(1-2):90-6. View in: Pubmed

      • Respiratory impedance following bronchoscopic or surgical lung volume reduction for emphysema. Respiration. 2005 Jul-Aug; 72(4):406-17. View in: Pubmed

      • Lung resection in patients with preoperative FEV1 < 35% predicted. Chest. 2005 Jun; 127(6):1984-90. View in: Pubmed

      • Surgical palliative care in thoracic diseases. Surg Clin North Am. 2005 Apr; 85(2):315-28. View in: Pubmed

      • High risk of brain metastases in surgically staged IIIA non-small-cell lung cancer patients treated with surgery, chemotherapy, and radiation. J Clin Oncol. 2005 Mar 01; 23(7):1530-7. View in: Pubmed

      • Prevention, early detection, and management of complications after 328 consecutive extrapleural pneumonectomies. J Thorac Cardiovasc Surg. 2004 Jul; 128(1):138-46. View in: Pubmed

      • Relationship between a history of antecedent cancer and the probability of malignancy for a solitary pulmonary nodule. Chest. 2004 Jun; 125(6):2175-81. View in: Pubmed

      • Vaccination with irradiated, autologous melanoma cells engineered to secrete granulocyte-macrophage colony-stimulating factor by adenoviral-mediated gene transfer augments antitumor immunity in patients with metastatic melanoma. J Clin Oncol. 2003 Sep 01; 21(17):3343-50. View in: Pubmed

      • Microangiectasias: structural regulators of lymphocyte transmigration. Proc Natl Acad Sci U S A. 2003 Jun 10; 100(12):7231-4. View in: Pubmed

      • Ambulatory monitoring of cumulative free-living activity. IEEE Eng Med Biol Mag. 2003 May-Jun; 22(3):89-95. View in: Pubmed

      • The role of muscle flaps in pulmonary aspergillosis. Plast Reconstr Surg. 2003 Mar; 111(3):1147-50. View in: Pubmed

      • Vaccination with irradiated autologous tumor cells engineered to secrete granulocyte-macrophage colony-stimulating factor augments antitumor immunity in some patients with metastatic non-small-cell lung carcinoma. J Clin Oncol. 2003 Feb 15; 21(4):624-30. View in: Pubmed

      • Visual representation of cell subpopulation from flow cytometry data. AMIA Annu Symp Proc. 2003; 893. View in: Pubmed

      • Dynamic deformation of migratory efferent lymph-derived cells "trapped" in the inflammatory microcirculation. J Cell Physiol. 2003 Jan; 194(1):54-62. View in: Pubmed

      • Spatial variation of plasma flow in the oxazolone-stimulated microcirculation. Inflamm Res. 2002 Dec; 51(12):572-8. View in: Pubmed

      • Physiological characterization of variability in response to lung volume reduction surgery. J Appl Physiol (1985). 2003 Jan; 94(1):20-30. View in: Pubmed

      • Stimulation of regional lymphatic and blood flow by epicutaneous oxazolone. J Appl Physiol (1985). 2002 Sep; 93(3):966-73. View in: Pubmed

      • Outcomes and cost-effectiveness of alternative staging strategies for non-small-cell lung cancer. J Clin Oncol. 2002 Jan 01; 20(1):263-73. View in: Pubmed

      • Using a neural network with flow cytometry histograms to recognize cell surface protein binding patterns. Proc AMIA Symp. 2002; 380-4. View in: Pubmed

      • Biochemical changes in the efferent lymph plasma after oxazolone stimulation. Dev Comp Immunol. 2002 Jan; 26(1):111-9. View in: Pubmed

      • Matching of flow-cytometry histograms using information theory in feature space. Proc AMIA Symp. 2002; 929-33. View in: Pubmed

      • Transthoracic esophagectomy with radical mediastinal and abdominal lymph node dissection and cervical esophagogastrostomy for esophageal carcinoma. Ann Thorac Surg. 2001 Dec; 72(6):1918-24; discussion 1924-5. View in: Pubmed

      • Focal topographic changes in inflammatory microcirculation associated with lymphocyte slowing and transmigration. Am J Physiol Heart Circ Physiol. 2001 Oct; 281(4):H1742-50. View in: Pubmed

      • Effect of shear stress on efferent lymph-derived lymphocytes in contact with activated endothelial monolayers. In Vitro Cell Dev Biol Anim. 2001 Oct; 37(9):599-605. View in: Pubmed

      • Combined antegrade and retrograde dilation: a new endoscopic technique in the management of complex esophageal obstruction. Gastrointest Endosc. 2001 Sep; 54(3):368-72. View in: Pubmed

      • Epstein--Barr virus post-transplant lymphoproliferative disease and virus-specific therapy: pharmacological re-activation of viral target genes with arginine butyrate. Transpl Infect Dis. 2001 Sep; 3(3):177-85. View in: Pubmed

      • Induction of the Epstein-Barr virus thymidine kinase gene with concomitant nucleoside antivirals as a therapeutic strategy for Epstein-Barr virus-associated malignancies. Curr Opin Oncol. 2001 Sep; 13(5):360-7. View in: Pubmed

      • Biphasic response of the regional lymphatics in the normal lymphocyte transfer reaction. Transplantation. 2001 Aug 15; 72(3):516-22. View in: Pubmed

      • Bronchoscopic volume reduction: a safe and effective alternative to surgical therapy for emphysema. Am J Respir Crit Care Med. 2001 Jul 15; 164(2):295-301. View in: Pubmed

      • Cell adhesion molecule expression in the sheep thymus. Dev Comp Immunol. 2001 Jun-Jul; 25(5-6):519-30. View in: Pubmed

      • Cytolytic peptides induce biphasic permeability changes in mammalian cell membranes. J Immunol Methods. 2001 Jun 01; 252(1-2):63-71. View in: Pubmed

      • Inspiratory lung impedance in COPD: effects of PEEP and immediate impact of lung volume reduction surgery. J Appl Physiol (1985). 2001 May; 90(5):1833-41. View in: Pubmed

      • Sequential thoracic metastasectomy prolongs survival by re-establishing local control within the chest. J Thorac Cardiovasc Surg. 2001 Apr; 121(4):657-67. View in: Pubmed

      • Aldehyde fixation of thiol-reactive fluorescent cytoplasmic probes for tracking cell migration. J Histochem Cytochem. 2001 Apr; 49(4):511-8. View in: Pubmed

      • Comparison of physiological and radiological screening for lung volume reduction surgery. Am J Respir Crit Care Med. 2001 Apr; 163(5):1068-73. View in: Pubmed

      • Interpreting improvement in expiratory flows after lung volume reduction surgery in terms of flow limitation theory. Am J Respir Crit Care Med. 2001 Apr; 163(5):1074-80. View in: Pubmed

      • Stochastic regulation of cell migration from the efferent lymph to oxazolone-stimulated skin. J Immunol. 2001 Feb 01; 166(3):1517-23. View in: Pubmed

      • Molecular identification using flow cytometry histograms and information theory. Proc AMIA Symp. 2001; 776-80. View in: Pubmed

      • Bronchioloalveolar carcinoma of the lung: recurrences and survival in patients with stage I disease. J Thorac Cardiovasc Surg. 2001 Jan; 121(1):42-7. View in: Pubmed

      • Nodal stage after induction therapy for stage IIIA lung cancer determines patient survival. Ann Thorac Surg. 2000 Dec; 70(6):1826-31. View in: Pubmed

      • Angiocentric recruitment of lymphocytes into the lung after the intrabronchial instillation of antigen. Exp Lung Res. 2000 Mar; 26(2):89-103. View in: Pubmed

      • Generation of sheep X (sheep X mouse) heterohybridoma cell line expressing the beta-1 integrin membrane molecule. Hybridoma. 2000 Feb; 19(1):81-7. View in: Pubmed

      • Surveillance transbronchial lung biopsies: implication for survival after lung transplantation. J Thorac Cardiovasc Surg. 2000 Jan; 119(1):27-37. View in: Pubmed

      • Dendritic cells in the pathophysiology of sarcoidal reactions. In Vivo. 2000 Jan-Feb; 14(1):209-12. View in: Pubmed

      • Treatment of patients with lung cancer and severe emphysema. Chest. 1999 Dec; 116(6 Suppl):477S-479S. View in: Pubmed

      • Management of the solitary pulmonary nodule: role of thoracoscopy in diagnosis and therapy. Chest. 1999 Dec; 116(6 Suppl):523S-524S. View in: Pubmed

      • New surgical options for elderly lung cancer patients. Chest. 1999 Dec; 116(6 Suppl):480S-485S. View in: Pubmed

      • Causes of allograft dysfunction after single lung transplantation for emphysema: extrinsic restriction versus intrinsic obstruction. Brigham and Women's Hospital Lung Transplantation Group. J Heart Lung Transplant. 1999 Oct; 18(10):986-93. View in: Pubmed

      • Pretreatment staging by endoscopic ultrasonography does not predict complete response to neoadjuvant chemoradiation in patients with esophageal carcinoma. Cancer. 1999 Sep 01; 86(5):764-9. View in: Pubmed

      • Model of functional restriction in chronic obstructive pulmonary disease, transplantation, and lung reduction surgery. Am J Respir Crit Care Med. 1999 Sep; 160(3):821-8. View in: Pubmed

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      75 Francis Street Boston, MA 02215
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