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Steven J. Mentzer, MD


Surgical Oncology

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Physician

  • Professor of Surgery, Harvard Medical School

Clinical Interests

  • Esophageal cancer
  • Hyperhidrosis and neurogenic tumors
  • Lung and pleural cancer
  • Lung transplantation
  • Mediastinal tumors
  • Minimally invasive and robotic thoracic surgery

Contact Information

  • Office Phone Number617-732-6703
  • Fax617-730-2898

Bio

Dr. Mentzer received his MD in 1981 from the University of Minnesota. He completed his general surgery training at Brigham and Women's Hospital and his cardiothoracic surgery fellowship at the University of Toronto. He also completed a research fellowship at DFCI, where he investigated the molecular mechanisms involved in the regulation of T lymphocyte function. He is board certified in general surgery, cardiothoracic surgery, and surgical critical care.

Board Certification:

  • Surgery, 1989
  • Surgical Critical Care, 1994
  • Thoracic Surgery, 1991

Fellowship:

  • Toronto General Hospital, Thoracic Surgery

Residency:

  • Brigham and Women's Hospital, General Surgery

Medical School:

  • University of Minnesota, Minneapolis School of Medicine

Research

Mechanisms of Lymphocyte Recirculation and Recruitment

In the mammalian immune system, cell migration plays an important role in the host defense against a variety of antigenic challenges. Cell migration is the process that delivers lymphocytes to virally infected tissues, organ allografts, or growing tumors. Understanding the mechanism of lymphocyte homing to the site of antigen challenge offers the potential for regulating this process clinically. For example, it would be desirable to enhance lymphocyte migration into virally infected tissues and malignant tumors, but suppress lymphocyte migration into organ allografts.In recent years, attempts to define the mechanism of lymphocyte homing to the site of inflammation have focused on cell adhesion molecules. These molecules are expressed on the cell surface and appear to regulate the interaction of lymphocytes with the endothelial cells that line the vessel wall. Our approach was to study the function of these molecules under physiologic conditions both in vitro and in vivo. Using a video microscopy chamber to simulate flow conditions in the inflammatory microcirculation, we studied the contribution of these cell adhesion molecules to lymphocyte movement, adhesion, and locomotion. The regulation of lymphocyte migration can be clarified by selectively inhibiting or augmenting the function of these cell adhesion molecules.Cell migration to the site of antigen challenge is a process that involves not only lymphocytes and endothelial cells, but complex microhemodynamic forces as well. The forces at the vessel wall appear to be important determinants of whether cells exit the microcirculation or remain in the flow stream. For example, during lymphocytic inflammation, microhemodynamic forces can vary widely as the microcirculation undergoes dramatic structural adaptation. It is possible that these structural changes facilitate lymphocyte transmigration. To study the effect of microhemodynamic forces on lymphocyte migration, we tracked migrating lymphocytes from the efferent lymph to the antigen-stimulated microcirculation. Using fluorescence and dark-field intravital video microscopy, we directly observed the movements of cells in the microcirculation. Defining the molecular and physiologic mechanisms of lymphocyte migration into the inflammatory tissue has led to new approaches to the inhibition and augmentation of cell migration in vivo.

Biomaterial-Assisted Anastomotic Healing: Serosal Adhesion of Pectin Films. Polymers (Basel). 2021 Aug 21; 13(16).
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COVID-19 is a systemic vascular hemopathy: insight for mechanistic and clinical aspects. Angiogenesis. 2021 Jun 28.
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Visualization of SARS-CoV-2 in the Lung. Reply. N Engl J Med. 2020 12 31; 383(27):2689-2690.
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Outcomes of superior segmentectomy versus lower lobectomy for superior segment Stage I non-small-cell lung cancer are equivalent: An analysis of 196 patients at a single, high volume institution. J Surg Oncol. 2021 Feb; 123(2):570-578.
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Adjuvant therapy following induction therapy and surgery improves survival in N2-positive non-small cell lung cancer. J Surg Oncol. 2021 Feb; 123(2):579-586.
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Inflammation and intussusceptive angiogenesis in COVID-19: everything in and out of flow. Eur Respir J. 2020 11; 56(5).
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Impact of Neoadjuvant Chemoradiation on Adverse Events After Bronchial Sleeve Resection. Ann Thorac Surg. 2021 Sep; 112(3):890-896.
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Improved outcomes utilizing a novel pectin-based pleural sealant following acute lung injury. J Trauma Acute Care Surg. 2020 11; 89(5):915-919.
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Mesopolysaccharides: The extracellular surface layer of visceral organs. PLoS One. 2020; 15(9):e0238798.
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Pulmonary Vascular Pathology in Covid-19. Reply. N Engl J Med. 2020 08 27; 383(9):888-889.
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Visualizing pectin polymer-polymer entanglement produced by interfacial water movement. Carbohydr Polym. 2020 Oct 15; 246:116618.
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Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19. N Engl J Med. 2020 07 09; 383(2):120-128.
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Water-Dependent Blending of Pectin Films: The Mechanics of Conjoined Biopolymers. Molecules. 2020 Apr 30; 25(9).
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Single-Cell Transcriptional Profiling of Cells Derived From Regenerating Alveolar Ducts. Front Med (Lausanne). 2020; 7:112.
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Morphomolecular motifs of pulmonary neoangiogenesis in interstitial lung diseases. Eur Respir J. 2020 03; 55(3).
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Completion pneumonectomy is safe and effective in select patients with recurrent non-small cell lung cancer. J Thorac Dis. 2020 Mar; 12(3):217-222.
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The Effect of Calcium on the Cohesive Strength and Flexural Properties of Low-Methoxyl Pectin Biopolymers. Molecules. 2019 Dec 24; 25(1).
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Pectin biopolymer mechanics and microstructure associated with polysaccharide phase transitions. J Biomed Mater Res A. 2020 02; 108(2):246-253.
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Analysis of pectin biopolymer phase states using acoustic emissions. Carbohydr Polym. 2020 Jan 01; 227:115282.
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Why do myofibroblasts preferentially accumulate on the convex surface of the remodeling lung after pneumonectomy? J Theor Biol. 2019 10 21; 479:90-96.
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Structural heteropolysaccharides as air-tight sealants of the human pleura. . 2019 04; 107(3):799-806.
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Pressure-decay testing of pleural air leaks in intact murine lungs: evidence for peripheral airway regulation. Physiol Rep. 2018 05; 6(10):e13712.
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Free-Floating Mesothelial Cells in Pleural Fluid After Lung Surgery. Front Med (Lausanne). 2018; 5:89.
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The puzzling mechanism of compensatory lung growth. Stem Cell Investig. 2018; 5:8.
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Functional Mechanics of a Pectin-Based Pleural Sealant after Lung Injury. Tissue Eng Part A. 2018 05; 24(9-10):695-702.
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Pleural mechanics and the pathophysiology of air leaks. J Thorac Cardiovasc Surg. 2018 05; 155(5):2182-2189.
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Structural and functional evidence for the scaffolding effect of alveolar blood vessels. Exp Lung Res. 2017 Nov - Dec; 43(9-10):337-346.
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Pneumonectomy is safe and effective for non-small cell lung cancer following induction therapy. J Thorac Dis. 2017 Nov; 9(11):4447-4453.
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Plexiform Vasculopathy in Chronic Thromboembolic Pulmonary Hypertension. Am J Respir Crit Care Med. 2017 10 15; 196(8):e48-e51.
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Utility and reproducibility of 3-dimensional printed models in pre-operative planning of complex thoracic tumors. J Surg Oncol. 2017 Sep; 116(3):407-415.
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Structural Heteropolysaccharide Adhesion to the Glycocalyx of Visceral Mesothelium. Tissue Eng Part A. 2018 02; 24(3-4):199-206.
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Evidence for pleural epithelial-mesenchymal transition in murine compensatory lung growth. PLoS One. 2017; 12(5):e0177921.
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Extracellular Assembly of the Elastin Cable Line Element in the Developing Lung. Anat Rec (Hoboken). 2017 Sep; 300(9):1670-1679.
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Alveolar septal patterning during compensatory lung growth: Part II the effect of parenchymal pressure gradients. J Theor Biol. 2017 05 21; 421:168-178.
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Effects of nintedanib on the microvascular architecture in a lung fibrosis model. Angiogenesis. 2017 Aug; 20(3):359-372.
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Pulmonary microvascular architecture in hereditary haemorrhagic telangiectasia. Thorax. 2017 09; 72(9):861-863.
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Deformation-induced transitional myofibroblasts contribute to compensatory lung growth. . 2017 Jan 01; 312(1):L79-L88.
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Neoadjuvant irinotecan, cisplatin, and concurrent radiation therapy with celecoxib for patients with locally advanced esophageal cancer. BMC Cancer. 2016 07 13; 16:468.
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Interstitial fluid flow of alveolar primary septa after pneumonectomy. J Theor Biol. 2016 07 07; 400:118-28.
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Elastin Cables Define the Axial Connective Tissue System in the Murine Lung. Anat Rec (Hoboken). 2015 Nov; 298(11):1960-8.
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Three-dimensional image analytical detection of intussusceptive pillars in murine lung. J Microsc. 2015 Dec; 260(3):326-37.
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Remodeling of alveolar septa after murine pneumonectomy. . 2015 Jun 15; 308(12):L1237-44.
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Laser microdissection of the alveolar duct enables single-cell genomic analysis. Front Oncol. 2014; 4:260.
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Stretch-induced intussuceptive and sprouting angiogenesis in the chick chorioallantoic membrane. Microvasc Res. 2014 Sep; 95:60-7.
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Intussusceptive angiogenesis: expansion and remodeling of microvascular networks. Angiogenesis. 2014 Jul; 17(3):499-509.
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Relationship between margin distance and local recurrence among patients undergoing wedge resection for small (=2 cm) non-small cell lung cancer. J Thorac Cardiovasc Surg. 2014 Apr; 147(4):1169-75; discussion 1175-7.
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Sprouting and intussusceptive angiogenesis in postpneumonectomy lung growth: mechanisms of alveolar neovascularization. Angiogenesis. 2014 Jul; 17(3):541-51.
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Mapping cyclic stretch in the postpneumonectomy murine lung. J Appl Physiol (1985). 2013 Nov 01; 115(9):1370-8.
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Effect of unilateral diaphragmatic paralysis on postpneumonectomy lung growth. . 2013 Sep 15; 305(6):L439-45.
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Postoperative antibacterial prophylaxis for the prevention of infectious complications associated with tube thoracostomy in patients undergoing elective general thoracic surgery: a double-blind, placebo-controlled, randomized trial. JAMA Surg. 2013 May; 148(5):440-6.
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Alveolar epithelial dynamics in postpneumonectomy lung growth. Anat Rec (Hoboken). 2013 Mar; 296(3):495-503.
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Intussusceptive remodeling of vascular branch angles in chemically-induced murine colitis. Microvasc Res. 2013 May; 87:75-82.
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Migration of CD11b+ accessory cells during murine lung regeneration. Stem Cell Res. 2013 May; 10(3):267-77.
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Detection of murine post-pneumonectomy lung regeneration by 18FDG PET imaging. EJNMMI Res. 2012 Sep 21; 2(1):48.
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Computational analysis of lung deformation after murine pneumonectomy. [corrected]. Comput Methods Biomech Biomed Engin. 2014; 17(8):838-44.
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Alveolar macrophage dynamics in murine lung regeneration. J Cell Physiol. 2012 Sep; 227(9):3208-15.
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Mechanostructural adaptations preceding postpneumonectomy lung growth. Exp Lung Res. 2012 Oct; 38(8):396-405.
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Evidence for adult lung growth in humans. N Engl J Med. 2012 Jul 19; 367(3):244-7.
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Cross-circulation and cell distribution kinetics in parabiotic mice. J Cell Physiol. 2012 Feb; 227(2):821-8.
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Lobectomy versus sublobar resection for small (2 cm or less) non-small cell lung cancers. Ann Thorac Surg. 2011 Nov; 92(5):1819-23; discussion 1824-5.
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Spatial dependence of alveolar angiogenesis in post-pneumonectomy lung growth. Angiogenesis. 2012 Mar; 15(1):23-32.
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A morphometric study of mechanotransductively induced dermal neovascularization. Plast Reconstr Surg. 2011 Oct; 128(4):288e-299e.
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CD34+ progenitor to endothelial cell transition in post-pneumonectomy angiogenesis. Am J Respir Cell Mol Biol. 2012 Mar; 46(3):283-9.
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A framework for analytical characterization of monoclonal antibodies based on reactivity profiles in different tissues. Bioinformatics. 2011 Oct 01; 27(19):2746-53.
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Angiogenesis gene expression in murine endothelial cells during post-pneumonectomy lung growth. Respir Res. 2011 Jul 27; 12:98.
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Dynamic determination of oxygenation and lung compliance in murine pneumonectomy. Exp Lung Res. 2011 Jun; 37(5):301-9.
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Intravascular pillars and pruning in the extraembryonic vessels of chick embryos. Dev Dyn. 2011 Jun; 240(6):1335-43.
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Angiogenesis in wounds treated by microdeformational wound therapy. Ann Surg. 2011 Feb; 253(2):402-9.
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Blood flow shapes intravascular pillar geometry in the chick chorioallantoic membrane. J Angiogenes Res. 2010 Jul 07; 2:11.
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Inflammation-induced intussusceptive angiogenesis in murine colitis. Anat Rec (Hoboken). 2010 May; 293(5):849-57.
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Outcomes of patients with stage III nonsmall cell lung cancer treated with chemotherapy and radiation with and without surgery. Cancer. 2009 Sep 15; 115(18):4156-66.
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Hierarchical clustering of monoclonal antibody reactivity patterns in nonhuman species. Cytometry A. 2009 Sep; 75(9):734-42.
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Computational flow dynamics in a geometric model of intussusceptive angiogenesis. Microvasc Res. 2009 Dec; 78(3):286-93.
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Blood flow patterns spatially associated with platelet aggregates in murine colitis. Anat Rec (Hoboken). 2009 Aug; 292(8):1143-53.
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The role of extrapleural pneumonectomy in the management of pleural cancers. J Clin Oncol. 2009 May 20; 27(15_suppl):7577.
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Vascular microarchitecture of murine colitis-associated lymphoid angiogenesis. Anat Rec (Hoboken). 2009 May; 292(5):621-32.
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Spatial calibration of structured illumination fluorescence microscopy using capillary tissue phantoms. Microsc Res Tech. 2009 Feb; 72(2):85-92.
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Bimodal oscillation frequencies of blood flow in the inflammatory colon microcirculation. Anat Rec (Hoboken). 2009 Jan; 292(1):65-72.
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Effect of intraluminal pillars on particle motion in bifurcated microchannels. In Vitro Cell Dev Biol Anim. 2008 Nov-Dec; 44(10):426-33.
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Pneumonectomy after chemoradiation: the Dana-Farber Cancer Institute/Brigham and Women's Hospital experience. Cancer. 2008 Mar 01; 112(5):1106-13.
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Bridging mucosal vessels associated with rhythmically oscillating blood flow in murine colitis. Anat Rec (Hoboken). 2008 Jan; 291(1):74-82.
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Unresectable adenoid cystic carcinoma of the trachea treated with chemoradiation. J Clin Oncol. 2007 Dec 01; 25(34):5521-3.
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Tensile forces stimulate vascular remodeling and epidermal cell proliferation in living skin. Ann Surg. 2007 Nov; 246(5):896-902.
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Interactions of blood cell constituents: experimental investigation and computational modeling by discrete particle dynamics algorithm. Microvasc Res. 2008 Mar; 75(2):279-84.
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Biological and optical properties of fluorescent nanoparticles developed for intravascular imaging. Microsc Res Tech. 2007 Sep; 70(9):776-81.
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Osteomalacia associated with a fibroblast growth factor-23 secreting chest wall tumor. J Thorac Cardiovasc Surg. 2007 Sep; 134(3):803-5.
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Factors predicting poor survival after resection of stage IA non-small cell lung cancer. J Thorac Cardiovasc Surg. 2007 Oct; 134(4):850-6.
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Murine microvideo endoscopy of the colonic microcirculation. J Surg Res. 2007 Sep; 142(1):97-103.
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Sources of graft restriction after single lung transplantation for emphysema. J Thorac Cardiovasc Surg. 2007 Jul; 134(1):204-9.
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Insulin receptor activation in solitary fibrous tumours. J Pathol. 2007 Apr; 211(5):550-554.
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Modified T-tube repair of delayed esophageal perforation results in a low mortality rate similar to that seen with acute perforations. Ann Thorac Surg. 2007 Mar; 83(3):1129-33.
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The murine bronchopulmonary microcirculation in hapten-induced inflammation. J Thorac Cardiovasc Surg. 2007 Jan; 133(1):97-103.
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Optimizing the selection of surgical candidates for lung volume reduction surgery. Semin Thorac Cardiovasc Surg. 2007; 19(2):151-6.
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Inflammation-responsive focal constrictors in the mouse ear microcirculation. J Anat. 2006 Dec; 209(6):807-16.
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A phase 1/2 trial of arginine butyrate and ganciclovir in patients with Epstein-Barr virus-associated lymphoid malignancies. Blood. 2007 Mar 15; 109(6):2571-8.
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Structural adaptations in the murine colon microcirculation associated with hapten-induced inflammation. Gut. 2007 Apr; 56(4):518-23.
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Multiframe particle tracking in intravital imaging: defining Lagrangian coordinates in the microcirculation. Biotechniques. 2006 Nov; 41(5):597-601.
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Multi-image particle tracking velocimetry of the microcirculation using fluorescent nanoparticles. Microvasc Res. 2006 Jul-Sep; 72(1-2):27-33.
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Feature-guided clustering of multi-dimensional flow cytometry datasets. J Biomed Inform. 2007 Jun; 40(3):325-31.
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Phase I/II trial of Arginine Butyrate and ganciclovir in Epstein-Barr virus-associated lymphoid malignancies. J Clin Oncol. 2006 Jun 20; 24(18_suppl):7542.
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Structural mapping of immunoglobulin subclasses using multiplexed bead flow cytometry. Hybridoma (Larchmt). 2006 Jun; 25(3):133-8.
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Melittin-induced membrane permeability: a nonosmotic mechanism of cell death. In Vitro Cell Dev Biol Anim. 2005 Nov-Dec; 41(10):349-55.
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Vessel painting of the microcirculation using fluorescent lipophilic tracers. Microvasc Res. 2005 Jul; 70(1-2):90-6.
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Respiratory impedance following bronchoscopic or surgical lung volume reduction for emphysema. Respiration. 2005 Jul-Aug; 72(4):406-17.
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Lung resection in patients with preoperative FEV1 < 35% predicted. Chest. 2005 Jun; 127(6):1984-90.
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Surgical palliative care in thoracic diseases. Surg Clin North Am. 2005 Apr; 85(2):315-28.
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High risk of brain metastases in surgically staged IIIA non-small-cell lung cancer patients treated with surgery, chemotherapy, and radiation. J Clin Oncol. 2005 Mar 01; 23(7):1530-7.
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Prevention, early detection, and management of complications after 328 consecutive extrapleural pneumonectomies. J Thorac Cardiovasc Surg. 2004 Jul; 128(1):138-46.
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Relationship between a history of antecedent cancer and the probability of malignancy for a solitary pulmonary nodule. Chest. 2004 Jun; 125(6):2175-81.
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Vaccination with irradiated, autologous melanoma cells engineered to secrete granulocyte-macrophage colony-stimulating factor by adenoviral-mediated gene transfer augments antitumor immunity in patients with metastatic melanoma. J Clin Oncol. 2003 Sep 01; 21(17):3343-50.
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Microangiectasias: structural regulators of lymphocyte transmigration. Proc Natl Acad Sci U S A. 2003 Jun 10; 100(12):7231-4.
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Ambulatory monitoring of cumulative free-living activity. IEEE Eng Med Biol Mag. 2003 May-Jun; 22(3):89-95.
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The role of muscle flaps in pulmonary aspergillosis. Plast Reconstr Surg. 2003 Mar; 111(3):1147-50.
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Vaccination with irradiated autologous tumor cells engineered to secrete granulocyte-macrophage colony-stimulating factor augments antitumor immunity in some patients with metastatic non-small-cell lung carcinoma. J Clin Oncol. 2003 Feb 15; 21(4):624-30.
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Visual representation of cell subpopulation from flow cytometry data. AMIA Annu Symp Proc. 2003; 893.
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Dynamic deformation of migratory efferent lymph-derived cells "trapped" in the inflammatory microcirculation. J Cell Physiol. 2003 Jan; 194(1):54-62.
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Spatial variation of plasma flow in the oxazolone-stimulated microcirculation. Inflamm Res. 2002 Dec; 51(12):572-8.
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Physiological characterization of variability in response to lung volume reduction surgery. J Appl Physiol (1985). 2003 Jan; 94(1):20-30.
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Stimulation of regional lymphatic and blood flow by epicutaneous oxazolone. J Appl Physiol (1985). 2002 Sep; 93(3):966-73.
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Outcomes and cost-effectiveness of alternative staging strategies for non-small-cell lung cancer. J Clin Oncol. 2002 Jan 01; 20(1):263-73.
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Using a neural network with flow cytometry histograms to recognize cell surface protein binding patterns. Proc AMIA Symp. 2002; 380-4.
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Biochemical changes in the efferent lymph plasma after oxazolone stimulation. Dev Comp Immunol. 2002 Jan; 26(1):111-9.
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Matching of flow-cytometry histograms using information theory in feature space. Proc AMIA Symp. 2002; 929-33.
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Transthoracic esophagectomy with radical mediastinal and abdominal lymph node dissection and cervical esophagogastrostomy for esophageal carcinoma. Ann Thorac Surg. 2001 Dec; 72(6):1918-24; discussion 1924-5.
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Focal topographic changes in inflammatory microcirculation associated with lymphocyte slowing and transmigration. . 2001 Oct; 281(4):H1742-50.
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Effect of shear stress on efferent lymph-derived lymphocytes in contact with activated endothelial monolayers. In Vitro Cell Dev Biol Anim. 2001 Oct; 37(9):599-605.
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Combined antegrade and retrograde dilation: a new endoscopic technique in the management of complex esophageal obstruction. Gastrointest Endosc. 2001 Sep; 54(3):368-72.
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Epstein--Barr virus post-transplant lymphoproliferative disease and virus-specific therapy: pharmacological re-activation of viral target genes with arginine butyrate. Transpl Infect Dis. 2001 Sep; 3(3):177-85.
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Induction of the Epstein-Barr virus thymidine kinase gene with concomitant nucleoside antivirals as a therapeutic strategy for Epstein-Barr virus-associated malignancies. Curr Opin Oncol. 2001 Sep; 13(5):360-7.
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Biphasic response of the regional lymphatics in the normal lymphocyte transfer reaction. Transplantation. 2001 Aug 15; 72(3):516-22.
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Bronchoscopic volume reduction: a safe and effective alternative to surgical therapy for emphysema. Am J Respir Crit Care Med. 2001 Jul 15; 164(2):295-301.
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Cell adhesion molecule expression in the sheep thymus. Dev Comp Immunol. 2001 Jun-Jul; 25(5-6):519-30.
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Cytolytic peptides induce biphasic permeability changes in mammalian cell membranes. J Immunol Methods. 2001 Jun 01; 252(1-2):63-71.
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Inspiratory lung impedance in COPD: effects of PEEP and immediate impact of lung volume reduction surgery. J Appl Physiol (1985). 2001 May; 90(5):1833-41.
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Sequential thoracic metastasectomy prolongs survival by re-establishing local control within the chest. J Thorac Cardiovasc Surg. 2001 Apr; 121(4):657-67.
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Aldehyde fixation of thiol-reactive fluorescent cytoplasmic probes for tracking cell migration. J Histochem Cytochem. 2001 Apr; 49(4):511-8.
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Comparison of physiological and radiological screening for lung volume reduction surgery. Am J Respir Crit Care Med. 2001 Apr; 163(5):1068-73.
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Interpreting improvement in expiratory flows after lung volume reduction surgery in terms of flow limitation theory. Am J Respir Crit Care Med. 2001 Apr; 163(5):1074-80.
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Stochastic regulation of cell migration from the efferent lymph to oxazolone-stimulated skin. J Immunol. 2001 Feb 01; 166(3):1517-23.
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Molecular identification using flow cytometry histograms and information theory. Proc AMIA Symp. 2001; 776-80.
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Bronchioloalveolar carcinoma of the lung: recurrences and survival in patients with stage I disease. J Thorac Cardiovasc Surg. 2001 Jan; 121(1):42-7.
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Nodal stage after induction therapy for stage IIIA lung cancer determines patient survival. Ann Thorac Surg. 2000 Dec; 70(6):1826-31.
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Angiocentric recruitment of lymphocytes into the lung after the intrabronchial instillation of antigen. Exp Lung Res. 2000 Mar; 26(2):89-103.
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Generation of sheep X (sheep X mouse) heterohybridoma cell line expressing the beta-1 integrin membrane molecule. Hybridoma. 2000 Feb; 19(1):81-7.
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Surveillance transbronchial lung biopsies: implication for survival after lung transplantation. J Thorac Cardiovasc Surg. 2000 Jan; 119(1):27-37.
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Dendritic cells in the pathophysiology of sarcoidal reactions. In Vivo. 2000 Jan-Feb; 14(1):209-12.
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Treatment of patients with lung cancer and severe emphysema. Chest. 1999 Dec; 116(6 Suppl):477S-479S.
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Management of the solitary pulmonary nodule: role of thoracoscopy in diagnosis and therapy. Chest. 1999 Dec; 116(6 Suppl):523S-524S.
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New surgical options for elderly lung cancer patients. Chest. 1999 Dec; 116(6 Suppl):480S-485S.
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Causes of allograft dysfunction after single lung transplantation for emphysema: extrinsic restriction versus intrinsic obstruction. Brigham and Women's Hospital Lung Transplantation Group. J Heart Lung Transplant. 1999 Oct; 18(10):986-93.
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Pretreatment staging by endoscopic ultrasonography does not predict complete response to neoadjuvant chemoradiation in patients with esophageal carcinoma. Cancer. 1999 Sep 01; 86(5):764-9.
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Model of functional restriction in chronic obstructive pulmonary disease, transplantation, and lung reduction surgery. Am J Respir Crit Care Med. 1999 Sep; 160(3):821-8.
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Health-related quality of life improves following pulmonary rehabilitation and lung volume reduction surgery. Chest. 1999 Feb; 115(2):383-9.
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Patterns of recurrence and outcome for patients with clinical stage II non-small-cell lung cancer. Am J Clin Oncol. 1999 Feb; 22(1):8-14.
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Resection margins, extrapleural nodal status, and cell type determine postoperative long-term survival in trimodality therapy of malignant pleural mesothelioma: results in 183 patients. J Thorac Cardiovasc Surg. 1999 Jan; 117(1):54-63; discussion 63-5.
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Vaccination with irradiated autologous melanoma cells engineered to secrete human granulocyte-macrophage colony-stimulating factor generates potent antitumor immunity in patients with metastatic melanoma. Proc Natl Acad Sci U S A. 1998 Oct 27; 95(22):13141-6.
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Inflammatory cell distribution within and along asthmatic airways. Am J Respir Crit Care Med. 1998 Aug; 158(2):565-72.
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Genetic epidemiology of severe, early-onset chronic obstructive pulmonary disease. Risk to relatives for airflow obstruction and chronic bronchitis. Am J Respir Crit Care Med. 1998 Jun; 157(6 Pt 1):1770-8.
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Arginine butyrate-induced susceptibility to ganciclovir in an Epstein-Barr-virus-associated lymphoma. Blood Cells Mol Dis. 1998 Jun; 24(2):114-23.
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Relation between preoperative inspiratory lung resistance and the outcome of lung-volume-reduction surgery for emphysema. N Engl J Med. 1998 Apr 23; 338(17):1181-5.
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Clinical radiation pneumonitis and radiographic changes after thoracic radiation therapy for lung carcinoma. Cancer. 1998 Mar 01; 82(5):842-50.
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Malignant effusive disease of the pleura and pericardium. Chest. 1997 Oct; 112(4 Suppl):291S-295S.
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Mediastinoscopy, thoracoscopy, and video-assisted thoracic surgery in the diagnosis and staging of lung cancer. Chest. 1997 Oct; 112(4 Suppl):239S-241S.
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No-cut thoracoscopic lung plication: a new technique for lung volume reduction surgery. J Am Coll Surg. 1997 Jul; 185(1):25-32.
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Mediastinoscopy, thoracoscopy, and video-assisted thoracic surgery in the diagnosis and staging of lung cancer. Hematol Oncol Clin North Am. 1997 Jun; 11(3):435-47.
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Neoadjuvant therapy for surgically staged IIIA N2 non-small cell lung cancer (NSCLC). Lung Cancer. 1997 May; 17(1):147-61.
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Patterns of failure after trimodality therapy for malignant pleural mesothelioma. Ann Thorac Surg. 1997 Feb; 63(2):334-8.
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A phase I study of vaccination with autologous, irradiated melanoma cells engineered to secrete human granulocyte-macrophage colony stimulating factor. Hum Gene Ther. 1997 Jan 01; 8(1):111-23.
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Video-assisted thoracic surgery in the elderly. A review of 307 cases. Chest. 1996 Sep; 110(3):751-8.
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Extrapleural pneumonectomy in the multimodality therapy of malignant pleural mesothelioma. Results in 120 consecutive patients. Ann Surg. 1996 Sep; 224(3):288-94; discussion 294-6.
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Sarcoidlike reaction in patients with malignancy. Radiology. 1996 Jul; 200(1):255-61.
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Immunoblastic lymphoma of donor origin in the allograft after lung transplantation. Transplantation. 1996 Jun 27; 61(12):1720-5.
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Laryngeal mask airway for therapeutic fiberoptic bronchoscopic procedures. J Cardiothorac Vasc Anesth. 1996 Jun; 10(4):519-20.
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Chest wall invasive non-small cell lung cancer: patterns of failure and implications for a revised staging system. Ann Surg Oncol. 1996 May; 3(3):261-9.
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LFA-1 and L-selectin regulation of recirculating lymphocyte tethering and rolling on lung microvascular endothelium. Am J Respir Cell Mol Biol. 1996 Apr; 14(4):398-406.
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Prospective analysis of pneumonectomy: risk factors for major morbidity and cardiac dysrhythmias. Ann Thorac Surg. 1996 Mar; 61(3):977-82.
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Hybridoma screening for cell adhesion molecules using multiple parallel comparisons in conditions of flow. Hybridoma. 1996 Feb; 15(1):43-7.
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Optimal therapy of malignant pleural effusions. Int J Oncol. 1996 Jan; 8(1):183-90.
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The safety and versatility of video-thoracoscopy: a prospective analysis of 895 consecutive cases. J Am Coll Surg. 1995 Aug; 181(2):113-20.
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Characterization of a hypoxia-responsive adhesion molecule for leukocytes on human endothelial cells. J Immunol. 1995 Jul 15; 155(2):802-10.
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Thoracoscopy and video-assisted thoracic surgery in the treatment of lung cancer. Chest. 1995 Jun; 107(6 Suppl):298S-301S.
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Expression of membrane glycoconjugates on sheep lung endothelium. Lab Invest. 1995 Apr; 72(4):445-52.
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In situ fluorescence labeling of sheep lung microvascular endothelium. In Vitro Cell Dev Biol Anim. 1995 Apr; 31(4):310-5.
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Potential mechanism of vasomotor dysregulation after lung transplantation for primary pulmonary hypertension. J Heart Lung Transplant. 1995 Mar-Apr; 14(2):387-93.
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Cytogenetic and histologic findings in 17 pulmonary chondroid hamartomas: evidence for a pathogenetic relationship with lipomas and leiomyomas. Genes Chromosomes Cancer. 1995 Mar; 12(3):220-3.
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Hybridoma screening using an amplified fluorescence microassay to quantify immunoglobulin concentration. Hybridoma. 1995 Feb; 14(1):75-8.
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Immunoreactivity in lung cancer. Chest Surg Clin N Am. 1995 Feb; 5(1):57-71.
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Single-lung transplantation in situs inversus. Ann Thorac Surg. 1994 Oct; 58(4):1176-8.
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Affinity membrane identification of immunoglobulin subclass in hybridoma screening. Hybridoma. 1994 Oct; 13(5):431-5.
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Membrane glycoconjugates expressed on sheep airway epithelium. J Histochem Cytochem. 1994 Oct; 42(10):1341-7.
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o-phthaldehyde fluorescence microassay for the determination of antibody concentration. J Immunol Methods. 1994 Jun 24; 172(2):141-5.
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Mediastinal invasion by bronchogenic carcinoma: CT signs. Radiology. 1994 Mar; 190(3):841-6.
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Ethical considerations in lung retransplantation. J Heart Lung Transplant. 1994 Jan-Feb; 13(1 Pt 1):56-8.
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Oxygen tension regulates neutrophil adhesion to human endothelial cells via an LFA-1-dependent mechanism. J Cell Physiol. 1993 Dec; 157(3):569-78.
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Multimodality therapy of patients with stage IIIA, N2 non-small-cell lung cancer. Impact of preoperative chemotherapy on resectability and downstaging. J Thorac Cardiovasc Surg. 1993 Oct; 106(4):696-702.
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Staged antrectomy and thoracoscopic truncal vagotomy for perforated peptic ulcer disease. Ann Thorac Surg. 1993 Jun; 55(6):1571-3.
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Node status has prognostic significance in the multimodality therapy of diffuse, malignant mesothelioma. J Clin Oncol. 1993 Jun; 11(6):1172-8.
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Patterns of lung involvement by malignant lymphoma. Surgery. 1993 May; 113(5):507-14.
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Selected benefits of thoracotomy and chemotherapy for sarcoma metastatic to the lung. J Surg Oncol. 1993 May; 53(1):54-9.
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Surgical resection in the management of small-cell carcinoma of the lung. Chest. 1993 Apr; 103(4 Suppl):349S-351S.
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Extrapleural pneumonectomy in the setting of a multimodality approach to malignant mesothelioma. Chest. 1993 Apr; 103(4 Suppl):377S-381S.
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Preoperative assessment of patients undergoing pulmonary resection. Chest. 1993 Apr; 103(4 Suppl):342S-345S.
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Sleeve lobectomy, segmentectomy, and thoracoscopy in the management of carcinoma of the lung. Chest. 1993 Apr; 103(4 Suppl):415S-417S.
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Hypoxia induces lymphocyte adhesion to human mesenchymal cells via an LFA-1-dependent mechanism. Am J Physiol. 1993 Mar; 264(3 Pt 1):C617-24.
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Semi-dry PhastTransfer detection of biotinylated cell surface molecules. Electrophoresis. 1993 Jan-Feb; 14(1-2):73-7.
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Clonal rearrangement of chromosome band 6p21 in the mesenchymal component of pulmonary chondroid hamartoma. Cancer Res. 1992 Nov 15; 52(22):6224-8.
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Limited pulmonary resections for congenital cystic adenomatoid malformation of the lung. J Pediatr Surg. 1992 Nov; 27(11):1410-3.
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Extrapleural pneumonectomy in the treatment of malignant pleural mesothelioma. Ann Thorac Surg. 1992 Nov; 54(5):941-6.
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Cloning hybridomas in a reversible three-dimensional alginate matrix. Hybridoma. 1992 Oct; 11(5):645-52.
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Improved technique for hilar vascular stapling. Ann Thorac Surg. 1992 Jan; 53(1):165-6.
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Extrapleural pneumonectomy, chemotherapy, and radiotherapy in the treatment of diffuse malignant pleural mesothelioma. J Thorac Cardiovasc Surg. 1991 Jul; 102(1):10-4; discussion 14-5.
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Distinct effects of interferon-gamma and MHC class I surface antigen levels on resistance of the K562 tumor cell line to natural killer-mediated lysis. Cell Immunol. 1990 Oct 15; 130(2):329-38.
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Soluble and surface-bound immunoglobulin triggers human monocyte activation and hydrogen peroxide release. Exp Hematol. 1990 Aug; 18(7):812-7.
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Induction of HLA class I surface expression recruits low-affinity cytolytic T lymphocytes. Int Arch Allergy Appl Immunol. 1990; 91(4):437-40.
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Alloreactivity studied with mutants of HLA-A2. Proc Natl Acad Sci U S A. 1989 Nov; 86(22):8936-40.
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Temperature requirements and kinetics of T cell signaling. Velocity of triggering correlates with functional effects of anti-CD3 mAb. J Immunol. 1989 May 01; 142(9):2971-80.
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Functional domains of the CD11a adhesion molecule in lymphokine activated killer (LAK)-mediated cytolysis. J Clin Lab Immunol. 1988 Dec; 27(4):155-61.
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Interleukin-1, tumor necrosis factor, and the production of colony-stimulating factors by cultured mesenchymal cells. Blood. 1988 Oct; 72(4):1316-23.
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Intercellular adhesion molecule-1 (ICAM-1) is involved in the cytolytic T lymphocyte interaction with a human synovial cell line. J Cell Physiol. 1988 Oct; 137(1):173-8.
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Membrane-bound anti-CD3 monoclonal antibodies trigger cytolytic T-lymphocyte-mediated tumor lysis. Arch Surg. 1988 Oct; 123(10):1280-5.
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Human T-cell leukemia virus type I infection of CD4+ or CD8+ cytotoxic T-cell clones results in immortalization with retention of antigen specificity. J Virol. 1988 Aug; 62(8):2942-50.
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The role of CD18 in phorbol ester-induced human monocyte-mediated cytotoxicity. Cell Immunol. 1988 Aug; 115(1):66-77.
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Surgical therapy of localized abdominal non-Hodgkin's lymphomas. Surgery. 1988 Jun; 103(6):609-14.
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Site-directed mutagenesis of class I HLA genes. Role of glycosylation in surface expression and functional recognition. J Exp Med. 1987 Nov 01; 166(5):1329-50.
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Sialophorin, a surface sialoglycoprotein defective in the Wiskott-Aldrich syndrome, is involved in human T lymphocyte proliferation. J Exp Med. 1987 May 01; 165(5):1383-92.
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CTL adhesion and antigen recognition are discrete steps in the human CTL-target cell interaction. J Immunol. 1987 Mar 01; 138(5):1325-30.
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Alpha and beta subunits of the LFA-1 membrane molecule are involved in human monocyte-endothelial cell adhesion. J Cell Physiol. 1987 Mar; 130(3):410-5.
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Splenic enlargement and hyperfunction as indications for splenectomy in chronic leukemia. Ann Surg. 1987 Jan; 205(1):13-7.
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Local recurrence and the deep resection margin in carcinoma of the breast. Surg Gynecol Obstet. 1986 Dec; 163(6):513-7.
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Mapping functional epitopes of the human LFA-1 glycoprotein: monoclonal antibody inhibition of NK and CTL effectors. Hum Immunol. 1986 Nov; 17(3):288-96.
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Abnormal cytolytic activity of lymphocyte function-associated antigen-1-deficient human cytolytic T lymphocyte clones. J Clin Invest. 1986 Nov; 78(5):1387-91.
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Spontaneous aggregation as a mechanism for human monocyte purification. Cell Immunol. 1986 Sep; 101(2):312-9.
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Species-restricted recognition of transfected HLA-A2 and HLA-B7 by human CTL clones. J Immunol. 1986 Jul 15; 137(2):408-13.
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Interferon-gamma induction of LFA-1-mediated homotypic adhesion of human monocytes. J Immunol. 1986 Jul 01; 137(1):108-13.
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Gene mapping and somatic cell hybrid analysis of the role of human lymphocyte function-associated antigen-3 (LFA-3) in CTL-target cell interactions. J Immunol. 1986 Apr 15; 136(8):3085-91.
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Abdominal pain in neutropenic cancer patients. Cancer. 1986 Feb 01; 57(3):616-21.
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Adhesion of T lymphocytes to human endothelial cells is regulated by the LFA-1 membrane molecule. J Cell Physiol. 1986 Feb; 126(2):285-90.
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The role of functional cell surface antigens in T cell activation. Year Immunol. 1986; 2:39-59.
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Heritable lymphocyte function-associated antigen-1 deficiency: abnormalities of cytotoxicity and proliferation associated with abnormal expression of LFA-1. J Immunol. 1985 Nov; 135(5):3102-8.
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Why do patients with postsurgical acute tubular necrosis die? Arch Surg. 1985 Aug; 120(8):907-10.
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T3 monoclonal antibody activation of nonspecific cytolysis: a mechanism of CTL inhibition. J Immunol. 1985 Jul; 135(1):34-8.
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LFA-1 membrane molecule in the regulation of homotypic adhesions of human B lymphocytes. J Immunol. 1985 Jul; 135(1):9-11.
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Surgical implications for infusion chemotherapy. Cancer. 1984 Dec 01; 54(11 Suppl):2618-26.
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Recognition of HLA-A2 and -B7 antigens by cloned cytotoxic T lymphocytes after gene transfer into human and monkey, but not mouse, cells. Proc Natl Acad Sci U S A. 1984 Dec; 81(23):7549-53.
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Adductor muscle group excision. Surgery. 1982 Jun; 91(6):662-8.
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Tumor sponge implantation: an in vivo method for studying syngeneic, primary antitumor lymphocyte responses. Cancer Res. 1982 Feb; 42(2):397-404.
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The relative immunogenicity of murine tissues in vivo. Curr Surg. 1980 Nov-Dec; 37(6):435-8.
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Avoidance of the handicapped: an attributional ambiguity analysis. J Pers Soc Psychol. 1979 Dec; 37(12):2297-306.
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