Todd R. Golub, MD

Todd R. Golub, MD

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Todd R. Golub, MD

Dr. Golub received his MD in 1989 from the University of Chicago. After completing subspecialty clinical and research training at Harvard Medical School, he joined DFCI, where he is the Charles A. Dana Investigator in Human Cancer Genetics. In 2002, he was appointed investigator of the Howard Hughes Medical Institute in recognition of his work in cancer genomics. He was recently named founding Director of the Cancer Program of the Broad Institute of Harvard and MIT focusing on genomic medicine.



Professor of Pediatrics, Harvard Medical School

Recent Awards

  • Discover Magazine Inventor of the Year (Health Category)


  • Judson Daland Prize for Outstanding Achievement in Clinical Investigation, American Philosophical Society


  • Cornelius Rhoads Memorial Prize, American Association for Cancer Research


  • Career Award, Burroughs-Wellcome


  • Whitlock Prize in Hematopoiesis and Leukemia



    Genomic Approaches to Cancer

    Our laboratory focuses on the genetic basis of cancer, with particular emphasis on the use of new genomic and computer science approaches to cancer diagnosis and cancer biology. Having pioneered the use of DNA microarrays, or DNA chips, for cancer diagnosis, we are currently extending these techniques to gain insight into the molecular basis of lymphoma, lung cancer, prostate cancer, melanoma, brain tumors, and multiple myeloma. New efforts are using systematic functional genomic methods, including RNA interference (RNAi), to identify tumor suppressor genes and find potential Achilles' heels of cancer that might represent new therapeutic targets. Work is also under way to develop proteomic approaches to cancer cell characterization, including advanced mass spectrometry to identify activated kinases as well as proteins in blood samples that are diagnostic of cancer. Another area of research is the development of computational methods capable of extracting biologically or clinically meaningful signatures from complex genomic data. In addition, we are exploring novel approaches to the integration of genomics and chemistry. For example, we have established high-throughput screening methods for screening chemical compounds on the basis of their ability to modulate a gene expression signature of interest - a method particularly useful when the critical protein targets of a biological process are not yet known. Using this approach, called gene expression-based high throughput screening (GE-HTS), we have identified compounds capable of inducing the differentiation of acute myeloid leukemia (AML) cells. One of these compounds has advanced to clinical trial in patients with relapsed AML. Similar GE-HTS screening is in progress in models of androgen-dependent prostate cancer, neuroblastoma, Ewing sarcoma, sickle cell anemia, and embryonic stem cell differentiation.

    Research Departments


      • Partial gene suppression improves identification of cancer vulnerabilities when CRISPR-Cas9 knockout is pan-lethal. Genome Biol. 2023 08 23; 24(1):192. View in: Pubmed

      • Circulating tumor DNA association with residual cancer burden after neoadjuvant chemotherapy in triple-negative breast cancer in TBCRC 030. Ann Oncol. 2023 Oct; 34(10):899-906. View in: Pubmed

      • FDX1 regulates cellular protein lipoylation through direct binding to LIAS. J Biol Chem. 2023 09; 299(9):105046. View in: Pubmed

      • Translation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma. bioRxiv. 2023 May 06. View in: Pubmed

      • Single duplex DNA sequencing with CODEC detects mutations with high sensitivity. Nat Genet. 2023 05; 55(5):871-879. View in: Pubmed

      • Circulating tumor DNA association with residual cancer burden after neoadjuvant chemotherapy in triple-negative breast cancer in TBCRC 030. medRxiv. 2023 Mar 08. View in: Pubmed

      • FDX1 regulates cellular protein lipoylation through direct binding to LIAS. bioRxiv. 2023 Feb 04. View in: Pubmed

      • A nanoparticle priming agent reduces cellular uptake of cell-free DNA and enhances the sensitivity of liquid biopsies. bioRxiv. 2023 Jan 14. View in: Pubmed

      • An intravenous DNA-binding priming agent protects cell-free DNA and improves the sensitivity of liquid biopsies. bioRxiv. 2023 Jan 14. View in: Pubmed

      • BAF Complex Maintains Glioma Stem Cells in Pediatric H3K27M Glioma. Cancer Discov. 2022 12 02; 12(12):2880-2905. View in: Pubmed

      • Systematic profiling of conditional degron tag technologies for target validation studies. Nat Commun. 2022 09 20; 13(1):5495. View in: Pubmed

      • Liquid biopsy detection of genomic alterations in pediatric brain tumors from cell-free DNA in peripheral blood, CSF, and urine. Neuro Oncol. 2022 08 01; 24(8):1352-1363. View in: Pubmed

      • Publisher Correction: DNA-based copy number analysis confirms genomic evolution of PDX models. NPJ Precis Oncol. 2022 Jul 12; 6(1):50. View in: Pubmed

      • Proceedings of the fifth international Molecular Pathological Epidemiology (MPE) meeting. Cancer Causes Control. 2022 Aug; 33(8):1107-1120. View in: Pubmed

      • DNA-based copy number analysis confirms genomic evolution of PDX models. NPJ Precis Oncol. 2022 Apr 28; 6(1):30. View in: Pubmed

      • Phosphate dysregulation via the XPR1-KIDINS220 protein complex is a therapeutic vulnerability in ovarian cancer. Nat Cancer. 2022 06; 3(6):681-695. View in: Pubmed

      • Copper induces cell death by targeting lipoylated TCA cycle proteins. Science. 2022 03 18; 375(6586):1254-1261. View in: Pubmed

      • Massively parallel enrichment of low-frequency alleles enables duplex sequencing at low depth. Nat Biomed Eng. 2022 03; 6(3):257-266. View in: Pubmed

      • Duplex-Repair enables highly accurate sequencing, despite DNA damage. Nucleic Acids Res. 2022 01 11; 50(1):e1. View in: Pubmed

      • Author Correction: Fatty acid synthesis is required for breast cancer brain metastasis. Nat Cancer. 2021 11; 2(11):1243. View in: Pubmed

      • Publisher Correction: A metastasis map of human cancer cell lines. Nature. 2021 Nov; 599(7885):E7. View in: Pubmed

      • Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q. Cell Rep. 2021 Jul 13; 36(2):109367. View in: Pubmed

      • Genome-scale screens identify factors regulating tumor cell responses to natural killer cells. Nat Genet. 2021 08; 53(8):1196-1206. View in: Pubmed

      • Selective Modulation of a Pan-Essential Protein as a Therapeutic Strategy in Cancer. Cancer Discov. 2021 09; 11(9):2282-2299. View in: Pubmed

      • FATTY ACID SYNTHESIS IS REQUIRED FOR BREAST CANCER BRAIN METASTASIS. Nat Cancer. 2021 04; 2(4):414-428. View in: Pubmed

      • A first-generation pediatric cancer dependency map. Nat Genet. 2021 04; 53(4):529-538. View in: Pubmed

      • Noncanonical open reading frames encode functional proteins essential for cancer cell survival. Nat Biotechnol. 2021 06; 39(6):697-704. View in: Pubmed

      • Aneuploidy renders cancer cells vulnerable to mitotic checkpoint inhibition. Nature. 2021 02; 590(7846):486-491. View in: Pubmed

      • Cancer research needs a better map. Nature. 2021 01; 589(7843):514-516. View in: Pubmed

      • Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q. Cell Rep. 2020 12 15; 33(11):108493. View in: Pubmed

      • A metastasis map of human cancer cell lines. Nature. 2020 12; 588(7837):331-336. View in: Pubmed

      • Multiplexed single-cell transcriptional response profiling to define cancer vulnerabilities and therapeutic mechanism of action. Nat Commun. 2020 08 27; 11(1):4296. View in: Pubmed

      • Author Correction: Cas9 activates the p53 pathway and selects for p53-inactivating mutations. Nat Genet. 2020 Jul; 52(7):748-749. View in: Pubmed

      • The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K. Nature. 2020 09; 585(7824):293-297. View in: Pubmed

      • Cas9 activates the p53 pathway and selects for p53-inactivating mutations. Nat Genet. 2020 07; 52(7):662-668. View in: Pubmed

      • Sensitive Detection of Minimal Residual Disease in Patients Treated for Early-Stage Breast Cancer. Clin Cancer Res. 2020 06 01; 26(11):2556-2564. View in: Pubmed

      • The Angiosarcoma Project: enabling genomic and clinical discoveries in a rare cancer through patient-partnered research. Nat Med. 2020 02; 26(2):181-187. View in: Pubmed

      • Discovering the anti-cancer potential of non-oncology drugs by systematic viability profiling. Nat Cancer. 2020 02; 1(2):235-248. View in: Pubmed

      • Agreement between two large pan-cancer CRISPR-Cas9 gene dependency data sets. Nat Commun. 2019 12 20; 10(1):5817. View in: Pubmed

      • Author Correction: Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers. Nat Med. 2019 Dec; 25(12):1949. View in: Pubmed

      • Re-programing Chromatin with a Bifunctional LSD1/HDAC Inhibitor Induces Therapeutic Differentiation in DIPG. Cancer Cell. 2019 11 11; 36(5):528-544.e10. View in: Pubmed

      • Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers. Nat Med. 2019 09; 25(9):1415-1421. View in: Pubmed

      • Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors. Cell Rep. 2019 08 27; 28(9):2331-2344.e8. View in: Pubmed

      • Small Molecule Targets TMED9 and Promotes Lysosomal Degradation to Reverse Proteinopathy. Cell. 2019 07 25; 178(3):521-535.e23. View in: Pubmed

      • Structural mechanism of synergistic activation of Aurora kinase B/C by phosphorylated INCENP. Nat Commun. 2019 07 18; 10(1):3166. View in: Pubmed

      • Author Correction: Mitochondrial metabolism promotes adaptation to proteotoxic stress. Nat Chem Biol. 2019 Jul; 15(7):757. View in: Pubmed

      • Mitochondrial metabolism promotes adaptation to proteotoxic stress. Nat Chem Biol. 2019 07; 15(7):681-689. View in: Pubmed

      • Next-generation characterization of the Cancer Cell Line Encyclopedia. Nature. 2019 05; 569(7757):503-508. View in: Pubmed

      • WRN helicase is a synthetic lethal target in microsatellite unstable cancers. Nature. 2019 04; 568(7753):551-556. View in: Pubmed

      • Genomic evolution of cancer models: perils and opportunities. Nat Rev Cancer. 2019 02; 19(2):97-109. View in: Pubmed

      • Addendum: The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature. 2019 01; 565(7738):E5-E6. View in: Pubmed

      • Protection of tissue physicochemical properties using polyfunctional crosslinkers. Nat Biotechnol. 2018 Dec 17. View in: Pubmed

      • Drug and disease signature integration identifies synergistic combinations in glioblastoma. Nat Commun. 2018 12 14; 9(1):5315. View in: Pubmed

      • Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration. Nat Commun. 2018 11 02; 9(1):4610. View in: Pubmed

      • Retraction Note: Selective killing of cancer cells by a small molecule targeting the stress response to ROS. Nature. 2018 09; 561(7723):420. View in: Pubmed

      • Cytokine sensitivity screening highlights BMP4 pathway signaling as a therapeutic opportunity in ER+ breast cancer. FASEB J. 2019 02; 33(2):1644-1657. View in: Pubmed

      • Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry. Nat Genet. 2018 09; 50(9):1240-1246. View in: Pubmed

      • Genetic and transcriptional evolution alters cancer cell line drug response. Nature. 2018 08; 560(7718):325-330. View in: Pubmed

      • Author Correction: Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes. Nat Med. 2018 Aug; 24(8):1290-1291. View in: Pubmed

      • Publisher Correction: Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes. Nat Med. 2018 Aug; 24(8):1292. View in: Pubmed

      • Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes. Nat Med. 2018 05; 24(5):679-690. View in: Pubmed

      • Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq. Science. 2018 04 20; 360(6386):331-335. View in: Pubmed

      • A Library of Phosphoproteomic and Chromatin Signatures for Characterizing Cellular Responses to Drug Perturbations. Cell Syst. 2018 Apr 25; 6(4):424-443.e7. View in: Pubmed

      • Therapeutically targeting tumor microenvironment-mediated drug resistance in estrogen receptor-positive breast cancer. J Exp Med. 2018 03 05; 215(3):895-910. View in: Pubmed

      • Association of Cell-Free DNA Tumor Fraction and Somatic Copy Number Alterations With Survival in Metastatic Triple-Negative Breast Cancer. J Clin Oncol. 2018 02 20; 36(6):543-553. View in: Pubmed

      • High-throughput Phenotyping of Lung Cancer Somatic Mutations. Cancer Cell. 2017 12 11; 32(6):884. View in: Pubmed

      • CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2. J Clin Invest. 2018 01 02; 128(1):446-462. View in: Pubmed

      • A dataset of images and morphological profiles of 30 000 small-molecule treatments using the Cell Painting assay. Gigascience. 2017 12 01; 6(12):1-5. View in: Pubmed

      • Evaluation of RNAi and CRISPR technologies by large-scale gene expression profiling in the Connectivity Map. PLoS Biol. 2017 Nov; 15(11):e2003213. View in: Pubmed

      • A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles. Cell. 2017 Nov 30; 171(6):1437-1452.e17. View in: Pubmed

      • The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations. Cell Syst. 2018 01 24; 6(1):13-24. View in: Pubmed

      • Scalable whole-exome sequencing of cell-free DNA reveals high concordance with metastatic tumors. Nat Commun. 2017 11 06; 8(1):1324. View in: Pubmed

      • Computational correction of copy number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells. Nat Genet. 2017 Dec; 49(12):1779-1784. View in: Pubmed

      • Common and cell-type specific responses to anti-cancer drugs revealed by high throughput transcript profiling. Nat Commun. 2017 10 30; 8(1):1186. View in: Pubmed

      • Patient-derived xenografts undergo mouse-specific tumor evolution. Nat Genet. 2017 Nov; 49(11):1567-1575. View in: Pubmed

      • Erratum: The microRNA miR-31 inhibits CD8+ T cell function in chronic viral infection. Nat Immunol. 2017 09 19; 18(10):1173. View in: Pubmed

      • Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine. Science. 2017 09 15; 357(6356):1156-1160. View in: Pubmed

      • A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer. Nat Genet. 2017 Oct; 49(10):1476-1486. View in: Pubmed

      • Defining a Cancer Dependency Map. Cell. 2017 Jul 27; 170(3):564-576.e16. View in: Pubmed

      • Recurrent and functional regulatory mutations in breast cancer. Nature. 2017 07 06; 547(7661):55-60. View in: Pubmed

      • High-throughput validation of ceRNA regulatory networks. BMC Genomics. 2017 05 30; 18(1):418. View in: Pubmed

      • The microRNA miR-31 inhibits CD8+ T cell function in chronic viral infection. Nat Immunol. 2017 Jul; 18(7):791-799. View in: Pubmed

      • Direct evidence for a polygenic etiology in familial multiple myeloma. Blood Adv. 2017 Apr 11; 1(10):619-623. View in: Pubmed

      • The Drug Repurposing Hub: a next-generation drug library and information resource. Nat Med. 2017 04 07; 23(4):405-408. View in: Pubmed

      • Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq. Science. 2017 03 31; 355(6332). View in: Pubmed

      • LACTB is a tumour suppressor that modulates lipid metabolism and cell state. Nature. 2017 03 30; 543(7647):681-686. View in: Pubmed

      • DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis. Nat Chem Biol. 2017 Jan; 13(1):46-53. View in: Pubmed

      • Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma. Nature. 2016 11 10; 539(7628):309-313. View in: Pubmed

      • Genetic interrogation of circulating multiple myeloma cells at single-cell resolution. Sci Transl Med. 2016 11 02; 8(363):363ra147. View in: Pubmed

      • 334 A Functional Screen Identifies miRNAs that Induce Radioresistance in Glioblastomas. Neurosurgery. 2016 Aug; 63 Suppl 1:197-8. View in: Pubmed

      • High-throughput Phenotyping of Lung Cancer Somatic Mutations. Cancer Cell. 2016 08 08; 30(2):214-228. View in: Pubmed

      • Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond. PLoS Pathog. 2016 07; 12(7):e1005763. View in: Pubmed

      • The landscape of chromosomal aberrations in breast cancer mouse models reveals driver-specific routes to tumorigenesis. Nat Commun. 2016 07 04; 7:12160. View in: Pubmed

      • Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting. Cancer Discov. 2016 08; 6(8):914-29. View in: Pubmed

      • Systematic Functional Interrogation of Rare Cancer Variants Identifies Oncogenic Alleles. Cancer Discov. 2016 07; 6(7):714-26. View in: Pubmed

      • miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells. Cancer Cell. 2016 Apr 11; 29(4):602-606. View in: Pubmed

      • High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines. Nat Biotechnol. 2016 Apr; 34(4):419-23. View in: Pubmed

      • MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells. Science. 2016 Mar 11; 351(6278):1214-8. View in: Pubmed

      • miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells. Cancer Cell. 2016 Feb 08; 29(2):214-28. View in: Pubmed

      • Corrigendum: The genomic landscape of juvenile myelomonocytic leukemia. Nat Genet. 2016 Jan; 48(1):101. View in: Pubmed

      • Targetable genetic features of primary testicular and primary central nervous system lymphomas. Blood. 2016 Feb 18; 127(7):869-81. View in: Pubmed

      • The genomic landscape of juvenile myelomonocytic leukemia. Nat Genet. 2015 Nov; 47(11):1326-1333. View in: Pubmed

      • Comprehensive assessment of cancer missense mutation clustering in protein structures. Proc Natl Acad Sci U S A. 2015 Oct 06; 112(40):E5486-95. View in: Pubmed

      • Corrigendum: Selective killing of cancer cells by a small molecule targeting the stress response to ROS. Nature. 2015 Oct 22; 526(7574):596. View in: Pubmed

      • An ecosystem of cancer cell line factories to support a cancer dependency map. Nat Rev Genet. 2015 Jul; 16(7):373-4. View in: Pubmed

      • Genomic Correlate of Exceptional Erlotinib Response in Head and Neck Squamous Cell Carcinoma. JAMA Oncol. 2015 May; 1(2):238-44. View in: Pubmed

      • A Maltose-Binding Protein Fusion Construct Yields a Robust Crystallography Platform for MCL1. PLoS One. 2015; 10(4):e0125010. View in: Pubmed

      • Expression profiles of 151 pediatric low-grade gliomas reveal molecular differences associated with location and histological subtype. Neuro Oncol. 2015 Nov; 17(11):1486-96. View in: Pubmed

      • Niche-Based Screening in Multiple Myeloma Identifies a Kinesin-5 Inhibitor with Improved Selectivity over Hematopoietic Progenitors. Cell Rep. 2015 Feb 10; 10(5):755-770. View in: Pubmed

      • Genetic modifiers of EGFR dependence in non-small cell lung cancer. Proc Natl Acad Sci U S A. 2014 Dec 30; 111(52):18661-6. View in: Pubmed

      • Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma. Proc Natl Acad Sci U S A. 2014 Dec 23; 111(51):E5564-73. View in: Pubmed

      • Erratum: Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies. Sci Data. 2014; 1:140044. View in: Pubmed

      • Single Diastereomer of a Macrolactam Core Binds Specifically to Myeloid Cell Leukemia 1 (MCL1). ACS Med Chem Lett. 2014 Dec 11; 5(12):1308-12. View in: Pubmed

      • Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies. Sci Data. 2014; 1:140035. View in: Pubmed

      • A functional screen identifies miRs that induce radioresistance in glioblastomas. Mol Cancer Res. 2014 Dec; 12(12):1767-78. View in: Pubmed

      • The genomic landscape of pediatric Ewing sarcoma. Cancer Discov. 2014 Nov; 4(11):1326-41. View in: Pubmed

      • Toward performance-diverse small-molecule libraries for cell-based phenotypic screening using multiplexed high-dimensional profiling. Proc Natl Acad Sci U S A. 2014 Jul 29; 111(30):10911-6. View in: Pubmed

      • A high-throughput, multiplexed assay for superfamily-wide profiling of enzyme activity. Nat Chem Biol. 2014 Aug; 10(8):656-63. View in: Pubmed

      • LINCS Canvas Browser: interactive web app to query, browse and interrogate LINCS L1000 gene expression signatures. Nucleic Acids Res. 2014 Jul; 42(Web Server issue):W449-60. View in: Pubmed

      • Whole-exome sequencing of circulating tumor cells provides a window into metastatic prostate cancer. Nat Biotechnol. 2014 May; 32(5):479-84. View in: Pubmed

      • Integrated genomic analysis illustrates the central role of JAK-STAT pathway activation in myeloproliferative neoplasm pathogenesis. Blood. 2014 May 29; 123(22):e123-33. View in: Pubmed

      • Epidermal growth factor receptor inhibition attenuates liver fibrosis and development of hepatocellular carcinoma. Hepatology. 2014 Apr; 59(4):1577-90. View in: Pubmed

      • Widespread genetic heterogeneity in multiple myeloma: implications for targeted therapy. Cancer Cell. 2014 Jan 13; 25(1):91-101. View in: Pubmed

      • Discovery and saturation analysis of cancer genes across 21 tumour types. Nature. 2014 Jan 23; 505(7484):495-501. View in: Pubmed

      • Multiplex cytological profiling assay to measure diverse cellular states. PLoS One. 2013; 8(12):e80999. View in: Pubmed

      • A phase II study of the EGFR inhibitor gefitinib in patients with acute myeloid leukemia. Leuk Res. 2014 Apr; 38(4):430-4. View in: Pubmed

      • Niche-based screening identifies small-molecule inhibitors of leukemia stem cells. Nat Chem Biol. 2013 Dec; 9(12):840-848. View in: Pubmed

      • CXCR4 pathway associated with family history of melanoma. Cancer Causes Control. 2014 Jan; 25(1):125-32. View in: Pubmed

      • Tight coordination of protein translation and HSF1 activation supports the anabolic malignant state. Science. 2013 Jul 19; 341(6143):1238303. View in: Pubmed

      • Mutational heterogeneity in cancer and the search for new cancer-associated genes. Nature. 2013 Jul 11; 499(7457):214-218. View in: Pubmed

      • SYK inhibition modulates distinct PI3K/AKT- dependent survival pathways and cholesterol biosynthesis in diffuse large B cell lymphomas. Cancer Cell. 2013 Jun 10; 23(6):826-38. View in: Pubmed

      • Punctuated evolution of prostate cancer genomes. Cell. 2013 Apr 25; 153(3):666-77. View in: Pubmed

      • Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity. Nat Genet. 2013 May; 45(5):478-86. View in: Pubmed

      • Prognostic gene expression signature for patients with hepatitis C-related early-stage cirrhosis. Gastroenterology. 2013 May; 144(5):1024-30. View in: Pubmed

      • Expression profiling of archival tumors for long-term health studies. Clin Cancer Res. 2012 Nov 15; 18(22):6136-46. View in: Pubmed

      • Dual suppression of the cyclin-dependent kinase inhibitors CDKN2C and CDKN1A in human melanoma. J Natl Cancer Inst. 2012 Nov 07; 104(21):1673-9. View in: Pubmed

      • AACR Cancer Progress Report 2012. Clin Cancer Res. 2012 Nov 01; 18(21 Suppl):S1-100. View in: Pubmed

      • Integrative analysis reveals an outcome-associated and targetable pattern of p53 and cell cycle deregulation in diffuse large B cell lymphoma. Cancer Cell. 2012 Sep 11; 22(3):359-72. View in: Pubmed

      • Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion. Nature. 2012 Jul 26; 487(7408):500-4. View in: Pubmed

      • A remarkably simple genome underlies highly malignant pediatric rhabdoid cancers. J Clin Invest. 2012 Aug; 122(8):2983-8. View in: Pubmed

      • Sequence analysis of mutations and translocations across breast cancer subtypes. Nature. 2012 Jun 20; 486(7403):405-9. View in: Pubmed

      • Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer. Nat Genet. 2012 May 20; 44(6):685-9. View in: Pubmed

      • Melanoma genome sequencing reveals frequent PREX2 mutations. Nature. 2012 May 09; 485(7399):502-6. View in: Pubmed

      • Chemical genomics identifies small-molecule MCL1 repressors and BCL-xL as a predictor of MCL1 dependency. Cancer Cell. 2012 Apr 17; 21(4):547-62. View in: Pubmed

      • The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature. 2012 Mar 28; 483(7391):603-7. View in: Pubmed

      • Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing. Proc Natl Acad Sci U S A. 2012 Mar 06; 109(10):3879-84. View in: Pubmed

      • STK33 kinase inhibitor BRD-8899 has no effect on KRAS-dependent cancer cell viability. Proc Natl Acad Sci U S A. 2012 Feb 21; 109(8):2860-5. View in: Pubmed

      • SF3B1 and other novel cancer genes in chronic lymphocytic leukemia. N Engl J Med. 2011 Dec 29; 365(26):2497-506. View in: Pubmed

      • PAK1 is a breast cancer oncogene that coordinately activates MAPK and MET signaling. Oncogene. 2012 Jul 19; 31(29):3397-408. View in: Pubmed

      • Analysis of genomic aberrations and gene expression profiling identifies novel lesions and pathways in myeloproliferative neoplasms. Blood Cancer J. 2011 Nov; 1(11):e40. View in: Pubmed

      • Amplification of CRKL induces transformation and epidermal growth factor receptor inhibitor resistance in human non-small cell lung cancers. Cancer Discov. 2011 Dec; 1(7):608-25. View in: Pubmed

      • Stem cell gene expression programs influence clinical outcome in human leukemia. Nat Med. 2011 Aug 28; 17(9):1086-93. View in: Pubmed

      • The mutational landscape of head and neck squamous cell carcinoma. Science. 2011 Aug 26; 333(6046):1157-60. View in: Pubmed

      • Selective killing of cancer cells by a small molecule targeting the stress response to ROS. Nature. 2011 Jul 13; 475(7355):231-4. View in: Pubmed

      • Humanized mice with ectopic artificial liver tissues. Proc Natl Acad Sci U S A. 2011 Jul 19; 108(29):11842-7. View in: Pubmed

      • mRNA expression signature of Gleason grade predicts lethal prostate cancer. J Clin Oncol. 2011 Jun 10; 29(17):2391-6. View in: Pubmed

      • Initial genome sequencing and analysis of multiple myeloma. Nature. 2011 Mar 24; 471(7339):467-72. View in: Pubmed

      • MicroRNA-based classification of hepatocellular carcinoma and oncogenic role of miR-517a. Gastroenterology. 2011 May; 140(5):1618-28.e16. View in: Pubmed

      • The genomic complexity of primary human prostate cancer. Nature. 2011 Feb 10; 470(7333):214-20. View in: Pubmed

      • SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression. Nature. 2011 Feb 10; 470(7333):269-73. View in: Pubmed

      • Signatures of murine B-cell development implicate Yy1 as a regulator of the germinal center-specific program. Proc Natl Acad Sci U S A. 2011 Feb 15; 108(7):2873-8. View in: Pubmed

      • Densely interconnected transcriptional circuits control cell states in human hematopoiesis. Cell. 2011 Jan 21; 144(2):296-309. View in: Pubmed

      • COT drives resistance to RAF inhibition through MAP kinase pathway reactivation. Nature. 2010 Dec 16; 468(7326):968-72. View in: Pubmed

      • Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma. Blood. 2010 Oct 28; 116(17):3268-77. View in: Pubmed

      • MicroRNA miR-125a controls hematopoietic stem cell number. Proc Natl Acad Sci U S A. 2010 Aug 10; 107(32):14229-34. View in: Pubmed

      • Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease. Proc Natl Acad Sci U S A. 2010 Jul 13; 107(28):12617-22. View in: Pubmed

      • Integrative genome comparison of primary and metastatic melanomas. PLoS One. 2010 May 24; 5(5):e10770. View in: Pubmed

      • Chronic cisplatin treatment promotes enhanced damage repair and tumor progression in a mouse model of lung cancer. Genes Dev. 2010 Apr 15; 24(8):837-52. View in: Pubmed

      • Counterpoint: Data first. Nature. 2010 Apr 01; 464(7289):679. View in: Pubmed

      • The connectivity map links iron regulatory protein-1-mediated inhibition of hypoxia-inducible factor-2a translation to the anti-inflammatory 15-deoxy-delta12,14-prostaglandin J2. Cancer Res. 2010 Apr 15; 70(8):3071-9. View in: Pubmed

      • Molecular sampling of prostate cancer: a dilemma for predicting disease progression. BMC Med Genomics. 2010 Mar 16; 3:8. View in: Pubmed

      • The landscape of somatic copy-number alteration across human cancers. Nature. 2010 Feb 18; 463(7283):899-905. View in: Pubmed

      • Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell. 2010 Jan 19; 17(1):98-110. View in: Pubmed

      • Dicer1 functions as a haploinsufficient tumor suppressor. Genes Dev. 2009 Dec 01; 23(23):2700-4. View in: Pubmed

      • Empirical Bayes analysis of quantitative proteomics experiments. PLoS One. 2009 Oct 14; 4(10):e7454. View in: Pubmed

      • Proteomic and genetic approaches identify Syk as an AML target. Cancer Cell. 2009 Oct 06; 16(4):281-94. View in: Pubmed

      • MicroRNA dynamics in the stages of tumorigenesis correlate with hallmark capabilities of cancer. Genes Dev. 2009 Sep 15; 23(18):2152-65. View in: Pubmed

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