Wendy S. Garrett, MD, PhD

Wendy S. Garrett, MD, PhD

Medical Oncology

Contact Information

Office Phone Number






Professor of Medicine, Harvard Medical School


Clinical Interests

Gastrointestinal malignancies

Board Certification

  • Internal Medicine
  • Medical Oncology


  • Dana-Farber Cancer Institute, Medical Oncology


  • Brigham and Women's Hospital, Internal Medicine

Medical School

  • Yale University


    • Inverse relationship between Fusobacterium nucleatum amount and tumor CD274 (PD-L1) expression in colorectal carcinoma. Clin Transl Immunology. 2023; 12(8):e1453. View in: Pubmed

    • Bacteria in cancer initiation, promotion and progression. Nat Rev Cancer. 2023 09; 23(9):600-618. View in: Pubmed

    • The gut microbiome modifies the associations of short- and long-term physical activity with body weight changes. Microbiome. 2023 05 30; 11(1):121. View in: Pubmed

    • Engineered Escherichia coli for the in situ secretion of therapeutic nanobodies in the gut. Cell Host Microbe. 2023 04 12; 31(4):634-649.e8. View in: Pubmed

    • Questioning the fetal microbiome illustrates pitfalls of low-biomass microbial studies. Nature. 2023 01; 613(7945):639-649. View in: Pubmed

    • Faecalibaculum rodentium remodels retinoic acid signaling to govern eosinophil-dependent intestinal epithelial homeostasis. Cell Host Microbe. 2022 09 14; 30(9):1295-1310.e8. View in: Pubmed

    • Western-Style Diet, pks Island-Carrying Escherichia coli, and Colorectal Cancer: Analyses From Two Large Prospective Cohort Studies. Gastroenterology. 2022 10; 163(4):862-874. View in: Pubmed

    • Discovery of bioactive microbial gene products in inflammatory bowel disease. Nature. 2022 06; 606(7915):754-760. View in: Pubmed

    • Colorectal cancer: the facts in the case of the microbiota. J Clin Invest. 2022 02 15; 132(4). View in: Pubmed

    • Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response. Science. 2021 Dec 24; 374(6575):1632-1640. View in: Pubmed

    • Publisher Correction: Overview of the Microbiome Among Nurses study (Micro-N) as an example of prospective characterization of the microbiome within cohort studies. Nat Protoc. 2021 Sep; 16(9):4538. View in: Pubmed

    • The Sulfur Microbial Diet and Risk of Colorectal Cancer by Molecular Subtypes and Intratumoral Microbial Species in Adult Men. Clin Transl Gastroenterol. 2021 08 01; 12(8):e00338. View in: Pubmed

    • The Sulfur Microbial Diet Is Associated With Increased Risk of Early-Onset Colorectal Cancer Precursors. Gastroenterology. 2021 11; 161(5):1423-1432.e4. View in: Pubmed

    • Dietary fiber intake, the gut microbiome, and chronic systemic inflammation in a cohort of adult men. Genome Med. 2021 06 17; 13(1):102. View in: Pubmed

    • Overview of the Microbiome Among Nurses study (Micro-N) as an example of prospective characterization of the microbiome within cohort studies. Nat Protoc. 2021 06; 16(6):2724-2731. View in: Pubmed

    • Microbial Nourishment for Undernutrition. N Engl J Med. 2021 04 22; 384(16):1566-1567. View in: Pubmed

    • Aspirin Modulation of the Colorectal Cancer-Associated Microbe Fusobacterium nucleatum. mBio. 2021 04 06; 12(2). View in: Pubmed

    • A framework for microbiome science in public health. Nat Med. 2021 05; 27(5):766-774. View in: Pubmed

    • Association of Fusobacterium nucleatum with Specific T-cell Subsets in the Colorectal Carcinoma Microenvironment. Clin Cancer Res. 2021 05 15; 27(10):2816-2826. View in: Pubmed

    • Fusobacterium nucleatum drives a pro-inflammatory intestinal microenvironment through metabolite receptor-dependent modulation of IL-17 expression. Gut Microbes. 2021 Jan-Dec; 13(1):1987780. View in: Pubmed

    • Diet posttranslationally modifies the mouse gut microbial proteome to modulate renal function. Science. 2020 09 18; 369(6510):1518-1524. View in: Pubmed

    • Colon Cancer-Associated Fusobacterium nucleatum May Originate From the Oral Cavity and Reach Colon Tumors via the Circulatory System. Front Cell Infect Microbiol. 2020; 10:400. View in: Pubmed

    • Interleukin-13 drives metabolic conditioning of muscle to endurance exercise. Science. 2020 05 01; 368(6490). View in: Pubmed

    • Structure of the Mucosal and Stool Microbiome in Lynch Syndrome. Cell Host Microbe. 2020 04 08; 27(4):585-600.e4. View in: Pubmed

    • Enterococcus in Graft-versus-Host Disease. N Engl J Med. 2020 03 12; 382(11):1064-1066. View in: Pubmed

    • Association of autophagy status with amount of Fusobacterium nucleatum in colorectal cancer. J Pathol. 2020 04; 250(4):397-408. View in: Pubmed

    • Immune recognition of microbial metabolites. Nat Rev Immunol. 2020 02; 20(2):91-92. View in: Pubmed

    • The Taste Receptor TAS1R3 Regulates Small Intestinal Tuft Cell Homeostasis. Immunohorizons. 2020 01 24; 4(1):23-32. View in: Pubmed

    • Association Between Sulfur-Metabolizing Bacterial Communities in Stool and Risk of Distal Colorectal Cancer in Men. Gastroenterology. 2020 04; 158(5):1313-1325. View in: Pubmed

    • Expression of Free Fatty Acid Receptor 2 by Dendritic Cells Prevents Their Expression of Interleukin 27 and Is Required for Maintenance of Mucosal Barrier and Immune Response Against Colorectal Tumors in Mice. Gastroenterology. 2020 04; 158(5):1359-1372.e9. View in: Pubmed

    • Metabolite-Sensing Receptor Ffar2 Regulates Colonic Group 3 Innate Lymphoid Cells and Gut Immunity. Immunity. 2019 11 19; 51(5):871-884.e6. View in: Pubmed

    • The gut microbiota and colon cancer. Science. 2019 06 21; 364(6446):1133-1135. View in: Pubmed

    • The cancer microbiome. Nat Rev Cancer. 2019 07; 19(7):371-376. View in: Pubmed

    • Challenges in IBD Research: Preclinical Human IBD Mechanisms. Inflamm Bowel Dis. 2019 05 16; 25(Suppl 2):S5-S12. View in: Pubmed

    • Fusobacterium nucleatum - symbiont, opportunist and oncobacterium. Nat Rev Microbiol. 2019 03; 17(3):156-166. View in: Pubmed

    • Butyrate Makes Macrophages "Go Nuclear" against Bacterial Pathogens. Immunity. 2019 02 19; 50(2):275-278. View in: Pubmed

    • The human gut bacterial genotoxin colibactin alkylates DNA. Science. 2019 02 15; 363(6428). View in: Pubmed

    • Calcium Intake and Risk of Colorectal Cancer According to Tumor-infiltrating T Cells. Cancer Prev Res (Phila). 2019 05; 12(5):283-294. View in: Pubmed

    • The Crohn's disease polymorphism, ATG16L1 T300A, alters the gut microbiota and enhances the local Th1/Th17 response. Elife. 2019 01 22; 8. View in: Pubmed

    • Comparative genomics and genome biology of Campylobacter showae. Emerg Microbes Infect. 2019; 8(1):827-840. View in: Pubmed

    • The Unfolding Story of ATF6, Microbial Dysbiosis, and Colorectal Cancer. Gastroenterology. 2018 11; 155(5):1309-1311. View in: Pubmed

    • The Amount of Bifidobacterium Genus in Colorectal Carcinoma Tissue in Relation to Tumor Characteristics and Clinical Outcome. Am J Pathol. 2018 12; 188(12):2839-2852. View in: Pubmed

    • Fusobacterium nucleatum in Colorectal Cancer Relates to Immune Response Differentially by Tumor Microsatellite Instability Status. Cancer Immunol Res. 2018 11; 6(11):1327-1336. View in: Pubmed

    • Diets That Promote Colon Inflammation Associate With Risk of Colorectal Carcinomas That Contain Fusobacterium nucleatum. Clin Gastroenterol Hepatol. 2018 10; 16(10):1622-1631.e3. View in: Pubmed

    • Integrative analysis of exogenous, endogenous, tumour and immune factors for precision medicine. Gut. 2018 06; 67(6):1168-1180. View in: Pubmed

    • A single-cell survey of the small intestinal epithelium. Nature. 2017 11 16; 551(7680):333-339. View in: Pubmed

    • Take DAT, Flu! Immunity. 2017 09 19; 47(3):400-402. View in: Pubmed

    • Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine. Science. 2017 09 15; 357(6356):1156-1160. View in: Pubmed

    • Association Between Inflammatory Diet Pattern and Risk of Colorectal Carcinoma Subtypes Classified by Immune Responses to Tumor. Gastroenterology. 2017 12; 153(6):1517-1530.e14. View in: Pubmed

    • Fluoride Depletes Acidogenic Taxa in Oral but Not Gut Microbial Communities in Mice. mSystems. 2017 Jul-Aug; 2(4). View in: Pubmed

    • Fighting Fire with Fiber: Preventing T Cell Infiltration in Diabetes. Cell Metab. 2017 Jul 05; 26(1):8-10. View in: Pubmed

    • Association of Dietary Patterns With Risk of Colorectal Cancer Subtypes Classified by Fusobacterium nucleatum in Tumor Tissue. JAMA Oncol. 2017 Jul 01; 3(7):921-927. View in: Pubmed

    • Long-term use of antibiotics and risk of colorectal adenoma. Gut. 2018 04; 67(4):672-678. View in: Pubmed

    • Tumor SQSTM1 (p62) expression and T cells in colorectal cancer. Oncoimmunology. 2017; 6(3):e1284720. View in: Pubmed

    • Gut microbiota in 2016: A banner year for gut microbiota research. Nat Rev Gastroenterol Hepatol. 2017 02; 14(2):78-80. View in: Pubmed

    • QseC inhibition as an antivirulence approach for colitis-associated bacteria. Proc Natl Acad Sci U S A. 2017 01 03; 114(1):142-147. View in: Pubmed

    • Gut microbiota induce IGF-1 and promote bone formation and growth. Proc Natl Acad Sci U S A. 2016 11 22; 113(47):E7554-E7563. View in: Pubmed

    • Fusobacterium nucleatum in Colorectal Carcinoma Tissue According to Tumor Location. Clin Transl Gastroenterol. 2016 Nov 03; 7(11):e200. View in: Pubmed

    • Gut Microbiota, Inflammation, and Colorectal Cancer. Annu Rev Microbiol. 2016 09 08; 70:395-411. View in: Pubmed

    • Marine ?-3 Polyunsaturated Fatty Acid Intake and Risk of Colorectal Cancer Characterized by Tumor-Infiltrating T Cells. JAMA Oncol. 2016 Sep 01; 2(9):1197-206. View in: Pubmed

    • Fap2 Mediates Fusobacterium nucleatum Colorectal Adenocarcinoma Enrichment by Binding to Tumor-Expressed Gal-GalNAc. Cell Host Microbe. 2016 Aug 10; 20(2):215-25. View in: Pubmed

    • Regular Aspirin Use Associates With Lower Risk of Colorectal Cancers With Low Numbers of Tumor-Infiltrating Lymphocytes. Gastroenterology. 2016 11; 151(5):879-892.e4. View in: Pubmed

    • Gut microbiota, metabolites and host immunity. Nat Rev Immunol. 2016 05 27; 16(6):341-52. View in: Pubmed

    • The reproductive tracts of two malaria vectors are populated by a core microbiome and by gender- and swarm-enriched microbial biomarkers. Sci Rep. 2016 Apr 18; 6:24207. View in: Pubmed

    • Ecological robustness of the gut microbiota in response to ingestion of transient food-borne microbes. ISME J. 2016 09; 10(9):2235-45. View in: Pubmed

    • Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut. Science. 2016 Mar 18; 351(6279):1329-33. View in: Pubmed

    • Fusobacterium nucleatum in colorectal carcinoma tissue and patient prognosis. Gut. 2016 12; 65(12):1973-1980. View in: Pubmed

    • Fusobacterium nucleatum and T Cells in Colorectal Carcinoma. JAMA Oncol. 2015 Aug; 1(5):653-61. View in: Pubmed

    • From cell biology to the microbiome: An intentional infinite loop. J Cell Biol. 2015 Jul 06; 210(1):7-8. View in: Pubmed

    • CCL2 Promotes Colorectal Carcinogenesis by Enhancing Polymorphonuclear Myeloid-Derived Suppressor Cell Population and Function. Cell Rep. 2015 Jul 14; 12(2):244-57. View in: Pubmed

    • Host lysozyme-mediated lysis of Lactococcus lactis facilitates delivery of colitis-attenuating superoxide dismutase to inflamed colons. Proc Natl Acad Sci U S A. 2015 Jun 23; 112(25):7803-8. View in: Pubmed

    • Host microbiota constantly control maturation and function of microglia in the CNS. Nat Neurosci. 2015 Jul; 18(7):965-77. View in: Pubmed

    • Cancer and the microbiota. Science. 2015 Apr 03; 348(6230):80-6. View in: Pubmed

    • A reproducible approach to high-throughput biological data acquisition and integration. PeerJ. 2015; 3:e791. View in: Pubmed

    • Gut microbiota. Microbiota organization--a key to understanding CRC development. Nat Rev Gastroenterol Hepatol. 2015 Mar; 12(3):128-9. View in: Pubmed

    • Binding of the Fap2 protein of Fusobacterium nucleatum to human inhibitory receptor TIGIT protects tumors from immune cell attack. Immunity. 2015 Feb 17; 42(2):344-355. View in: Pubmed

    • Nutrients, foods, and colorectal cancer prevention. Gastroenterology. 2015 May; 148(6):1244-60.e16. View in: Pubmed

    • Near-zero growth kinetics of Pseudomonas putida deduced from proteomic analysis. Environ Microbiol. 2015 Jan; 17(1):215-28. View in: Pubmed

    • Relating the metatranscriptome and metagenome of the human gut. Proc Natl Acad Sci U S A. 2014 Jun 03; 111(22):E2329-38. View in: Pubmed

    • Microbes, microbiota, and colon cancer. Cell Host Microbe. 2014 Mar 12; 15(3):317-28. View in: Pubmed

    • Gut microbiome composition and function in experimental colitis during active disease and treatment-induced remission. ISME J. 2014 Jul; 8(7):1403-17. View in: Pubmed

    • Microbes and inflammation in colorectal cancer. Cancer Immunol Res. 2013 Sep; 1(3):150-7. View in: Pubmed

    • Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment. Cell Host Microbe. 2013 Aug 14; 14(2):207-15. View in: Pubmed

    • Sequence-based discovery of Bradyrhizobium enterica in cord colitis syndrome. N Engl J Med. 2013 Aug 08; 369(6):517-28. View in: Pubmed

    • Functional profiling of the gut microbiome in disease-associated inflammation. Genome Med. 2013; 5(7):65. View in: Pubmed

    • The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Science. 2013 Aug 02; 341(6145):569-73. View in: Pubmed

    • Antibody to a conserved antigenic target is protective against diverse prokaryotic and eukaryotic pathogens. Proc Natl Acad Sci U S A. 2013 Jun 11; 110(24):E2209-18. View in: Pubmed

    • Computational meta'omics for microbial community studies. Mol Syst Biol. 2013 May 14; 9:666. View in: Pubmed

    • Kwashiorkor and the gut microbiota. N Engl J Med. 2013 May 02; 368(18):1746-7. View in: Pubmed

    • Exploring host-microbiota interactions in animal models and humans. Genes Dev. 2013 Apr 01; 27(7):701-18. View in: Pubmed

    • A complex microworld in the gut: gut microbiota and cardiovascular disease connectivity. Nat Med. 2012 Aug; 18(8):1188-9. View in: Pubmed

    • Tumor necrosis factor a inhibits expression of the iron regulating hormone hepcidin in murine models of innate colitis. PLoS One. 2012; 7(5):e38136. View in: Pubmed

    • Genomic analysis identifies association of Fusobacterium with colorectal carcinoma. Genome Res. 2012 Feb; 22(2):292-8. View in: Pubmed

    • Metagenomic biomarker discovery and explanation. Genome Biol. 2011 Jun 24; 12(6):R60. View in: Pubmed

    • Bacteria, food, and cancer. F1000 Biol Rep. 2011; 3:12. View in: Pubmed

    • The gut microbiota and mucosal T cells. Front Microbiol. 2011; 2:111. View in: Pubmed

    • Severity of innate immune-mediated colitis is controlled by the cytokine deficiency-induced colitis susceptibility-1 (Cdcs1) locus. Proc Natl Acad Sci U S A. 2011 Apr 26; 108(17):7137-41. View in: Pubmed

    • Host and gut microbiota symbiotic factors: lessons from inflammatory bowel disease and successful symbionts. Cell Microbiol. 2011 Apr; 13(4):508-17. View in: Pubmed

    • Current concepts of the intestinal microbiota and the pathogenesis of infection. Curr Infect Dis Rep. 2011 Feb; 13(1):28-34. View in: Pubmed

    • Bifidobacterium animalis subsp. lactis fermented milk product reduces inflammation by altering a niche for colitogenic microbes. Proc Natl Acad Sci U S A. 2010 Oct 19; 107(42):18132-7. View in: Pubmed

    • Enterobacteriaceae act in concert with the gut microbiota to induce spontaneous and maternally transmitted colitis. Cell Host Microbe. 2010 Sep 16; 8(3):292-300. View in: Pubmed

    • Homeostasis and inflammation in the intestine. Cell. 2010 Mar 19; 140(6):859-70. View in: Pubmed

    • Colitis-associated colorectal cancer driven by T-bet deficiency in dendritic cells. Cancer Cell. 2009 Sep 08; 16(3):208-19. View in: Pubmed

    • T-bet-/- RAG2-/- ulcerative colitis: the role of T-bet as a peacekeeper of host-commensal relationships. Cytokine. 2009 Oct-Nov; 48(1-2):144-7. View in: Pubmed

    • Liver metastasis in a case of adenoid cystic carcinoma of the Bartholin's gland: a rare presentation. Arch Gynecol Obstet. 2009 May; 279(5):747-50. View in: Pubmed

    • Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system. Cell. 2007 Oct 05; 131(1):33-45. View in: Pubmed

    • Activation of lysosomal function during dendritic cell maturation. Science. 2003 Feb 28; 299(5611):1400-3. View in: Pubmed

    • Dendritic cell maturation triggers retrograde MHC class II transport from lysosomes to the plasma membrane. Nature. 2002 Aug 29; 418(6901):988-94. View in: Pubmed

    • Differential presentation of a soluble exogenous tumor antigen, NY-ESO-1, by distinct human dendritic cell populations. Proc Natl Acad Sci U S A. 2002 Aug 06; 99(16):10629-34. View in: Pubmed

    • Defective antigen processing in GILT-free mice. Science. 2001 Nov 09; 294(5545):1361-5. View in: Pubmed

    • Developmental control of endocytosis in dendritic cells by Cdc42. Cell. 2000 Aug 04; 102(3):325-34. View in: Pubmed

    • Transport of peptide-MHC class II complexes in developing dendritic cells. Science. 2000 Apr 21; 288(5465):522-7. View in: Pubmed


    Location Avtar

    Dana-Farber Cancer Institute

    450 Brookline Avenue Boston, MA 02215
    Get Directions

    Dana-Farber Cancer Institute

    Location Avtar

    Dana-Farber Cancer Institute

    450 Brookline Avenue Boston, MA 02215
    Get Direction
    42.3374, -71.1082