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Wendy S. Garrett, MD, PhD


Medical Oncology

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Physician

  • Physician
  • Associate Professor of Medicine, Harvard Medical School

Centers/Programs

Clinical Interests

  • Gastrointestinal malignancies

Contact Information

  • Appointments877-332-4294
  • Office Phone Number877-332-4294

Board Certification:

  • Internal Medicine
  • Medical Oncology

Fellowship:

  • Dana-Farber Cancer Institute, Medical Oncology

Residency:

  • Brigham and Women's Hospital, Internal Medicine

Medical School:

  • Yale University

Research

Association of Fusobacterium nucleatum with Specific T Cell Subsets in the Colorectal Carcinoma Microenvironment. Clin Cancer Res. 2021 Feb 25.
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Diet posttranslationally modifies the mouse gut microbial proteome to modulate renal function. Science. 2020 09 18; 369(6510):1518-1524.
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Colon Cancer-Associated Fusobacterium nucleatum May Originate From the Oral Cavity and Reach Colon Tumors via the Circulatory System. Front Cell Infect Microbiol. 2020; 10:400.
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Interleukin-13 drives metabolic conditioning of muscle to endurance exercise. Science. 2020 05 01; 368(6490).
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Structure of the Mucosal and Stool Microbiome in Lynch Syndrome. Cell Host Microbe. 2020 04 08; 27(4):585-600.e4.
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Enterococcus in Graft-versus-Host Disease. N Engl J Med. 2020 03 12; 382(11):1064-1066.
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Association of autophagy status with amount of Fusobacterium nucleatum in colorectal cancer. J Pathol. 2020 04; 250(4):397-408.
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Immune recognition of microbial metabolites. Nat Rev Immunol. 2020 02; 20(2):91-92.
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The Taste Receptor TAS1R3 Regulates Small Intestinal Tuft Cell Homeostasis. Immunohorizons. 2020 01 24; 4(1):23-32.
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Association Between Sulfur-Metabolizing Bacterial Communities in Stool and Risk of Distal Colorectal Cancer in Men. Gastroenterology. 2020 04; 158(5):1313-1325.
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Expression of Free Fatty Acid Receptor 2 by Dendritic Cells Prevents Their Expression of Interleukin 27 and Is Required for Maintenance of Mucosal Barrier and Immune Response Against Colorectal Tumors in Mice. Gastroenterology. 2020 04; 158(5):1359-1372.e9.
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Metabolite-Sensing Receptor Ffar2 Regulates Colonic Group 3 Innate Lymphoid Cells and Gut Immunity. Immunity. 2019 11 19; 51(5):871-884.e6.
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The gut microbiota and colon cancer. Science. 2019 06 21; 364(6446):1133-1135.
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The cancer microbiome. Nat Rev Cancer. 2019 07; 19(7):371-376.
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Challenges in IBD Research: Preclinical Human IBD Mechanisms. Inflamm Bowel Dis. 2019 05 16; 25(Suppl 2):S5-S12.
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Fusobacterium nucleatum - symbiont, opportunist and oncobacterium. Nat Rev Microbiol. 2019 03; 17(3):156-166.
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Butyrate Makes Macrophages "Go Nuclear" against Bacterial Pathogens. Immunity. 2019 02 19; 50(2):275-278.
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The human gut bacterial genotoxin colibactin alkylates DNA. Science. 2019 02 15; 363(6428).
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Calcium Intake and Risk of Colorectal Cancer According to Tumor-infiltrating T Cells. Cancer Prev Res (Phila). 2019 05; 12(5):283-294.
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The Crohn's disease polymorphism, ATG16L1 T300A, alters the gut microbiota and enhances the local Th1/Th17 response. Elife. 2019 01 22; 8.
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Comparative genomics and genome biology of Campylobacter showae. Emerg Microbes Infect. 2019; 8(1):827-840.
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The Unfolding Story of ATF6, Microbial Dysbiosis, and Colorectal Cancer. Gastroenterology. 2018 11; 155(5):1309-1311.
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The Amount of Bifidobacterium Genus in Colorectal Carcinoma Tissue in Relation to Tumor Characteristics and Clinical Outcome. Am J Pathol. 2018 12; 188(12):2839-2852.
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Fusobacterium nucleatum in Colorectal Cancer Relates to Immune Response Differentially by Tumor Microsatellite Instability Status. Cancer Immunol Res. 2018 11; 6(11):1327-1336.
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Diets That Promote Colon Inflammation Associate With Risk of Colorectal Carcinomas That Contain Fusobacterium nucleatum. Clin Gastroenterol Hepatol. 2018 10; 16(10):1622-1631.e3.
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Integrative analysis of exogenous, endogenous, tumour and immune factors for precision medicine. Gut. 2018 06; 67(6):1168-1180.
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A single-cell survey of the small intestinal epithelium. Nature. 2017 11 16; 551(7680):333-339.
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Take DAT, Flu! Immunity. 2017 09 19; 47(3):400-402.
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Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine. Science. 2017 09 15; 357(6356):1156-1160.
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Association Between Inflammatory Diet Pattern and Risk of Colorectal Carcinoma Subtypes Classified by Immune Responses to Tumor. Gastroenterology. 2017 12; 153(6):1517-1530.e14.
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Fluoride Depletes Acidogenic Taxa in Oral but Not Gut Microbial Communities in Mice. mSystems. 2017 Jul-Aug; 2(4).
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Fighting Fire with Fiber: Preventing T Cell Infiltration in Diabetes. Cell Metab. 2017 Jul 05; 26(1):8-10.
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Association of Dietary Patterns With Risk of Colorectal Cancer Subtypes Classified by Fusobacterium nucleatum in Tumor Tissue. JAMA Oncol. 2017 Jul 01; 3(7):921-927.
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Long-term use of antibiotics and risk of colorectal adenoma. Gut. 2018 04; 67(4):672-678.
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Tumor SQSTM1 (p62) expression and T cells in colorectal cancer. Oncoimmunology. 2017; 6(3):e1284720.
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Gut microbiota in 2016: A banner year for gut microbiota research. Nat Rev Gastroenterol Hepatol. 2017 02; 14(2):78-80.
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QseC inhibition as an antivirulence approach for colitis-associated bacteria. Proc Natl Acad Sci U S A. 2017 01 03; 114(1):142-147.
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Gut microbiota induce IGF-1 and promote bone formation and growth. Proc Natl Acad Sci U S A. 2016 11 22; 113(47):E7554-E7563.
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Fusobacterium nucleatum in Colorectal Carcinoma Tissue According to Tumor Location. Clin Transl Gastroenterol. 2016 Nov 03; 7(11):e200.
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Gut Microbiota, Inflammation, and Colorectal Cancer. Annu Rev Microbiol. 2016 09 08; 70:395-411.
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Marine ?-3 Polyunsaturated Fatty Acid Intake and Risk of Colorectal Cancer Characterized by Tumor-Infiltrating T Cells. JAMA Oncol. 2016 Sep 01; 2(9):1197-206.
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Fap2 Mediates Fusobacterium nucleatum Colorectal Adenocarcinoma Enrichment by Binding to Tumor-Expressed Gal-GalNAc. . 2016 Aug 10; 20(2):215-25.
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Regular Aspirin Use Associates With Lower Risk of Colorectal Cancers With Low Numbers of Tumor-Infiltrating Lymphocytes. Gastroenterology. 2016 11; 151(5):879-892.e4.
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Gut microbiota, metabolites and host immunity. Nat Rev Immunol. 2016 05 27; 16(6):341-52.
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The reproductive tracts of two malaria vectors are populated by a core microbiome and by gender- and swarm-enriched microbial biomarkers. Sci Rep. 2016 Apr 18; 6:24207.
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Ecological robustness of the gut microbiota in response to ingestion of transient food-borne microbes. ISME J. 2016 09; 10(9):2235-45.
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Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut. Science. 2016 Mar 18; 351(6279):1329-33.
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Fusobacterium nucleatum in colorectal carcinoma tissue and patient prognosis. Gut. 2016 12; 65(12):1973-1980.
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Fusobacterium nucleatum and T Cells in Colorectal Carcinoma. JAMA Oncol. 2015 Aug; 1(5):653-61.
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From cell biology to the microbiome: An intentional infinite loop. J Cell Biol. 2015 Jul 06; 210(1):7-8.
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CCL2 Promotes Colorectal Carcinogenesis by Enhancing Polymorphonuclear Myeloid-Derived Suppressor Cell Population and Function. Cell Rep. 2015 Jul 14; 12(2):244-57.
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Host lysozyme-mediated lysis of Lactococcus lactis facilitates delivery of colitis-attenuating superoxide dismutase to inflamed colons. Proc Natl Acad Sci U S A. 2015 Jun 23; 112(25):7803-8.
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Host microbiota constantly control maturation and function of microglia in the CNS. Nat Neurosci. 2015 Jul; 18(7):965-77.
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Cancer and the microbiota. Science. 2015 Apr 03; 348(6230):80-6.
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A reproducible approach to high-throughput biological data acquisition and integration. PeerJ. 2015; 3:e791.
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Gut microbiota. Microbiota organization--a key to understanding CRC development. Nat Rev Gastroenterol Hepatol. 2015 Mar; 12(3):128-9.
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Binding of the Fap2 protein of Fusobacterium nucleatum to human inhibitory receptor TIGIT protects tumors from immune cell attack. Immunity. 2015 Feb 17; 42(2):344-355.
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Nutrients, foods, and colorectal cancer prevention. Gastroenterology. 2015 May; 148(6):1244-60.e16.
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Near-zero growth kinetics of Pseudomonas putida deduced from proteomic analysis. Environ Microbiol. 2015 Jan; 17(1):215-28.
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Relating the metatranscriptome and metagenome of the human gut. Proc Natl Acad Sci U S A. 2014 Jun 03; 111(22):E2329-38.
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Microbes, microbiota, and colon cancer. . 2014 Mar 12; 15(3):317-28.
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Gut microbiome composition and function in experimental colitis during active disease and treatment-induced remission. ISME J. 2014 Jul; 8(7):1403-17.
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Microbes and inflammation in colorectal cancer. Cancer Immunol Res. 2013 Sep; 1(3):150-7.
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Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment. . 2013 Aug 14; 14(2):207-15.
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Sequence-based discovery of Bradyrhizobium enterica in cord colitis syndrome. N Engl J Med. 2013 Aug 08; 369(6):517-28.
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Functional profiling of the gut microbiome in disease-associated inflammation. Genome Med. 2013; 5(7):65.
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The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Science. 2013 Aug 02; 341(6145):569-73.
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Antibody to a conserved antigenic target is protective against diverse prokaryotic and eukaryotic pathogens. Proc Natl Acad Sci U S A. 2013 Jun 11; 110(24):E2209-18.
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Computational meta'omics for microbial community studies. Mol Syst Biol. 2013 May 14; 9:666.
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Kwashiorkor and the gut microbiota. N Engl J Med. 2013 May 02; 368(18):1746-7.
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Exploring host-microbiota interactions in animal models and humans. Genes Dev. 2013 Apr 01; 27(7):701-18.
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A complex microworld in the gut: gut microbiota and cardiovascular disease connectivity. Nat Med. 2012 Aug; 18(8):1188-9.
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Tumor necrosis factor a inhibits expression of the iron regulating hormone hepcidin in murine models of innate colitis. PLoS One. 2012; 7(5):e38136.
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Genomic analysis identifies association of Fusobacterium with colorectal carcinoma. Genome Res. 2012 Feb; 22(2):292-8.
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Metagenomic biomarker discovery and explanation. Genome Biol. 2011 Jun 24; 12(6):R60.
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Bacteria, food, and cancer. F1000 Biol Rep. 2011; 3:12.
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The gut microbiota and mucosal T cells. Front Microbiol. 2011; 2:111.
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Severity of innate immune-mediated colitis is controlled by the cytokine deficiency-induced colitis susceptibility-1 (Cdcs1) locus. Proc Natl Acad Sci U S A. 2011 Apr 26; 108(17):7137-41.
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Host and gut microbiota symbiotic factors: lessons from inflammatory bowel disease and successful symbionts. Cell Microbiol. 2011 Apr; 13(4):508-17.
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Current concepts of the intestinal microbiota and the pathogenesis of infection. Curr Infect Dis Rep. 2011 Feb; 13(1):28-34.
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Bifidobacterium animalis subsp. lactis fermented milk product reduces inflammation by altering a niche for colitogenic microbes. Proc Natl Acad Sci U S A. 2010 Oct 19; 107(42):18132-7.
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Enterobacteriaceae act in concert with the gut microbiota to induce spontaneous and maternally transmitted colitis. . 2010 Sep 16; 8(3):292-300.
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Homeostasis and inflammation in the intestine. Cell. 2010 Mar 19; 140(6):859-70.
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Colitis-associated colorectal cancer driven by T-bet deficiency in dendritic cells. Cancer Cell. 2009 Sep 08; 16(3):208-19.
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T-bet-/- RAG2-/- ulcerative colitis: the role of T-bet as a peacekeeper of host-commensal relationships. Cytokine. 2009 Oct-Nov; 48(1-2):144-7.
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Liver metastasis in a case of adenoid cystic carcinoma of the Bartholin's gland: a rare presentation. Arch Gynecol Obstet. 2009 May; 279(5):747-50.
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Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system. Cell. 2007 Oct 05; 131(1):33-45.
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Activation of lysosomal function during dendritic cell maturation. Science. 2003 Feb 28; 299(5611):1400-3.
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Dendritic cell maturation triggers retrograde MHC class II transport from lysosomes to the plasma membrane. Nature. 2002 Aug 29; 418(6901):988-94.
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Differential presentation of a soluble exogenous tumor antigen, NY-ESO-1, by distinct human dendritic cell populations. Proc Natl Acad Sci U S A. 2002 Aug 06; 99(16):10629-34.
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Defective antigen processing in GILT-free mice. Science. 2001 Nov 09; 294(5545):1361-5.
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Developmental control of endocytosis in dendritic cells by Cdc42. Cell. 2000 Aug 04; 102(3):325-34.
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Transport of peptide-MHC class II complexes in developing dendritic cells. Science. 2000 Apr 21; 288(5465):522-7.
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Location

Dana-Farber Cancer Institute
450 Brookline Avenue
Boston, MA 02215
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