In This Issue
- Introduction by Joseph Antin, MD - One of the major challenges in the past 40 years of stem cell transplantation has been donor availability.
- Clinical Practice Spotlight: Management of Graft-versus-Host Disease (GVHD) - Risk factors for GVHD include greater degree of HLA mismatch between donor and recipient; stem cell source (the risk of GVHD with peripheral blood stem cells is greater than with bone marrow stem cells, which is, in turn, greater than with umbilical cord blood); gender mismatch with the donor; multiparity of a female donor; and more intensive conditioning regimens.
- Clinical Trial Spotlight: Bortezomib-Based GVHD Prophylaxis - Allogeneic hematopoietic stem cell transplantation (HSCT) represents a potentially curative option for patients with advanced or aggressive hematologic malignancies.
- Complex Case Study: Four Stem Cell Transplants for Acute Myeloid Leukemia (AML) - In 2003, a then-48-year-old woman who is an avid distance runner presented to her primary care physician after noticing unusual fatigue during a 10-kilometer race.
- Complex Case Study: The Patient's Perspective - While running the Saint Patrick's Road Race on March 22, 2003, near my home in western Massachusetts, I could hardly catch my breath.
- Research Spotlight: Transformation of Hematopoietic Cell Transplantation from Stem to Stern - For patients with active, advanced acute myeloid leukemia (AML) and chronic lymphoid leukemia (CLL) who are undergoing HSCT.