Advances in Hematologic Malignancies Issue 5, Fall 2016

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In This Issue

  • Clinical Trial Spotlight-Trial #12-537 Ipilimumab for Patients Who Relapse after Allogeneic Transplantation - Patients with hematologic malignancies who relapse after allogeneic transplantation have few effective therapeutic options and generally have a poor prognosis.
  • Immunomodulation in Multiple Myeloma - Effective cancer immunotherapy represents a major paradigm shift in the treatment of solid and hematologic malignancies. From the development of monoclonal antibodies (MoAb) to antibody-drug conjugates targeting cancer-associated epitopes until the most recent checkpoint blockade and bioengineered chimeric antigen receptor (CAR) T cells, the natural history of several types of cancer has been radically impacted by these treatments.
  • PD-1 Blockade in Classical Hodgkin Lymphoma - Using the power of the human immune system to combat cancer has been a long-standing goal in oncology. In the last few years, an important milestone on the way to this goal has been the understanding of immune checkpoint pathways.
  • Research Spotlight: New Frontiers in Cellular Therapies – 360 Degrees of Immuno-oncology - Allogeneic hematopoietic stem cell transplantation (HSCT) is the original cellular therapy. When HSCT is used for treatment of patients with leukemia and other hematologic malignancies, clinicians hope that polyclonal T cells from healthy donors will recognize tumor cells that the patient's own T cells do not, thereby exerting an anti-neoplastic "graft-versus-leukemia" (GvL) effect.

Additional Resources

Hematologic Oncology Treatment Center
Clinical Trials for Hematologic Malignancies
Older Adult Hematologic Malignancy Program

Hematologic Malignancies: Physician Resources

If you are a clinician specializing in the field of hematologic oncology, we can help you refer a patient, explore open clinical trials, learn about CME events, and more.

View our full list of hematologic malignancies resources for referring providers.

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