Image-Guided Gynecologic Brachytherapy

Status: Recruiting
Phase: Phase 2
Diagnosis: GYN: Cervical Cancer, GYN: Endometrial/Uterine Cancer
NCT ID: NCT01399658 (View complete trial on ClinicalTrials.gov)
DFCI Protocol ID: 11-098

 

Standard therapy for gynecologic cancers involves the use of brachytherapy, also called internal radiation therapy or implant radiation. The treatment being studied consists of standard brachytherapy with the additional use of MRI to guide the insertion of radioactive applicators. The purpose of the study is to find out whether MRI-guided brachytherapy is practical and beneficial when compared to the standard CT-guided brachytherapy placement. The investigators are hoping that this MRI procedure will decrease the risk of giving too high a radiation dose to the bladder or bowel.

 

Conducting Institutions:
Dana-Farber Cancer Institute, Brigham and Women's Hospital

Overall PI:
Akila Viswanathan, MD, Brigham and Women's Hospital

Site-responsible Investigators:

Contacts:
Dana-Farber Cancer Institute: Barbara Silver, 617-525-7393, bsilver@partners.org

Eligibility Criteria

Inclusion Criteria: - Histologically or cytologically confirmed carcinoma of the cervix (Stage I-IVA), carcinoma of the uterus (Stage IIIB), carcinoma of the vagina (Stage I-IVA), or carcinoma of the vulva (stage I-IVA) - Life expectancy > 6 months - MRI of the pelvis and/or PET-CT within 4 months prior to entering study Exclusion Criteria: - Uncontrolled intercurrent illness - Pacemaker, brain aneurysm clip, inner ear implant, neurostimulator, or metal fragments in the eye
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