Andrew Aguirre, MD, PhD, in collaboration with the Cancer
Dependency Map (DepMap) project at Dana-Farber and the Broad Institute of MIT
and Harvard, reports in Cell Reports a genetic dependency that could be present in more than
30% of all cancers. In this study led by co-first authors Brenton Paolella, PhD,
and Jasper Neggers, PhD, of the Aguirre Lab, large-scale CRISPR-SpCas9 and RNA
interference (RNAi) loss-of-function screening of more than 600 cancer cell
lines was implemented to systematically define synthetic lethal vulnerabilities
associated with genomic loss of established tumor suppression genes ...