A recent study in Cancer Cell reveals an
important resistance mechanism to T cell-mediated cytotoxicity for
Triple-Negative Breast Cancer (TNBC) cells through the identification and
mechanistic study of the transcription factor SOX4. First author Argis Bagati,
PhD, and senior author Kai Wucherpfennig, MD, PhD, of Dana-Farber focused on
the transcription factor SOX4 as it is associated with cancer cell invasion,
wherein high expression of SOX4 is associated with a poor prognosis in many
human cancers, in particular TNBC ... Study results suggest that further
research in the targeting of the integrin αvβ6-TGFβ-SOX4 pathway will provide
therapeutic opportunities for TNBC and other highly aggressive human cancers of
epithelial origin ...