Basic Chemistry and Chemical Biology

Pushing the boundaries of basic science fuels the advancement of more applied scientific interests in the program. We are developing new organic and analytical methodologies, and are studying the basic principles of chemical and biological mechanisms, since both are essential enablers of our more translational efforts.

Our recent focus includes new organic chemistry methodology towards natural product-like compounds and libraries, and improved biologically compatible reactions, as well as mass spectrometry (MS)-based proteomic analytical strategies that speed up small molecule and degrader discoveries, and new nuclear magnetic resonance (NMR) spectroscopy techniques that push up the size limits of this technique, especially for intrinsically disordered proteins (IDPs).

Several of our labs are involved in these activities:

  • The Arthanari Lab is developing new pulse sequences that push the boundaries of NMR spectroscopy.
  • The Kim Lab is advancing organic chemistry reactions that enable natural product synthesis.
  • The Marto Lab is creating new MS methodologies for analyzing complex biological samples.