Alexandra Golby, MD

Alexandra Golby, MD


Contact Information

Office Phone Number








Director of Image-Guided Neurosurgery, Brigham and Women's Hospital
Co-Director AMIGO (advanced multi-modality image-guided OR), Brigham and Women's Hospital
Co-Director Clinical fMRI, Brigham and Women's Hospital
Haley Distinguished Chair in the Neurosciences, Brigham and Women's Hospital
Professor of Neurosurgery, Professor of Radiology, Harvard Medical School


Clinical Interests

Brain mapping, Brain metastases, Functional MRI, Gliomas, Image-guided surgery, Laser interstitial thermal therapy (LTT), Malignant and benign brain tumors, Meningiomas, Tumors in critical brain areas

Board Certification

  • Neurosurgery, 2007


  • Centre Hospitialier de Grenoble, Grenoble France, Functional Neurosurgery
  • Congress of Neurological Surgeons Dandy Fellow, Functional Neurosurgery


  • Brigham and Women's Hospital/Boston Children's Hospital
  • Stanford University School of Medicine, Neurosurgery

Medical School

  • Stanford University School of Medicine

Recent Awards

  • CIMIT Young Clinicians Award 2008
  • Brigham and Womens Hospital inaugural recipient New Innovators Award 2010-11


    The Golby Lab pursues translational research multi-modality image-guided neurosurgery with a particular interest in functional brain mapping.

    Dr. Golby's research involves the application of brain mapping techniques to neurosurgical patients as well as neuroscientific investigations into the brain basis of neurologic functions. These efforts are centered on improving surgery for patients with epilepsy and brain tumors, particularly those whose pathology is intimately involved with critical brain regions. The Golby Lab is a translational multidisciplinary group of investigators focusing on functional brain mapping using both structural and functional imaging techniques to guide neurosurgical planning and intra-operative decision making. This work aims to integrate information acquired from pre-operative brain mapping with intra-operative brain mapping and intra-operative imaging to define functional brain anatomy for surgical planning. We use multiple functional brain mapping techniques (fMRI, diffusion tensor imaging, and intracranial EEG) and structural and molecular imaging techniques to better define individual functional anatomy in patients with neurosurgical diseases, cross-validate information acquired through different techniques, and gain a better understanding of the relationship between these different brain signals. The goal is to provide the surgeon with optimal information to perform less invasive, safer, and more effective interventions. We are also interested in how the brain may reorganize in the face of injury. The Golby Lab is funded by the Brain Science Foundation, The Klarman Family Foundation, CIMIT Harvard Catalyst, and the National Institutes of Health, allowing her to assemble a team of extraordinary scientists from different backgrounds, working collaboratively to advance the field of image-guided surgery and functional brain imaging.


      • ReMIND: The Brain Resection Multimodal Imaging Database. medRxiv. 2023 Sep 15. View in: Pubmed

      • Real-Time Dynamic Data Driven Deformable Registration for Image-Guided Neurosurgery: Computational Aspects. ArXiv. 2023 Sep 06. View in: Pubmed

      • Deep Learning for Detection and Localization of B-Lines in Lung Ultrasound. IEEE J Biomed Health Inform. 2023 09; 27(9):4352-4361. View in: Pubmed

      • Glasgow coma scale pupil score (GCS-P) and the hospital mortality in severe traumatic brain injury: analysis of 1,066 Brazilian patients. Arq Neuropsiquiatr. 2023 05; 81(5):452-459. View in: Pubmed

      • Directionally encoded color track density imaging in brain tumor patients: A potential application to neuro-oncology surgical planning. Neuroimage Clin. 2023; 38:103412. View in: Pubmed

      • SlicerCBM: automatic framework for biomechanical analysis of the brain. Int J Comput Assist Radiol Surg. 2023 Oct; 18(10):1925-1940. View in: Pubmed

      • Surgical approach to the treatment of pituicytoma. Report of five cases and a literature review. World Neurosurg X. 2023 Jul; 19:100186. View in: Pubmed

      • Mapping Resection Progress by Tool-Tip Tracking during Brain Tumor Surgery for Real-Time Estimation of Residual Tumor. Cancers (Basel). 2023 Jan 29; 15(3). View in: Pubmed

      • Superficial white matter analysis: An efficient point-cloud-based deep learning framework with supervised contrastive learning for consistent tractography parcellation across populations and dMRI acquisitions. Med Image Anal. 2023 04; 85:102759. View in: Pubmed

      • Global cancer surgery in low-resource settings: A strengths, weaknesses, opportunities, and threats analysis. Cancer. 2023 03 01; 129(5):671-684. View in: Pubmed

      • A Tool-free Neuronavigation Method based on Single-view Hand Tracking. Comput Methods Biomech Biomed Eng Imaging Vis. 2023; 11(4):1307-1315. View in: Pubmed

      • Transcranial MR-Guided Focused Ultrasound and Hyperostosis Calvariae Diffusa: Case Report and Systematic Review of the Literature. Stereotact Funct Neurosurg. 2022 Dec 15; 100(5-6):331-339. View in: Pubmed

      • Oncometabolite d-2HG alters T cell metabolism to impair CD8+ T cell function. Science. 2022 09 30; 377(6614):1519-1529. View in: Pubmed

      • Tumor BOLD connectivity profile correlates with glioma patients' survival. Neurooncol Adv. 2022 Jan-Dec; 4(1):vdac153. View in: Pubmed

      • Using temporal and structural data to reconstruct 3D cerebral vasculature from a pair of 2D digital subtraction angiography sequences. Comput Med Imaging Graph. 2022 07; 99:102076. View in: Pubmed

      • Target receptor identification and subsequent treatment of resected brain tumors with encapsulated and engineered allogeneic stem cells. Nat Commun. 2022 05 19; 13(1):2810. View in: Pubmed

      • NousNav: A low-cost neuronavigation system for deployment in lower-resource settings. Int J Comput Assist Radiol Surg. 2022 Sep; 17(9):1745-1750. View in: Pubmed

      • Pose Estimation and Non-Rigid Registration for Augmented Reality During Neurosurgery. IEEE Trans Biomed Eng. 2022 04; 69(4):1310-1317. View in: Pubmed

      • Converting sounds to meaning with ventral semantic language networks: integration of interdisciplinary data on brain connectivity, direct electrical stimulation and clinical disconnection syndromes. Brain Struct Funct. 2022 Jun; 227(5):1545-1564. View in: Pubmed

      • Multimodal Intraoperative Image-Driven Surgery for Skull Base Chordomas and Chondrosarcomas. Cancers (Basel). 2022 Feb 15; 14(4). View in: Pubmed

      • Automatic framework for patient-specific modelling of tumour resection-induced brain shift. Comput Biol Med. 2022 Jan 30; 143:105271. View in: Pubmed

      • White matter association tracts underlying language and theory of mind: An investigation of 809 brains from the Human Connectome Project. Neuroimage. 2022 02 01; 246:118739. View in: Pubmed

      • Biopsy Artifact in Laser Interstitial Thermal Therapy: A Technical Note. Front Oncol. 2021; 11:746416. View in: Pubmed

      • Computer simulation of tumour resection-induced brain deformation by a meshless approach. Int J Numer Method Biomed Eng. 2022 01; 38(1):e3539. View in: Pubmed

      • Tractography methods and findings in brain tumors and traumatic brain injury. Neuroimage. 2021 12 15; 245:118651. View in: Pubmed

      • The Evolving Role of Neurosurgical Intervention for Central Nervous System Tumors. Hematol Oncol Clin North Am. 2022 02; 36(1):63-75. View in: Pubmed

      • Estimation of High Framerate Digital Subtraction Angiography Sequences at Low Radiation Dose. Med Image Comput Comput Assist Interv. 2021 Sep-Oct; 12906:171-180. View in: Pubmed

      • Tractography dissection variability: What happens when 42 groups dissect 14 white matter bundles on the same dataset? Neuroimage. 2021 11; 243:118502. View in: Pubmed

      • Personalised, image-guided, noninvasive brain stimulation in gliomas: Rationale, challenges and opportunities. EBioMedicine. 2021 Aug; 70:103514. View in: Pubmed

      • Movie-watching fMRI for presurgical language mapping in patients with brain tumour. J Neurol Neurosurg Psychiatry. 2022 02; 93(2):220-221. View in: Pubmed

      • Comparison of multiple tractography methods for reconstruction of the retinogeniculate visual pathway using diffusion MRI. Hum Brain Mapp. 2021 08 15; 42(12):3887-3904. View in: Pubmed

      • Challenges and Opportunities of Intraoperative 3D Ultrasound With Neuronavigation in Relation to Intraoperative MRI. Front Oncol. 2021; 11:656519. View in: Pubmed

      • Enhancement of semantic integration reasoning by tRNS. Cogn Affect Behav Neurosci. 2021 08; 21(4):736-746. View in: Pubmed

      • Adaptive Physics-Based Non-Rigid Registration for Immersive Image-Guided Neuronavigation Systems. Front Digit Health. 2020; 2:613608. View in: Pubmed

      • Newly discovered neuron-to-glioma communication: new noninvasive therapeutic opportunities on the horizon? Neurooncol Adv. 2021 Jan-Dec; 3(1):vdab018. View in: Pubmed

      • Intraoperative Imaging for High-Grade Glioma Surgery. Neurosurg Clin N Am. 2021 Jan; 32(1):47-54. View in: Pubmed

      • Predicted Microscopic Cortical Brain Images for Optimal Craniotomy Positioning and Visualization. Comput Methods Biomech Biomed Eng Imaging Vis. 2020; 9(4):407-413. View in: Pubmed

      • Deformation Aware Augmented Reality for Craniotomy using 3D/2D Non-rigid Registration of Cortical Vessels. Med Image Comput Comput Assist Interv. 2020 Oct; 12264:735-744. View in: Pubmed

      • Frequency and Evolution of New Postoperative Enhancement on 3 Tesla Intraoperative and Early Postoperative Magnetic Resonance Imaging. Neurosurgery. 2020 08 01; 87(2):238-246. View in: Pubmed

      • Focused Ultrasound Strategies for Brain Tumor Therapy. Oper Neurosurg (Hagerstown). 2020 07 01; 19(1):9-18. View in: Pubmed

      • Abdominal Insufflation Is Associated With Increase of Intracranial Pressure in Patients With Normal Pressure Hydrocephalus. Oper Neurosurg (Hagerstown). 2020 07 01; 19(1):53-56. View in: Pubmed

      • Deep white matter analysis (DeepWMA): Fast and consistent tractography segmentation. Med Image Anal. 2020 10; 65:101761. View in: Pubmed

      • Creation of a novel trigeminal tractography atlas for automated trigeminal nerve identification. Neuroimage. 2020 10 15; 220:117063. View in: Pubmed

      • Blood-brain barrier disruption and delivery of irinotecan in a rat model using a clinical transcranial MRI-guided focused ultrasound system. Sci Rep. 2020 05 29; 10(1):8766. View in: Pubmed

      • Reactivation of Motor-Related Gamma Activity in Human NREM Sleep. Front Neurosci. 2020; 14:449. View in: Pubmed

      • Alignment of Cortical Vessels viewed through the Surgical Microscope with Preoperative Imaging to Compensate for Brain Shift. Proc SPIE Int Soc Opt Eng. 2020 Feb; 11315. View in: Pubmed

      • SlicerDMRI: Diffusion MRI and Tractography Research Software for Brain Cancer Surgery Planning and Visualization. JCO Clin Cancer Inform. 2020 03; 4:299-309. View in: Pubmed

      • Clinical Utility of Preoperative Bilingual Language fMRI Mapping in Patients with Brain Tumors. J Neuroimaging. 2020 03; 30(2):175-183. View in: Pubmed

      • Hormone levels are related to functional compensation in prolactinomas: A resting-state fMRI study. J Neurol Sci. 2020 Apr 15; 411:116720. View in: Pubmed

      • Introduction. Advances and future directions in brain mapping in neurosurgery. Neurosurg Focus. 2020 02 01; 48(2):E1. View in: Pubmed

      • Mapping cognitive and emotional networks in neurosurgical patients using resting-state functional magnetic resonance imaging. Neurosurg Focus. 2020 02 01; 48(2):E9. View in: Pubmed

      • Preoperative functional MRI use in neurooncology patients: a clinician survey. Neurosurg Focus. 2020 02 01; 48(2):E11. View in: Pubmed

      • Editorial. Probing the tract organization of language: Heschl's gyrus fiber intersection area. Neurosurg Focus. 2020 02 01; 48(2):E8. View in: Pubmed

      • Sex Effect on Presurgical Language Mapping in Patients With a Brain Tumor. Front Neurosci. 2020; 14:4. View in: Pubmed

      • Anatomical assessment of trigeminal nerve tractography using diffusion MRI: A comparison of acquisition b-values and single- and multi-fiber tracking strategies. Neuroimage Clin. 2020; 25:102160. View in: Pubmed

      • Intraoperative Use of Functional MRI for Surgical Decision Making after Limited or Infeasible Electrocortical Stimulation Mapping. J Neuroimaging. 2020 03; 30(2):184-191. View in: Pubmed

      • Neural Interactions Underlying Visuomotor Associations in the Human Brain. Cereb Cortex. 2019 12 17; 29(11):4551-4567. View in: Pubmed

      • REVIEW: MR elastography of brain tumors. Neuroimage Clin. 2020; 25:102109. View in: Pubmed

      • Deep white matter analysis: fast, consistent tractography segmentation across populations and dMRI acquisitions. Med Image Comput Comput Assist Interv. 2019 Oct; 11766:599-608. View in: Pubmed

      • Tensor-valued diffusion MRI in under 3 minutes: an initial survey of microscopic anisotropy and tissue heterogeneity in intracranial tumors. Magn Reson Med. 2020 02; 83(2):608-620. View in: Pubmed

      • A comparison of thin-plate spline deformation and finite element modeling to compensate for brain shift during tumor resection. Int J Comput Assist Radiol Surg. 2020 Jan; 15(1):75-85. View in: Pubmed

      • Deformable MRI-Ultrasound registration using correlation-based attribute matching for brain shift correction: Accuracy and generality in multi-site data. Neuroimage. 2019 11 15; 202:116094. View in: Pubmed

      • Acoustic feedback enables safe and reliable carboplatin delivery across the blood-brain barrier with a clinical focused ultrasound system and improves survival in a rat glioma model. Theranostics. 2019; 9(21):6284-6299. View in: Pubmed

      • Commentary: Extent of Resection and Residual Tumor Thresholds for Postoperative Total Seizure Freedom in Epileptic Adult Patients Harboring a Supratentorial Diffuse Low-Grade Glioma. Neurosurgery. 2019 08 01; 85(2):E341-E342. View in: Pubmed

      • Quantitative Wide-Field Imaging Techniques for Fluorescence Guided Neurosurgery. Front Surg. 2019; 6:31. View in: Pubmed

      • Frameless Stereotactic Navigation during Insular Glioma Resection using Fusion of Three-Dimensional Rotational Angiography and Magnetic Resonance Imaging. World Neurosurg. 2019 Jun; 126:322-330. View in: Pubmed

      • Test-retest reproducibility of white matter parcellation using diffusion MRI tractography fiber clustering. Hum Brain Mapp. 2019 07; 40(10):3041-3057. View in: Pubmed

      • Preliminary Results Comparing Thin Plate Splines with Finite Element Methods for Modeling Brain Deformation during Neurosurgery using Intraoperative Ultrasound. Proc SPIE Int Soc Opt Eng. 2019 Feb; 10951. View in: Pubmed

      • Functional MRI Task Comparison for Language Mapping in Neurosurgical Patients. J Neuroimaging. 2019 05; 29(3):348-356. View in: Pubmed

      • Neurosurgical Resection and Stereotactic Radiation Versus Stereotactic Radiation Alone in Patients with a Single or Solitary Brain Metastasis. World Neurosurg. 2019 Feb; 122:e1557-e1561. View in: Pubmed

      • Using the variogram for vector outlier screening: application to feature-based image registration. Int J Comput Assist Radiol Surg. 2018 Dec; 13(12):1871-1880. View in: Pubmed

      • Non-rigid registration of 3D ultrasound for neurosurgery using automatic feature detection and matching. Int J Comput Assist Radiol Surg. 2018 Oct; 13(10):1525-1538. View in: Pubmed

      • Free water modeling of peritumoral edema using multi-fiber tractography: Application to tracking the arcuate fasciculus for neurosurgical planning. PLoS One. 2018; 13(5):e0197056. View in: Pubmed

      • 3D printing and intraoperative neuronavigation tailoring for skull base reconstruction after extended endoscopic endonasal surgery: proof of concept. J Neurosurg. 2018 03 02; 130(1):248-255. View in: Pubmed

      • Image Registration to Compensate for EPI Distortion in Patients with Brain Tumors: An Evaluation of Tract-Specific Effects. J Neuroimaging. 2018 03; 28(2):173-182. View in: Pubmed

      • Challenges and techniques for presurgical brain mapping with functional MRI. Neuroimage Clin. 2018; 17:794-803. View in: Pubmed

      • SlicerDMRI: Open Source Diffusion MRI Software for Brain Cancer Research. Cancer Res. 2017 11 01; 77(21):e101-e103. View in: Pubmed

      • Salvage re-irradiation for recurrent high-grade glioma and comparison to bevacizumab alone. J Neurooncol. 2017 Dec; 135(3):581-591. View in: Pubmed

      • Retrospective study comparing model-based deformation correction to intraoperative magnetic resonance imaging for image-guided neurosurgery. J Med Imaging (Bellingham). 2017 Jul; 4(3):035003. View in: Pubmed

      • Performance of unscented Kalman filter tractography in edema: Analysis of the two-tensor model. Neuroimage Clin. 2017; 15:819-831. View in: Pubmed

      • White matter tractography for neurosurgical planning: A topography-based review of the current state of the art. Neuroimage Clin. 2017; 15:659-672. View in: Pubmed

      • Practice guideline summary: Use of fMRI in the presurgical evaluation of patients with epilepsy: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology. Neurology. 2017 Jan 24; 88(4):395-402. View in: Pubmed

      • Automated white matter fiber tract identification in patients with brain tumors. Neuroimage Clin. 2017; 13:138-153. View in: Pubmed

      • Association between shunt-responsive idiopathic normal pressure hydrocephalus and alcohol. J Neurosurg. 2017 Aug; 127(2):240-248. View in: Pubmed

      • Applications of Ultrasound in the Resection of Brain Tumors. J Neuroimaging. 2017 01; 27(1):5-15. View in: Pubmed

      • Multimodal Navigation in Endoscopic Transsphenoidal Resection of Pituitary Tumors Using Image-Based Vascular and Cranial Nerve Segmentation: A Prospective Validation Study. World Neurosurg. 2016 Nov; 95:406-413. View in: Pubmed

      • Label-Free Neurosurgical Pathology with Stimulated Raman Imaging. Cancer Res. 2016 06 15; 76(12):3451-62. View in: Pubmed

      • Right inferior longitudinal fasciculus lesions disrupt visual-emotional integration. Soc Cogn Affect Neurosci. 2016 06; 11(6):945-51. View in: Pubmed

      • Utility of intraoperative imaging. Neurosurg Focus. 2016 Mar; 40(3):E1. View in: Pubmed

      • Optical technologies for intraoperative neurosurgical guidance. Neurosurg Focus. 2016 Mar; 40(3):E8. View in: Pubmed

      • Vaccination with Irradiated Autologous Tumor Cells Mixed with Irradiated GM-K562 Cells Stimulates Antitumor Immunity and T Lymphocyte Activation in Patients with Recurrent Malignant Glioma. Clin Cancer Res. 2016 06 15; 22(12):2885-96. View in: Pubmed

      • An Electrocorticography Grid with Conductive Nanoparticles in a Polymer Thick Film on an Organic Substrate Improves CT and MR Imaging. Radiology. 2016 08; 280(2):595-601. View in: Pubmed

      • Corticospinal tract modeling for neurosurgical planning by tracking through regions of peritumoral edema and crossing fibers using two-tensor unscented Kalman filter tractography. Int J Comput Assist Radiol Surg. 2016 Aug; 11(8):1475-86. View in: Pubmed

      • Multimodal navigated skull base tumor resection using image-based vascular and cranial nerve segmentation: A prospective pilot study. Surg Neurol Int. 2015; 6:172. View in: Pubmed

      • Intraoperative real-time MRI-guided stereotactic biopsy followed by laser thermal ablation for progressive brain metastases after radiosurgery. J Clin Neurosci. 2016 Feb; 24:68-73. View in: Pubmed

      • Altered functional connectivity in lesional peduncular hallucinosis with REM sleep behavior disorder. Cortex. 2016 Jan; 74:96-106. View in: Pubmed

      • Pre-operative image-based segmentation of the cranial nerves and blood vessels in microvascular decompression: Can we prevent unnecessary explorations? Clin Neurol Neurosurg. 2015 Dec; 139:159-65. View in: Pubmed

      • Tendon-Driven Continuum Robot for Endoscopic Surgery: Preclinical Development and Validation of a Tension Propagation Model. IEEE ASME Trans Mechatron. 2015 Oct; 20(5):2252-2263. View in: Pubmed

      • The DTI Challenge: Toward Standardized Evaluation of Diffusion Tensor Imaging Tractography for Neurosurgery. J Neuroimaging. 2015 Nov-Dec; 25(6):875-82. View in: Pubmed

      • Rapid Intraoperative Molecular Characterization of Glioma. JAMA Oncol. 2015 Aug; 1(5):662-7. View in: Pubmed

      • The Value of Pre- and Intraoperative Adjuncts on the Extent of Resection of Hemispheric Low-Grade Gliomas: A Retrospective Analysis. J Neurol Surg A Cent Eur Neurosurg. 2016 Mar; 77(2):79-87. View in: Pubmed

      • "Countersinking" of reservoir in an irradiated patients can decrease tension on scalp closure. Surg Neurol Int. 2015; 6(Suppl 11):S334-6. View in: Pubmed

      • Salvage whole brain radiotherapy or stereotactic radiosurgery after initial stereotactic radiosurgery for 1-4 brain metastases. J Neurooncol. 2015 Sep; 124(3):429-37. View in: Pubmed

      • Incidence, risk factors, and reasons for hospitalization among glioblastoma patients receiving chemoradiation. J Neurooncol. 2015 Aug; 124(1):137-46. View in: Pubmed

      • A New Paradigm for Individual Subject Language Mapping: Movie-Watching fMRI. J Neuroimaging. 2015 Sep-Oct; 25(5):710-20. View in: Pubmed

      • Intraoperative Magnetic Resonance Imaging in Intracranial Glioma Resection: A Single-Center, Retrospective Blinded Volumetric Study. World Neurosurg. 2015 Aug; 84(2):528-36. View in: Pubmed

      • Hypofractionated versus standard radiation therapy with or without temozolomide for older glioblastoma patients. Int J Radiat Oncol Biol Phys. 2015 Jun 01; 92(2):384-9. View in: Pubmed

      • Reconstruction of the arcuate fasciculus for surgical planning in the setting of peritumoral edema using two-tensor unscented Kalman filter tractography. Neuroimage Clin. 2015; 7:815-22. View in: Pubmed

      • Clinical implementation of integrated whole-genome copy number and mutation profiling for glioblastoma. Neuro Oncol. 2015 Oct; 17(10):1344-55. View in: Pubmed

      • "Extraoperative" MRI (eoMRI) for Brain Tumor Surgery: Initial Results at a Single Institution. World Neurosurg. 2015 Jun; 83(6):921-8. View in: Pubmed

      • Smart stylet: the development and use of a bedside external ventricular drain image-guidance system. Stereotact Funct Neurosurg. 2015; 93(1):50-8. View in: Pubmed

      • Comparison of seeding methods for visualization of the corticospinal tracts using single tensor tractography. Clin Neurol Neurosurg. 2015 Feb; 129:44-9. View in: Pubmed

      • Multimodal imaging for improved diagnosis and treatment of cancers. Cancer. 2015 Mar 15; 121(6):817-27. View in: Pubmed

      • Decoupling function and anatomy in atlases of functional connectivity patterns: language mapping in tumor patients. Neuroimage. 2014 Dec; 103:462-475. View in: Pubmed

      • Comparative effectiveness of frame-based, frameless, and intraoperative magnetic resonance imaging-guided brain biopsy techniques. World Neurosurg. 2015 Mar; 83(3):261-8. View in: Pubmed

      • Local control after fractionated stereotactic radiation therapy for brain metastases. J Neurooncol. 2014 Nov; 120(2):339-46. View in: Pubmed

      • Intraoperative mass spectrometry mapping of an onco-metabolite to guide brain tumor surgery. Proc Natl Acad Sci U S A. 2014 Jul 29; 111(30):11121-6. View in: Pubmed

      • Adjuvant radiation therapy, local recurrence, and the need for salvage therapy in atypical meningioma. Neuro Oncol. 2014 Nov; 16(11):1547-53. View in: Pubmed

      • Tumor associated seizures in glioblastomas are influenced by survival gene expression in a region-specific manner: a gene expression imaging study. Epilepsy Res. 2014 Jul; 108(5):843-52. View in: Pubmed

      • Neural dynamics underlying target detection in the human brain. J Neurosci. 2014 Feb 19; 34(8):3042-55. View in: Pubmed

      • Atypical presentation of cerebral schistosomiasis four years after exposure to Schistosoma mansoni. Epilepsy Behav Case Rep. 2014; 2:80-5. View in: Pubmed

      • Mass spectrometry imaging as a tool for surgical decision-making. J Mass Spectrom. 2013 Nov; 48(11):i. View in: Pubmed

      • Mass spectrometry imaging as a tool for surgical decision-making. J Mass Spectrom. 2013 Nov; 48(11):1178-87. View in: Pubmed

      • Focal cortical dysplasia IIb presenting as slowly progressive aphasia mimicking a brain tumor. Seizure. 2014 Feb; 23(2):161-3. View in: Pubmed

      • Rapid, label-free detection of brain tumors with stimulated Raman scattering microscopy. Sci Transl Med. 2013 Sep 04; 5(201):201ra119. View in: Pubmed

      • Hemispheric lateralization interrupted: material-specific memory deficits in temporal lobe epilepsy. Front Hum Neurosci. 2013 Sep 02; 7:546. View in: Pubmed

      • Effect of disease and recovery on functional anatomy in brain tumor patients: insights from functional MRI and diffusion tensor imaging. Imaging Med. 2013 Aug 01; 5(4):333-346. View in: Pubmed

      • Fiber clustering versus the parcellation-based connectome. Neuroimage. 2013 Oct 15; 80:283-9. View in: Pubmed

      • Bayesian characterization of uncertainty in intra-subject non-rigid registration. Med Image Anal. 2013 Jul; 17(5):538-55. View in: Pubmed

      • Clinical applications and future directions of functional MRI. Semin Neurol. 2012 Sep; 32(4):466-75. View in: Pubmed

      • Ambient mass spectrometry for the intraoperative molecular diagnosis of human brain tumors. Proc Natl Acad Sci U S A. 2013 Jan 29; 110(5):1611-6. View in: Pubmed

      • Defining language networks from resting-state fMRI for surgical planning--a feasibility study. Hum Brain Mapp. 2014 Mar; 35(3):1018-30. View in: Pubmed

      • GBM volumetry using the 3D Slicer medical image computing platform. Sci Rep. 2013; 3:1364. View in: Pubmed

      • Surgery, virtual reality, and the future. Stud Health Technol Inform. 2013; 184:vii - xiii. View in: Pubmed

      • Extended Broca's area in the functional connectome of language in adults: combined cortical and subcortical single-subject analysis using fMRI and DTI tractography. Brain Topogr. 2013 Jul; 26(3):428-41. View in: Pubmed

      • PTFOS: flexible and absorbable intracranial electrodes for magnetic resonance imaging. PLoS One. 2012; 7(9):e41187. View in: Pubmed

      • Temporal stability of visually selective responses in intracranial field potentials recorded from human occipital and temporal lobes. J Neurophysiol. 2012 Dec; 108(11):3073-86. View in: Pubmed

      • Neuronavigation in the surgical management of brain tumors: current and future trends. Expert Rev Med Devices. 2012 Sep; 9(5):491-500. View in: Pubmed

      • Functional and structural differences in the hippocampus associated with memory deficits in adult survivors of acute lymphoblastic leukemia. Pediatr Blood Cancer. 2013 Feb; 60(2):293-300. View in: Pubmed

      • Visual pathway study using in vivo diffusion tensor imaging tractography to complement classic anatomy. Neurosurgery. 2012 Mar; 70(1 Suppl Operative):145-56; discussion 156. View in: Pubmed

      • Chiasmal visual loss after retinal detachment. Neurology. 2012 Jan 10; 78(2):150. View in: Pubmed

      • Outcomes after discontinuation of antiepileptic drugs after surgery in patients with low grade brain tumors and meningiomas. J Neurooncol. 2012 May; 107(3):565-70. View in: Pubmed

      • Unbiased groupwise registration of white matter tractography. Med Image Comput Comput Assist Interv. 2012; 15(Pt 3):123-30. View in: Pubmed

      • Classifying human brain tumors by lipid imaging with mass spectrometry. Cancer Res. 2012 Feb 01; 72(3):645-54. View in: Pubmed

      • fMRI-DTI modeling via landmark distance atlases for prediction and detection of fiber tracts. Neuroimage. 2012 Mar; 60(1):456-70. View in: Pubmed

      • Quickest detection of drug-resistant seizures: an optimal control approach. Epilepsy Behav. 2011 Dec; 22 Suppl 1:S49-60. View in: Pubmed

      • Pneumatically driven finger movement: a novel passive functional MR imaging technique for presurgical motor and sensory mapping. AJNR Am J Neuroradiol. 2013 Jan; 34(1):E5-7. View in: Pubmed

      • Neurosurgery Clinics of North America. Functional imaging. Preface. Neurosurg Clin N Am. 2011 Apr; 22(2):xiii-xiv. View in: Pubmed

      • Development of a clinical functional magnetic resonance imaging service. Neurosurg Clin N Am. 2011 Apr; 22(2):307-14, x. View in: Pubmed

      • Multimodal image registration for preoperative planning and image-guided neurosurgical procedures. Neurosurg Clin N Am. 2011 Apr; 22(2):197-206, viii. View in: Pubmed

      • Special surgical considerations for functional brain mapping. Neurosurg Clin N Am. 2011 Apr; 22(2):111-32, vii. View in: Pubmed

      • A new metric for detecting change in slowly evolving brain tumors: validation in meningioma patients. Neurosurgery. 2011 Mar; 68(1 Suppl Operative):225-33. View in: Pubmed

      • Development of stereotactic mass spectrometry for brain tumor surgery. Neurosurgery. 2011 Feb; 68(2):280-89; discussion 290. View in: Pubmed

      • Intraoperative real-time querying of white matter tracts during frameless stereotactic neuronavigation. Neurosurgery. 2011 Feb; 68(2):506-16; discussion 516. View in: Pubmed

      • Interactive diffusion tensor tractography visualization for neurosurgical planning. Neurosurgery. 2011 Feb; 68(2):496-505. View in: Pubmed

      • The neurosurgical anatomy of the sphenoid sinus and sellar floor in endoscopic transsphenoidal surgery. J Neurosurg. 2011 May; 114(5):1319-30. View in: Pubmed

      • Learning an atlas of a cognitive process in its functional geometry. Inf Process Med Imaging. 2011; 22:135-46. View in: Pubmed

      • Discrimination of human astrocytoma subtypes by lipid analysis using desorption electrospray ionization imaging mass spectrometry. Angew Chem Int Ed Engl. 2010 Aug 09; 49(34):5953-6. View in: Pubmed

      • Low yield of clinically significant transesophageal echocardiographic findings in patients with lacunar stroke. J Stroke Cerebrovasc Dis. 1995; 5(1):39-43. View in: Pubmed

      • Current dipole orientation and distribution of epileptiform activity correlates with cortical thinning in left mesiotemporal epilepsy. Neuroimage. 2010 Oct 01; 52(4):1238-42. View in: Pubmed

      • Robust selectivity to two-object images in human visual cortex. Curr Biol. 2010 May 11; 20(9):872-9. View in: Pubmed

      • A combined fMRI and DTI examination of functional language lateralization and arcuate fasciculus structure: Effects of degree versus direction of hand preference. Brain Cogn. 2010 Jul; 73(2):85-92. View in: Pubmed

      • Morphological characteristics of brain tumors causing seizures. Arch Neurol. 2010 Mar; 67(3):336-42. View in: Pubmed

      • Origins of intraoperative MRI. Magn Reson Imaging Clin N Am. 2010 Feb; 18(1):1-10. View in: Pubmed

      • Functional Geometry Alignment and Localization of Brain Areas. Adv Neural Inf Process Syst. 2010; 1:1225-1233. View in: Pubmed

      • The fiber laterality histogram: a new way to measure white matter asymmetry. Med Image Comput Comput Assist Interv. 2010; 13(Pt 2):225-32. View in: Pubmed

      • OpenIGTLink: an open network protocol for image-guided therapy environment. Int J Med Robot. 2009 Dec; 5(4):423-34. View in: Pubmed

      • Threshold-independent functional MRI determination of language dominance: a validation study against clinical gold standards. Epilepsy Behav. 2009 Oct; 16(2):288-97. View in: Pubmed

      • Orbitocranial wooden foreign body: a pre-, intra-, and postoperative chronicle: case report. Neurosurgery. 2009 Aug; 65(2):E383-4; discussion E384. View in: Pubmed

      • High b-value apparent diffusion-weighted images from CURVE-ball DTI. J Magn Reson Imaging. 2009 Jul; 30(1):243-8. View in: Pubmed

      • Contributions to singing ability by the posterior portion of the superior temporal gyrus of the non-language-dominant hemisphere: first evidence from subdural cortical stimulation, Wada testing, and fMRI. Cortex. 2010 Mar; 46(3):343-53. View in: Pubmed

      • Origins of intraoperative MRI. Neurosurg Clin N Am. 2009 Apr; 20(2):137-46. View in: Pubmed

      • An intraoperative brain shift monitor using shear mode transcranial ultrasound: preliminary results. J Ultrasound Med. 2009 Feb; 28(2):191-203. View in: Pubmed

      • Tract-based morphometry for white matter group analysis. Neuroimage. 2009 Apr 15; 45(3):832-44. View in: Pubmed

      • Comparison of blocked and event-related fMRI designs for pre-surgical language mapping. Neuroimage. 2009 Aug; 47 Suppl 2:T107-15. View in: Pubmed

      • Resolving crossings in the corticospinal tract by two-tensor streamline tractography: Method and clinical assessment using fMRI. Neuroimage. 2009 Aug; 47 Suppl 2:T98-106. View in: Pubmed

      • A Surgical Planning Method for Functional MRI Assessment of Language Dominance: Influences from Threshold, Region-of-Interest, and Stimulus Mode. Publisher Springer New York ISSN 1931-7557 (Print) 1931-7565 (Online) Issue Volume 2, Number 2 / June, 2008 . Brain Imaging and Behavior. 2008; 2(2):59-73. View in: Pubmed

      • Group independent component analysis of language fMRI from word generation tasks. Neuroimage. 2008 Sep 01; 42(3):1214-25. View in: Pubmed

      • Identification of language areas from event-related fMRI paradigms using data-driven method. The Cognitive Neuroscience Society 2008 Annual meeting, San Francisco, CA, USA, April 12-15, 2008. . 2008. View in: Pubmed

      • Compensation of geometric distortion effects on intraoperative magnetic resonance imaging for enhanced visualization in image-guided neurosurgery. Neurosurgery. 2008 Mar; 62(3 Suppl 1):209-15; discussion 215-6. View in: Pubmed

      • FMRI Functional Language in Broca's and Wernicke's Areas: Effects of Handedness on Inter- versus Intra-Hemispheric Relationships. 2008. View in: Pubmed

      • Quantification of white matter fiber orientation at tumor margins with diffusion tensor invariant gradients. Proc Intl Soc Mag Reson Med. 2008. View in: Pubmed

      • Identification of Essential Language Areas by Combination of fMRI from Different Tasks using Probabilistic Independent Component Analysis . 2008. View in: Pubmed

      • Comparison of the deformations of brain tissues caused by tumor in seizure and non-seizure patients . 2008 5th IEEE International Symposium on Biomedical Imaging. 2008. View in: Pubmed

      • Fieldmap-free retrospective registration and distortion correction for EPI-based functional imaging. Med Image Comput Comput Assist Interv. 2008; 11(Pt 2):271-9. View in: Pubmed

      • Role of pre- and intraoperative imaging and neuronavigation in neurosurgery. Expert Rev Med Devices. 2008 Jan; 5(1):65-73. View in: Pubmed

      • Quantitative comparison of functional MRI and direct electrocortical stimulation for functional mapping. Int J Med Robot. 2007 Sep; 3(3):262-70. View in: Pubmed

      • Object naming is a more sensitive measure of speech localization than number counting: Converging evidence from direct cortical stimulation and fMRI. Neuroimage. 2007; 37 Suppl 1:S100-8. View in: Pubmed

      • Functional brain mapping and its applications to neurosurgery. Neurosurgery. 2007 Apr; 60(4 Suppl 2):185-201; discussion 201-2. View in: Pubmed

      • In Press: Malignant Cerebral Gliomas: treatment strategies and considerations. In: Neurosurgical Oncology. Black PM, Park J, Eds. 2007. View in: Pubmed

      • Tract-based morphometry. . Med Image Comput Comput Assist Interv. . 2007; 10(pt 2):161-8. View in: Pubmed

      • Grid-Enabled Software Environment for Enhanced Dynamic Data-Driven Visualization and Navigation during Image-Guided Neurosurgery. ICCS 2007: International Conference on Computer Science. 2007. View in: Pubmed

      • Quantification of white matter fiber orientation at tumor margins with diffusion tensor invariant gradients. 15th Annual Meeting of International Society for Magnetic Resonance in Medicine (ISMRM),. 2007. View in: Pubmed

      • Atypical language organization in epilepsy. In: Behavioral Aspects of Epilepsy: Principles and Practice. Schacter S, Ed. 2007. View in: Pubmed

      • Grid-Enabled Software Environment for Enhanced Dynamic Data-Driven Visualization and Navigation during Image-Guided Neurosurgery. ICCS 2007: International Conference on Computer Science. 2007. View in: Pubmed

      • The emerging field of neurosurgical oncology: novel techniques to optimize outcomes and minimize mishaps. Clin Neurosurg. 2007; 54:36-46. View in: Pubmed

      • In Press: Neurosurgical Treatment Planning. In: Textbook of Neuro-Oncology Neuro-Imaging. Newton HB, Jolesz FA, Eds. 2007. View in: Pubmed

      • Tract-based morphometry. Med Image Comput Comput Assist Interv. 2007; 10(Pt 2):161-8. View in: Pubmed

      • Non-rigid alignment of pre-operative MRI, fMRI, and DT-MRI with intra-operative MRI for enhanced visualization and navigation in image-guided neurosurgery. Neuroimage. 2007 Apr 01; 35(2):609-24. View in: Pubmed

      • Rater-dependent accuracy in predicting the spatial location of functional centers on anatomical MR images. Clin Neurol Neurosurg. 2007 Apr; 109(3):225-35. View in: Pubmed

      • Image-guided neurosurgery at Brigham and Women's Hospital. IEEE Eng Med Biol Mag. 2006 Sep-Oct; 25(5):67-73. View in: Pubmed

      • Functional MRI of memory in the hippocampus: Laterality indices may be more meaningful if calculated from whole voxel distributions. Neuroimage. 2006 Aug 15; 32(2):592-602. View in: Pubmed

      • Integrated image- and function-guided surgery in eloquent cortex: a technique report. Int J Med Robot. 2006 Mar; 2(1):75-83. View in: Pubmed

      • Imaging and visual analysis - Toward real-time image guided neurosurgery using distributed and grid computing. Proceedings of the ACM/IEEE SC2006. 2006. View in: Pubmed

      • Integrated image and function-guided surgery in eloquent cortex: A technique report. Int J of Med Robotics and Computer Assisted Surgery. 2006; 2:75-83. View in: Pubmed

      • The brain basis for episodic memory: insights from functional MRI, intracranial EEG, and patients with epilepsy. Epilepsy Behav. 2006 Feb; 8(1):115-26. View in: Pubmed

      • Robust nonrigid registration to capture brain shift from intraoperative MRI. IEEE Trans Med Imaging. 2005 Nov; 24(11):1417-27. View in: Pubmed

      • Atypical language representation in epilepsy: implications for injury-induced reorganization of brain function. Epilepsy Behav. 2005 Jun; 6(4):473-87. View in: Pubmed

      • Memory encoding in Alzheimer's disease: an fMRI study of explicit and implicit memory. Brain. 2005 Apr; 128(Pt 4):773-87. View in: Pubmed

      • Functional Brain Mapping for Minimally Invasive Neurosurgery. Black P, Proctor, M, Eds. In: Minimally Invasive Neurosurgery. 2005. View in: Pubmed

      • Functional MRI memory mapping for epilepsy surgery planning: A case report. Journal of Epilepsy and Clinical Electrophysiology. 2005; 11(1):39-44. View in: Pubmed

      • Determination of Cerebral dominance from vocalized language using region-of-interest analysis. Society for Neuroscience, 35th Annual Meeting, Washington, DC. 2005. View in: Pubmed

      • Hybrid Formulation of the Model-Based Non-rigid Registration Problem to Improve Accuracy and Robustness. MICCAI. 2005; (2):295-302. View in: Pubmed

      • Visualization of eloquent systems for vocalized language by integration of MEG, fMRI, and DTI: applications in surgical neuronavigation. M.E.G. Clinical Applications Conference, Xylocastro, Greece. (Winner of 2005 Excellence Award). 2005. View in: Pubmed

      • Material-Specific Memory Encoding Lateralization in an Event-Related fMRI Study. Neuroimage. 2005; 26((Suppl1):S31). View in: Pubmed

      • Hybrid formulation of the model-based non-rigid registration problem to improve accuracy and robustness. Med Image Comput Comput Assist Interv. 2005; 8(Pt 2):295-302. View in: Pubmed

      • Capturing intraoperative deformations: research experience at Brigham and Women's Hospital. Med Image Anal. 2005 Apr; 9(2):145-62. View in: Pubmed

      • Predictions of location of functional cortex as compared to fMRI results: How accurate are we?. 34th Annual Meeting-Society for Neuroscience, San Diego, CA. 2004. View in: Pubmed

      • Evaluating requirements for spatial resolution of fMRI for neurosurgical planning. Hum Brain Mapp. 2004 Jan; 21(1):34-43. View in: Pubmed

      • An Anisotropic Material Model for Image Guided Neurosurgery. MICCAI 2004: 7th International Conference, Proceedings, Part II. 2004; 267 – 275. View in: Pubmed

      • Confrontation Naming is a More Sensitive Measure of Speech Localization than Number Counting: Converging Evidence from Direct Cortical Stimulation and fMRI. Congress of Neurological Surgeons 54th Annual meeting. 2004. View in: Pubmed

      • Pneumatically driven finger movement: a novel, passive fMRI technique for pre-surgical motor and sensory mapping. Congress of Neurological Surgeons 54th Annual Meeting. 2004; 54th. View in: Pubmed

      • Comment on: Functional magnetic resonance imaging integrated neuronavigation: Correlation between lesion-to-motor cortex distance and outcome. Krishnan et al. Neurosurgery. 2004; 55(4):914-915 . View in: Pubmed

      • Diffusion Tensor and Functional MRI Fusion with Anatomical MRI for Image-Guided Neurosurgery. LNCS. 2003; 407-415(2878). View in: Pubmed

      • Memory lateralization in medial temporal lobe epilepsy assessed by functional MRI. Epilepsia. 2002 Aug; 43(8):855-63. View in: Pubmed

      • Minimalist approach: functional mapping. Clin Neurosurg. 2002; 49:90-102. View in: Pubmed

      • Material-specific lateralization in the medial temporal lobe and prefrontal cortex during memory encoding. Brain. 2001 Sep; 124(Pt 9):1841-54. View in: Pubmed

      • Differential responses in the fusiform region to same-race and other-race faces. Nat Neurosci. 2001 Aug; 4(8):845-50. View in: Pubmed

      • Fractionated stereotactic radiosurgery and preservation of hearing in patients with vestibular schwannoma: a preliminary report. Neurosurgery. 1999 Dec; 45(6):1299-305; discussion 1305-7. View in: Pubmed

      • Direct and combined revascularization in pediatric moyamoya disease. Neurosurgery. 1999 Jul; 45(1):50-8; discussion 58-60. View in: Pubmed

      • Three-fraction stereotactic radiosurgery for treatment of vestibular schwannoma in patients with Neurofibromatosis type II. Journal of Radiosurgery. 1999; 2:215-221. View in: Pubmed

      • Trigeminal neuralgia resulting from infarction of the root entry zone of the trigeminal nerve: case report. Neurosurgery. 1998 Sep; 43(3):620-2; discussion 622-3. View in: Pubmed

      • Stereotactic Neurosurgery. In: A Manual of Surgical Procedures for Anesthesiologists, Jaffe R, Samuels S, Eds. 1998. View in: Pubmed

      • Unexpected recovery from anoxic-ischemic coma. Neurology. 1995 Aug; 45(8):1629-30. View in: Pubmed

      • Detection of carotid stenosis. From NASCET results to clinical practice. Stroke. 1995 Aug; 26(8):1325-8. View in: Pubmed

      • Low Yield of Clinically Significant Transesophageal Echocardiographic Findings in Patients with Lacunar Stroke. J Stroke Cerebrovasc Dis. 1995; 5:39-43. View in: Pubmed

      • Neurologic Recovery from Vegetative State Following Cardiac Arrest. Neurology. 1995; 45(8):1629-30. View in: Pubmed

      • Transesophageal echocardiography and carotid ultrasound in patients with cerebral ischemia: prevalence of findings and recurrent stroke risk. J Am Coll Cardiol. 1994 Jun; 23(7):1598-603. View in: Pubmed

      • Asymptomatic microemboli-Reply. Neurology. 1993; 43(9):1865-1865 . View in: Pubmed

      • Failure of high-dose heparin to prevent recurrent cardioembolic strokes in a pregnant patient with a mechanical heart valve. Neurology. 1992 Nov; 42(11):2204-6. View in: Pubmed

      • Monoclonal antibodies to murine CD3 epsilon define distinct epitopes, one of which may interact with CD4 during T cell activation. J Immunol. 1989 Jun 15; 142(12):4169-75. View in: Pubmed

      • Monoclonal Antibodies to Murine CD3 Define Distinct Epitopes, One of Which May Interact with CD4 During T-Cell Activation. Journal of Immunology. 1989; 142:4169-4175. View in: Pubmed


      Location Avtar

      Brigham and Women's Hospital

      75 Francis Street Boston, MA 02115
      Get Directions
      Location Avtar

      Brigham and Women's Hospital

      75 Francis Street Boston, MA 02215
      Get Directions

      Brigham and Women's Hospital

      Location Avtar

      Brigham and Women's Hospital

      75 Francis Street Boston, MA 02115
      Get Direction
      42.3362, -71.1067

      Brigham and Women's Hospital

      Location Avtar

      Brigham and Women's Hospital

      75 Francis Street Boston, MA 02215
      Get Direction
      42.3362, -71.1067

      Discovery and Insights