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Alexandra Golby, MD


Neurosurgery

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Physician

  • Director of Image-Guided Neurosurgery, Brigham and Women's Hospital
  • Co-Director AMIGO (advanced multi-modality image-guided OR), Brigham and Women's Hospital
  • Co-Director Clinical fMRI, Brigham and Women's Hospital
  • Haley Distinguished Chair in the Neurosciences, Brigham and Women's Hospital
  • Professor of Neurosurgery, Professor of Radiology, Harvard Medical School

Centers/Programs

Clinical Interests

  • Brain mapping
  • Brain metastases
  • Functional MRI
  • Gliomas
  • Image-guided surgery
  • Malignant and benign brain tumors
  • Meningiomas
  • Tumors in critical brain areas

Diseases Treated

  • Brain Metastasis
  • Brain Tumors
  • Craniopharyngiomas
  • Glioblastoma
  • Low-Grade Glioma
  • Lymphoma, Primary CNS
  • Meningioma
  • Pituitary Tumors

Contact Information

  • Appointments617-732-6600
  • Office Phone Number617-525-7373
  • Fax617-713-3050

Board Certification:

  • Neurosurgery, 2007

Fellowship:

  • Centre Hospitialier de Grenoble, Grenoble France, Functional Neurosurgery
  • Congress of Neurological Surgeons Dandy Fellow, Functional Neurosurgery

Residency:

  • Brigham and Women's Hospital/Boston Children's Hospital
  • Stanford University School of Medicine, Neurosurgery

Medical School:

  • Stanford University School of Medicine

Recent Awards:

  • CIMIT Young Clinicians Award 2008
  • Brigham and Womens Hospital inaugural recipient New Innovators Award 2010-11

Research

The Golby Lab pursues translational research multi-modality image-guided neurosurgery with a particular interest in functional brain mapping.

Dr. Golby's research involves the application of brain mapping techniques to neurosurgical patients as well as neuroscientific investigations into the brain basis of neurologic functions. These efforts are centered on improving surgery for patients with epilepsy and brain tumors, particularly those whose pathology is intimately involved with critical brain regions. The Golby Lab is a translational multidisciplinary group of investigators focusing on functional brain mapping using both structural and functional imaging techniques to guide neurosurgical planning and intra-operative decision making. This work aims to integrate information acquired from pre-operative brain mapping with intra-operative brain mapping and intra-operative imaging to define functional brain anatomy for surgical planning. We use multiple functional brain mapping techniques (fMRI, diffusion tensor imaging, and intracranial EEG) and structural and molecular imaging techniques to better define individual functional anatomy in patients with neurosurgical diseases, cross-validate information acquired through different techniques, and gain a better understanding of the relationship between these different brain signals. The goal is to provide the surgeon with optimal information to perform less invasive, safer, and more effective interventions. We are also interested in how the brain may reorganize in the face of injury. The Golby Lab is funded by the Brain Science Foundation, The Klarman Family Foundation, CIMIT Harvard Catalyst, and the National Institutes of Health, allowing her to assemble a team of extraordinary scientists from different backgrounds, working collaboratively to advance the field of image-guided surgery and functional brain imaging.

Tractography dissection variability: What happens when 42 groups dissect 14 white matter bundles on the same dataset? Neuroimage. 2021 Aug 22; 243:118502.
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Personalised, image-guided, noninvasive brain stimulation in gliomas: Rationale, challenges and opportunities. EBioMedicine. 2021 Aug; 70:103514.
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Movie-watching fMRI for presurgical language mapping in patients with brain tumour. J Neurol Neurosurg Psychiatry. 2021 Jun 25.
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Comparison of multiple tractography methods for reconstruction of the retinogeniculate visual pathway using diffusion MRI. Hum Brain Mapp. 2021 Aug 15; 42(12):3887-3904.
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Challenges and Opportunities of Intraoperative 3D Ultrasound With Neuronavigation in Relation to Intraoperative MRI. Front Oncol. 2021; 11:656519.
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Enhancement of semantic integration reasoning by tRNS. Cogn Affect Behav Neurosci. 2021 08; 21(4):736-746.
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Newly discovered neuron-to-glioma communication: new noninvasive therapeutic opportunities on the horizon? Neurooncol Adv. 2021 Jan-Dec; 3(1):vdab018.
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Intraoperative Imaging for High-Grade Glioma Surgery. Neurosurg Clin N Am. 2021 Jan; 32(1):47-54.
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Deformation Aware Augmented Reality for Craniotomy using 3D/2D Non-rigid Registration of Cortical Vessels. Med Image Comput Comput Assist Interv. 2020 Oct; 12264:735-744.
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Frequency and Evolution of New Postoperative Enhancement on 3 Tesla Intraoperative and Early Postoperative Magnetic Resonance Imaging. Neurosurgery. 2020 08 01; 87(2):238-246.
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Focused Ultrasound Strategies for Brain Tumor Therapy. Oper Neurosurg (Hagerstown). 2020 07 01; 19(1):9-18.
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Abdominal Insufflation Is Associated With Increase of Intracranial Pressure in Patients With Normal Pressure Hydrocephalus. Oper Neurosurg (Hagerstown). 2020 07 01; 19(1):53-56.
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Deep white matter analysis (DeepWMA): Fast and consistent tractography segmentation. Med Image Anal. 2020 10; 65:101761.
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Creation of a novel trigeminal tractography atlas for automated trigeminal nerve identification. Neuroimage. 2020 10 15; 220:117063.
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Blood-brain barrier disruption and delivery of irinotecan in a rat model using a clinical transcranial MRI-guided focused ultrasound system. Sci Rep. 2020 05 29; 10(1):8766.
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Reactivation of Motor-Related Gamma Activity in Human NREM Sleep. Front Neurosci. 2020; 14:449.
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Alignment of Cortical Vessels viewed through the Surgical Microscope with Preoperative Imaging to Compensate for Brain Shift. Proc SPIE Int Soc Opt Eng. 2020 Feb; 11315.
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SlicerDMRI: Diffusion MRI and Tractography Research Software for Brain Cancer Surgery Planning and Visualization. JCO Clin Cancer Inform. 2020 03; 4:299-309.
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Clinical Utility of Preoperative Bilingual Language fMRI Mapping in Patients with Brain Tumors. J Neuroimaging. 2020 03; 30(2):175-183.
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Hormone levels are related to functional compensation in prolactinomas: A resting-state fMRI study. J Neurol Sci. 2020 Apr 15; 411:116720.
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Introduction. Advances and future directions in brain mapping in neurosurgery. Neurosurg Focus. 2020 02 01; 48(2):E1.
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Mapping cognitive and emotional networks in neurosurgical patients using resting-state functional magnetic resonance imaging. Neurosurg Focus. 2020 02 01; 48(2):E9.
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Preoperative functional MRI use in neurooncology patients: a clinician survey. Neurosurg Focus. 2020 02 01; 48(2):E11.
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Editorial. Probing the tract organization of language: Heschl's gyrus fiber intersection area. Neurosurg Focus. 2020 02 01; 48(2):E8.
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Sex Effect on Presurgical Language Mapping in Patients With a Brain Tumor. Front Neurosci. 2020; 14:4.
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Anatomical assessment of trigeminal nerve tractography using diffusion MRI: A comparison of acquisition b-values and single- and multi-fiber tracking strategies. Neuroimage Clin. 2020; 25:102160.
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Intraoperative Use of Functional MRI for Surgical Decision Making after Limited or Infeasible Electrocortical Stimulation Mapping. J Neuroimaging. 2020 03; 30(2):184-191.
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Neural Interactions Underlying Visuomotor Associations in the Human Brain. Cereb Cortex. 2019 12 17; 29(11):4551-4567.
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REVIEW: MR elastography of brain tumors. Neuroimage Clin. 2020; 25:102109.
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Deep white matter analysis: fast, consistent tractography segmentation across populations and dMRI acquisitions. Med Image Comput Comput Assist Interv. 2019 Oct; 11766:599-608.
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Tensor-valued diffusion MRI in under 3 minutes: an initial survey of microscopic anisotropy and tissue heterogeneity in intracranial tumors. Magn Reson Med. 2020 02; 83(2):608-620.
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A comparison of thin-plate spline deformation and finite element modeling to compensate for brain shift during tumor resection. Int J Comput Assist Radiol Surg. 2020 Jan; 15(1):75-85.
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Deformable MRI-Ultrasound registration using correlation-based attribute matching for brain shift correction: Accuracy and generality in multi-site data. Neuroimage. 2019 11 15; 202:116094.
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Acoustic feedback enables safe and reliable carboplatin delivery across the blood-brain barrier with a clinical focused ultrasound system and improves survival in a rat glioma model. Theranostics. 2019; 9(21):6284-6299.
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Commentary: Extent of Resection and Residual Tumor Thresholds for Postoperative Total Seizure Freedom in Epileptic Adult Patients Harboring a Supratentorial Diffuse Low-Grade Glioma. Neurosurgery. 2019 08 01; 85(2):E341-E342.
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Quantitative Wide-Field Imaging Techniques for Fluorescence Guided Neurosurgery. Front Surg. 2019; 6:31.
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Frameless Stereotactic Navigation during Insular Glioma Resection using Fusion of Three-Dimensional Rotational Angiography and Magnetic Resonance Imaging. World Neurosurg. 2019 Jun; 126:322-330.
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Test-retest reproducibility of white matter parcellation using diffusion MRI tractography fiber clustering. Hum Brain Mapp. 2019 07; 40(10):3041-3057.
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Preliminary Results Comparing Thin Plate Splines with Finite Element Methods for Modeling Brain Deformation during Neurosurgery using Intraoperative Ultrasound. Proc SPIE Int Soc Opt Eng. 2019 Feb; 10951.
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Functional MRI Task Comparison for Language Mapping in Neurosurgical Patients. J Neuroimaging. 2019 05; 29(3):348-356.
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Neurosurgical Resection and Stereotactic Radiation Versus Stereotactic Radiation Alone in Patients with a Single or Solitary Brain Metastasis. World Neurosurg. 2019 Feb; 122:e1557-e1561.
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Using the variogram for vector outlier screening: application to feature-based image registration. Int J Comput Assist Radiol Surg. 2018 Dec; 13(12):1871-1880.
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Non-rigid registration of 3D ultrasound for neurosurgery using automatic feature detection and matching. Int J Comput Assist Radiol Surg. 2018 Oct; 13(10):1525-1538.
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Free water modeling of peritumoral edema using multi-fiber tractography: Application to tracking the arcuate fasciculus for neurosurgical planning. PLoS One. 2018; 13(5):e0197056.
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3D printing and intraoperative neuronavigation tailoring for skull base reconstruction after extended endoscopic endonasal surgery: proof of concept. J Neurosurg. 2018 03 02; 130(1):248-255.
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Image Registration to Compensate for EPI Distortion in Patients with Brain Tumors: An Evaluation of Tract-Specific Effects. J Neuroimaging. 2018 03; 28(2):173-182.
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Challenges and techniques for presurgical brain mapping with functional MRI. Neuroimage Clin. 2018; 17:794-803.
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SlicerDMRI: Open Source Diffusion MRI Software for Brain Cancer Research. Cancer Res. 2017 11 01; 77(21):e101-e103.
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Salvage re-irradiation for recurrent high-grade glioma and comparison to bevacizumab alone. J Neurooncol. 2017 Dec; 135(3):581-591.
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Retrospective study comparing model-based deformation correction to intraoperative magnetic resonance imaging for image-guided neurosurgery. J Med Imaging (Bellingham). 2017 Jul; 4(3):035003.
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Performance of unscented Kalman filter tractography in edema: Analysis of the two-tensor model. Neuroimage Clin. 2017; 15:819-831.
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White matter tractography for neurosurgical planning: A topography-based review of the current state of the art. Neuroimage Clin. 2017; 15:659-672.
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Practice guideline summary: Use of fMRI in the presurgical evaluation of patients with epilepsy: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology. Neurology. 2017 Jan 24; 88(4):395-402.
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Automated white matter fiber tract identification in patients with brain tumors. Neuroimage Clin. 2017; 13:138-153.
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Association between shunt-responsive idiopathic normal pressure hydrocephalus and alcohol. J Neurosurg. 2017 Aug; 127(2):240-248.
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Applications of Ultrasound in the Resection of Brain Tumors. J Neuroimaging. 2017 01; 27(1):5-15.
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Multimodal Navigation in Endoscopic Transsphenoidal Resection of Pituitary Tumors Using Image-Based Vascular and Cranial Nerve Segmentation: A Prospective Validation Study. World Neurosurg. 2016 Nov; 95:406-413.
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Label-Free Neurosurgical Pathology with Stimulated Raman Imaging. Cancer Res. 2016 06 15; 76(12):3451-62.
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Right inferior longitudinal fasciculus lesions disrupt visual-emotional integration. Soc Cogn Affect Neurosci. 2016 06; 11(6):945-51.
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Utility of intraoperative imaging. Neurosurg Focus. 2016 Mar; 40(3):E1.
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Optical technologies for intraoperative neurosurgical guidance. Neurosurg Focus. 2016 Mar; 40(3):E8.
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Vaccination with Irradiated Autologous Tumor Cells Mixed with Irradiated GM-K562 Cells Stimulates Antitumor Immunity and T Lymphocyte Activation in Patients with Recurrent Malignant Glioma. Clin Cancer Res. 2016 06 15; 22(12):2885-96.
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An Electrocorticography Grid with Conductive Nanoparticles in a Polymer Thick Film on an Organic Substrate Improves CT and MR Imaging. Radiology. 2016 08; 280(2):595-601.
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Corticospinal tract modeling for neurosurgical planning by tracking through regions of peritumoral edema and crossing fibers using two-tensor unscented Kalman filter tractography. Int J Comput Assist Radiol Surg. 2016 Aug; 11(8):1475-86.
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Multimodal navigated skull base tumor resection using image-based vascular and cranial nerve segmentation: A prospective pilot study. Surg Neurol Int. 2015; 6:172.
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Intraoperative real-time MRI-guided stereotactic biopsy followed by laser thermal ablation for progressive brain metastases after radiosurgery. J Clin Neurosci. 2016 Feb; 24:68-73.
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Altered functional connectivity in lesional peduncular hallucinosis with REM sleep behavior disorder. Cortex. 2016 Jan; 74:96-106.
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Pre-operative image-based segmentation of the cranial nerves and blood vessels in microvascular decompression: Can we prevent unnecessary explorations? Clin Neurol Neurosurg. 2015 Dec; 139:159-65.
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Tendon-Driven Continuum Robot for Endoscopic Surgery: Preclinical Development and Validation of a Tension Propagation Model. IEEE ASME Trans Mechatron. 2015 Oct; 20(5):2252-2263.
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The DTI Challenge: Toward Standardized Evaluation of Diffusion Tensor Imaging Tractography for Neurosurgery. J Neuroimaging. 2015 Nov-Dec; 25(6):875-82.
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Rapid Intraoperative Molecular Characterization of Glioma. JAMA Oncol. 2015 Aug; 1(5):662-7.
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The Value of Pre- and Intraoperative Adjuncts on the Extent of Resection of Hemispheric Low-Grade Gliomas: A Retrospective Analysis. J Neurol Surg A Cent Eur Neurosurg. 2016 Mar; 77(2):79-87.
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"Countersinking" of reservoir in an irradiated patients can decrease tension on scalp closure. Surg Neurol Int. 2015; 6(Suppl 11):S334-6.
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Salvage whole brain radiotherapy or stereotactic radiosurgery after initial stereotactic radiosurgery for 1-4 brain metastases. J Neurooncol. 2015 Sep; 124(3):429-37.
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Incidence, risk factors, and reasons for hospitalization among glioblastoma patients receiving chemoradiation. J Neurooncol. 2015 Aug; 124(1):137-46.
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A New Paradigm for Individual Subject Language Mapping: Movie-Watching fMRI. J Neuroimaging. 2015 Sep-Oct; 25(5):710-20.
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Intraoperative Magnetic Resonance Imaging in Intracranial Glioma Resection: A Single-Center, Retrospective Blinded Volumetric Study. World Neurosurg. 2015 Aug; 84(2):528-36.
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Hypofractionated versus standard radiation therapy with or without temozolomide for older glioblastoma patients. Int J Radiat Oncol Biol Phys. 2015 Jun 01; 92(2):384-9.
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Reconstruction of the arcuate fasciculus for surgical planning in the setting of peritumoral edema using two-tensor unscented Kalman filter tractography. Neuroimage Clin. 2015; 7:815-22.
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Clinical implementation of integrated whole-genome copy number and mutation profiling for glioblastoma. Neuro Oncol. 2015 Oct; 17(10):1344-55.
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"Extraoperative" MRI (eoMRI) for Brain Tumor Surgery: Initial Results at a Single Institution. World Neurosurg. 2015 Jun; 83(6):921-8.
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Smart stylet: the development and use of a bedside external ventricular drain image-guidance system. Stereotact Funct Neurosurg. 2015; 93(1):50-8.
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Comparison of seeding methods for visualization of the corticospinal tracts using single tensor tractography. Clin Neurol Neurosurg. 2015 Feb; 129:44-9.
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Multimodal imaging for improved diagnosis and treatment of cancers. Cancer. 2015 Mar 15; 121(6):817-27.
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Decoupling function and anatomy in atlases of functional connectivity patterns: language mapping in tumor patients. Neuroimage. 2014 Dec; 103:462-475.
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Comparative effectiveness of frame-based, frameless, and intraoperative magnetic resonance imaging-guided brain biopsy techniques. World Neurosurg. 2015 Mar; 83(3):261-8.
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Local control after fractionated stereotactic radiation therapy for brain metastases. J Neurooncol. 2014 Nov; 120(2):339-46.
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Intraoperative mass spectrometry mapping of an onco-metabolite to guide brain tumor surgery. Proc Natl Acad Sci U S A. 2014 Jul 29; 111(30):11121-6.
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Adjuvant radiation therapy, local recurrence, and the need for salvage therapy in atypical meningioma. Neuro Oncol. 2014 Nov; 16(11):1547-53.
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Tumor associated seizures in glioblastomas are influenced by survival gene expression in a region-specific manner: a gene expression imaging study. Epilepsy Res. 2014 Jul; 108(5):843-52.
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Neural dynamics underlying target detection in the human brain. J Neurosci. 2014 Feb 19; 34(8):3042-55.
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Atypical presentation of cerebral schistosomiasis four years after exposure to Schistosoma mansoni. Epilepsy Behav Case Rep. 2014; 2:80-5.
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Mass spectrometry imaging as a tool for surgical decision-making. J Mass Spectrom. 2013 Nov; 48(11):i.
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Mass spectrometry imaging as a tool for surgical decision-making. J Mass Spectrom. 2013 Nov; 48(11):1178-87.
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Focal cortical dysplasia IIb presenting as slowly progressive aphasia mimicking a brain tumor. Seizure. 2014 Feb; 23(2):161-3.
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Rapid, label-free detection of brain tumors with stimulated Raman scattering microscopy. Sci Transl Med. 2013 Sep 04; 5(201):201ra119.
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Hemispheric lateralization interrupted: material-specific memory deficits in temporal lobe epilepsy. Front Hum Neurosci. 2013 Sep 02; 7:546.
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Effect of disease and recovery on functional anatomy in brain tumor patients: insights from functional MRI and diffusion tensor imaging. Imaging Med. 2013 Aug 01; 5(4):333-346.
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Fiber clustering versus the parcellation-based connectome. Neuroimage. 2013 Oct 15; 80:283-9.
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Bayesian characterization of uncertainty in intra-subject non-rigid registration. Med Image Anal. 2013 Jul; 17(5):538-55.
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Clinical applications and future directions of functional MRI. Semin Neurol. 2012 Sep; 32(4):466-75.
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Ambient mass spectrometry for the intraoperative molecular diagnosis of human brain tumors. Proc Natl Acad Sci U S A. 2013 Jan 29; 110(5):1611-6.
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Defining language networks from resting-state fMRI for surgical planning--a feasibility study. Hum Brain Mapp. 2014 Mar; 35(3):1018-30.
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GBM volumetry using the 3D Slicer medical image computing platform. Sci Rep. 2013; 3:1364.
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Surgery, virtual reality, and the future. Stud Health Technol Inform. 2013; 184:vii - xiii.
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Extended Broca's area in the functional connectome of language in adults: combined cortical and subcortical single-subject analysis using fMRI and DTI tractography. Brain Topogr. 2013 Jul; 26(3):428-41.
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PTFOS: flexible and absorbable intracranial electrodes for magnetic resonance imaging. PLoS One. 2012; 7(9):e41187.
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Temporal stability of visually selective responses in intracranial field potentials recorded from human occipital and temporal lobes. J Neurophysiol. 2012 Dec; 108(11):3073-86.
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Neuronavigation in the surgical management of brain tumors: current and future trends. Expert Rev Med Devices. 2012 Sep; 9(5):491-500.
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Functional and structural differences in the hippocampus associated with memory deficits in adult survivors of acute lymphoblastic leukemia. Pediatr Blood Cancer. 2013 Feb; 60(2):293-300.
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Visual pathway study using in vivo diffusion tensor imaging tractography to complement classic anatomy. Neurosurgery. 2012 Mar; 70(1 Suppl Operative):145-56; discussion 156.
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Chiasmal visual loss after retinal detachment. Neurology. 2012 Jan 10; 78(2):150.
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Outcomes after discontinuation of antiepileptic drugs after surgery in patients with low grade brain tumors and meningiomas. J Neurooncol. 2012 May; 107(3):565-70.
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Unbiased groupwise registration of white matter tractography. Med Image Comput Comput Assist Interv. 2012; 15(Pt 3):123-30.
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Classifying human brain tumors by lipid imaging with mass spectrometry. Cancer Res. 2012 Feb 01; 72(3):645-54.
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fMRI-DTI modeling via landmark distance atlases for prediction and detection of fiber tracts. Neuroimage. 2012 Mar; 60(1):456-70.
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Quickest detection of drug-resistant seizures: an optimal control approach. Epilepsy Behav. 2011 Dec; 22 Suppl 1:S49-60.
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Pneumatically driven finger movement: a novel passive functional MR imaging technique for presurgical motor and sensory mapping. AJNR Am J Neuroradiol. 2013 Jan; 34(1):E5-7.
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Neurosurgery Clinics of North America. Functional imaging. Preface. Neurosurg Clin N Am. 2011 Apr; 22(2):xiii-xiv.
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Development of a clinical functional magnetic resonance imaging service. Neurosurg Clin N Am. 2011 Apr; 22(2):307-14, x.
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Multimodal image registration for preoperative planning and image-guided neurosurgical procedures. Neurosurg Clin N Am. 2011 Apr; 22(2):197-206, viii.
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Special surgical considerations for functional brain mapping. Neurosurg Clin N Am. 2011 Apr; 22(2):111-32, vii.
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A new metric for detecting change in slowly evolving brain tumors: validation in meningioma patients. Neurosurgery. 2011 Mar; 68(1 Suppl Operative):225-33.
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Development of stereotactic mass spectrometry for brain tumor surgery. Neurosurgery. 2011 Feb; 68(2):280-89; discussion 290.
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Intraoperative real-time querying of white matter tracts during frameless stereotactic neuronavigation. Neurosurgery. 2011 Feb; 68(2):506-16; discussion 516.
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Interactive diffusion tensor tractography visualization for neurosurgical planning. Neurosurgery. 2011 Feb; 68(2):496-505.
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The neurosurgical anatomy of the sphenoid sinus and sellar floor in endoscopic transsphenoidal surgery. J Neurosurg. 2011 May; 114(5):1319-30.
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Learning an atlas of a cognitive process in its functional geometry. Inf Process Med Imaging. 2011; 22:135-46.
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Discrimination of human astrocytoma subtypes by lipid analysis using desorption electrospray ionization imaging mass spectrometry. Angew Chem Int Ed Engl. 2010 Aug 09; 49(34):5953-6.
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Low yield of clinically significant transesophageal echocardiographic findings in patients with lacunar stroke. J Stroke Cerebrovasc Dis. 1995; 5(1):39-43.
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Current dipole orientation and distribution of epileptiform activity correlates with cortical thinning in left mesiotemporal epilepsy. Neuroimage. 2010 Oct 01; 52(4):1238-42.
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Robust selectivity to two-object images in human visual cortex. Curr Biol. 2010 May 11; 20(9):872-9.
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A combined fMRI and DTI examination of functional language lateralization and arcuate fasciculus structure: Effects of degree versus direction of hand preference. Brain Cogn. 2010 Jul; 73(2):85-92.
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Morphological characteristics of brain tumors causing seizures. Arch Neurol. 2010 Mar; 67(3):336-42.
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Origins of intraoperative MRI. Magn Reson Imaging Clin N Am. 2010 Feb; 18(1):1-10.
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Functional Geometry Alignment and Localization of Brain Areas. Adv Neural Inf Process Syst. 2010; 1:1225-1233.
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The fiber laterality histogram: a new way to measure white matter asymmetry. Med Image Comput Comput Assist Interv. 2010; 13(Pt 2):225-32.
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OpenIGTLink: an open network protocol for image-guided therapy environment. Int J Med Robot. 2009 Dec; 5(4):423-34.
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Threshold-independent functional MRI determination of language dominance: a validation study against clinical gold standards. Epilepsy Behav. 2009 Oct; 16(2):288-97.
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Orbitocranial wooden foreign body: a pre-, intra-, and postoperative chronicle: case report. Neurosurgery. 2009 Aug; 65(2):E383-4; discussion E384.
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High b-value apparent diffusion-weighted images from CURVE-ball DTI. J Magn Reson Imaging. 2009 Jul; 30(1):243-8.
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Contributions to singing ability by the posterior portion of the superior temporal gyrus of the non-language-dominant hemisphere: first evidence from subdural cortical stimulation, Wada testing, and fMRI. Cortex. 2010 Mar; 46(3):343-53.
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Origins of intraoperative MRI. Neurosurg Clin N Am. 2009 Apr; 20(2):137-46.
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An intraoperative brain shift monitor using shear mode transcranial ultrasound: preliminary results. J Ultrasound Med. 2009 Feb; 28(2):191-203.
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Tract-based morphometry for white matter group analysis. Neuroimage. 2009 Apr 15; 45(3):832-44.
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Comparison of blocked and event-related fMRI designs for pre-surgical language mapping. Neuroimage. 2009 Aug; 47 Suppl 2:T107-15.
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Resolving crossings in the corticospinal tract by two-tensor streamline tractography: Method and clinical assessment using fMRI. Neuroimage. 2009 Aug; 47 Suppl 2:T98-106.
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A Surgical Planning Method for Functional MRI Assessment of Language Dominance: Influences from Threshold, Region-of-Interest, and Stimulus Mode. Publisher Springer New York ISSN 1931-7557 (Print) 1931-7565 (Online) Issue Volume 2, Number 2 / June, 2008 . Brain Imaging and Behavior. 2008; 2(2):59-73.

Group independent component analysis of language fMRI from word generation tasks. Neuroimage. 2008 Sep 01; 42(3):1214-25.
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Identification of language areas from event-related fMRI paradigms using data-driven method. The Cognitive Neuroscience Society 2008 Annual meeting, San Francisco, CA, USA, April 12-15, 2008. . 2008.

Compensation of geometric distortion effects on intraoperative magnetic resonance imaging for enhanced visualization in image-guided neurosurgery. Neurosurgery. 2008 Mar; 62(3 Suppl 1):209-15; discussion 215-6.
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FMRI Functional Language in Broca's and Wernicke's Areas: Effects of Handedness on Inter- versus Intra-Hemispheric Relationships. 2008.

Quantification of white matter fiber orientation at tumor margins with diffusion tensor invariant gradients. Proc Intl Soc Mag Reson Med. 2008.

Identification of Essential Language Areas by Combination of fMRI from Different Tasks using Probabilistic Independent Component Analysis . 2008.

Comparison of the deformations of brain tissues caused by tumor in seizure and non-seizure patients . 2008 5th IEEE International Symposium on Biomedical Imaging. 2008.

Fieldmap-free retrospective registration and distortion correction for EPI-based functional imaging. Med Image Comput Comput Assist Interv. 2008; 11(Pt 2):271-9.
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Role of pre- and intraoperative imaging and neuronavigation in neurosurgery. Expert Rev Med Devices. 2008 Jan; 5(1):65-73.
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Quantitative comparison of functional MRI and direct electrocortical stimulation for functional mapping. Int J Med Robot. 2007 Sep; 3(3):262-70.
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Object naming is a more sensitive measure of speech localization than number counting: Converging evidence from direct cortical stimulation and fMRI. Neuroimage. 2007; 37 Suppl 1:S100-8.
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Functional brain mapping and its applications to neurosurgery. Neurosurgery. 2007 Apr; 60(4 Suppl 2):185-201; discussion 201-2.
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In Press: Malignant Cerebral Gliomas: treatment strategies and considerations. In: Neurosurgical Oncology. Black PM, Park J, Eds. 2007.

Tract-based morphometry. . Med Image Comput Comput Assist Interv. . 2007; 10(pt 2):161-8.

Grid-Enabled Software Environment for Enhanced Dynamic Data-Driven Visualization and Navigation during Image-Guided Neurosurgery. ICCS 2007: International Conference on Computer Science. 2007.

Quantification of white matter fiber orientation at tumor margins with diffusion tensor invariant gradients. 15th Annual Meeting of International Society for Magnetic Resonance in Medicine (ISMRM),. 2007.

Atypical language organization in epilepsy. In: Behavioral Aspects of Epilepsy: Principles and Practice. Schacter S, Ed. 2007.

Grid-Enabled Software Environment for Enhanced Dynamic Data-Driven Visualization and Navigation during Image-Guided Neurosurgery. ICCS 2007: International Conference on Computer Science. 2007.

The emerging field of neurosurgical oncology: novel techniques to optimize outcomes and minimize mishaps. Clin Neurosurg. 2007; 54:36-46.
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In Press: Neurosurgical Treatment Planning. In: Textbook of Neuro-Oncology Neuro-Imaging. Newton HB, Jolesz FA, Eds. 2007.

Tract-based morphometry. Med Image Comput Comput Assist Interv. 2007; 10(Pt 2):161-8.
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Non-rigid alignment of pre-operative MRI, fMRI, and DT-MRI with intra-operative MRI for enhanced visualization and navigation in image-guided neurosurgery. Neuroimage. 2007 Apr 01; 35(2):609-24.
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Rater-dependent accuracy in predicting the spatial location of functional centers on anatomical MR images. Clin Neurol Neurosurg. 2007 Apr; 109(3):225-35.
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Image-guided neurosurgery at Brigham and Women's Hospital. IEEE Eng Med Biol Mag. 2006 Sep-Oct; 25(5):67-73.
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Functional MRI of memory in the hippocampus: Laterality indices may be more meaningful if calculated from whole voxel distributions. Neuroimage. 2006 Aug 15; 32(2):592-602.
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Integrated image- and function-guided surgery in eloquent cortex: a technique report. Int J Med Robot. 2006 Mar; 2(1):75-83.
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Imaging and visual analysis - Toward real-time image guided neurosurgery using distributed and grid computing. Proceedings of the ACM/IEEE SC2006. 2006.

Integrated image and function-guided surgery in eloquent cortex: A technique report. Int J of Med Robotics and Computer Assisted Surgery. 2006; 2:75-83.

The brain basis for episodic memory: insights from functional MRI, intracranial EEG, and patients with epilepsy. Epilepsy Behav. 2006 Feb; 8(1):115-26.
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Robust nonrigid registration to capture brain shift from intraoperative MRI. IEEE Trans Med Imaging. 2005 Nov; 24(11):1417-27.
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Atypical language representation in epilepsy: implications for injury-induced reorganization of brain function. Epilepsy Behav. 2005 Jun; 6(4):473-87.
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Memory encoding in Alzheimer's disease: an fMRI study of explicit and implicit memory. Brain. 2005 Apr; 128(Pt 4):773-87.
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Functional Brain Mapping for Minimally Invasive Neurosurgery. Black P, Proctor, M, Eds. In: Minimally Invasive Neurosurgery. 2005.

Functional MRI memory mapping for epilepsy surgery planning: A case report. Journal of Epilepsy and Clinical Electrophysiology. 2005; 11(1):39-44.

Determination of Cerebral dominance from vocalized language using region-of-interest analysis. Society for Neuroscience, 35th Annual Meeting, Washington, DC. 2005.

Hybrid Formulation of the Model-Based Non-rigid Registration Problem to Improve Accuracy and Robustness. MICCAI. 2005; (2):295-302.

Visualization of eloquent systems for vocalized language by integration of MEG, fMRI, and DTI: applications in surgical neuronavigation. M.E.G. Clinical Applications Conference, Xylocastro, Greece. (Winner of 2005 Excellence Award). 2005.

Material-Specific Memory Encoding Lateralization in an Event-Related fMRI Study. Neuroimage. 2005; 26((Suppl1):S31).

Hybrid formulation of the model-based non-rigid registration problem to improve accuracy and robustness. Med Image Comput Comput Assist Interv. 2005; 8(Pt 2):295-302.
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Capturing intraoperative deformations: research experience at Brigham and Women's Hospital. Med Image Anal. 2005 Apr; 9(2):145-62.
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Predictions of location of functional cortex as compared to fMRI results: How accurate are we?. 34th Annual Meeting-Society for Neuroscience, San Diego, CA. 2004.

Evaluating requirements for spatial resolution of fMRI for neurosurgical planning. Hum Brain Mapp. 2004 Jan; 21(1):34-43.
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An Anisotropic Material Model for Image Guided Neurosurgery. MICCAI 2004: 7th International Conference, Proceedings, Part II. 2004; 267 – 275.

Confrontation Naming is a More Sensitive Measure of Speech Localization than Number Counting: Converging Evidence from Direct Cortical Stimulation and fMRI. Congress of Neurological Surgeons 54th Annual meeting. 2004.

Pneumatically driven finger movement: a novel, passive fMRI technique for pre-surgical motor and sensory mapping. Congress of Neurological Surgeons 54th Annual Meeting. 2004; 54th.

Comment on: Functional magnetic resonance imaging integrated neuronavigation: Correlation between lesion-to-motor cortex distance and outcome. Krishnan et al. Neurosurgery. 2004; 55(4):914-915 .

Diffusion Tensor and Functional MRI Fusion with Anatomical MRI for Image-Guided Neurosurgery. LNCS. 2003; 407-415(2878).

Memory lateralization in medial temporal lobe epilepsy assessed by functional MRI. Epilepsia. 2002 Aug; 43(8):855-63.
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Minimalist approach: functional mapping. Clin Neurosurg. 2002; 49:90-102.
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Material-specific lateralization in the medial temporal lobe and prefrontal cortex during memory encoding. Brain. 2001 Sep; 124(Pt 9):1841-54.
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Differential responses in the fusiform region to same-race and other-race faces. Nat Neurosci. 2001 Aug; 4(8):845-50.
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Fractionated stereotactic radiosurgery and preservation of hearing in patients with vestibular schwannoma: a preliminary report. Neurosurgery. 1999 Dec; 45(6):1299-305; discussion 1305-7.
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Direct and combined revascularization in pediatric moyamoya disease. Neurosurgery. 1999 Jul; 45(1):50-8; discussion 58-60.
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Three-fraction stereotactic radiosurgery for treatment of vestibular schwannoma in patients with Neurofibromatosis type II. Journal of Radiosurgery. 1999; 2:215-221.

Trigeminal neuralgia resulting from infarction of the root entry zone of the trigeminal nerve: case report. Neurosurgery. 1998 Sep; 43(3):620-2; discussion 622-3.
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Stereotactic Neurosurgery. In: A Manual of Surgical Procedures for Anesthesiologists, Jaffe R, Samuels S, Eds. 1998.

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Detection of carotid stenosis. From NASCET results to clinical practice. Stroke. 1995 Aug; 26(8):1325-8.
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Transesophageal echocardiography and carotid ultrasound in patients with cerebral ischemia: prevalence of findings and recurrent stroke risk. J Am Coll Cardiol. 1994 Jun; 23(7):1598-603.
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