Ennio A. Chiocca, MD, PhD

The Case for Neurosurgical Intervention in Cancer Neuroscience. Neurosurgery. 2024 Jun 21. View in: Pubmed

Targeting IGF2-IGF1R Signaling to Reprogram the Tumor Microenvironment for Enhanced Viro-Immunotherapy. Neuro Oncol. 2024 Jun 10. View in: Pubmed

Phantom limb pain, traumatic neuroma, or nerve sheath tumor? Illustrative case. J Neurosurg Case Lessons. 2024 Apr 15; 7(16). View in: Pubmed

The heterogeneous sensitivity of pediatric brain tumors to different oncolytic viruses is predicted by unique gene expression profiles. Mol Ther Oncol. 2024 Jun 20; 32(2):200804. View in: Pubmed

Lessons learned from phase 3 trials of immunotherapy for glioblastoma: Time for longitudinal sampling? Neuro Oncol. 2024 02 02; 26(2):211-225. View in: Pubmed

Oncolytic immunoactivation associates with survival in a glioblastoma clinical trial. Neuro Oncol. 2024 02 02; 26(2):209-210. View in: Pubmed

Improved immunostaining of nanostructures and cells in human brain specimens through expansion-mediated protein decrowding. Sci Transl Med. 2024 Jan 31; 16(732):eabo0049. View in: Pubmed

Antigen presentation deficiency, mesenchymal differentiation, and resistance to immunotherapy in the murine syngeneic CT2A tumor model. Front Immunol. 2023; 14:1297932. View in: Pubmed

Clinical trial links oncolytic immunoactivation to survival in glioblastoma. Nature. 2023 Nov; 623(7985):157-166. View in: Pubmed

Inaugural Results of the Individualized Screening Trial of Innovative Glioblastoma Therapy: A Phase II Platform Trial for Newly Diagnosed Glioblastoma Using Bayesian Adaptive Randomization. J Clin Oncol. 2023 Dec 20; 41(36):5524-5535. View in: Pubmed

Intratumoral drug-releasing microdevices allow in situ high-throughput pharmaco phenotyping in patients with gliomas. Sci Transl Med. 2023 09 06; 15(712):eadi0069. View in: Pubmed

Combined gene therapies for high-grade glioma. Lancet Oncol. 2023 09; 24(9):949-950. View in: Pubmed

Oncolytic viral therapy: a review and promising future directions. J Neurosurg. 2024 Feb 01; 140(2):319-327. View in: Pubmed

Intracranial stimulation for brain cancer-The case for implantable, intracranial tumor treating fields. Neurooncol Adv. 2023 Jan-Dec; 5(1):vdad100. View in: Pubmed

Recent oncolytic virotherapy clinical trials outline a roadmap for the treatment of high-grade glioma. Neurooncol Adv. 2023 Jan-Dec; 5(1):vdad081. View in: Pubmed

Clinical Importance of the lncRNA NEAT1 in Cancer Patients Treated with Immune Checkpoint Inhibitors. Clin Cancer Res. 2023 06 13; 29(12):2226-2238. View in: Pubmed

Uncovering transcriptomic landscape alterations of CAN-2409 in in vitro and in vivo glioma models. Front Med (Lausanne). 2023; 10:1140352. View in: Pubmed

PPRX-1701, a nanoparticle formulation of 6'-bromoindirubin acetoxime, improves delivery and shows efficacy in preclinical GBM models. Cell Rep Med. 2023 05 16; 4(5):101019. View in: Pubmed

The Role of Long Noncoding Ribonucleic Acids in Glioblastoma: What the Neurosurgeon Should Know. Neurosurgery. 2023 06 01; 92(6):1104-1111. View in: Pubmed

Reduced time to imaging, length of stay, and hospital charges following implementation of a novel postoperative pathway for craniotomy. J Neurosurg. 2023 08 01; 139(2):373-384. View in: Pubmed

Cerebellar High-Grade Glioma: A Translationally Oriented Review of the Literature. Cancers (Basel). 2022 Dec 28; 15(1). View in: Pubmed

Dual Immunostimulatory Pathway Agonism through a Synthetic Nanocarrier Triggers Robust Anti-Tumor Immunity in Murine Glioblastoma. Adv Mater. 2023 Feb; 35(7):e2208782. View in: Pubmed

The emerging field of oncolytic virus-based cancer immunotherapy. Trends Cancer. 2023 02; 9(2):122-139. View in: Pubmed

Specific targeting of glioblastoma with an oncolytic virus expressing a cetuximab-CCL5 fusion protein via innate and adaptive immunity. Nat Cancer. 2022 11; 3(11):1318-1335. View in: Pubmed

Variants of the adeno-associated virus serotype 9 with enhanced penetration of the blood-brain barrier in rodents and primates. Nat Biomed Eng. 2022 11; 6(11):1257-1271. View in: Pubmed

Treat and repeat: oncolytic virus therapy for brain cancer. Nat Med. 2022 08; 28(8):1540-1542. View in: Pubmed

Perturbing DDR signaling enhances cytotoxic effects of local oncolytic virotherapy and modulates the immune environment in glioma. Mol Ther Oncolytics. 2022 Sep 15; 26:275-288. View in: Pubmed

Carole A. Miller, MD: Matriarch of the Ohio State University's Department of Neurosurgery. World Neurosurg. 2022 10; 166:33-38. View in: Pubmed

STING activation promotes robust immune response and NK cell-mediated tumor regression in glioblastoma models. Proc Natl Acad Sci U S A. 2022 07 12; 119(28):e2111003119. View in: Pubmed

Clinical utility of targeted next-generation sequencing assay in IDH-wildtype glioblastoma for therapy decision-making. Neuro Oncol. 2022 07 01; 24(7):1140-1149. View in: Pubmed

The current state of glioma data registries. Neurooncol Adv. 2022 Jan-Dec; 4(1):vdac099. View in: Pubmed

Combined immunotherapy with controlled interleukin-12 gene therapy and immune checkpoint blockade in recurrent glioblastoma: An open-label, multi-institutional phase I trial. Neuro Oncol. 2022 06 01; 24(6):951-963. View in: Pubmed

Target receptor identification and subsequent treatment of resected brain tumors with encapsulated and engineered allogeneic stem cells. Nat Commun. 2022 05 19; 13(1):2810. View in: Pubmed

Agent-based computational modeling of glioblastoma predicts that stromal density is central to oncolytic virus efficacy. iScience. 2022 Jun 17; 25(6):104395. View in: Pubmed

NOTCH-Induced MDSC Recruitment after oHSV Virotherapy in CNS Cancer Models Modulates Antitumor Immunotherapy. Clin Cancer Res. 2022 04 01; 28(7):1460-1473. View in: Pubmed

Advances in local therapy for glioblastoma - taking the fight to the tumour. Nat Rev Neurol. 2022 04; 18(4):221-236. View in: Pubmed

Tumor-Associated Macrophages/Microglia in Glioblastoma Oncolytic Virotherapy: A Double-Edged Sword. Int J Mol Sci. 2022 Feb 04; 23(3). View in: Pubmed

Immune Checkpoint Inhibition in GBM Primed with Radiation by Engineered Extracellular Vesicles. ACS Nano. 2022 02 22; 16(2):1940-1953. View in: Pubmed

Activity of PD-1 blockade with nivolumab among patients with recurrent atypical/anaplastic meningioma: phase II trial results. Neuro Oncol. 2022 01 05; 24(1):101-113. View in: Pubmed

Autoimmune Cytopenias and Dysregulated Immunophenotype Act as Warning Signs of Inborn Errors of Immunity: Results From a Prospective Study. Front Immunol. 2021; 12:790455. View in: Pubmed

Systemic high-dose dexamethasone treatment may modulate the efficacy of intratumoral viral oncolytic immunotherapy in glioblastoma models. J Immunother Cancer. 2022 01; 10(1). View in: Pubmed

Quantitative imaging of apoptosis following oncolytic virotherapy by magnetic resonance fingerprinting aided by deep learning. Nat Biomed Eng. 2022 05; 6(5):648-657. View in: Pubmed

Glial and myeloid heterogeneity in the brain tumour microenvironment. Nat Rev Cancer. 2021 12; 21(12):786-802. View in: Pubmed

The Evolving Role of Neurosurgical Intervention for Central Nervous System Tumors. Hematol Oncol Clin North Am. 2022 02; 36(1):63-75. View in: Pubmed

Treatment of glioblastoma with current oHSV variants reveals differences in efficacy and immune cell recruitment. Mol Ther Oncolytics. 2021 Sep 24; 22:444-453. View in: Pubmed

Evolution of the Neurosurgeon's Role in Clinical Trials for Glioblastoma: A Systematic Overview of the Clinicaltrials.Gov Database. Neurosurgery. 2021 07 15; 89(2):196-203. View in: Pubmed

The Current Landscape of Oncolytic Herpes Simplex Viruses as Novel Therapies for Brain Malignancies. Viruses. 2021 06 17; 13(6). View in: Pubmed

Neurosurgery Research and Education Foundation funding conversion to National Institutes of Health funding. J Neurosurg. 2022 Jan 01; 136(1):287-294. View in: Pubmed

Cytomegalovirus infection of glioblastoma cells leads to NF-?B dependent upregulation of the c-MET oncogenic tyrosine kinase. Cancer Lett. 2021 08 10; 513:26-35. View in: Pubmed

Role of surgery for glioblastoma: response to letters from Dr. Gerritsen and his colleagues and Dr. Vargas Lopez. Neuro Oncol. 2021 03 25; 23(3):506-507. View in: Pubmed

Unique challenges for glioblastoma immunotherapy-discussions across neuro-oncology and non-neuro-oncology experts in cancer immunology. Meeting Report from the 2019 SNO Immuno-Oncology Think Tank. Neuro Oncol. 2021 03 25; 23(3):356-375. View in: Pubmed

Oncolytic Virus Therapy Alters the Secretome of Targeted Glioblastoma Cells. Cancers (Basel). 2021 Mar 14; 13(6). View in: Pubmed

Biographies of international women leaders in neurosurgery. Neurosurg Focus. 2021 03; 50(3):E19. View in: Pubmed

Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis. Cell. 2021 03 04; 184(5):1281-1298.e26. View in: Pubmed

Therapeutic cancer vaccines for pediatric malignancies: advances, challenges, and emerging technologies. Neurooncol Adv. 2021 Jan-Dec; 3(1):vdab027. View in: Pubmed

Targeting glioblastoma using a novel peptide specific to a deglycosylated isoform of brevican. Adv Ther (Weinh). 2021 Apr; 4(4). View in: Pubmed

The nuclear DICER-circular RNA complex drives the deregulation of the glioblastoma cell microRNAome. Sci Adv. 2020 12; 6(51). View in: Pubmed

HSV-1 Oncolytic Viruses from Bench to Bedside: An Overview of Current Clinical Trials. Cancers (Basel). 2020 Nov 26; 12(12). View in: Pubmed

Redesigned reporter gene for improved proton exchange-based molecular MRI contrast. Sci Rep. 2020 11 26; 10(1):20664. View in: Pubmed

Concurrent Dexamethasone Limits the Clinical Benefit of Immune Checkpoint Blockade in Glioblastoma. Clin Cancer Res. 2021 01 01; 27(1):276-287. View in: Pubmed

Oncolytic HSV Vectors and Anti-Tumor Immunity. Curr Issues Mol Biol. 2021; 41:381-468. View in: Pubmed

Glioblastoma in adults: a Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions. Neuro Oncol. 2020 08 17; 22(8):1073-1113. View in: Pubmed

Letter: Adaptation Under Fire: Two Harvard Neurosurgical Services During the COVID-19 Pandemic. Neurosurgery. 2020 08 01; 87(2):E173-E177. View in: Pubmed

National Institute of Neurological Disorders and Stroke: current funding status, opportunities, challenges, emerging scientific advances, and recommendations for neurosurgery. J Neurosurg. 2020 10 01; 133(4):1264-1269. View in: Pubmed

A Platinum(IV) Prodrug-Perfluoroaryl Macrocyclic Peptide Conjugate Enhances Platinum Uptake in the Brain. J Med Chem. 2020 07 09; 63(13):6741-6747. View in: Pubmed

Extracellular Vesicles Induce Mesenchymal Transition and Therapeutic Resistance in Glioblastomas through NF-?B/STAT3 Signaling. Adv Biosyst. 2020 12; 4(12):e1900312. View in: Pubmed

Tumor Interferon Signaling Is Regulated by a lncRNA INCR1 Transcribed from the PD-L1 Locus. Mol Cell. 2020 06 18; 78(6):1207-1223.e8. View in: Pubmed

Hypoxic Roadmap of Glioblastoma-Learning about Directions and Distances in the Brain Tumor Environment. Cancers (Basel). 2020 May 13; 12(5). View in: Pubmed

Immune Escape Mediated by Exosomal PD-L1 in Cancer. Adv Biosyst. 2020 12; 4(12):e2000017. View in: Pubmed

Editorial. COVID-19 and academic neurosurgery. J Neurosurg. 2020 07 01; 133(1):8-9. View in: Pubmed

Mechanisms and therapeutic implications of hypermutation in gliomas. Nature. 2020 04; 580(7804):517-523. View in: Pubmed

Cytomegalovirus Encephalopathy during Brain Tumor Irradiation. Clin Cancer Res. 2020 07 01; 26(13):3077-3078. View in: Pubmed

KLF4K409Q-mutated meningiomas show enhanced hypoxia signaling and respond to mTORC1 inhibitor treatment. Acta Neuropathol Commun. 2020 04 03; 8(1):41. View in: Pubmed

Preclinical Toxicology of rQNestin34.5v.2: An Oncolytic Herpes Virus with Transcriptional Regulation of the ICP34.5 Neurovirulence Gene. Mol Ther Methods Clin Dev. 2020 Jun 12; 17:871-893. View in: Pubmed

Glioblastoma infiltration of both tumor- and virus-antigen specific cytotoxic T cells correlates with experimental virotherapy responses. Sci Rep. 2020 03 20; 10(1):5095. View in: Pubmed

FASN Is a Biomarker Enriched in Malignant Glioma-Derived Extracellular Vesicles. Int J Mol Sci. 2020 Mar 12; 21(6). View in: Pubmed

Targeting glioma-initiating cells via the tyrosine metabolic pathway. J Neurosurg. 2021 03 01; 134(3):721-732. View in: Pubmed

Correction: Arming an Oncolytic Herpes Simplex Virus Type 1 with a Single-chain Fragment Variable Antibody against PD-1 for Experimental Glioblastoma Therapy. Clin Cancer Res. 2020 Feb 01; 26(3):758. View in: Pubmed

GBM-Targeted oHSV Armed with Matrix Metalloproteinase 9 Enhances Anti-tumor Activity and Animal Survival. Mol Ther Oncolytics. 2019 Dec 20; 15:214-222. View in: Pubmed

Letter: When Less is More: Dexamethasone Dosing for Brain Tumors. Neurosurgery. 2019 09 01; 85(3):E607-E608. View in: Pubmed

Regulatable interleukin-12 gene therapy in patients with recurrent high-grade glioma: Results of a phase 1 trial. Sci Transl Med. 2019 08 14; 11(505). View in: Pubmed

Characterization of single microvesicles in plasma from glioblastoma patients. Neuro Oncol. 2019 05 06; 21(5):606-615. View in: Pubmed

Proteomic Analysis Implicates Vimentin in Glioblastoma Cell Migration. Cancers (Basel). 2019 Apr 03; 11(4). View in: Pubmed

Radiation-Induced Targeted Nanoparticle-Based Gene Delivery for Brain Tumor Therapy. ACS Nano. 2019 04 23; 13(4):4028-4040. View in: Pubmed

Imaging flow cytometry facilitates multiparametric characterization of extracellular vesicles in malignant brain tumours. J Extracell Vesicles. 2019; 8(1):1588555. View in: Pubmed

Frameless Stereotactic Navigation during Insular Glioma Resection using Fusion of Three-Dimensional Rotational Angiography and Magnetic Resonance Imaging. World Neurosurg. 2019 Jun; 126:322-330. View in: Pubmed

Cytomegalovirus promotes murine glioblastoma growth via pericyte recruitment and angiogenesis. J Clin Invest. 2019 03 11; 129(4):1671-1683. View in: Pubmed

Molecular responses to immune checkpoint blockade in glioblastoma. Nat Med. 2019 03; 25(3):359-361. View in: Pubmed

Pneumatosis Intestinalis After Molecular-Targeted Therapy. World Neurosurg. 2019 05; 125:312-315. View in: Pubmed

The functional synergism of microRNA clustering provides therapeutically relevant epigenetic interference in glioblastoma. Nat Commun. 2019 01 25; 10(1):442. View in: Pubmed

Amendments: Publisher Correction: An oncolytic herpesvirus expressing E-cadherin improves survival in mouse models of glioblastoma. Nat Biotechnol. 2019 01 03; 37(1):102. View in: Pubmed

Viral and other therapies for recurrent glioblastoma: is a 24-month durable response unusual? Neuro Oncol. 2019 01 01; 21(1):14-25. View in: Pubmed

Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial. Nature. 2019 01; 565(7738):234-239. View in: Pubmed

An oncolytic herpesvirus expressing E-cadherin improves survival in mouse models of glioblastoma. Nat Biotechnol. 2018 Nov 26. View in: Pubmed

Viruses in cancer therapy - from benchwarmers to quarterbacks. Nat Rev Clin Oncol. 2018 11; 15(11):657-658. View in: Pubmed

The multiple protective roles and molecular mechanisms of melatonin and its precursor N-acetylserotonin in targeting brain injury and liver damage and in maintaining bone health. Free Radic Biol Med. 2019 01; 130:215-233. View in: Pubmed

Arming an Oncolytic Herpes Simplex Virus Type 1 with a Single-chain Fragment Variable Antibody against PD-1 for Experimental Glioblastoma Therapy. Clin Cancer Res. 2019 01 01; 25(1):290-299. View in: Pubmed

A PDGFRa-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine. Nat Commun. 2018 08 06; 9(1):3116. View in: Pubmed

Immunotherapy for glioblastoma: going viral. Nat Med. 2018 08; 24(8):1094-1096. View in: Pubmed

Immune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesicles. Sci Adv. 2018 03; 4(3):eaar2766. View in: Pubmed

Toxicity and Efficacy of a Novel GADD34-expressing Oncolytic HSV-1 for the Treatment of Experimental Glioblastoma. Clin Cancer Res. 2018 06 01; 24(11):2574-2584. View in: Pubmed

Endoscopic Endonasal Resection of a Suprasellar Pituitary Adenoma Mimicking Tuberculum Sellae Meningioma in a Patient with an Intrasellar Persistent Trigeminal Artery. J Neurol Surg B Skull Base. 2018 Apr; 79(Suppl 3):S285-S286. View in: Pubmed

Adult Tethered Cord Syndrome Following Chiari Decompression. World Neurosurg. 2018 Apr; 112:205-208. View in: Pubmed

Preclinical investigation of combined gene-mediated cytotoxic immunotherapy and immune checkpoint blockade in glioblastoma. Neuro Oncol. 2018 01 22; 20(2):225-235. View in: Pubmed

Modeling tumor immunity of mouse glioblastoma by exhausted CD8+ T cells. Sci Rep. 2018 01 09; 8(1):208. View in: Pubmed

Multiplexed Profiling of Single Extracellular Vesicles. ACS Nano. 2018 01 23; 12(1):494-503. View in: Pubmed

Oncolytic viruses sensitize human tumor cells for NY-ESO-1 tumor antigen recognition by CD4+ effector T cells. Oncoimmunology. 2018; 7(3):e1407897. View in: Pubmed

Anticancer activity of osmium(VI) nitrido complexes in patient-derived glioblastoma initiating cells and in vivo mouse models. Cancer Lett. 2018 03 01; 416:138-148. View in: Pubmed

Development of a Function-Blocking Antibody Against Fibulin-3 as a Targeted Reagent for Glioblastoma. Clin Cancer Res. 2018 02 15; 24(4):821-833. View in: Pubmed

Immunotherapy for glioblastoma: on the sidelines or in the game? Discov Med. 2017 11; 24(133):201-208. View in: Pubmed

Perfluoroarene-Based Peptide Macrocycles to Enhance Penetration Across the Blood-Brain Barrier. J Am Chem Soc. 2017 11 08; 139(44):15628-15631. View in: Pubmed

Detection of wild-type EGFR amplification and EGFRvIII mutation in CSF-derived extracellular vesicles of glioblastoma patients. Neuro Oncol. 2017 Oct 19; 19(11):1494-1502. View in: Pubmed

Salvage re-irradiation for recurrent high-grade glioma and comparison to bevacizumab alone. J Neurooncol. 2017 Dec; 135(3):581-591. View in: Pubmed

Human Cytomegalovirus is Present in Alveolar Soft Part Sarcoma. Appl Immunohistochem Mol Morphol. 2017 Oct; 25(9):615-619. View in: Pubmed

The Fc Domain of Immunoglobulin Is Sufficient to Bridge NK Cells with Virally Infected Cells. Immunity. 2017 07 18; 47(1):159-170.e10. View in: Pubmed

Blood-brain-barrier spheroids as an in vitro screening platform for brain-penetrating agents. Nat Commun. 2017 06 06; 8:15623. View in: Pubmed

MicroRNA-Mediated Dynamic Bidirectional Shift between the Subclasses of Glioblastoma Stem-like Cells. Cell Rep. 2017 06 06; 19(10):2026-2032. View in: Pubmed

Oncolytic Viruses in Cancer Treatment: A Review. JAMA Oncol. 2017 Jun 01; 3(6):841-849. View in: Pubmed

Dissecting inherent intratumor heterogeneity in patient-derived glioblastoma culture models. Neuro Oncol. 2017 06 01; 19(6):820-832. View in: Pubmed

MicroRNA Signatures and Molecular Subtypes of Glioblastoma: The Role of Extracellular Transfer. Stem Cell Reports. 2017 06 06; 8(6):1497-1505. View in: Pubmed

Launching Effectiveness Research to Guide Practice in Neurosurgery: A National Institute Neurological Disorders and Stroke Workshop Report. Neurosurgery. 2017 04 01; 80(4):505-514. View in: Pubmed

A Phase I Trial of Ad.hIFN-ß Gene Therapy for Glioma. Mol Ther. 2008 Mar; 16(3):618-626. View in: Pubmed

Tannous et al. Respond. Mol Ther. 2009 Aug; 17(8):1311-1312. View in: Pubmed

Frontal dermoid cyst coexisting with suprasellar craniopharyngioma: a spectrum of ectodermally derived epithelial-lined cystic lesions? Neurosurg Focus. 2016 12; 41(6):E16. View in: Pubmed

Glioma and microglia, a double entendre. Nat Immunol. 2016 10 19; 17(11):1240-1242. View in: Pubmed

Association between shunt-responsive idiopathic normal pressure hydrocephalus and alcohol. J Neurosurg. 2017 Aug; 127(2):240-248. View in: Pubmed

The Long Non-coding RNA HIF1A-AS2 Facilitates the Maintenance of Mesenchymal Glioblastoma Stem-like Cells in Hypoxic Niches. Cell Rep. 2016 06 14; 15(11):2500-9. View in: Pubmed

Design of a Microfluidic Chip for Magnetic-Activated Sorting of One-Bead-One-Compound Libraries. ACS Comb Sci. 2016 06 13; 18(6):271-8. View in: Pubmed

A combinational therapy of EGFR-CAR NK cells and oncolytic herpes simplex virus 1 for breast cancer brain metastases. Oncotarget. 2016 May 10; 7(19):27764-77. View in: Pubmed

Extracellular Vesicles from High-Grade Glioma Exchange Diverse Pro-oncogenic Signals That Maintain Intratumoral Heterogeneity. Cancer Res. 2016 05 15; 76(10):2876-81. View in: Pubmed

Extracellular Vesicles and MicroRNAs: Their Role in Tumorigenicity and Therapy for Brain Tumors. Cell Mol Neurobiol. 2016 Apr; 36(3):361-76. View in: Pubmed

Therapeutic potential of targeting microRNA-10b in established intracranial glioblastoma: first steps toward the clinic. EMBO Mol Med. 2016 Mar 01; 8(3):268-87. View in: Pubmed

BKM-120 (Buparlisib): A Phosphatidyl-Inositol-3 Kinase Inhibitor with Anti-Invasive Properties in Glioblastoma. Sci Rep. 2016 Feb 05; 6:20189. View in: Pubmed

Phase II multicenter study of gene-mediated cytotoxic immunotherapy as adjuvant to surgical resection for newly diagnosed malignant glioma. Neuro Oncol. 2016 08; 18(8):1137-45. View in: Pubmed

Current State of Immune-Based Therapies for Glioblastoma. Am Soc Clin Oncol Educ Book. 2016; 35:e132-9. View in: Pubmed

Experimental therapies: gene therapies and oncolytic viruses. Handb Clin Neurol. 2016; 134:183-97. View in: Pubmed

Cancer immunotherapy: A vaccine from plant virus proteins. Nat Nanotechnol. 2016 Mar; 11(3):214-5. View in: Pubmed

TGFß Treatment Enhances Glioblastoma Virotherapy by Inhibiting the Innate Immune Response. Cancer Res. 2015 Dec 15; 75(24):5273-82. View in: Pubmed

Awake Craniotomy and Intraoperative MRI for Maximal Safe Resection in a Case of an Extensive Left Frontal and Insular Low-grade Glioma: 3-Dimensional Operative Video. Oper Neurosurg (Hagerstown). 2015 Dec 01; 11(4):578. View in: Pubmed

Combining HDAC inhibitors with oncolytic virotherapy for cancer therapy. Oncolytic Virother. 2015; 4:183-91. View in: Pubmed

Reconstruction of Rare Skull Metastases Using Free Latissimus Dorsi Flap and the Role of Preoperative Embolization in Hypervascular Skull Tumors. J Craniofac Surg. 2015 Nov; 26(8):2289-92. View in: Pubmed

Histone deacetylase 6 inhibition enhances oncolytic viral replication in glioma. J Clin Invest. 2015 Nov 02; 125(11):4269-80. View in: Pubmed

Awake right hemisphere brain surgery. J Clin Neurosci. 2015 Dec; 22(12):1921-7. View in: Pubmed

Oncolytic Virus-Mediated Immunotherapy: A Combinatorial Approach for Cancer Treatment. J Clin Oncol. 2015 Sep 01; 33(25):2812-4. View in: Pubmed

In vitro screening of clinical drugs identifies sensitizers of oncolytic viral therapy in glioblastoma stem-like cells. Gene Ther. 2015 Dec; 22(12):947-59. View in: Pubmed

Response to energy depletion: miR-451/AMPK loop. Oncotarget. 2015 Jul 20; 6(20):17851-2. View in: Pubmed

CAR-Engineered NK Cells Targeting Wild-Type EGFR and EGFRvIII Enhance Killing of Glioblastoma and Patient-Derived Glioblastoma Stem Cells. Sci Rep. 2015 Jul 09; 5:11483. View in: Pubmed

Incidence, risk factors, and reasons for hospitalization among glioblastoma patients receiving chemoradiation. J Neurooncol. 2015 Aug; 124(1):137-46. View in: Pubmed

One size should not fit all: advancing toward personalized glioblastoma therapy. Discov Med. 2015 Jun; 19(107):471-7. View in: Pubmed

Extracranial growth of glioblastoma multiforme. J Clin Neurosci. 2015 Sep; 22(9):1521-3. View in: Pubmed

A cross-talk network that facilitates tumor virotherapy. Nat Med. 2015 May; 21(5):426-7. View in: Pubmed

Glucose-based regulation of miR-451/AMPK signaling depends on the OCT1 transcription factor. Cell Rep. 2015 May 12; 11(6):902-909. View in: Pubmed

Potentiating oncolytic viral therapy through an understanding of the initial immune responses to oncolytic viral infection. Curr Opin Virol. 2015 Aug; 13:25-32. View in: Pubmed

Hypofractionated versus standard radiation therapy with or without temozolomide for older glioblastoma patients. Int J Radiat Oncol Biol Phys. 2015 Jun 01; 92(2):384-9. View in: Pubmed

Modeling cytomegalovirus infection in mouse tumor models. Front Oncol. 2015; 5:61. View in: Pubmed

Clinical implementation of integrated whole-genome copy number and mutation profiling for glioblastoma. Neuro Oncol. 2015 Oct; 17(10):1344-55. View in: Pubmed

The Role of Radiation Therapy in Gross Totally Resected Meningiomas. World Neurosurg. 2015 Jul; 84(1):9-11. View in: Pubmed

MicroRNA-10b inhibition reduces E2F1-mediated transcription and miR-15/16 activity in glioblastoma. Oncotarget. 2015 Feb 28; 6(6):3770-83. View in: Pubmed

Editorial: the management of low-grade glioma in adults. Neurosurg Focus. 2015 Jan; 38(1):E8. View in: Pubmed

Introduction: a focus on low-grade glioma. Neurosurg Focus. 2015 Jan; 38(1):E2. View in: Pubmed

Superficial greater petrosal neuropathy. Neurol Clin Pract. 2014 Dec; 4(6):505-507. View in: Pubmed

Interferon-stimulated gene 15 (ISG15) and ISG15-linked proteins can associate with members of the selective autophagic process, histone deacetylase 6 (HDAC6) and SQSTM1/p62. J Biol Chem. 2015 Jan 16; 290(3):1485-95. View in: Pubmed

Belonging to a network--microRNAs, extracellular vesicles, and the glioblastoma microenvironment. Neuro Oncol. 2015 May; 17(5):652-62. View in: Pubmed

Predicting outcomes: recursive partitioning analysis (RPA) prognostic algorithm for patients with metastatic sarcoma to the brain. World Neurosurg. 2014 Dec; 82(6):1030-2. View in: Pubmed

Use of miRNA response sequences to block off-target replication and increase the safety of an unattenuated, glioblastoma-targeted oncolytic HSV. Mol Ther. 2015 Jan; 23(1):99-107. View in: Pubmed

Immunotherapy advances for glioblastoma. Neuro Oncol. 2014 Nov; 16(11):1441-58. View in: Pubmed

Skull base chordomas and chondrosarcomas: a population-based analysis. World Neurosurg. 2015 Apr; 83(4):468-70. View in: Pubmed

Evolution of malignant glioma treatment: from chemotherapy to vaccines to viruses. Neurosurgery. 2014 Aug; 61 Suppl 1:74-83. View in: Pubmed

Annexin A2 regulates angiogenesis and invasion phenotypes of malignant glioma. Neuro Oncol. 2014 Jul; 16 Suppl 3:iii10. View in: Pubmed

Cytomegalovirus contributes to glioblastoma in the context of tumor suppressor mutations. Neuro Oncol. 2014 Jul; 16 Suppl 3:iii8. View in: Pubmed

Low-grade gliomas and quality of life. World Neurosurg. 2014 Jul-Aug; 82(1-2):e133-4. View in: Pubmed

How much is enough? The question of extent of resection in glioblastoma multiforme. World Neurosurg. 2014 Jul-Aug; 82(1-2):e109-10. View in: Pubmed

Image-guided maximal resection of intrinsic tumors. World Neurosurg. 2014 Nov; 82(5):604-5. View in: Pubmed

Oncolytic viruses targeting tumor stem cells. Cancer Res. 2014 Jul 01; 74(13):3396-8. View in: Pubmed

Oncolytic viruses and their application to cancer immunotherapy. Cancer Immunol Res. 2014 Apr; 2(4):295-300. View in: Pubmed

Who benefits from surgery for brain metastases? World Neurosurg. 2014 Jul-Aug; 82(1-2):e115-6. View in: Pubmed

Phase 1 clinical trial of intratumoral reovirus infusion for the treatment of recurrent malignant gliomas in adults. Mol Ther. 2014 May; 22(5):1056-62. View in: Pubmed

No free lunch: secondary neoplasms after stereotactic radiation. World Neurosurg. 2015 Mar; 83(3):330-1. View in: Pubmed

Glioma virus therapies between bench and bedside. Neuro Oncol. 2014 Mar; 16(3):334-51. View in: Pubmed

Genetic validation of the protein arginine methyltransferase PRMT5 as a candidate therapeutic target in glioblastoma. Cancer Res. 2014 Mar 15; 74(6):1752-65. View in: Pubmed

Modification of HSV-1 to an oncolytic virus. Methods Mol Biol. 2014; 1144:117-27. View in: Pubmed

Extracellular vesicles modulate the glioblastoma microenvironment via a tumor suppression signaling network directed by miR-1. Cancer Res. 2014 Feb 01; 74(3):738-750. View in: Pubmed

Academic productivity in today's training climate: a fellowship's impact. World Neurosurg. 2015 Mar; 83(3):328-9. View in: Pubmed

Switching a replication-defective adenoviral vector into a replication-competent, oncolytic adenovirus. J Virol. 2014 Jan; 88(1):345-53. View in: Pubmed

Strategies in gene therapy for glioblastoma. Cancers (Basel). 2013 Oct 23; 5(4):1271-305. View in: Pubmed

DNA demethylating agents synergize with oncolytic HSV1 against malignant gliomas. Clin Cancer Res. 2013 Nov 01; 19(21):5952-9. View in: Pubmed

From localization to pathways: the continuing evolution of diffusion tensor imaging. World Neurosurg. 2014 Jul-Aug; 82(1-2):e47-8. View in: Pubmed

Oncolytic virotherapy for gliomas: steps toward the future. CNS Oncol. 2013 Sep; 2(5):389-92. View in: Pubmed

Methylation markers of malignant potential in meningiomas. J Neurosurg. 2013 Oct; 119(4):899-906. View in: Pubmed

Toxicology and Biodistribution Studies for MGH2.1, an Oncolytic Virus that Expresses Two Prodrug-activating Genes, in Combination with Prodrugs. Mol Ther Nucleic Acids. 2013 Aug 06; 2:e113. View in: Pubmed

STAT3 activation promotes oncolytic HSV1 replication in glioma cells. PLoS One. 2013; 8(8):e71932. View in: Pubmed

Mutations in glioblastoma oncosuppressive pathways pave the way for oncomodulatory activity of cytomegalovirus. Oncoimmunology. 2013 Sep 01; 2(9):e25620. View in: Pubmed

The integrin inhibitor cilengitide enhances the anti-glioma efficacy of vasculostatin-expressing oncolytic virus. Cancer Gene Ther. 2013 Aug; 20(8):437-44. View in: Pubmed

Adult cerebellar glioblastomas: a distinct entity or parcel of the whole? World Neurosurg. 2013 Dec; 80(6):e181-3. View in: Pubmed

MicroRNA-128 coordinately targets Polycomb Repressor Complexes in glioma stem cells. Neuro Oncol. 2013 Sep; 15(9):1212-24. View in: Pubmed

Cytomegalovirus contributes to glioblastoma in the context of tumor suppressor mutations. Cancer Res. 2013 Jun 01; 73(11):3441-50. View in: Pubmed

An update on vaccine therapy and other immunotherapeutic approaches for glioblastoma. Expert Rev Vaccines. 2013 Jun; 12(6):597-615. View in: Pubmed

Gene expression profiling of the anti-glioma effect of Cilengitide. Springerplus. 2013 Dec; 2(1):160. View in: Pubmed

Editorial: Glioblastoma multiforme and laser interstitial thermal therapy. J Neurosurg. 2013 Jun; 118(6):1199-200; discussion 1200-1. View in: Pubmed

Uncovering a novel mechanism whereby NK cells interfere with glioblastoma virotherapy. Oncoimmunology. 2013 Apr 01; 2(4):e23658. View in: Pubmed

"Infectious" optimism for treatment of hepatocellular carcinoma. Mol Ther. 2013 Apr; 21(4):722-4. View in: Pubmed

Editorial: Tumor and antiepileptic drugs: clinical article. J Neurosurg. 2013 Jun; 118(6):1181-2; discussion 1182. View in: Pubmed

Editorial: Intraoperative magnetic resonance spectroscopy and gliomas. J Neurosurg. 2013 Jun; 118(6):1188-9; discussion 1189-90. View in: Pubmed

Neoplasm development after stereotactic radiosurgery for arteriovenous malformations. World Neurosurg. 2014 Sep-Oct; 82(3-4):304-6. View in: Pubmed

Nanotechnology-based strategies for the diagnosis and treatment of intracranial neoplasms. World Neurosurg. 2013 Jul-Aug; 80(1-2):53-5. View in: Pubmed

Stereotactic radiosurgery and atypical meningiomas. J Neurosurg. 2013 Aug; 119(2):472-4. View in: Pubmed

Editorial: postoperative ischemia. J Neurosurg. 2013 Apr; 118(4):799-800; discussion 800. View in: Pubmed

Expression of HSV-1 receptors in EBV-associated lymphoproliferative disease determines susceptibility to oncolytic HSV. Gene Ther. 2013 Jul; 20(7):761-9. View in: Pubmed

Comparative effectiveness of antinociceptive gene therapies in animal models of diabetic neuropathic pain. Gene Ther. 2013 Jul; 20(7):742-50. View in: Pubmed

The spectrum of vaccine therapies for patients with glioblastoma multiforme. Curr Treat Options Oncol. 2012 Dec; 13(4):437-50. View in: Pubmed

NK cells impede glioblastoma virotherapy through NKp30 and NKp46 natural cytotoxicity receptors. Nat Med. 2012 Dec; 18(12):1827-34. View in: Pubmed

Quantitative analysis of surgical exposure and maneuverability associated with the endoscope and the microscope in the retrosigmoid and various posterior petrosectomy approaches to the petroclival region using computer tomograpy-based frameless stereotaxy. A cadaveric study. Clin Neurol Neurosurg. 2013 Jul; 115(7):1058-62. View in: Pubmed

Proteomics-based analysis of invasion-related proteins in malignant gliomas. Neuropathology. 2013 Jun; 33(3):264-75. View in: Pubmed

Editorial: glioblastoma and surgery. J Neurosurg. 2013 Apr; 118(4):809-11; discussion 810-1. View in: Pubmed

Effective treatment of an orthotopic xenograft model of human glioblastoma using an EGFR-retargeted oncolytic herpes simplex virus. Mol Ther. 2013 Mar; 21(3):561-9. View in: Pubmed

Cytomegalovirus infection leads to pleomorphic rhabdomyosarcomas in Trp53+/- mice. Cancer Res. 2012 Nov 15; 72(22):5669-74. View in: Pubmed

Bimodal anti-glioma mechanisms of cilengitide demonstrated by novel invasive glioma models. Neuropathology. 2013 Apr; 33(2):162-74. View in: Pubmed

Von Hippel-Lindau disease and pregnancy. J Neurosurg. 2012 Nov; 117(5):815-6; discussion 816-7. View in: Pubmed

Editorial: radiosurgery and atypical meningiomas. J Neurosurg. 2012 Oct; 117(4):676-8. View in: Pubmed

Editorial: meningioma and radiotherapy. J Neurosurg. 2012 Oct; 117(4):666-8. View in: Pubmed

Anti-angiogenic gene therapy in the treatment of malignant gliomas. Neurosci Lett. 2012 Oct 11; 527(2):62-70. View in: Pubmed

Editorial: dural tail sign. J Neurosurg. 2012 Oct; 117(4):643-4. View in: Pubmed

Editorial: functional neurooncology. J Neurosurg. 2012 Sep; 117(3):463-4; discussion 464-5. View in: Pubmed

Copper chelation enhances antitumor efficacy and systemic delivery of oncolytic HSV. Clin Cancer Res. 2012 Sep 15; 18(18):4931-41. View in: Pubmed

Oncolytic HSV-1 virotherapy: clinical experience and opportunities for progress. Curr Pharm Biotechnol. 2012 Jul; 13(9):1842-51. View in: Pubmed

Stage IV melanoma. J Neurosurg. 2012 Aug; 117(2):225-6; discussion 226. View in: Pubmed

Do meningioma patients benefit from antiepileptic drug treatment? World Neurosurg. 2013 Mar-Apr; 79(3-4):433-4. View in: Pubmed

Convection-enhanced delivery. J Neurosurg. 2012 Aug; 117(2):193-5; discussion 195-6. View in: Pubmed

Treatment for paragangliomas: passing the test of time. World Neurosurg. 2012 May-Jun; 77(5-6):639-41. View in: Pubmed

In-training factors predictive of choosing and sustaining a productive academic career path in neurological surgery. Neurosurgery. 2012 Apr; 70(4):1024-32. View in: Pubmed

Family history of cancer in benign brain tumor subtypes versus gliomas. Front Oncol. 2012; 2:19. View in: Pubmed

The histone deacetylase inhibitor valproic acid lessens NK cell action against oncolytic virus-infected glioblastoma cells by inhibition of STAT5/T-BET signaling and generation of gamma interferon. J Virol. 2012 Apr; 86(8):4566-77. View in: Pubmed

Oral tocotrienols are transported to human tissues and delay the progression of the model for end-stage liver disease score in patients. J Nutr. 2012 Mar; 142(3):513-9. View in: Pubmed

Perioperative mortality. J Neurosurg. 2012 Apr; 116(4):821-2; discussion 822-4. View in: Pubmed

Editorial: urinary tract infection. J Neurosurg. 2012 Apr; 116(4):909; discussion 910. View in: Pubmed

Gene and viral therapy for glioblastoma: a review of clinical trials and future directions. Cancer J. 2012 Jan-Feb; 18(1):82-8. View in: Pubmed

Reprogramming of the tumour microenvironment by stromal PTEN-regulated miR-320. Nat Cell Biol. 2011 Dec 18; 14(2):159-67. View in: Pubmed

Deciphering the Multifaceted Relationship between Oncolytic Viruses and Natural Killer Cells. Adv Virol. 2012; 2012:702839. View in: Pubmed

Bringing the endovascular neurosurgeon into the neuro-oncology treatment team. World Neurosurg. 2012 Jan; 77(1):59-61. View in: Pubmed

Novel animal glioma models that separately exhibit two different invasive and angiogenic phenotypes of human glioblastomas. World Neurosurg. 2012 Dec; 78(6):670-82. View in: Pubmed

Meningioma-toward an improved understanding of the role of sex steroids in tumor development and progression. World Neurosurg. 2011 Nov; 76(5):409-11. View in: Pubmed

Understanding glioma invasion: a necessity for effective therapy. World Neurosurg. 2013 Sep-Oct; 80(3-4):281-3. View in: Pubmed

Hope and challenges for dendritic cell-based vaccine therapy for glioblastoma. World Neurosurg. 2012 May-Jun; 77(5-6):633-5. View in: Pubmed

Molecular and genetic characterization of meningiomas: future predictive assays and "personalized" treatment. World Neurosurg. 2013 Feb; 79(2):247-8. View in: Pubmed

Antitumor efficacy of 34.5ENVE: a transcriptionally retargeted and "Vstat120"-expressing oncolytic virus. Mol Ther. 2012 Feb; 20(2):287-97. View in: Pubmed

Performing Quality Research in an Era of Reforms. Neurosurgery. 2011 Sep 01; 58(CN_suppl_1):72-78. View in: Pubmed

Glioma cell migration on three-dimensional nanofiber scaffolds is regulated by substrate topography and abolished by inhibition of STAT3 signaling. Neoplasia. 2011 Sep; 13(9):831-40. View in: Pubmed

Stroke and heart disease: the "also-rans" of radiation exposure. World Neurosurg. 2011 Sep-Oct; 76(3-4):216. View in: Pubmed

Clinical and economic outcomes of low-field intraoperative MRI-guided tumor resection neurosurgery. J Magn Reson Imaging. 2011 Nov; 34(5):1022-30. View in: Pubmed

Phase IB study of gene-mediated cytotoxic immunotherapy adjuvant to up-front surgery and intensive timing radiation for malignant glioma. J Clin Oncol. 2011 Sep 20; 29(27):3611-9. View in: Pubmed

Use of 5-aminolevulinic acid for visualization of low-grade gliomas. J Neurosurg. 2011 Oct; 115(4):737-8; discussion 738-9. View in: Pubmed

A viral strategy to ambush tumors. Nat Med. 2011 Jul 07; 17(7):784-5. View in: Pubmed

Neoplastic meningitis. J Neurosurg. 2011 Oct; 115(4):728-9; discussion 729. View in: Pubmed

Prognosis and treatment of melanoma metastases to the central nervous system: lots of retrospective data, very few certainties. World Neurosurg. 2011 Jul-Aug; 76(1-2):48-50. View in: Pubmed

Indirubins decrease glioma invasion by blocking migratory phenotypes in both the tumor and stromal endothelial cell compartments. Cancer Res. 2011 Aug 15; 71(16):5374-80. View in: Pubmed

Low Karnofsky Performance Scale score and glioblastoma multiforme. J Neurosurg. 2011 Aug; 115(2):217-8; discussion 218-9. View in: Pubmed

Central nervous system cancers. J Natl Compr Canc Netw. 2011 Apr; 9(4):352-400. View in: Pubmed

Measuring versus seeing. J Neurosurg. 2011 Jul; 115(1):9-10; discussion 10. View in: Pubmed

Extent of resection. J Neurosurg. 2011 Jul; 115(1):1-2; discussion 2. View in: Pubmed

Preoperative comorbidity scores and intangible neurosurgical wisdom. World Neurosurg. 2011 Feb; 75(2):215-6. View in: Pubmed

Intraoperative MRI (ioMRI) in the setting of awake craniotomies for supratentorial glioma resection. Acta Neurochir Suppl. 2011; 109:43-8. View in: Pubmed

Performing quality research in an era of reforms. Clin Neurosurg. 2011; 58:72-8. View in: Pubmed

Chondroitinase ABC I-mediated enhancement of oncolytic virus spread and antitumor efficacy. Clin Cancer Res. 2011 Mar 15; 17(6):1362-72. View in: Pubmed

Finding drugs against CD133+ glioma subpopulations. J Neurosurg. 2011 Mar; 114(3):648; discussion 648-50. View in: Pubmed

Potential role of miRNAs and their inhibitors in glioma treatment. Expert Rev Anticancer Ther. 2010 Nov; 10(11):1753-62. View in: Pubmed

Long-term outcomes of patients with spinal cord gliomas treated by modern conformal radiation techniques. Int J Radiat Oncol Biol Phys. 2011 Sep 01; 81(1):232-8. View in: Pubmed

Multiple craniotomies. J Neurosurg. 2011 Mar; 114(3):574-5; discussion 575. View in: Pubmed

Neurosurgical "pearls" and neurosurgical evidence. J Neurosurg. 2010 Aug; 113(2):179; discussion 179-80. View in: Pubmed

Treating glioblastoma multiforme with electrical fields. World Neurosurg. 2010 Aug-Sep; 74(2-3):208-11. View in: Pubmed

Monoclonal antibodies. J Neurosurg. 2010 Aug; 113(2):190; discussion 190-1. View in: Pubmed

Meningioma surgery. J Neurosurg. 2011 Mar; 114(3):695; discussion 696. View in: Pubmed

microRNA-451: A conditional switch controlling glioma cell proliferation and migration. Cell Cycle. 2010 Jul 15; 9(14):2742-8. View in: Pubmed

A retrospective cohort-matched comparison of conscious sedation versus general anesthesia for supratentorial glioma resection. Clinical article. J Neurosurg. 2011 Mar; 114(3):633-9. View in: Pubmed

The many functions of microRNAs in glioblastoma. World Neurosurg. 2010 Jun; 73(6):598-601. View in: Pubmed

MicroRNA-451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cells. Mol Cell. 2010 Mar 12; 37(5):620-32. View in: Pubmed

Directing systemic oncolytic viral delivery to tumors via carrier cells. Cytokine Growth Factor Rev. 2010 Apr-Jun; 21(2-3):119-26. View in: Pubmed

Allergy and inflammatory transcriptome is predominantly negatively correlated with CD133 expression in glioblastoma. Neuro Oncol. 2010 Apr; 12(4):320-7. View in: Pubmed

The neuronal microRNA miR-326 acts in a feedback loop with notch and has therapeutic potential against brain tumors. J Neurosci. 2009 Dec 02; 29(48):15161-8. View in: Pubmed

Quantitative analysis of complex glioma cell migration on electrospun polycaprolactone using time-lapse microscopy. Tissue Eng Part C Methods. 2009 Dec; 15(4):531-40. View in: Pubmed

Enhanced antitumor efficacy of vasculostatin (Vstat120) expressing oncolytic HSV-1. Mol Ther. 2010 Feb; 18(2):285-94. View in: Pubmed

"Buy one get one free": armed viruses for the treatment of cancer cells and their microenvironment. Curr Gene Ther. 2009 Oct; 9(5):341-55. View in: Pubmed

Anesthesia for brain tumor resection using intraoperative magnetic resonance imaging (iMRI) with the Polestar N-20 system: experience and challenges. J Clin Anesth. 2009 Aug; 21(5):371-6. View in: Pubmed

The predictive value of low-field strength magnetic resonance imaging for intraoperative residual tumor detection. Clinical article. J Neurosurg. 2009 Aug; 111(2):252-7. View in: Pubmed

Spinal angiography and epidural venography in juvenile muscular atrophy of the distal arm "Hirayama disease". Muscle Nerve. 2009 Aug; 40(2):206-12. View in: Pubmed

Reversal of neurological deficit after chemotherapy in BCL-6-positive neurolymphomatosis. Case report. J Neurosurg. 2009 Aug; 111(2):247-51. View in: Pubmed

A mathematical model for pattern formation of glioma cells outside the tumor spheroid core. J Theor Biol. 2009 Oct 07; 260(3):359-71. View in: Pubmed

Gene- and viral-based therapies for brain tumors. Neurotherapeutics. 2009 Jul; 6(3):547-57. View in: Pubmed

Pharmacologic and chemical adjuvants in tumor virotherapy. Chem Rev. 2009 Jul; 109(7):3125-40. View in: Pubmed

The Gs-linked receptor GPR3 inhibits the proliferation of cerebellar granule cells during postnatal development. PLoS One. 2009 Jun 15; 4(6):e5922. View in: Pubmed

MicroRNAs and glioblastoma; the stem cell connection. Cell Death Differ. 2010 Feb; 17(2):221-8. View in: Pubmed

Lack of epidural pressure change with neck flexion in a patient with Hirayama disease: case report. Neurosurgery. 2009 Jun; 64(6):E1196-7; discussion E1197. View in: Pubmed

Emerging functions of microRNAs in glioblastoma. J Neurooncol. 2009 May; 92(3):297-306. View in: Pubmed

Physiological transgene regulation and functional complementation of a neurological disease gene deficiency in neurons. Mol Ther. 2009 Sep; 17(9):1517-26. View in: Pubmed

Design and application of oncolytic HSV vectors for glioblastoma therapy. Expert Rev Neurother. 2009 Apr; 9(4):505-17. View in: Pubmed

ICP0 inhibits the decrease of HSV amplicon-mediated transgene expression. Mol Ther. 2009 Apr; 17(4):707-15. View in: Pubmed

Phase ib trial of oncolytic herpes virus G207 shows safety of multiple injections and documents viral replication. Mol Ther. 2009 Jan; 17(1):8-9. View in: Pubmed

Targeting of the Bmi-1 oncogene/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and self-renewal. Cancer Res. 2008 Nov 15; 68(22):9125-30. View in: Pubmed

Modeling the effects of resection, radiation and chemotherapy in glioblastoma. J Neurooncol. 2009 Feb; 91(3):287-93. View in: Pubmed

Stable transgene expression from HSV amplicon vectors in the brain: potential involvement of immunoregulatory signals. Mol Ther. 2008 Oct; 16(10):1727-36. View in: Pubmed

Lithium inhibits invasion of glioma cells; possible involvement of glycogen synthase kinase-3. Neuro Oncol. 2008 Oct; 10(5):690-9. View in: Pubmed

Histone deacetylase inhibitors augment antitumor efficacy of herpes-based oncolytic viruses. Mol Ther. 2008 Sep; 16(9):1546-55. View in: Pubmed

Oncolytic HSV-1 infection of tumors induces angiogenesis and upregulates CYR61. Mol Ther. 2008 Aug; 16(8):1382-91. View in: Pubmed

microRNA-7 inhibits the epidermal growth factor receptor and the Akt pathway and is down-regulated in glioblastoma. Cancer Res. 2008 May 15; 68(10):3566-72. View in: Pubmed

Central nervous system cancers. J Natl Compr Canc Netw. 2008 May; 6(5):456-504. View in: Pubmed

Being old is no fun: treatment of glioblastoma multiforme in the elderly. J Neurosurg. 2008 Apr; 108(4):639-40. View in: Pubmed

Efficacy and safety of the oncolytic herpes simplex virus rRp450 alone and combined with cyclophosphamide. Mol Ther. 2008 May; 16(5):879-85. View in: Pubmed

Oncolytic herpes virus with defective ICP6 specifically replicates in quiescent cells with homozygous genetic mutations in p16. Oncogene. 2008 Jul 10; 27(30):4249-54. View in: Pubmed

Solitary pituitary sarcoidosis with normal endocrine function: case report. J Neurosurg. 2008 Mar; 108(3):591-4. View in: Pubmed

The host response to cancer virotherapy. Curr Opin Mol Ther. 2008 Feb; 10(1):38-45. View in: Pubmed

A phase I trial of Ad.hIFN-beta gene therapy for glioma. Mol Ther. 2008 Mar; 16(3):618-26. View in: Pubmed

Effect of tumor microenvironment modulation on the efficacy of oncolytic virus therapy. J Natl Cancer Inst. 2007 Dec 05; 99(23):1768-81. View in: Pubmed

Progress and prospects: gene therapy clinical trials (part 2). Gene Ther. 2007 Nov; 14(22):1555-63. View in: Pubmed

Depletion of peripheral macrophages and brain microglia increases brain tumor titers of oncolytic viruses. Cancer Res. 2007 Oct 01; 67(19):9398-406. View in: Pubmed

Estimating the cell density and invasive radius of three-dimensional glioblastoma tumor spheroids grown in vitro. Appl Opt. 2007 Aug 01; 46(22):5110-8. View in: Pubmed

C2/C3 pathologic fractures from polyostotic fibrous dysplasia of the cervical spine treated with percutaneous vertebroplasty. Eur Spine J. 2007 Dec; 16 Suppl 3:250-4. View in: Pubmed

Early STAT1 activation after systemic delivery of HSV amplicon vectors suppresses transcription of the vector-encoded transgene. Mol Ther. 2007 Nov; 15(11):2017-26. View in: Pubmed

Gliomas and venous thromboembolism: how common? J Neurosurg. 2007 Apr; 106(4):599-600; discussion 600. View in: Pubmed

A retrospective analysis of reasons for reoperation following initially successful peripheral nerve stimulation. J Neurosurg. 2007 Mar; 106(3):388-90. View in: Pubmed

Oncolytic viruses driven by tumor-specific promoters. Curr Cancer Drug Targets. 2007 Mar; 7(2):181-9. View in: Pubmed

Neurosurgical robotics: a review of brain and spine applications. J Robot Surg. 2007; 1(1):39-43. View in: Pubmed

The status of gene therapy for brain tumors. Expert Opin Biol Ther. 2007 Feb; 7(2):197-208. View in: Pubmed

Personalizing oncolytic virotherapy? Mol Ther. 2007 Jan; 15(1):6-7. View in: Pubmed

GNOSIS: guidelines for neuro-oncology: standards for investigational studies--reporting of surgically based therapeutic clinical trials. J Neurooncol. 2007 Apr; 82(2):211-20. View in: Pubmed

Oncolytic viruses: extreme treatment for an extreme disease. Future Microbiol. 2006 Dec; 1(4):351-3. View in: Pubmed

Cyclophosphamide increases transgene expression mediated by an oncolytic adenovirus in glioma-bearing mice monitored by bioluminescence imaging. Mol Ther. 2006 Dec; 14(6):779-88. View in: Pubmed

Tumor stromal-derived factor-1 recruits vascular progenitors to mitotic neovasculature, where microenvironment influences their differentiated phenotypes. Cancer Res. 2006 Sep 15; 66(18):9054-64. View in: Pubmed

Cyclophosphamide enhances glioma virotherapy by inhibiting innate immune responses. Proc Natl Acad Sci U S A. 2006 Aug 22; 103(34):12873-8. View in: Pubmed

Prognostic indicators. J Neurosurg. 2006 Aug; 105(2):161-2; discussion 162. View in: Pubmed

Imaging immediate-early and strict-late promoter activity during oncolytic herpes simplex virus type 1 infection and replication in tumors. Gene Ther. 2006 Dec; 13(24):1731-6. View in: Pubmed

Gene therapeutics: the future of brain tumor therapy? Expert Rev Anticancer Ther. 2006 Jul; 6(7):1053-64. View in: Pubmed

Gene therapy for glioblastoma. Neurosurg Focus. 2006 Apr 15; 20(4):E18. View in: Pubmed

Brain tumor imaging and surgical management: the neurosurgeon's perspective. Top Magn Reson Imaging. 2006 Apr; 17(2):121-6. View in: Pubmed

Development of a rapid method to generate multiple oncolytic HSV vectors and their in vivo evaluation using syngeneic mouse tumor models. Gene Ther. 2006 Apr; 13(8):705-14. View in: Pubmed

Genetic strategies for brain tumor therapy. Cancer Gene Ther. 2006 Mar; 13(3):225-33. View in: Pubmed

Glioma virotherapy: effects of innate immune suppression and increased viral replication capacity. Cancer Res. 2006 Feb 15; 66(4):2314-9. View in: Pubmed

Cyclophosphamide allows for in vivo dose reduction of a potent oncolytic virus. Cancer Res. 2005 Dec 15; 65(24):11255-8. View in: Pubmed

Tissue inhibitor of metalloproteinase-3 expression from an oncolytic adenovirus inhibits matrix metalloproteinase activity in vivo without affecting antitumor efficacy in malignant glioma. Cancer Res. 2005 Oct 15; 65(20):9398-405. View in: Pubmed

Central nervous system cancers: Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2005 Sep; 3(5):644-90. View in: Pubmed

Contribution of bone marrow-derived cells to blood vessels in ischemic tissues and tumors. Mol Ther. 2005 Dec; 12(6):994-1005. View in: Pubmed

885 Braingate: Turning Thought into Action-First Experience with a Human Neuromotor Prosthesis. Neurosurgery. 2005 Aug 01; 57(2):425. View in: Pubmed

Brain tumor oncolysis with replication-conditional herpes simplex virus type 1 expressing the prodrug-activating genes, CYP2B1 and secreted human intestinal carboxylesterase, in combination with cyclophosphamide and irinotecan. Cancer Res. 2005 Aug 01; 65(15):6850-7. View in: Pubmed

Diagnostic criteria for schwannomatosis. Neurology. 2005 Jun 14; 64(11):1838-45. View in: Pubmed

An oncolytic HSV-1 mutant expressing ICP34.5 under control of a nestin promoter increases survival of animals even when symptomatic from a brain tumor. Cancer Res. 2005 Apr 01; 65(7):2832-9. View in: Pubmed

A phase I open-label, dose-escalation, multi-institutional trial of injection with an E1B-Attenuated adenovirus, ONYX-015, into the peritumoral region of recurrent malignant gliomas, in the adjuvant setting. Mol Ther. 2004 Nov; 10(5):958-66. View in: Pubmed

Infectious delivery of the 132 kb CDKN2A/CDKN2B genomic DNA region results in correctly spliced gene expression and growth suppression in glioma cells. Gene Ther. 2004 Aug; 11(15):1195-204. View in: Pubmed

[Molecular imaging of transgene expression in brain tumors]. No Shinkei Geka. 2004 Aug; 32(8):805-24. View in: Pubmed

Neurosurgical delivery of chemotherapeutics, targeted toxins, genetic and viral therapies in neuro-oncology. J Neurooncol. 2004 Aug-Sep; 69(1-3):101-17. View in: Pubmed

The combination of adenoviral HSV TK gene therapy and radiation is effective in athymic mouse glioblastoma xenografts without increasing toxic side effects. J Neurooncol. 2004 Mar-Apr; 67(1-2):177-88. View in: Pubmed

Replicative oncolytic herpes simplex viruses in combination cancer therapies. Curr Gene Ther. 2004 Mar; 4(1):41-51. View in: Pubmed

Glial tumor grading and outcome prediction using dynamic spin-echo MR susceptibility mapping compared with conventional contrast-enhanced MR: confounding effect of elevated rCBV of oligodendrogliomas [corrected]. AJNR Am J Neuroradiol. 2004 Feb; 25(2):214-21. View in: Pubmed

Altered expression of antiviral cytokine mRNAs associated with cyclophosphamide's enhancement of viral oncolysis. Gene Ther. 2004 Jan; 11(2):214-23. View in: Pubmed

Cytochrome p450-based gene therapies for cancer. Methods Mol Med. 2004; 90:203-22. View in: Pubmed

An HSV amplicon-based helper system for helper-dependent adenoviral vectors. Biochem Biophys Res Commun. 2003 Aug 08; 307(4):826-30. View in: Pubmed

Development of a novel non-human primate model for preclinical gene vector safety studies. Determining the effects of intracerebral HSV-1 inoculation in the common marmoset: a comparative study. Gene Ther. 2003 Aug; 10(15):1225-33. View in: Pubmed

Gene therapy: a primer for neurosurgeons. Neurosurgery. 2003 Aug; 53(2):364-73; discussion 373. View in: Pubmed

Functional response of tumor vasculature to PaCO2: determination of total and microvascular blood volume by MRI. Neoplasia. 2003 Jul-Aug; 5(4):330-8. View in: Pubmed

Effects of innate immunity on herpes simplex virus and its ability to kill tumor cells. Gene Ther. 2003 Jun; 10(11):983-90. View in: Pubmed

Potentiated gene delivery to tumors using herpes simplex virus/Epstein-Barr virus/RV tribrid amplicon vectors. Hum Gene Ther. 2003 May 01; 14(7):611-26. View in: Pubmed

PTEN decreases in vivo vascularization of experimental gliomas in spite of proangiogenic stimuli. Cancer Res. 2003 May 01; 63(9):2300-5. View in: Pubmed

Infectious delivery of a 135-kb LDLR genomic locus leads to regulated complementation of low-density lipoprotein receptor deficiency in human cells. Mol Ther. 2003 May; 7(5 Pt 1):604-12. View in: Pubmed

Viral therapy for glioblastoma. Cancer J. 2003 May-Jun; 9(3):167-79. View in: Pubmed

Oncolytic viruses for the therapy of brain tumors and other solid malignancies: a review. Front Biosci. 2003 May 01; 8:e346-60. View in: Pubmed

Genetically engineered herpes simplex viral vectors in the treatment of brain tumors: a review. Cancer Invest. 2003 Apr; 21(2):278-92. View in: Pubmed

Improved HSV-1 amplicon packaging system using ICP27-deleted, oversized HSV-1 BAC DNA. Methods Mol Med. 2003; 76:51-60. View in: Pubmed

Oncolytic viruses. Nat Rev Cancer. 2002 Dec; 2(12):938-50. View in: Pubmed

In vivo 3-T MR spectroscopy in the distinction of recurrent glioma versus radiation effects: initial experience. Radiology. 2002 Dec; 225(3):871-9. View in: Pubmed

MRI of transgene expression: correlation to therapeutic gene expression. Neoplasia. 2002 Nov-Dec; 4(6):523-30. View in: Pubmed

Prodrug bioactivation and oncolysis of diffuse liver metastases by a herpes simplex virus 1 mutant that expresses the CYP2B1 transgene. Cancer. 2002 Sep 01; 95(5):1171-81. View in: Pubmed

Regulation of herpes simplex virus gamma(1)34.5 expression and oncolysis of diffuse liver metastases by Myb34.5. J Clin Invest. 2002 Apr; 109(7):871-82. View in: Pubmed

Intra-arterial delivery of p53-containing adenoviral vector into experimental brain tumors. Cancer Gene Ther. 2002 Mar; 9(3):228-35. View in: Pubmed

Guided genes for tumor warfare. Nat Biotechnol. 2002 Mar; 20(3):235-6. View in: Pubmed

The complement response against an oncolytic virus is species-specific in its activation pathways. Mol Ther. 2002 Mar; 5(3):275-82. View in: Pubmed

Massive growth of a meningioma into the brachial plexus and thoracic cavity after intraspinal and supraclavicular resection. Case report and review of the literature. J Neurosurg. 2002 Jan; 96(1 Suppl):107-11. View in: Pubmed

An infectious transfer and expression system for genomic DNA loci in human and mouse cells. Nat Biotechnol. 2001 Nov; 19(11):1067-70. View in: Pubmed

Comparative analyses of transgene delivery and expression in tumors inoculated with a replication-conditional or -defective viral vector. Cancer Res. 2001 Jul 15; 61(14):5336-9. View in: Pubmed

Pattern of self-organization in tumour systems: complex growth dynamics in a novel brain tumour spheroid model. Cell Prolif. 2001 Apr; 34(2):115-34. View in: Pubmed

Positron emission tomography-based imaging of transgene expression mediated by replication-conditional, oncolytic herpes simplex virus type 1 mutant vectors in vivo. Cancer Res. 2001 Apr 01; 61(7):2983-95. View in: Pubmed

Improved helper virus-free packaging system for HSV amplicon vectors using an ICP27-deleted, oversized HSV-1 DNA in a bacterial artificial chromosome. Mol Ther. 2001 Apr; 3(4):591-601. View in: Pubmed

Intraneoplastic polymer-based delivery of cyclophosphamide for intratumoral bioconversion by a replicating oncolytic viral vector. Cancer Res. 2001 Feb 01; 61(3):864-8. View in: Pubmed

Emergence of a subpopulation in a computational model of tumor growth. J Theor Biol. 2000 Dec 07; 207(3):431-41. View in: Pubmed

Primary lymphoma of peripheral nerve: report of four cases. Am J Surg Pathol. 2000 Sep; 24(9):1257-65. View in: Pubmed

Cytotoxicity, apoptosis, and viral replication in tumor cells treated with oncolytic ribonucleotide reductase-defective herpes simplex type 1 virus (hrR3) combined with ionizing radiation. Cancer Gene Ther. 2000 Jul; 7(7):1051-9. View in: Pubmed

Oncolysis of diffuse hepatocellular carcinoma by intravascular administration of a replication-competent, genetically engineered herpesvirus. Cancer Res. 2000 Jun 01; 60(11):2790-5. View in: Pubmed

Advances in neurofibromatosis 2 (NF2): a workshop report. J Neurogenet. 2000 Jun; 14(2):63-106. View in: Pubmed

Complement depletion facilitates the infection of multiple brain tumors by an intravascular, replication-conditional herpes simplex virus mutant. J Virol. 2000 May; 74(10):4765-75. View in: Pubmed

Thymidine kinase activation of ganciclovir in recurrent malignant gliomas: a gene-marking and neuropathological study. J Neurosurg. 2000 May; 92(5):804-11. View in: Pubmed

Simulated brain tumor growth dynamics using a three-dimensional cellular automaton. J Theor Biol. 2000 Apr 21; 203(4):367-82. View in: Pubmed

[Herpes simplex type-1 virus-based vectors for gene therapy]. Nihon Rinsho. 2000 Apr; 58(4):822-7. View in: Pubmed

Multicolumn infusion of gene therapy cells into human brain tumors: technical report. Neurosurgery. 2000 Mar; 46(3):663-8; discussion 668-9. View in: Pubmed

In vivo magnetic resonance imaging of transgene expression. Nat Med. 2000 Mar; 6(3):351-5. View in: Pubmed

An oncolytic herpes simplex virus type 1 selectively destroys diffuse liver metastases from colon carcinoma. FASEB J. 2000 Feb; 14(2):301-11. View in: Pubmed

Cellular automaton of idealized brain tumor growth dynamics. Biosystems. 2000 Feb; 55(1-3):119-27. View in: Pubmed

Oncolytic viruses as novel anticancer agents: turning one scourge against another. Expert Opin Investig Drugs. 2000 Feb; 9(2):311-27. View in: Pubmed

Solitary sciatic nerve lymphoma as an initial manifestation of diffuse neurolymphomatosis. Case report and review of the literature. J Neurosurg. 2000 Jan; 92(1):165-9. View in: Pubmed

Single-step conversion of cells to retrovirus vector producers with herpes simplex virus-Epstein-Barr virus hybrid amplicons. J Virol. 1999 Dec; 73(12):10426-39. View in: Pubmed

B-myb promoter retargeting of herpes simplex virus gamma34.5 gene-mediated virulence toward tumor and cycling cells. J Virol. 1999 Sep; 73(9):7556-64. View in: Pubmed

Multimodal cancer treatment mediated by a replicating oncolytic virus that delivers the oxazaphosphorine/rat cytochrome P450 2B1 and ganciclovir/herpes simplex virus thymidine kinase gene therapies. Cancer Res. 1999 Aug 15; 59(16):3861-5. View in: Pubmed

Oncolytic virus therapy of multiple tumors in the brain requires suppression of innate and elicited antiviral responses. Nat Med. 1999 Aug; 5(8):881-7. View in: Pubmed

Inhibition of NF2-negative and NF2-positive primary human meningioma cell proliferation by overexpression of merlin due to vector-mediated gene transfer. J Neurosurg. 1999 Jul; 91(1):85-92. View in: Pubmed

Cerebrovascular Biology and the various neural barriers: challenges and future directions. Neurosurgery. 1999 Mar; 44(3):604-8; discussion 608-9. View in: Pubmed

Intraarterial delivery of adenovirus vectors and liposome-DNA complexes to experimental brain neoplasms. Hum Gene Ther. 1999 Jan 20; 10(2):311-8. View in: Pubmed

Neurogenetic surgery: current limitations and the promise of gene- and virus-based therapies. Clin Neurosurg. 1999; 45:226-46. View in: Pubmed

A review of gene therapy for the treatment of central nervous system tumors. Crit Rev Oncog. 1999; 10(4):261-74. View in: Pubmed

Intra-arterial virus and nonvirus vector-mediated gene transfer to experimental rat brain tumors. Front Radiat Ther Oncol. 1999; 33:227-40. View in: Pubmed

Selective delivery of herpes virus vectors to experimental brain tumors using RMP-7. Cancer Gene Ther. 1999 Jan-Feb; 6(1):14-20. View in: Pubmed

Influence of p53 on herpes simplex virus type 1 vectors for cancer gene therapy. J Gastrointest Surg. 1999 Jan-Feb; 3(1):34-48. View in: Pubmed

Herpes simplex virus type 1 DNA amplified as bacterial artificial chromosome in Escherichia coli: rescue of replication-competent virus progeny and packaging of amplicon vectors. Hum Gene Ther. 1998 Dec 10; 9(18):2787-94. View in: Pubmed

Cancer gene therapy using a replication-competent herpes simplex virus type 1 vector. Ann Surg. 1998 Sep; 228(3):366-74. View in: Pubmed

Gene therapy for tumors of the central nervous system. Surg Oncol Clin N Am. 1998 Jul; 7(3):589-602. View in: Pubmed

New prodrug activation gene therapy for cancer using cytochrome P450 4B1 and 2-aminoanthracene/4-ipomeanol. Hum Gene Ther. 1998 Jun 10; 9(9):1261-73. View in: Pubmed

Pre-existing herpes simplex virus 1 (HSV-1) immunity decreases, but does not abolish, gene transfer to experimental brain tumors by a HSV-1 vector. Gene Ther. 1998 Jun; 5(6):809-19. View in: Pubmed

Petroclival meningioma presenting with pathological laughter. Neurology. 1998 Jun; 50(6):1918-9. View in: Pubmed

Long-term survival in a rodent brain tumor model by bradykinin-enhanced intra-arterial delivery of a therapeutic herpes simplex virus vector. Cancer Gene Ther. 1998 May-Jun; 5(3):158-62. View in: Pubmed

An oncolytic viral mutant that delivers the CYP2B1 transgene and augments cyclophosphamide chemotherapy. Nat Biotechnol. 1998 May; 16(5):444-8. View in: Pubmed

Measuring transferrin receptor gene expression by NMR imaging. Biochim Biophys Acta. 1998 Apr 24; 1402(3):239-49. View in: Pubmed

Effects on brain tumor cell proliferation by an adenovirus vector that bears the interleukin-4 gene. J Neurovirol. 1998 Apr; 4(2):237-41. View in: Pubmed

Synergistic anticancer effects of ganciclovir/thymidine kinase and 5-fluorocytosine/cytosine deaminase gene therapies. J Natl Cancer Inst. 1998 Mar 04; 90(5):370-80. View in: Pubmed

Co-expression of Fas and Fas ligand in malignant glial tumors and cell lines. Acta Neuropathol. 1998 Mar; 95(3):287-90. View in: Pubmed

Marker gene transfer and oncolysis of human Y79 retinoblastoma cells mediated by herpes simplex virus mutants. Ophthalmic Res. 1998; 30(1):30-6. View in: Pubmed

A chimeric fusion protein of cytochrome CYP4B1 and green fluorescent protein for detection of pro-drug activating gene delivery and for gene therapy in malignant glioma. Adv Exp Med Biol. 1998; 451:393-403. View in: Pubmed

Therapeutic efficiency and safety of a second-generation replication-conditional HSV1 vector for brain tumor gene therapy. Hum Gene Ther. 1997 Nov 20; 8(17):2057-68. View in: Pubmed

Regression of experimental brain tumors with 6-thioxanthine and Escherichia coli gpt gene therapy. Hum Gene Ther. 1997 Nov 20; 8(17):2043-55. View in: Pubmed

The effect of ganciclovir on herpes simplex virus-mediated oncolysis. J Surg Res. 1997 May; 69(2):413-7. View in: Pubmed

Long-term survival in a rodent model of disseminated brain tumors by combined intrathecal delivery of herpes vectors and ganciclovir treatment. Hum Gene Ther. 1996 Oct 20; 7(16):1989-94. View in: Pubmed

A novel 'piggyback' packaging system for herpes simplex virus amplicon vectors. Hum Gene Ther. 1996 Oct 20; 7(16):2003-13. View in: Pubmed

Enhancement of gene therapy specificity for diffuse colon carcinoma liver metastases with recombinant herpes simplex virus. Ann Surg. 1996 Sep; 224(3):323-9; discussion 329-30. View in: Pubmed

The subtemporal-transpetrous approach for excision of petroclival tumors. Am J Otol. 1996 Sep; 17(5):773-9. View in: Pubmed

Escherichia coli gpt gene sensitizes rat glioma cells to killing by 6-thioxanthine or 6-thioguanine. Cancer Gene Ther. 1996 May-Jun; 3(3):155-62. View in: Pubmed

Herpes vector-mediated delivery of marker genes to disseminated central nervous system tumors. Hum Gene Ther. 1996 Feb 10; 7(3):291-300. View in: Pubmed

Comparison of intracerebral inoculation and osmotic blood-brain barrier disruption for delivery of adenovirus, herpesvirus, and iron oxide particles to normal rat brain. Am J Pathol. 1995 Dec; 147(6):1840-51. View in: Pubmed

Selective uptake of viral and monocrystalline particles delivered intra-arterially to experimental brain neoplasms. Hum Gene Ther. 1995 Dec; 6(12):1543-52. View in: Pubmed

Transgene inheritance and retroviral infection contribute to the efficiency of gene expression in solid tumors inoculated with retroviral vector producer cells. Gene Ther. 1995 Oct; 2(8):531-8. View in: Pubmed

Gene therapy for brain tumors. Brain Pathol. 1995 Oct; 5(4):345-81. View in: Pubmed

Diffusible cytotoxic metabolites contribute to the in vitro bystander effect associated with the cyclophosphamide/cytochrome P450 2B1 cancer gene therapy paradigm. Clin Cancer Res. 1995 Oct; 1(10):1171-7. View in: Pubmed

Enhancement of interleukin-4-mediated tumor regression in athymic mice by in situ retroviral gene transfer. Hum Gene Ther. 1995 Apr; 6(4):437-43. View in: Pubmed

Brain tumor gene therapy in mice with a novel "suicide" gene: the cyclophosphamide-activating CYP2B1 gene. Clin Neurosurg. 1995; 42:370-82. View in: Pubmed

[Gene therapy for brain tumors: gene therapy for malignant brain tumors using prodrug-sensitivity genes (series 4)]. No Shinkei Geka. 1994 Dec; 22(12):1099-110. View in: Pubmed

Long-term survival of rats harboring brain neoplasms treated with ganciclovir and a herpes simplex virus vector that retains an intact thymidine kinase gene. Cancer Res. 1994 Nov 15; 54(22):5745-51. View in: Pubmed

Deep sylvian fissure meningioma without dural attachment in an adult: case report. Neurosurgery. 1994 Nov; 35(5):944-6; discussion 946. View in: Pubmed

Antitumor activity and reporter gene transfer into rat brain neoplasms inoculated with herpes simplex virus vectors defective in thymidine kinase or ribonucleotide reductase. Gene Ther. 1994 Sep; 1(5):323-31. View in: Pubmed

Experimental tumor therapy in mice using the cyclophosphamide-activating cytochrome P450 2B1 gene. Hum Gene Ther. 1994 Aug; 5(8):969-78. View in: Pubmed

Nerve growth factor protects against herpes simplex virus type 1 neurotoxicity in the rat striatum. Neuroreport. 1994 Apr 14; 5(8):993-6. View in: Pubmed

Gene transfer into experimental brain tumors mediated by adenovirus, herpes simplex virus, and retrovirus vectors. Hum Gene Ther. 1994 Feb; 5(2):183-91. View in: Pubmed

Treatment of glioma by engineered interleukin 4-secreting cells. Cancer Res. 1993 Jul 01; 53(13):3125-8. View in: Pubmed

Growth of human acoustic neuromas, neurofibromas and schwannomas in the subrenal capsule and sciatic nerve of the nude mouse. J Neurooncol. 1992 Oct; 14(2):101-12. View in: Pubmed

Isolation and characterization of cDNA clones to mouse macrophage and human endothelial cell tissue transglutaminases. J Biol Chem. 1991 Jan 05; 266(1):478-83. View in: Pubmed

Inhibition of growth and angiogenesis of human neurofibrosarcoma by heparin and hydrocortisone. J Neurosurg. 1990 Sep; 73(3):429-35. View in: Pubmed

Transfer and expression of the lacZ gene in rat brain neurons mediated by herpes simplex virus mutants. New Biol. 1990 Aug; 2(8):739-46. View in: Pubmed

Growth of human schwannomas in the subrenal capsule of the nude mouse. Neurosurgery. 1990 Apr; 26(4):598-605. View in: Pubmed

Stereotactic radiofrequency thermal cingulotomy for obsessive compulsive disorder. J Neuropsychiatry Clin Neurosci. 1990; 2(3):331-6. View in: Pubmed

Regulation of tissue transglutaminase gene expression as a molecular model for retinoid effects on proliferation and differentiation. J Cell Biochem. 1989 Mar; 39(3):293-304. View in: Pubmed

Retinoids as generalized regulators of cellular growth and differentiation. Am J Med Sci. 1988 Sep; 296(3):164-70. View in: Pubmed

The molecular basis of retinoic acid action. Transcriptional regulation of tissue transglutaminase gene expression in macrophages. J Biol Chem. 1988 Aug 15; 263(23):11584-9. View in: Pubmed

Retinoid--regulated expression of tissue transglutaminase in normal and leukemic myeloid cells. Adv Exp Med Biol. 1988; 231:63-71. View in: Pubmed

Transglutaminases and their regulation: implications for polyamine metabolism. Adv Exp Med Biol. 1988; 250:391-401. View in: Pubmed