Jeffrey A. Meyerhardt, MD, MPH, FASCO

Jeffrey A. Meyerhardt, MD, MPH, FASCO

Medical Oncology

Contact Information

Office Phone Number

617-632-6855

Fax

617-632-5370

Appointments

617-332-4294
617-632-5929

Biography

Jeffrey A. Meyerhardt, MD, MPH, FASCO

Dr. Meyerhardt received his MD from Yale School of Medicine in 1997. He completed a residency in internal medicine at Beth Israel Deaconness Medical Center, in Boston, followed by a medical oncology fellowship at DFCI. He joined the Gastrointestinal Cancer Center at DFCI in 2002..

Researcher

Physician

Chief Clinical Research Officer
Co-Director, Colon and Rectal Cancer Center
Douglas Gray Woodruff Chair in Colorectal Cancer Research
Senior Physician
Professor of Medicine, Harvard Medical School

Centers/Programs

Clinical Interests

Gastrointestinal cancers

Board Certification

  • Medical Oncology, 2003

Fellowship

  • Dana-Farber/Partners CancerCare, Medical Oncology

Residency

  • Beth Israel Deaconess Medical Center, Internal Medicine

Medical School

  • Yale University School of Medicine

Recent Awards

  • Irving Jancock Fellow, Dana-Farber Cancer Institute 2002
  • Tisch Outstanding Achievement Award 2004
  • The George P. Canellos Award for Excellence In Clinical Investigation and Patient Care (2006)

Research

    Diet and Lifestyle Studies in Patients with Colorectal Cancer

    We have a strong interest in the influence of diet and lifestyle on outcomes among patients with colorectal cancer. While much research has focused on the impact of host factors on the risk of developing colorectal cancer, little data are available to suggest how these factors impact on treatment-related toxicities or long-term outcomes among patients already diagnosed with the disease. Using databases from large oncology cooperative group trials, the Nurses Health Study, and Health Professionals Follow-up Study, we have analyzed the influence of diet and lifestyle on outcomes in early-stage colorectal cancer patients. We have been involved in studies of physical activity, diet, smoking, obesity, weight change, COX inhibitors and vitamin D in colorectal cancer survivors. Based on these studies, I am the principal investigator of a national randomized trial (CALGB 80702) that will test celecoxib as adjunctive therapy to standard treatment for stage III colon cancer. The trial is under development with the National Cancer Institute. I serve as a Project co-Leader for the Gastrointestinal Cancer SPORE of Dana-Farber / Harvard Cancer Center. We are studying molecular pathways associated with sensitivity and resistance to monoclonal antibodies against the epidermal growth factor receptor for colorectal cancer. Finally, I am involved in mid-stage testing of novel agents for colorectal cancer. I have served as the principal investigator and co-investigator on multiple phase I / II trials

    Publications

      • Exercise and nutrition to improve cancer Treatment-Related outcomes (ENICTO). J Natl Cancer Inst. 2024 Aug 08. View in: Pubmed

      • An Empirical Dietary Pattern Associated with the Gut Microbial Features in Relation to Colorectal Cancer Risk. Gastroenterology. 2024 Aug 06. View in: Pubmed

      • Alliance A022104/NRG-GI010: The Janus Rectal Cancer Trial: a randomized phase II/III trial testing the efficacy of triplet versus doublet chemotherapy regarding clinical complete response and disease-free survival in patients with locally advanced rectal cancer. BMC Cancer. 2024 Jul 26; 24(1):901. View in: Pubmed

      • Clinicopathological, molecular, and prognostic features of colorectal carcinomas with KRAS c.34G>T (p.G12C) mutation. Cancer Sci. 2024 Jul 22. View in: Pubmed

      • Effect of resistance training on physical function during chemotherapy in colon cancer. JNCI Cancer Spectr. 2024 Jul 01; 8(4). View in: Pubmed

      • Metabolomic signatures of inflammation and metabolic dysregulation in relation to colorectal cancer risk. J Natl Cancer Inst. 2024 Jul 01; 116(7):1126-1136. View in: Pubmed

      • Experience and Needs of Patients With Young-Onset Colorectal Cancer and Their Caregivers: A Qualitative Study. JCO Oncol Pract. 2024 Jun 28; OP2400002. View in: Pubmed

      • Effects of exercise or metformin on myokine concentrations in patients with breast and colorectal cancer: A phase II multi-centre factorial randomized trial. J Cachexia Sarcopenia Muscle. 2024 Aug; 15(4):1520-1527. View in: Pubmed

      • Improved Survival With Adjuvant Cyclooxygenase 2 Inhibition in PIK3CA-Activated Stage III Colon Cancer: CALGB/SWOG 80702 (Alliance). J Clin Oncol. 2024 Jun 18; JCO2301680. View in: Pubmed

      • Colon Cancer, Version 3.2024, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2024 06; 22(2 D). View in: Pubmed

      • Standardizing data collection in adjuvant colon cancer trials: A consensus project from the IDEA and ACCENT international consortia and national experts. Eur J Cancer. 2024 Jul; 206:114118. View in: Pubmed

      • Identifying modifiable risk factors to prevent aggressive colorectal cancer. Int J Cancer. 2024 Oct 01; 155(7):1191-1202. View in: Pubmed

      • Appendectomy and Long-term Colorectal Cancer Incidence, Overall and by Tumor Fusobacterium nucleatum Status. Ann Surg. 2024 May 06. View in: Pubmed

      • ALLIANCE A022104/NRG-GI010: The Janus Rectal Cancer Trial: a randomized phase II/III trial testing the efficacy of triplet versus doublet chemotherapy regarding clinical complete response and disease-free survival in patients with locally advanced rectal cancer. medRxiv. 2024 Apr 27. View in: Pubmed

      • RAS/RAF Comutation and ERBB2 Copy Number Modulates HER2 Heterogeneity and Responsiveness to HER2-directed Therapy in Colorectal Cancer. Clin Cancer Res. 2024 Apr 15; 30(8):1669-1684. View in: Pubmed

      • Ultra-processed food consumption and mortality among patients with stages I-III colorectal cancer: a prospective cohort study. EClinicalMedicine. 2024 May; 71:102572. View in: Pubmed

      • Oxaliplatin-Based Adjuvant Chemotherapy in Older Patients With Stage III Colon Cancer: An ACCENT/IDEA Pooled Analysis of 12 Trials. J Clin Oncol. 2024 Jul 01; 42(19):2295-2305. View in: Pubmed

      • Postoperative chemotherapy relative dose intensity and overall survival in patients with colon cancer. Cancer Chemother Pharmacol. 2024 Mar 23. View in: Pubmed

      • Radiation Therapy Quality Assurance Analysis of Alliance A021501: Preoperative mFOLFIRINOX or mFOLFIRINOX Plus Hypofractionated Radiation Therapy for Borderline Resectable Adenocarcinoma of the Pancreas. Int J Radiat Oncol Biol Phys. 2024 Mar 15. View in: Pubmed

      • CALGB 80802 (Alliance): Impact of Sorafenib with and without Doxorubicin on Hepatitis C Infection in Patients with Advanced Hepatocellular Carcinoma. Cancer Res Commun. 2024 03 07; 4(3):682-690. View in: Pubmed

      • Alliance for clinical trials in Oncology (Alliance) trial A022101/NRG-GI009: a pragmatic randomized phase III trial evaluating total ablative therapy for patients with limited metastatic colorectal cancer: evaluating radiation, ablation, and surgery (ERASur). BMC Cancer. 2024 Feb 13; 24(1):201. View in: Pubmed

      • Post-diagnostic multivitamin supplement use and colorectal cancer survival: A prospective cohort study. Cancer. 2024 Jun 15; 130(12):2169-2179. View in: Pubmed

      • Biomarkers of pembrolizumab efficacy in advanced anal squamous cell carcinoma: analysis of a phase II clinical trial and a cohort of long-term responders. J Immunother Cancer. 2024 01 25; 12(1). View in: Pubmed

      • Effect of home-based resistance training on chemotherapy relative dose intensity and tolerability in colon cancer: The FORCE randomized control trial. Cancer. 2024 May 15; 130(10):1858-1868. View in: Pubmed

      • Cancer Diagnoses After Recent Weight Loss. JAMA. 2024 01 23; 331(4):318-328. View in: Pubmed

      • Advances in Adherence Reporting of Resistance Training in a Clinical Trial during Adjuvant Chemotherapy for Colon Cancer. Med Sci Sports Exerc. 2024 Jun 01; 56(6):1186-1195. View in: Pubmed

      • Alliance for Clinical Trials in Oncology (Alliance) trial A022101/NRG-GI009: A pragmatic randomized phase III trial evaluating total ablative therapy for patients with limited metastatic colorectal cancer: evaluating radiation, ablation, and surgery (ERASur). Res Sq. 2023 Dec 23. View in: Pubmed

      • The dose-response effect of aerobic exercise on inflammation in colon cancer survivors. Front Oncol. 2023; 13:1257767. View in: Pubmed

      • Alliance A151945: Accrual and characteristics of adolescent and young adult patients in Alliance trials from 2000 to 2017. Cancer. 2024 03 01; 130(5):750-769. View in: Pubmed

      • D3-creatine dilution, computed tomography and dual-energy X-ray absorptiometry for assessing myopenia and physical function in colon cancer: A cross-sectional study. J Cachexia Sarcopenia Muscle. 2023 12; 14(6):2768-2778. View in: Pubmed

      • The metabolic potential of inflammatory and insulinaemic dietary patterns and risk of type 2 diabetes. Diabetologia. 2024 Jan; 67(1):88-101. View in: Pubmed

      • Body Composition, Relative Dose Intensity, and Adverse Events among Patients with Colon Cancer. Cancer Epidemiol Biomarkers Prev. 2023 10 02; 32(10):1373-1381. View in: Pubmed

      • Diffuse Cutaneous Aphthosis After Combined Targeted Cancer Therapies and Responsive to Pentoxifylline. JAMA Dermatol. 2023 10 01; 159(10):1136-1139. View in: Pubmed

      • Vitamin C intake and colorectal cancer survival according to KRAS and BRAF mutation: a prospective study in two US cohorts. Br J Cancer. 2023 11; 129(11):1793-1800. View in: Pubmed

      • Being Breastfed in Infancy and Risk of Colorectal Cancer and Precursor Lesions. Clin Gastroenterol Hepatol. 2024 Jul; 22(7):1508-1517.e11. View in: Pubmed

      • Physical activity in recurrent colon cancer: Cancer and Leukemia Group B/SWOG 80702 (Alliance). Cancer. 2023 12 01; 129(23):3724-3734. View in: Pubmed

      • Inverse relationship between Fusobacterium nucleatum amount and tumor CD274 (PD-L1) expression in colorectal carcinoma. Clin Transl Immunology. 2023; 12(8):e1453. View in: Pubmed

      • Assessment and Prognostic Value of Inflammatory Biomarkers in Patients With Colon Cancer-Reply. JAMA Oncol. 2023 08 01; 9(8):1153-1154. View in: Pubmed

      • Plasma 25-Hydroxyvitamin D Levels and Survival in Stage III Colon Cancer: Findings from CALGB/SWOG 80702 (Alliance). Clin Cancer Res. 2023 07 14; 29(14):2621-2630. View in: Pubmed

      • Dietary Inflammatory and Insulinemic Potentials, Plasma Metabolome and Risk of Colorectal Cancer. Metabolites. 2023 Jun 12; 13(6). View in: Pubmed

      • Bayesian risk prediction model for colorectal cancer mortality through integration of clinicopathologic and genomic data. NPJ Precis Oncol. 2023 Jun 10; 7(1):57. View in: Pubmed

      • Preoperative Treatment of Locally Advanced Rectal Cancer. N Engl J Med. 2023 Jul 27; 389(4):322-334. View in: Pubmed

      • Patient-Reported Outcomes During and After Treatment for Locally Advanced Rectal Cancer in the PROSPECT Trial (Alliance N1048). J Clin Oncol. 2023 07 20; 41(21):3724-3734. View in: Pubmed

      • Highly Sensitive Circulating Tumor DNA Assay Aids Clinical Management of Radiographically Occult Isolated Peritoneal Metastases in Patients With GI Cancer. JCO Precis Oncol. 2023 06; 7:e2200572. View in: Pubmed

      • Anal Carcinoma, Version 2.2023, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2023 06; 21(6):653-677. View in: Pubmed

      • Sleep and cancer recurrence and survival in patients with resected Stage III colon cancer: findings from CALGB/SWOG 80702 (Alliance). Br J Cancer. 2023 08; 129(2):283-290. View in: Pubmed

      • Phase Ib and Expansion Study of Gemcitabine, Nab-Paclitaxel, and Ficlatuzumab in Patients With Metastatic Pancreatic Cancer. Oncologist. 2023 05 08; 28(5):425-432. View in: Pubmed

      • Histopathology images predict multi-omics aberrations and prognoses in colorectal cancer patients. Nat Commun. 2023 04 13; 14(1):2102. View in: Pubmed

      • Flavonoid intake and survival after diagnosis of colorectal cancer: a prospective study in 2 US cohorts. Am J Clin Nutr. 2023 06; 117(6):1121-1129. View in: Pubmed

      • Association between physical activity and the time course of cancer recurrence in stage III colon cancer. Br J Sports Med. 2023 Aug; 57(15):965-971. View in: Pubmed

      • Association of Inflammatory Biomarkers With Survival Among Patients With Stage III Colon Cancer. JAMA Oncol. 2023 03 01; 9(3):404-413. View in: Pubmed

      • Diagnostic TR-FRET assays for detection of antibodies in patient samples. Cell Rep Methods. 2023 03 27; 3(3):100421. View in: Pubmed

      • Quality of life among colorectal cancer survivors participating in a pilot randomized controlled trial of a web-based dietary intervention with text messages. Support Care Cancer. 2023 Feb 10; 31(3):155. View in: Pubmed

      • Combined PD-1, BRAF and MEK inhibition in BRAFV600E colorectal cancer: a phase 2 trial. Nat Med. 2023 02; 29(2):458-466. View in: Pubmed

      • Prognostic role of detailed colorectal location and tumor molecular features: analyses of 13,101 colorectal cancer patients including 2994 early-onset cases. J Gastroenterol. 2023 03; 58(3):229-245. View in: Pubmed

      • The Prevalence and Prognosis of Microsatellite Instability-High/Mismatch Repair-Deficient Colorectal Adenocarcinomas in the United States. JCO Precis Oncol. 2023 01; 7:e2200179. View in: Pubmed

      • Programmatic Precision Oncology Decision Support for Patients With Gastrointestinal Cancer. JCO Precis Oncol. 2023 01; 7:e2200342. View in: Pubmed

      • Optimizing intervention tools to improve nutrition and physical activity for colorectal cancer survivors (Tools To Be Fit): Study protocol of a randomized factorial experiment. Contemp Clin Trials. 2022 12; 123:107009. View in: Pubmed

      • Potential Mediators of Oxaliplatin-Induced Peripheral Neuropathy From Adjuvant Therapy in Stage III Colon Cancer: Findings From CALGB (Alliance)/SWOG 80702. J Clin Oncol. 2023 02 10; 41(5):1079-1091. View in: Pubmed

      • Identifying participants' preferences for modifiable chemotherapy-induced peripheral neuropathy prevention clinical trial factors: an adaptive choice-based conjoint analysis. Support Care Cancer. 2022 Dec; 30(12):9963-9973. View in: Pubmed

      • Prognostic role of inflammatory diets in colorectal cancer overall and in strata of tumor-infiltrating lymphocyte levels. Clin Transl Med. 2022 11; 12(11):e1114. View in: Pubmed

      • Prognostic Impact of Early Treatment and Oxaliplatin Discontinuation in Patients With Stage III Colon Cancer: An ACCENT/IDEA Pooled Analysis of 11 Adjuvant Trials. J Clin Oncol. 2023 02 01; 41(4):803-815. View in: Pubmed

      • Rectal Cancer, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2022 10; 20(10):1139-1167. View in: Pubmed

      • Long-term use of antihypertensive medications, hypertension and colorectal cancer risk and mortality: a prospective cohort study. Br J Cancer. 2022 11; 127(11):1974-1982. View in: Pubmed

      • Cancer Survivors' Perspectives of Virtual Yoga for Chronic Chemotherapy-Induced Peripheral Neuropathy Pain During the COVID-19 Pandemic. Comput Inform Nurs. 2022 Sep 01; 40(9):641-647. View in: Pubmed

      • Efficacy of Preoperative mFOLFIRINOX vs mFOLFIRINOX Plus Hypofractionated Radiotherapy for Borderline Resectable Adenocarcinoma of the Pancreas: The A021501 Phase 2 Randomized Clinical Trial. JAMA Oncol. 2022 09 01; 8(9):1263-1270. View in: Pubmed

      • Dietary fat in relation to all-cause mortality and cancer progression and death among people with metastatic colorectal cancer: Data from CALGB 80405 (Alliance)/SWOG 80405. Int J Cancer. 2023 01 15; 152(2):123-136. View in: Pubmed

      • Physical Activity in Stage III Colon Cancer: CALGB/SWOG 80702 (Alliance). J Clin Oncol. 2023 01 10; 41(2):243-254. View in: Pubmed

      • Exploring Patients' Understanding of Chemotherapy-Induced Peripheral Neuropathy. J Cancer Educ. 2023 06; 38(3):906-912. View in: Pubmed

      • Healthy and unhealthy plant-based diets in relation to the incidence of colorectal cancer overall and by molecular subtypes. Clin Transl Med. 2022 08; 12(8):e893. View in: Pubmed

      • Plasma Protein Biomarkers in Advanced or Metastatic Colorectal Cancer Patients Receiving Chemotherapy With Bevacizumab or Cetuximab: Results from CALGB 80405 (Alliance). Clin Cancer Res. 2022 07 01; 28(13):2779-2788. View in: Pubmed

      • Western-Style Diet, pks Island-Carrying Escherichia coli, and Colorectal Cancer: Analyses From Two Large Prospective Cohort Studies. Gastroenterology. 2022 10; 163(4):862-874. View in: Pubmed

      • Marital Status, Living Arrangement, and Cancer Recurrence and Survival in Patients with Stage III Colon Cancer: Findings from CALGB 89803 (Alliance). Oncologist. 2022 06 08; 27(6):e494-e505. View in: Pubmed

      • Sugar-sweetened beverage and sugar consumption and colorectal cancer incidence and mortality according to anatomic subsite. Am J Clin Nutr. 2022 06 07; 115(6):1481-1489. View in: Pubmed

      • Physical activity in older adults with metastatic gastrointestinal cancer: a pilot and feasibility study. BMJ Open Sport Exerc Med. 2022; 8(2):e001353. View in: Pubmed

      • The association of abdominal adiposity with premature discontinuation of postoperative chemotherapy in colon cancer. Clin Nutr. 2022 07; 41(7):1600-1604. View in: Pubmed

      • Exercise, Diet, and Weight Management During Cancer Treatment: ASCO Guideline. J Clin Oncol. 2022 08 01; 40(22):2491-2507. View in: Pubmed

      • Everolimus with or without bevacizumab in advanced pNET: CALGB 80701 (Alliance). Endocr Relat Cancer. 2022 05 09; 29(6):335-344. View in: Pubmed

      • Exploring Daily Salivary Cortisol Patterns as Biomarkers of Chronic Chemotherapy-Induced Peripheral Neuropathy Pain. Oncol Nurs Forum. 2022 05 01; 49(3):207-211. View in: Pubmed

      • Impact of Diet and Exercise on Colorectal Cancer. Hematol Oncol Clin North Am. 2022 06; 36(3):471-489. View in: Pubmed

      • Serological testing for SARS-CoV-2 antibodies of employees shows low transmission working in a cancer center. PLoS One. 2022; 17(4):e0266791. View in: Pubmed

      • Cetuximab and Irinotecan With or Without Bevacizumab in Refractory Metastatic Colorectal Cancer: BOND-3, an ACCRU Network Randomized Clinical Trial. Oncologist. 2022 04 05; 27(4):292-298. View in: Pubmed

      • Desmoplastic Reaction, Immune Cell Response, and Prognosis in Colorectal Cancer. Front Immunol. 2022; 13:840198. View in: Pubmed

      • American Cancer Society nutrition and physical activity guideline for cancer survivors. CA Cancer J Clin. 2022 05; 72(3):230-262. View in: Pubmed

      • Survival in Young-Onset Metastatic Colorectal Cancer: Findings From Cancer and Leukemia Group B (Alliance)/SWOG 80405. J Natl Cancer Inst. 2022 03 08; 114(3):427-435. View in: Pubmed

      • Metastatic Colorectal Cancer Outcomes by Age Among ARCAD First- and Second-Line Clinical Trials. JNCI Cancer Spectr. 2022 03 02; 6(2). View in: Pubmed

      • Plasma Metabolite Profiles of Red Meat, Poultry, and Fish Consumption, and Their Associations with Colorectal Cancer Risk. Nutrients. 2022 Feb 25; 14(5). View in: Pubmed

      • Quality of life of colorectal cancer survivors participating in a pilot randomized controlled trial of physical activity trackers and daily text messages. Support Care Cancer. 2022 May; 30(5):4557-4564. View in: Pubmed

      • Associations Between Unprocessed Red Meat and Processed Meat With Risk of Recurrence and Mortality in Patients With Stage III Colon Cancer. JAMA Netw Open. 2022 02 01; 5(2):e220145. View in: Pubmed

      • Age and comorbidity association with survival outcomes in metastatic colorectal cancer: CALGB 80405 analysis. J Geriatr Oncol. 2022 05; 13(4):469-479. View in: Pubmed

      • Plasma metabolomic profiles for colorectal cancer precursors in women. Eur J Epidemiol. 2022 Apr; 37(4):413-422. View in: Pubmed

      • Pre-diagnostic telomere length and colorectal cancer risk. Cancer Epidemiol. 2022 04; 77:102100. View in: Pubmed

      • Smoking and Incidence of Colorectal Cancer Subclassified by Tumor-Associated Macrophage Infiltrates. J Natl Cancer Inst. 2022 01 11; 114(1):68-77. View in: Pubmed

      • Diet- and Lifestyle-Based Prediction Models to Estimate Cancer Recurrence and Death in Patients With Stage III Colon Cancer (CALGB 89803/Alliance). J Clin Oncol. 2022 03 01; 40(7):740-751. View in: Pubmed

      • Coffee Intake of Colorectal Cancer Patients and Prognosis According to Histopathologic Lymphocytic Reaction and T-Cell Infiltrates. Mayo Clin Proc. 2022 01; 97(1):124-133. View in: Pubmed

      • Long-Term Statin Use, Total Cholesterol Level, and Risk of Colorectal Cancer: A Prospective Cohort Study. Am J Gastroenterol. 2022 01 01; 117(1):158-166. View in: Pubmed

      • Adjuvant Therapy for Stage II Colon Cancer: ASCO Guideline Update. J Clin Oncol. 2022 03 10; 40(8):892-910. View in: Pubmed

      • Spatial Organization and Prognostic Significance of NK and NKT-like Cells via Multimarker Analysis of the Colorectal Cancer Microenvironment. Cancer Immunol Res. 2022 02; 10(2):215-227. View in: Pubmed

      • A comprehensive overview of tumour deposits in colorectal cancer: Towards a next TNM classification. Cancer Treat Rev. 2022 Feb; 103:102325. View in: Pubmed

      • Neighborhood and Individual Socioeconomic Disadvantage and Survival Among Patients With Nonmetastatic Common Cancers. JAMA Netw Open. 2021 12 01; 4(12):e2139593. View in: Pubmed

      • Abdominal adipose tissue radiodensity is associated with survival after colorectal cancer. Am J Clin Nutr. 2021 12 01; 114(6):1917-1924. View in: Pubmed

      • Early-Onset Colorectal Adenocarcinoma in the IDEA Database: Treatment Adherence, Toxicities, and Outcomes With 3 and 6 Months of Adjuvant Fluoropyrimidine and Oxaliplatin. J Clin Oncol. 2021 12 20; 39(36):4009-4019. View in: Pubmed

      • Unrestrained eating behavior and risk of digestive system cancers: a prospective cohort study. Am J Clin Nutr. 2021 11 08; 114(5):1612-1624. View in: Pubmed

      • The Impact of COVID-19 on Clinical Trial Execution at the Dana-Farber Cancer Institute. J Natl Cancer Inst. 2021 11 02; 113(11):1453-1459. View in: Pubmed

      • Unrestrained eating behavior and risk of mortality: A prospective cohort study. Clin Nutr. 2021 11; 40(11):5419-5429. View in: Pubmed

      • Immune cell profiles in the tumor microenvironment of early-onset, intermediate-onset, and later-onset colorectal cancer. Cancer Immunol Immunother. 2022 Apr; 71(4):933-942. View in: Pubmed

      • Yoga for chronic chemotherapy-induced peripheral neuropathy pain: a pilot, randomized controlled trial. J Cancer Surviv. 2022 08; 16(4):882-891. View in: Pubmed

      • Association of PIK3CA mutation and PTEN loss with expression of CD274 (PD-L1) in colorectal carcinoma. Oncoimmunology. 2021; 10(1):1956173. View in: Pubmed

      • Combining tumor deposits with the number of lymph node metastases to improve the prognostic accuracy in stage III colon cancer: a post hoc analysis of the CALGB/SWOG 80702 phase III study (Alliance)?. Ann Oncol. 2021 10; 32(10):1267-1275. View in: Pubmed

      • Sugar-sweetened beverage, artificially sweetened beverage and sugar intake and colorectal cancer survival. Br J Cancer. 2021 09; 125(7):1016-1024. View in: Pubmed

      • Timing of Aspirin Use in Colorectal Cancer Chemoprevention: A Prospective Cohort Study. J Natl Cancer Inst. 2021 07 01; 113(7):841-851. View in: Pubmed

      • Discovery and Features of an Alkylating Signature in Colorectal Cancer. Cancer Discov. 2021 10; 11(10):2446-2455. View in: Pubmed

      • The Early Impact of the IDEA Collaboration Results: How the Results Changed Prescribing Practice. JNCI Cancer Spectr. 2021 08; 5(4). View in: Pubmed

      • Association of bowel movement frequency and laxative use with risk of hepatocellular carcinoma in US women and men. Int J Cancer. 2021 10 15; 149(8):1529-1535. View in: Pubmed

      • Randomized Phase II Study of PET Response-Adapted Combined Modality Therapy for Esophageal Cancer: Mature Results of the CALGB 80803 (Alliance) Trial. J Clin Oncol. 2021 09 01; 39(25):2803-2815. View in: Pubmed

      • Analysis of Survival Among Adults With Early-Onset Colorectal Cancer in the National Cancer Database. JAMA Netw Open. 2021 06 01; 4(6):e2112539. View in: Pubmed

      • Postdiagnostic dairy products intake and colorectal cancer survival in US males and females. Am J Clin Nutr. 2021 06 01; 113(6):1636-1646. View in: Pubmed

      • Weight stability masks changes in body composition in colorectal cancer: a retrospective cohort study. Am J Clin Nutr. 2021 06 01; 113(6):1482-1489. View in: Pubmed

      • Sugar-sweetened beverage intake in adulthood and adolescence and risk of early-onset colorectal cancer among women. Gut. 2021 12; 70(12):2330-2336. View in: Pubmed

      • Tumor Long Interspersed Nucleotide Element-1 (LINE-1) Hypomethylation in Relation to Age of Colorectal Cancer Diagnosis and Prognosis. Cancers (Basel). 2021 Apr 22; 13(9). View in: Pubmed

      • Race, Income, and Survival in Stage III Colon Cancer: CALGB 89803 (Alliance). JNCI Cancer Spectr. 2021 06; 5(3). View in: Pubmed

      • Effect of Celecoxib vs Placebo Added to Standard Adjuvant Therapy on Disease-Free Survival Among Patients With Stage III Colon Cancer: The CALGB/SWOG 80702 (Alliance) Randomized Clinical Trial. JAMA. 2021 04 06; 325(13):1277-1286. View in: Pubmed

      • Determining the optimal duration of adjuvant therapy in colon cancer. Clin Adv Hematol Oncol. 2021 04; 19(4):220-222. View in: Pubmed

      • Prognostic significance of myeloid immune cells and their spatial distribution in the colorectal cancer microenvironment. J Immunother Cancer. 2021 04; 9(4). View in: Pubmed

      • Prospective evaluation of dietary and lifestyle pattern indices with risk of colorectal cancer in a cohort of younger women. Ann Oncol. 2021 06; 32(6):778-786. View in: Pubmed

      • Simple Sugar and Sugar-Sweetened Beverage Intake During Adolescence and Risk of Colorectal Cancer Precursors. Gastroenterology. 2021 07; 161(1):128-142.e20. View in: Pubmed

      • Colon Cancer, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2021 03 02; 19(3):329-359. View in: Pubmed

      • Aspirin Use and Risk of Colorectal Cancer Among Older Adults. JAMA Oncol. 2021 Mar 01; 7(3):428-435. View in: Pubmed

      • Association of Fusobacterium nucleatum with Specific T-cell Subsets in the Colorectal Carcinoma Microenvironment. Clin Cancer Res. 2021 05 15; 27(10):2816-2826. View in: Pubmed

      • Preexisting Type 2 Diabetes and Survival among Patients with Colorectal Cancer. Cancer Epidemiol Biomarkers Prev. 2021 04; 30(4):757-764. View in: Pubmed

      • Association of Inflammatory and Insulinemic Potential of Diet and Lifestyle with Risk of Hepatocellular Carcinoma. Cancer Epidemiol Biomarkers Prev. 2021 04; 30(4):789-796. View in: Pubmed

      • Molecular Characterization and Therapeutic Targeting of Colorectal Cancers Harboring Receptor Tyrosine Kinase Fusions. Clin Cancer Res. 2021 03 15; 27(6):1695-1705. View in: Pubmed

      • Dairy intake during adolescence and risk of colorectal adenoma later in life. Br J Cancer. 2021 03; 124(6):1160-1168. View in: Pubmed

      • Plant-Based and Animal-Based Low-Carbohydrate Diets and Risk of Hepatocellular Carcinoma Among US Men and Women. Hepatology. 2021 01; 73(1):175-185. View in: Pubmed

      • Dietary intake of branched-chain amino acids and survival after colorectal cancer diagnosis. Int J Cancer. 2021 May 15; 148(10):2471-2480. View in: Pubmed

      • Recruitment strategies and design considerations in a trial of resistance training to prevent dose-limiting toxicities in colon cancer patients undergoing chemotherapy. Contemp Clin Trials. 2021 02; 101:106242. View in: Pubmed

      • Effect of duration of adjuvant chemotherapy for patients with stage III colon cancer (IDEA collaboration): final results from a prospective, pooled analysis of six randomised, phase 3 trials. Lancet Oncol. 2020 12; 21(12):1620-1629. View in: Pubmed

      • Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Body Composition among Patients with Advanced or Metastatic Colorectal Cancer: A Randomized Trial. Cancers (Basel). 2020 Nov 20; 12(11). View in: Pubmed

      • Association of Coffee Intake With Survival in Patients With Advanced or Metastatic Colorectal Cancer. JAMA Oncol. 2020 Nov 01; 6(11):1713-1721. View in: Pubmed

      • Moving through cancer: Setting the agenda to make exercise standard in oncology practice. Cancer. 2021 02 01; 127(3):476-484. View in: Pubmed

      • A Modified Tumor-Node-Metastasis Classification for Primary Operable Colorectal Cancer. JNCI Cancer Spectr. 2021 02; 5(1). View in: Pubmed

      • Risk Factors and Incidence of Colorectal Cancer According to Major Molecular Subtypes. JNCI Cancer Spectr. 2021 02; 5(1). View in: Pubmed

      • The Prognostic Role of Macrophage Polarization in the Colorectal Cancer Microenvironment. Cancer Immunol Res. 2021 01; 9(1):8-19. View in: Pubmed

      • Association of Diet Quality With Survival Among People With Metastatic Colorectal Cancer in the Cancer and Leukemia B and Southwest Oncology Group 80405 Trial. JAMA Netw Open. 2020 10 01; 3(10):e2023500. View in: Pubmed

      • Association of Low Muscle Mass and Low Muscle Radiodensity With Morbidity and Mortality for Colon Cancer Surgery. JAMA Surg. 2020 10 01; 155(10):942-949. View in: Pubmed

      • Anxiety, Depression, and Colorectal Cancer Survival: Results from Two Prospective Cohorts. J Clin Med. 2020 Sep 30; 9(10). View in: Pubmed

      • Prediagnostic Circulating Concentrations of Vitamin D Binding Protein and Survival among Patients with Colorectal Cancer. Cancer Epidemiol Biomarkers Prev. 2020 11; 29(11):2323-2331. View in: Pubmed

      • Coffee Intake and Colorectal Cancer Incidence According to T-Cell Response. JNCI Cancer Spectr. 2020 Dec; 4(6):pkaa068. View in: Pubmed

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      • Phase I dose-finding and pharmacologic study of cisplatin (P), irinotecan (C), and either capecitabine (X) or infusional 5-FU (F) in patients (pts) with advanced solid tumors. ESMO. 2004. View in: Pubmed

      • Phase II study of docetaxel, cisplatin, and irinotecan (TPC) in advanced esophageal and gastric cancer. Proc Am Soc Clin Oncol. 2004. View in: Pubmed

      • Phase II Cisplatin, Irinotecan, Celecoxib and Concurrent Radiation Therapy Followed by Surgery for Locally Advanced Esophageal Cancer. Gastrointestinal Cancer Symposium. 2004. View in: Pubmed

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      Locations

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      Dana-Farber Cancer Institute

      450 Brookline Avenue Boston, MA 02215
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      Dana-Farber Cancer Institute

      Location Avtar

      Dana-Farber Cancer Institute

      450 Brookline Avenue Boston, MA 02215
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      42.3374, -71.1082

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      Jeffrey A. Meyerhardt, MD, MPH, FASCO

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