Kenneth C. Anderson, MD

Kenneth C. Anderson, MD

Medical Oncology

Contact Information

Office Phone Number

617-632-2144

Fax

617-632-2140

Appointments

617-632-3823 (new)

Biography

Kenneth C. Anderson, MD

Dr. Anderson is the Kraft Family Professor of Medicine at Harvard Medical School as well as Director of the LeBow Institute for Myeloma Therapeutics and Jerome Lipper Multiple Myeloma Center at Dana-Farber Cancer Institute. He is a Doris Duke Distinguished Clinical Research Scientist and American Cancer Society Clinical Research Professor. After graduating from Johns Hopkins Medical School, he trained in internal medicine at Johns Hopkins Hospital, and then completed hematology, medical oncology, and tumor immunology training at the Dana-Farber Cancer Institute. Over the last four decades, he has focused his laboratory and clinical research studies on multiple myeloma. He has developed laboratory and animal models of the tumor in its microenvironment which have allowed for both identification of novel targets and validation of novel targeted therapies, and has then rapidly translated these studies to clinical trials culminating in FDA approval of novel targeted and immune therapies. His paradigm for identifying and validating targets in the tumor cell and its milieu has transformed myeloma therapy and markedly improved patient outcome.

Researcher

Physician

Program Director, Jerome Lipper Multiple Myeloma Center
Kraft Family Professor of Medicine, Harvard Medical School

Centers/Programs

Multiple Myeloma Program
Stem Cell Transplantation

Clinical Interests

Multiple myeloma, Stem cell/ bone marrow transplant

Diseases Treated

Board Certification

  • Internal Medicine, 1980

Fellowship

  • Dana-Farber Cancer Institute, Medical Oncology

Residency

  • Johns Hopkins School of Medicine, Internal Medicine

Medical School

  • Johns Hopkins University School of Medicine

Recent Awards

  • Robert A. Kyle Lifetime Achievement Award 2005
  • Doris Duke Distinguished Clinical Research Scientist
  • American Cancer Society Clinical Research Professor
  • The International Myeloma Workshop Waldenstrom’s Award
  • International Myeloma Foundation Robert A. Kyle Lifetime Achievement Award
  • American Association for Cancer Research Joseph H. Burchenal Award
  • American Society of Hematology William Dameshek Prize
  • Johns Hopkins Society of Scholars
  • Election to the Institute of Medicine of the National Academy of Sciences and the Royal Colleges of Physicians and of Pathologists (UK)
  • American Society of Clinical Oncology David A. Karnofsky Award
  • Hope Funds for Cancer Research Award of Excellence in Clinical Research
  • Ron Burton Humanitarian Award
  • Harvard Medical School Warren Alpert Foundation Prize
  • American Cancer Society Medal of Honor
  • Leonard P. Zakim Patient Advocacy Award
  • Samuel Waxman Research Foundation David Workman Memorial Award
  • University of Miami Sylvester Cancer Center Annual Zubrod Memorial Award

Research

    Novel Biologically Based Therapies for Multiple Myeloma
    Our long-term interest is to develop models of myeloma to define genetic and molecular mechanisms of growth, survival, and drug resistance in its bone marrow milieu. Our bench-to-bedside studies have identified novel targets, validated targeted therapies, and led to the approval of novel agents that have markedly prolonged patient survival. Ongoing efforts focus on protein catabolism, tumor microenvironment, immunotherapy, clinical translation of targeted therapies, and genomics, in order to both enhance understanding of myeloma heterogeneity and pathogenesis, as well as identify and validate next-generation novel small molecule and immune targeted therapies.  Protein Catabolism Our basic studies have defined the roles of the ubiquitin proteasomal cascade, as well as the alternative aggresomal pathway, regulating protein homeostasis in multiple myeloma.  In preclinical models, we have validated multiple agents targeting these pathways and then led clinical trials leading to their FDA approval.  Our studies of second generation proteasome inhibitors, histone deacetylase inhibitors, deubiquitylating enzyme inhibitors, and ubiquitin receptor inhibitors have further confirmed the therapeutic utility of targeting protein homeostasis in cancer. Tumor Microenvironment We have identified and characterized the role of adhesion molecules, extracellular matrix proteins, cytokines, and accessory cells in promoting tumor cell growth, survival, and drug resistance in the bone marrow microenvironment; and have validated therapies directed at these mechanisms. Immunomodulatory drugs have translated to clinical trials and FDA approval, and multiple first in man trials are ongoing. Immunotherapy We generated monoclonal antibodies for diagnosis and treatment of myeloma. We also defined the mechanisms and strategies to overcome immunosuppression and stimulate autologous anti-tumor immunity in myeloma including: single agents/combinations of immunomodulatory drugs, monoclonal antibodies, immunotoxins, checkpoint inhibitors, vaccines, histone deacetylase inhibitors, and cellular therapies. Clinical Translation of Novel Therapies Having validated proteasome inhibitors, immunomodulatory agents, and monoclonal antibodies in our preclinical models of myeloma in its bone marrow microenvironment, we have translated these studies to clinical trials leading to their FDA approval and transformed the treatment paradigm.  Our preclinical mechanistic studies have informed combinations of targeted therapies, which have prolonged the survival of patients three to four fold. Genomics/Epigenomics We have utilized genomic/epigenomic profiling of patient myeloma samples to: characterize disease pathogenesis; improve diagnosis, prognosis, and treatment; defined disease heterogeneity and clonality; delineate mechanisms of drug resistance and disease progression; and inform novel therapies for subsets of patients with myeloma.

    Publications

      • Differentiation of BCMA-specific induced pluripotent stem cells into rejuvenated CD8aß+ T cells targeting multiple myeloma. Blood. 2024 Mar 07; 143(10):895-911. View in: Pubmed

      • Round Table Discussion on Optimal Clinical Trial Design in Precursor Multiple Myeloma. Blood Cancer Discov. 2024 Mar 04; OF1-OF7. View in: Pubmed

      • Retraction: Ku86 Variant Expression and Function in Multiple Myeloma Cells Is Associated with Increased Sensitivity to DNA Damage. J Immunol. 2024 Feb 28. View in: Pubmed

      • DAMPening tumor immune escape: the role of ER chaperones in immunogenic chemotherapy. Antioxid Redox Signal. 2024 Feb 17. View in: Pubmed

      • Editor's Note: Targeting Akt and Heat Shock Protein 90 Produces Synergistic Multiple Myeloma Cell Cytotoxicity in the Bone Marrow Microenvironment. Clin Cancer Res. 2024 Feb 16; 30(4):922. View in: Pubmed

      • Epigenetic regulation of CD38/CD48 by KDM6A mediates NK cell response in multiple myeloma. Nat Commun. 2024 Feb 14; 15(1):1367. View in: Pubmed

      • Author Correction: Tumor cell-specific bioluminescence platform to identify stroma-induced changes to anticancer drug activity. Nat Med. 2024 Feb 14. View in: Pubmed

      • Role of minimal residual disease assessment in multiple myeloma. Haematologica. 2024 Feb 08. View in: Pubmed

      • Isatuximab-pomalidomide-dexamethasone versus pomalidomide-dexamethasone in patients with relapsed and refractory multiple myeloma: final overall survival analysis. Haematologica. 2024 Feb 01. View in: Pubmed

      • Author Correction: The Cyclophilin A-CD147 complex promotes the proliferation and homing of multiple myeloma cells. Nat Med. 2024 Jan 25. View in: Pubmed

      • Development and validation of an individualized and weighted Myeloma Prognostic Score System (MPSS) in patients with newly diagnosed multiple myeloma. Am J Hematol. 2024 Jan 21. View in: Pubmed

      • Longitudinal genetically detectable minimal residual disease by fluorescence in situ hybridization confers a poor prognosis in myeloma. Ther Adv Med Oncol. 2024; 16:17588359231221340. View in: Pubmed

      • Shrinking the divide: improving myeloma CART access. Blood Adv. 2024 01 09; 8(1):248-250. View in: Pubmed

      • BCMA-targeted bortezomib nanotherapy improves therapeutic efficacy, overcomes resistance, and modulates the immune microenvironment in multiple myeloma. Blood Cancer J. 2023 12 11; 13(1):184. View in: Pubmed

      • Nicotinamide-Expanded Allogeneic Natural Killer Cells with CD38 Deletion, Expressing an Enhanced CD38 Chimeric Antigen Receptor, Target Multiple Myeloma Cells. Int J Mol Sci. 2023 Dec 07; 24(24). View in: Pubmed

      • Immunomodulation of NK, NKT and B/T cell subtypes in relapsed/refractory multiple myeloma patients treated with pomalidomide along with velcade and dexamethasone and its association with improved progression-free survival. Front Oncol. 2023; 13:1271807. View in: Pubmed

      • Randomized Phase II Trial of Dendritic Cell/Myeloma Fusion Vaccine with Lenalidomide Maintenance after Upfront Autologous Hematopoietic Cell Transplantation for Multiple Myeloma: BMT CTN 1401. Clin Cancer Res. 2023 Dec 01; 29(23):4784-4796. View in: Pubmed

      • Monoallelic deletion of BCMA is a frequent feature in multiple myeloma. Blood Adv. 2023 11 14; 7(21):6599-6603. View in: Pubmed

      • Clinical perspectives on the optimal use of lenalidomide plus bortezomib and dexamethasone for the treatment of newly diagnosed multiple myeloma. Haematologica. 2023 11 01; 108(11):2894-2912. View in: Pubmed

      • Early relapse within 18 months is a powerful dynamic predictor for prognosis and could revise static risk distribution in multiple myeloma. Cancer. 2024 02 01; 130(3):421-432. View in: Pubmed

      • Correction: Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes. Leukemia. 2023 Oct; 37(10):2142. View in: Pubmed

      • Clinical Benefit of Autologous Stem Cell Transplantation for Patients with Multiple Myeloma Achieving Undetectable Minimal Residual Disease after Induction Treatment. Cancer Res Commun. 2023 09; 3(9):1770-1780. View in: Pubmed

      • Correction: UTX inactivation in germinal center B cells promotes the development of multiple myeloma with extramedullary disease. Leukemia. 2023 Sep; 37(9):1952. View in: Pubmed

      • A pandemic preparedness network for individuals living with compromised immune systems. Blood Adv. 2023 08 08; 7(15):3925-3927. View in: Pubmed

      • Monitoring, prophylaxis, and treatment of infections in patients with MM receiving bispecific antibody therapy: consensus recommendations from an expert panel. Blood Cancer J. 2023 08 01; 13(1):116. View in: Pubmed

      • Determinants of response and resistance to T cell-engaging therapies in multiple myeloma. Nat Rev Clin Oncol. 2023 08; 20(8):505-506. View in: Pubmed

      • Characterizing dry mass and volume changes in human multiple myeloma cells upon treatment with proteotoxic and genotoxic drugs. Clin Exp Med. 2023 Nov; 23(7):3821-3832. View in: Pubmed

      • CDK7 controls E2F- and MYC-driven proliferative and metabolic vulnerabilities in multiple myeloma. Blood. 2023 06 08; 141(23):2841-2852. View in: Pubmed

      • Ubiquitin receptor PSMD4/Rpn10 is a novel therapeutic target in multiple myeloma. Blood. 2023 05 25; 141(21):2599-2614. View in: Pubmed

      • UTX inactivation in germinal center B cells promotes the development of multiple myeloma with extramedullary disease. Leukemia. 2023 09; 37(9):1895-1907. View in: Pubmed

      • BRD9 Degradation Disrupts Ribosome Biogenesis in Multiple Myeloma. Clin Cancer Res. 2023 05 01; 29(9):1807-1821. View in: Pubmed

      • Report of consensus Panel 4 from the 11th International Workshop on Waldenstrom's macroglobulinemia on diagnostic and response criteria. Semin Hematol. 2023 03; 60(2):97-106. View in: Pubmed

      • Impact of bortezomib-based versus lenalidomide maintenance therapy on outcomes of patients with high-risk multiple myeloma. Cancer. 2023 07 15; 129(14):2179-2191. View in: Pubmed

      • High-dose melphalan treatment significantly increases mutational burden at relapse in multiple myeloma. Blood. 2023 04 06; 141(14):1724-1736. View in: Pubmed

      • Transcriptome Analysis of Diffuse Large B-Cell Lymphoma Cells Inducibly Expressing MyD88 L265P Mutation Identifies Upregulated CD44, LGALS3, NFKBIZ, and BATF as Downstream Targets of Oncogenic NF-?B Signaling. Int J Mol Sci. 2023 Mar 15; 24(6). View in: Pubmed

      • Development of a Covalent Inhibitor of c-Jun N-Terminal Protein Kinase (JNK) 2/3 with Selectivity over JNK1. J Med Chem. 2023 03 09; 66(5):3356-3371. View in: Pubmed

      • Heterogeneity of B cell lymphopoiesis in patients with premalignant and active myeloma. JCI Insight. 2023 02 08; 8(3). View in: Pubmed

      • Correction: Prolyl-tRNA synthetase as a novel therapeutic target in multiple myeloma. Blood Cancer J. 2023 Feb 07; 13(1):24. View in: Pubmed

      • Identification of disease-related aberrantly spliced transcripts in myeloma and strategies to target these alterations by RNA-based therapeutics. Blood Cancer J. 2023 02 03; 13(1):23. View in: Pubmed

      • A MIR17HG-derived long noncoding RNA provides an essential chromatin scaffold for protein interaction and myeloma growth. Blood. 2023 01 26; 141(4):391-405. View in: Pubmed

      • Prolyl-tRNA synthetase as a novel therapeutic target in multiple myeloma. Blood Cancer J. 2023 01 12; 13(1):12. View in: Pubmed

      • Improving NK cell function in multiple myeloma with NKTR-255, a novel polymer-conjugated human IL-15. Blood Adv. 2023 01 10; 7(1):9-19. View in: Pubmed

      • Dysfunctions of innate and adaptive immune tumor microenvironment in Waldenström macroglobulinemia. Int J Cancer. 2023 05 01; 152(9):1947-1963. View in: Pubmed

      • In-depth analysis of alternative splicing landscape in multiple myeloma and potential role of dysregulated splicing factors. Blood Cancer J. 2022 12 20; 12(12):171. View in: Pubmed

      • Author Correction: Functional dissection of inherited non-coding variation influencing multiple myeloma risk. Nat Commun. 2022 Dec 13; 13(1):7725. View in: Pubmed

      • The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission. Mol Cancer Ther. 2022 Nov 03; 21(11):1625-1631. View in: Pubmed

      • The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission. Mol Cancer Res. 2022 Nov 03; 20(11):1591-1597. View in: Pubmed

      • The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission. Blood Cancer Discov. 2022 11 02; 3(6):469-475. View in: Pubmed

      • The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission. Cancer Discov. 2022 Nov 02; 12(11):2475-2481. View in: Pubmed

      • The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission. Cancer Res. 2022 Nov 02; 82(21):3861-3867. View in: Pubmed

      • The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission. Cancer Immunol Res. 2022 11 02; 10(11):1282-1288. View in: Pubmed

      • The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission. Cancer Epidemiol Biomarkers Prev. 2022 11 02; 31(11):1995-2001. View in: Pubmed

      • The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission. Clin Cancer Res. 2022 Nov 01; 28(21):4593-4599. View in: Pubmed

      • The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission. Cancer Prev Res (Phila). 2022 Nov 01; 15(11):705-712. View in: Pubmed

      • Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes. Leukemia. 2022 12; 36(12):2835-2844. View in: Pubmed

      • Bispecific antibodies in multiple myeloma treatment: A journey in progress. Front Oncol. 2022; 12:1032775. View in: Pubmed

      • The International Consensus Classification of Mature Lymphoid Neoplasms: a report from the Clinical Advisory Committee. Blood. 2022 09 15; 140(11):1229-1253. View in: Pubmed

      • Quality of life, psychological distress, and prognostic perceptions in caregivers of patients with multiple myeloma. Blood Adv. 2022 09 13; 6(17):4967-4974. View in: Pubmed

      • ?-secretase inhibitors augment efficacy of BCMA-targeting bispecific antibodies against multiple myeloma cells without impairing T-cell activation and differentiation. Blood Cancer J. 2022 08 16; 12(8):118. View in: Pubmed

      • Promises and Challenges of Immunogenic Chemotherapy in Multiple Myeloma. Cells. 2022 08 14; 11(16). View in: Pubmed

      • Perspectives on the Risk-Stratified Treatment of Multiple Myeloma. Blood Cancer Discov. 2022 07 06; 3(4):273-284. View in: Pubmed

      • A new role for the SRC family kinase HCK as a driver of SYK activation in MYD88 mutated lymphomas. Blood Adv. 2022 06 14; 6(11):3332-3338. View in: Pubmed

      • Triplet Therapy, Transplantation, and Maintenance until Progression in Myeloma. N Engl J Med. 2022 07 14; 387(2):132-147. View in: Pubmed

      • Author Correction: Combination therapy targeting Erk1/2 and CDK4/6i in relapsed refractory multiple myeloma. Leukemia. 2022 Jun; 36(6):1700. View in: Pubmed

      • Unbiased cell surface proteomics identifies SEMA4A as an effective immunotherapy target for myeloma. Blood. 2022 04 21; 139(16):2471-2482. View in: Pubmed

      • Microenvironment Is a Key Determinant of Immune Checkpoint Inhibitor Response. Clin Cancer Res. 2022 04 14; 28(8):1479-1481. View in: Pubmed

      • Influence of Tyrosine Kinase Inhibition on Organic Anion Transporting Polypeptide 1B3-Mediated Uptake. Mol Pharmacol. 2022 06; 101(6):381-389. View in: Pubmed

      • Identification and validation of ecto-5' nucleotidase as an immunotherapeutic target in multiple myeloma. Blood Cancer J. 2022 04 01; 12(4):50. View in: Pubmed

      • Indirubin-3'-monoxime acts as proteasome inhibitor: Therapeutic application in multiple myeloma. EBioMedicine. 2022 Apr; 78:103950. View in: Pubmed

      • Quality of life, psychological distress, and prognostic perceptions in patients with multiple myeloma. Cancer. 2022 05 15; 128(10):1996-2004. View in: Pubmed

      • Isatuximab plus pomalidomide and low-dose dexamethasone versus pomalidomide and low-dose dexamethasone in patients with relapsed and refractory multiple myeloma (ICARIA-MM): follow-up analysis of a randomised, phase 3 study. Lancet Oncol. 2022 03; 23(3):416-427. View in: Pubmed

      • Gene Expression Profiling in Multiple Myeloma: Redefining the Paradigm of Risk-Adapted Treatment. Front Oncol. 2022; 12:820768. View in: Pubmed

      • Consensus guidelines and recommendations for infection prevention in multiple myeloma: a report from the International Myeloma Working Group. Lancet Haematol. 2022 Feb; 9(2):e143-e161. View in: Pubmed

      • Combination therapy targeting Erk1/2 and CDK4/6i in relapsed refractory multiple myeloma. Leukemia. 2022 04; 36(4):1088-1101. View in: Pubmed

      • Multiple myeloma cells depend on the DDI2/NRF1-mediated proteasome stress response for survival. Blood Adv. 2022 01 25; 6(2):429-440. View in: Pubmed

      • Clonal phylogeny and evolution of critical cytogenetic aberrations in multiple myeloma at single-cell level by QM-FISH. Blood Adv. 2022 01 25; 6(2):441-451. View in: Pubmed

      • Cell-free DNA for the detection of emerging treatment failure in relapsed/ refractory multiple myeloma. Leukemia. 2022 04; 36(4):1078-1087. View in: Pubmed

      • Functional dissection of inherited non-coding variation influencing multiple myeloma risk. Nat Commun. 2022 01 10; 13(1):151. View in: Pubmed

      • ASH Research Collaborative: a real-world data infrastructure to support real-world evidence development and learning healthcare systems in hematology. Blood Adv. 2021 12 14; 5(23):5429-5438. View in: Pubmed

      • Promising Antigens for the New Frontier of Targeted Immunotherapy in Multiple Myeloma. Cancers (Basel). 2021 Dec 06; 13(23). View in: Pubmed

      • IgM-MM is predominantly a pre-germinal center disorder and has a distinct genomic and transcriptomic signature from WM. Blood. 2021 11 18; 138(20):1980-1985. View in: Pubmed

      • The HCK/BTK inhibitor KIN-8194 is active in MYD88-driven lymphomas and overcomes mutated BTKCys481 ibrutinib resistance. Blood. 2021 11 18; 138(20):1966-1979. View in: Pubmed

      • Dynamic transcriptional reprogramming leads to immunotherapeutic vulnerabilities in myeloma. Nat Cell Biol. 2021 11; 23(11):1199-1211. View in: Pubmed

      • Author Correction: The biological significance of histone modifiers in multiple myeloma: clinical applications. Blood Cancer J. 2021 Oct 06; 11(10):165. View in: Pubmed

      • Correction: Preclinical validation of Alpha-Enolase (ENO1) as a novel immunometabolic target in multiple myeloma. Oncogene. 2021 Oct; 40(41):6057. View in: Pubmed

      • Minimal Residual Disease in Myeloma: Application for Clinical Care and New Drug Registration. Clin Cancer Res. 2021 10 01; 27(19):5195-5212. View in: Pubmed

      • BCMA-Specific ADC MEDI2228 and Daratumumab Induce Synergistic Myeloma Cytotoxicity via IFN-Driven Immune Responses and Enhanced CD38 Expression. Clin Cancer Res. 2021 10 01; 27(19):5376-5388. View in: Pubmed

      • A 3D-Bioprinted Multiple Myeloma Model. Adv Healthc Mater. 2022 04; 11(7):e2100884. View in: Pubmed

      • Indatuximab ravtansine plus dexamethasone with lenalidomide or pomalidomide in relapsed or refractory multiple myeloma: a multicentre, phase 1/2a study. Lancet Haematol. 2021 Nov; 8(11):e794-e807. View in: Pubmed

      • Single-Cell Profiling Reveals Metabolic Reprogramming as a Resistance Mechanism in BRAF-Mutated Multiple Myeloma. Clin Cancer Res. 2021 12 01; 27(23):6432-6444. View in: Pubmed

      • Corrigendum to <'Novel therapeutic strategies for multiple myeloma'> <[Experimental Hematology 2015; 43: 732-741]>. Exp Hematol. 2021 Nov; 103:75. View in: Pubmed

      • Novel Approaches to Treating Relapsed and Refractory Multiple Myeloma with a Focus on Recent Approvals of Belantamab Mafodotin and Selinexor. Clin Pharmacol. 2021; 13:169-180. View in: Pubmed

      • Correction: HDAC6 inhibitor WT161 downregulates growth factor receptors in breast cancer. Oncotarget. 2021 Aug 17; 12(17):1736. View in: Pubmed

      • Targeting LAG3/GAL-3 to overcome immunosuppression and enhance anti-tumor immune responses in multiple myeloma. Leukemia. 2022 01; 36(1):138-154. View in: Pubmed

      • Blood Cancer Discovery Turns One. Blood Cancer Discov. 2021 Jul; 2(4):289-290. View in: Pubmed

      • Blood Cancer Discovery Turns One. Blood Cancer Discov. 2021 07; 2(4):289-290. View in: Pubmed

      • ROBO1 Promotes Homing, Dissemination, and Survival of Multiple Myeloma within the Bone Marrow Microenvironment. Blood Cancer Discov. 2021 07; 2(4):338-353. View in: Pubmed

      • ERK signaling mediates resistance to immunomodulatory drugs in the bone marrow microenvironment. Sci Adv. 2021 06; 7(23). View in: Pubmed

      • Bortezomib induces anti-multiple myeloma immune response mediated by cGAS/STING pathway activation. Blood Cancer Discov. 2021 09; 2(5):468-483. View in: Pubmed

      • Lysine Demethylase 5A is Required for MYC Driven Transcription in Multiple Myeloma. Blood Cancer Discov. 2021 07; 2(4):370-387. View in: Pubmed

      • miR-15a/16-1 deletion in activated B cells promotes plasma cell and mature B-cell neoplasms. Blood. 2021 04 08; 137(14):1905-1919. View in: Pubmed

      • Facts and Hopes in Multiple Myeloma Immunotherapy. Clin Cancer Res. 2021 08 15; 27(16):4468-4477. View in: Pubmed

      • Expert review on soft-tissue plasmacytomas in multiple myeloma: definition, disease assessment and treatment considerations. Br J Haematol. 2021 08; 194(3):496-507. View in: Pubmed

      • Recommendations on eliminating racial disparities in multiple myeloma therapies: a step toward achieving equity in healthcare. Blood Cancer Discov. 2021 03; 2(2):119-124. View in: Pubmed

      • Treatment of relapsed and refractory multiple myeloma: recommendations from the International Myeloma Working Group. Lancet Oncol. 2021 03; 22(3):e105-e118. View in: Pubmed

      • Biallelic loss of BCMA as a resistance mechanism to CAR T cell therapy in a patient with multiple myeloma. Nat Commun. 2021 02 08; 12(1):868. View in: Pubmed

      • Harnessing the Immune System Against Multiple Myeloma: Challenges and Opportunities. Front Oncol. 2020; 10:606368. View in: Pubmed

      • Targeting ubiquitin-specific protease-7 in plasmacytoid dendritic cells triggers anti-myeloma immunity. Leukemia. 2021 08; 35(8):2435-2438. View in: Pubmed

      • Identification of novel anti-tumor therapeutic target via proteomic characterization of ubiquitin receptor ADRM1/Rpn13. Blood Cancer J. 2021 01 13; 11(1):13. View in: Pubmed

      • Signaling Pathway Mediating Myeloma Cell Growth and Survival. Cancers (Basel). 2021 Jan 08; 13(2). View in: Pubmed

      • Clinical features associated with COVID-19 outcome in multiple myeloma: first results from the International Myeloma Society data set. Blood. 2020 12 24; 136(26):3033-3040. View in: Pubmed

      • Melflufen and Dexamethasone in Heavily Pretreated Relapsed and Refractory Multiple Myeloma. J Clin Oncol. 2021 03 01; 39(7):757-767. View in: Pubmed

      • Outcomes of patients with hematologic malignancies and COVID-19: a report from the ASH Research Collaborative Data Hub. Blood Adv. 2020 12 08; 4(23):5966-5975. View in: Pubmed

      • A large meta-analysis establishes the role of MRD negativity in long-term survival outcomes in patients with multiple myeloma. Blood Adv. 2020 12 08; 4(23):5988-5999. View in: Pubmed

      • Cisplatin-Mediated Upregulation of APE2 Binding to MYH9 Provokes Mitochondrial Fragmentation and Acute Kidney Injury. Cancer Res. 2021 02 01; 81(3):713-723. View in: Pubmed

      • The JAK-STAT pathway regulates CD38 on myeloma cells in the bone marrow microenvironment: therapeutic implications. Blood. 2020 11 12; 136(20):2334-2345. View in: Pubmed

      • Clinical Features Associated with COVID-19 Outcome in MM: First Results from International Myeloma Society Dataset. Blood. 2020 Nov 06. View in: Pubmed

      • VIS832, a novel CD138-targeting monoclonal antibody, potently induces killing of human multiple myeloma and further synergizes with IMiDs or bortezomib in vitro and in vivo. Blood Cancer J. 2020 11 02; 10(11):110. View in: Pubmed

      • Novel prognostic scoring system for autologous hematopoietic cell transplantation in multiple myeloma. Br J Haematol. 2020 11; 191(3):442-452. View in: Pubmed

      • Immunotherapeutic and Targeted Approaches in Multiple Myeloma. Immunotargets Ther. 2020; 9:201-215. View in: Pubmed

      • Don't Compromise Myeloma Care Due to COVID-19 Pandemic! Blood Cancer Discov. 2020 11; 1(3):218-220. View in: Pubmed

      • Continuous lenalidomide and low-dose dexamethasone in patients with transplant-ineligible newly diagnosed MM: FIRST trial subanalysis of Canadian/US patients. Cancer Med. 2020 12; 9(23):8923-8930. View in: Pubmed

      • Multiple myeloma: the (r)evolution of current therapy and a glance into future. Haematologica. 2020 10 01; 105(10):2358-2367. View in: Pubmed

      • Revealing the impact of structural variants in multiple myeloma. Blood Cancer Discov. 2020 11; 1(3):258-273. View in: Pubmed

      • The immunomodulatory drugs lenalidomide and pomalidomide enhance the potency of AMG 701 in multiple myeloma preclinical models. Blood Adv. 2020 09 08; 4(17):4195-4207. View in: Pubmed

      • Elotuzumab, lenalidomide, and dexamethasone in RRMM: final overall survival results from the phase 3 randomized ELOQUENT-2 study. Blood Cancer J. 2020 09 04; 10(9):91. View in: Pubmed

      • Carfilzomib or bortezomib in combination with lenalidomide and dexamethasone for patients with newly diagnosed multiple myeloma without intention for immediate autologous stem-cell transplantation (ENDURANCE): a multicentre, open-label, phase 3, randomised, controlled trial. Lancet Oncol. 2020 10; 21(10):1317-1330. View in: Pubmed

      • Isatuximab Acts Through Fc-Dependent, Independent, and Direct Pathways to Kill Multiple Myeloma Cells. Front Immunol. 2020; 11:1771. View in: Pubmed

      • Multiple myeloma: the (r)evolution of current therapy and a glance into future. Haematologica. 2020 Jul 23. View in: Pubmed

      • YWHAE/14-3-3e expression impacts the protein load, contributing to proteasome inhibitor sensitivity in multiple myeloma. Blood. 2020 07 23; 136(4):468-479. View in: Pubmed

      • Genome-Wide Somatic Alterations in Multiple Myeloma Reveal a Superior Outcome Group. J Clin Oncol. 2020 09 20; 38(27):3107-3118. View in: Pubmed

      • Preclinical evaluation of CD8+ anti-BCMA mRNA CAR T cells for treatment of multiple myeloma. Leukemia. 2021 03; 35(3):752-763. View in: Pubmed

      • Correction: BCMA peptide-engineered nanoparticles enhance induction and function of antigen-specific CD8+ cytotoxic T lymphocytes against multiple myeloma: clinical applications. Leukemia. 2020 Jul; 34(7):1971. View in: Pubmed

      • Clonal hematopoiesis is associated with adverse outcomes in multiple myeloma patients undergoing transplant. Nat Commun. 2020 06 12; 11(1):2996. View in: Pubmed

      • IgH translocation with undefined partners is associated with superior outcome in multiple myeloma patients. Eur J Haematol. 2020 Sep; 105(3):326-334. View in: Pubmed

      • BCMA-Targeting Therapy: Driving a New Era of Immunotherapy in Multiple Myeloma. Cancers (Basel). 2020 Jun 05; 12(6). View in: Pubmed

      • Primary Plasma Cell Leukemia: Real-World Retrospective Study of 46 Patients From a Single-Center Study in China. Clin Lymphoma Myeloma Leuk. 2020 10; 20(10):e652-e659. View in: Pubmed

      • Genomic Profiling of Smoldering Multiple Myeloma Identifies Patients at a High Risk of Disease Progression. J Clin Oncol. 2020 07 20; 38(21):2380-2389. View in: Pubmed

      • Proteomic analysis identifies mechanism(s) of overcoming bortezomib resistance via targeting ubiquitin receptor Rpn13. Leukemia. 2021 02; 35(2):550-561. View in: Pubmed

      • Timing the initiation of multiple myeloma. Nat Commun. 2020 04 21; 11(1):1917. View in: Pubmed

      • Polycomb-like Protein 3 Induces Proliferation and Drug Resistance in Multiple Myeloma and Is Regulated by miRNA-15a. Mol Cancer Res. 2020 07; 18(7):1063-1073. View in: Pubmed

      • Long-Term Follow-up of CALGB (Alliance) 100001: Autologous Followed by Nonmyeloablative Allogeneic Transplant for Multiple Myeloma. Biol Blood Marrow Transplant. 2020 08; 26(8):1414-1424. View in: Pubmed

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      • Functional significance of novel neurotrophin-1/B cell-stimulating factor-3 (cardiotrophin-like cytokine) for human myeloma cell growth and survival. Br J Haematol. 2003 Dec; 123(5):869-78. View in: Pubmed

      • Broadening the spectrum of patient groups at risk for transfusion-associated GVHD: implications for universal irradiation of cellular blood components. Transfusion. 2003 Dec; 43(12):1652-4. View in: Pubmed

      • Antitumor activity of lysophosphatidic acid acyltransferase-beta inhibitors, a novel class of agents, in multiple myeloma. Cancer Res. 2003 Dec 01; 63(23):8428-36. View in: Pubmed

      • Biologic sequelae of c-Jun NH(2)-terminal kinase (JNK) activation in multiple myeloma cell lines. Oncogene. 2003 Nov 27; 22(54):8797-801. View in: Pubmed

      • GW654652, the pan-inhibitor of VEGF receptors, blocks the growth and migration of multiple myeloma cells in the bone marrow microenvironment. Blood. 2004 May 01; 103(9):3474-9. View in: Pubmed

      • Proteasome inhibitor PS-341 abrogates IL-6 triggered signaling cascades via caspase-dependent downregulation of gp130 in multiple myeloma. Oncogene. 2003 Nov 20; 22(52):8386-93. View in: Pubmed

      • A workshop on the marrow microenvironment and hematological malignancy. Cancer Res. 2003 Nov 01; 63(21):7539-41. View in: Pubmed

      • Complete response to donor lymphocyte infusion in multiple myeloma is associated with antibody responses to highly expressed antigens. Blood. 2004 Jan 15; 103(2):656-63. View in: Pubmed

      • Fluorescence imaging of multiple myeloma cells in a clinically relevant SCID/NOD in vivo model: biologic and clinical implications. Cancer Res. 2003 Oct 15; 63(20):6689-96. View in: Pubmed

      • Blockade of Hsp27 overcomes Bortezomib/proteasome inhibitor PS-341 resistance in lymphoma cells. Cancer Res. 2003 Oct 01; 63(19):6174-7. View in: Pubmed

      • The role of immunomodulatory drugs in multiple myeloma. Semin Hematol. 2003 Oct; 40(4 Suppl 4):23-32. View in: Pubmed

      • Effects of oligonucleotide N3'-->P5' thio-phosphoramidate (GRN163) targeting telomerase RNA in human multiple myeloma cells. Cancer Res. 2003 Oct 01; 63(19):6187-94. View in: Pubmed

      • Bortezomib: a novel therapy approved for multiple myeloma. Clin Adv Hematol Oncol. 2003 Oct; 1(10):596-600. View in: Pubmed

      • Immunomodulatory drug costimulates T cells via the B7-CD28 pathway. Blood. 2004 Mar 01; 103(5):1787-90. View in: Pubmed

      • Superoxide-dependent and -independent mitochondrial signaling during apoptosis in multiple myeloma cells. Oncogene. 2003 Sep 18; 22(40):6296-300. View in: Pubmed

      • Insulin-like growth factor-1 induces adhesion and migration in human multiple myeloma cells via activation of beta1-integrin and phosphatidylinositol 3'-kinase/AKT signaling. Cancer Res. 2003 Sep 15; 63(18):5850-8. View in: Pubmed

      • Identification of genes modulated in multiple myeloma using genetically identical twin samples. Blood. 2004 Mar 01; 103(5):1799-806. View in: Pubmed

      • Telomerase inhibition and cell growth arrest by G-quadruplex interactive agent in multiple myeloma. Mol Cancer Ther. 2003 Sep; 2(9):825-33. View in: Pubmed

      • Bortezomib (PS-341): a novel, first-in-class proteasome inhibitor for the treatment of multiple myeloma and other cancers. Cancer Control. 2003 Sep-Oct; 10(5):361-9. View in: Pubmed

      • Insights into the multistep transformation of MGUS to myeloma using microarray expression analysis. Blood. 2003 Dec 15; 102(13):4504-11. View in: Pubmed

      • Proteasome inhibitors disrupt the unfolded protein response in myeloma cells. Proc Natl Acad Sci U S A. 2003 Aug 19; 100(17):9946-51. View in: Pubmed

      • Novel therapeutic approaches for multiple myeloma. Immunol Rev. 2003 Aug; 194:164-76. View in: Pubmed

      • Apoptotic signaling in multiple myeloma: therapeutic implications. Int J Hematol. 2003 Aug; 78(2):114-20. View in: Pubmed

      • Hsp27 inhibits release of mitochondrial protein Smac in multiple myeloma cells and confers dexamethasone resistance. Blood. 2003 Nov 01; 102(9):3379-86. View in: Pubmed

      • A phase 2 study of bortezomib in relapsed, refractory myeloma. N Engl J Med. 2003 Jun 26; 348(26):2609-17. View in: Pubmed

      • NVP-LAQ824 is a potent novel histone deacetylase inhibitor with significant activity against multiple myeloma. Blood. 2003 Oct 01; 102(7):2615-22. View in: Pubmed

      • Viral antigen-specific CD8+ T-cell responses are impaired in multiple myeloma. Br J Haematol. 2003 Jun; 121(6):842-8. View in: Pubmed

      • Targeting proteasome inhibition in hematologic malignancies. Rev Clin Exp Hematol. 2003 Jun; 7(2):191-204. View in: Pubmed

      • Expansion of tumor-specific CD8+ T cell clones in patients with relapsed myeloma after donor lymphocyte infusion. Cancer Res. 2003 May 15; 63(10):2561-8. View in: Pubmed

      • Recombinant humanized anti-CD40 monoclonal antibody triggers autologous antibody-dependent cell-mediated cytotoxicity against multiple myeloma cells. Br J Haematol. 2003 May; 121(4):592-6. View in: Pubmed

      • Ex vivo induction of multiple myeloma-specific cytotoxic T lymphocytes. Blood. 2003 Aug 15; 102(4):1435-42. View in: Pubmed

      • Proteomic analyses in Waldenstrom's macroglobulinemia and other plasma cell dyscrasias. Semin Oncol. 2003 Apr; 30(2):156-60. View in: Pubmed

      • Novel biologically based therapies for Waldenstrom's macroglobulinemia. Semin Oncol. 2003 Apr; 30(2):309-12. View in: Pubmed

      • Treatment recommendations in Waldenstrom's macroglobulinemia: consensus panel recommendations from the Second International Workshop on Waldenstrom's Macroglobulinemia. Semin Oncol. 2003 Apr; 30(2):121-6. View in: Pubmed

      • Expression of serotherapy target antigens in Waldenstrom's macroglobulinemia: therapeutic applications and considerations. Semin Oncol. 2003 Apr; 30(2):248-52. View in: Pubmed

      • Characterization of the MM.1 human multiple myeloma (MM) cell lines: a model system to elucidate the characteristics, behavior, and signaling of steroid-sensitive and -resistant MM cells. Exp Hematol. 2003 Apr; 31(4):271-82. View in: Pubmed

      • JNK-dependent release of mitochondrial protein, Smac, during apoptosis in multiple myeloma (MM) cells. J Biol Chem. 2003 May 16; 278(20):17593-6. View in: Pubmed

      • New agents and approaches in the treatment of multiple myeloma. Clin Adv Hematol Oncol. 2003 Mar; 1(3):151-2. View in: Pubmed

      • Moving disease biology from the lab to the clinic. Cancer. 2003 Feb 01; 97(3 Suppl):796-801. View in: Pubmed

      • Molecular sequelae of histone deacetylase inhibition in human malignant B cells. Blood. 2003 May 15; 101(10):4055-62. View in: Pubmed

      • Nuclear factor-kappaB p65 mediates tumor necrosis factor alpha-induced nuclear translocation of telomerase reverse transcriptase protein. Cancer Res. 2003 Jan 01; 63(1):18-21. View in: Pubmed

      • The role of cytotoxic therapy with hematopoietic stem cell transplantation in the therapy of multiple myeloma: an evidence-based review. Biol Blood Marrow Transplant. 2003 Jan; 9(1):4-37. View in: Pubmed

      • Novel therapies for multiple myeloma. Br J Haematol. 2003 Jan; 120(1):10-7. View in: Pubmed

      • Multiple myeloma: how far have we come? Mayo Clin Proc. 2003 Jan; 78(1):15-7. View in: Pubmed

      • The extracellular calcium Ca2+o-sensing receptor is expressed in myeloma cells and modulates cell proliferation. Biochem Biophys Res Commun. 2002 Dec 13; 299(4):532-8. View in: Pubmed

      • Identification of genes regulated by 2-methoxyestradiol (2ME2) in multiple myeloma cells using oligonucleotide arrays. Blood. 2003 May 01; 101(9):3606-14. View in: Pubmed

      • Essential role of caveolae in interleukin-6- and insulin-like growth factor I-triggered Akt-1-mediated survival of multiple myeloma cells. J Biol Chem. 2003 Feb 21; 278(8):5794-801. View in: Pubmed

      • Moving disease biology from the laboratory to the clinic. Semin Oncol. 2002 Dec; 29(6 Suppl 17):17-20. View in: Pubmed

      • Molecular mechanisms of novel therapeutic approaches for multiple myeloma. Nat Rev Cancer. 2002 Dec; 2(12):927-37. View in: Pubmed

      • Synopsis of a research roundtable presented on cell signaling in myeloma: regulation of growth and apoptosis--opportunities for new drug discovery. Mol Cancer Ther. 2002 Dec; 1(14):1361-5. View in: Pubmed

      • CD40 induces human multiple myeloma cell migration via phosphatidylinositol 3-kinase/AKT/NF-kappa B signaling. Blood. 2003 Apr 01; 101(7):2762-9. View in: Pubmed

      • The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: therapeutic applications. Blood. 2003 Mar 15; 101(6):2377-80. View in: Pubmed

      • Thalidomide and immunomodulatory drugs as cancer therapy. Curr Opin Oncol. 2002 Nov; 14(6):635-40. View in: Pubmed

      • Immunomodulatory drug CC-5013 overcomes drug resistance and is well tolerated in patients with relapsed multiple myeloma. Blood. 2002 Nov 01; 100(9):3063-7. View in: Pubmed

      • Molecular sequelae of proteasome inhibition in human multiple myeloma cells. Proc Natl Acad Sci U S A. 2002 Oct 29; 99(22):14374-9. View in: Pubmed

      • Racial and ethnic composition of volunteer cord blood donors: comparison with volunteer unrelated marrow donors. Transfusion. 2002 Oct; 42(10):1279-84. View in: Pubmed

      • Molecular mechanisms mediating antimyeloma activity of proteasome inhibitor PS-341. Blood. 2003 Feb 15; 101(4):1530-4. View in: Pubmed

      • 2-Methoxyestradiol overcomes drug resistance in multiple myeloma cells. Blood. 2002 Sep 15; 100(6):2187-94. View in: Pubmed

      • Targeting p38 MAPK inhibits multiple myeloma cell growth in the bone marrow milieu. Blood. 2003 Jan 15; 101(2):703-5. View in: Pubmed

      • Novel biologically based therapeutic strategies in myeloma. Rev Clin Exp Hematol. 2002 Sep; 6(3):301-24. View in: Pubmed

      • The vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK222584 inhibits growth and migration of multiple myeloma cells in the bone marrow microenvironment. Cancer Res. 2002 Sep 01; 62(17):5019-26. View in: Pubmed

      • Novel therapies for multiple myeloma. Blood Rev. 2002 Sep; 16(3):167-74. View in: Pubmed

      • Proteasome inhibitor PS-341 inhibits human myeloma cell growth in vivo and prolongs survival in a murine model. Cancer Res. 2002 Sep 01; 62(17):4996-5000. View in: Pubmed

      • Telomerase inhibitors as anticancer therapy. Curr Med Chem Anticancer Agents. 2002 Sep; 2(5):567-75. View in: Pubmed

      • American Society of Clinical Oncology clinical practice guidelines: the role of bisphosphonates in multiple myeloma. J Clin Oncol. 2002 Sep 01; 20(17):3719-36. View in: Pubmed

      • Activation of NF-kappaB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma cells: therapeutic implications. Oncogene. 2002 Aug 22; 21(37):5673-83. View in: Pubmed

      • Novel biologically based therapies for multiple myeloma. Int J Hematol. 2002 Aug; 76 Suppl 1:340-1. View in: Pubmed

      • Arsenic trioxide inhibits growth of human multiple myeloma cells in the bone marrow microenvironment. Mol Cancer Ther. 2002 Aug; 1(10):851-60. View in: Pubmed

      • Absence of biologically important Kaposi sarcoma-associated herpesvirus gene products and virus-specific cellular immune responses in multiple myeloma. Blood. 2002 Jul 15; 100(2):698-700. View in: Pubmed

      • beta-lapachone, a novel plant product, overcomes drug resistance in human multiple myeloma cells. Exp Hematol. 2002 Jul; 30(7):711-20. View in: Pubmed

      • Cytokines modulate telomerase activity in a human multiple myeloma cell line. Cancer Res. 2002 Jul 01; 62(13):3876-82. View in: Pubmed

      • Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: therapeutic implications. Blood. 2002 Jun 15; 99(12):4525-30. View in: Pubmed

      • Immunologic effects of prophylactic donor lymphocyte infusion after allogeneic marrow transplantation for multiple myeloma. Blood. 2002 Jun 15; 99(12):4610-7. View in: Pubmed

      • Biologic sequelae of nuclear factor-kappaB blockade in multiple myeloma: therapeutic applications. Blood. 2002 Jun 01; 99(11):4079-86. View in: Pubmed

      • What is the proper threshold for platelet transfusion in patients with chemotherapy-induced thrombocytopenia? Crit Rev Oncol Hematol. 2002 May; 42(2):163-71. View in: Pubmed

      • The biological sequelae of stromal cell-derived factor-1alpha in multiple myeloma. Mol Cancer Ther. 2002 May; 1(7):539-44. View in: Pubmed

      • Telomerase overexpression in K562 leukemia cells protects against apoptosis by serum deprivation and double-stranded DNA break inducing agents, but not against DNA synthesis inhibitors. Cancer Lett. 2002 Apr 25; 178(2):187-97. View in: Pubmed

      • S-3-Amino-phthalimido-glutarimide inhibits angiogenesis and growth of B-cell neoplasias in mice. Cancer Res. 2002 Apr 15; 62(8):2300-5. View in: Pubmed

      • Immunization against murine multiple myeloma with fusions of dendritic and plasmacytoma cells is potentiated by interleukin 12. Blood. 2002 Apr 01; 99(7):2512-7. View in: Pubmed

      • Intracellular regulation of tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human multiple myeloma cells. Blood. 2002 Mar 15; 99(6):2162-71. View in: Pubmed

      • Translocation of Ku86/Ku70 to the multiple myeloma cell membrane: functional implications. Exp Hematol. 2002 Mar; 30(3):212-20. View in: Pubmed

      • NF-kappa B as a therapeutic target in multiple myeloma. J Biol Chem. 2002 May 10; 277(19):16639-47. View in: Pubmed

      • Identification of genes regulated by dexamethasone in multiple myeloma cells using oligonucleotide arrays. Oncogene. 2002 Feb 21; 21(9):1346-58. View in: Pubmed

      • CD40 activation induces p53-dependent vascular endothelial growth factor secretion in human multiple myeloma cells. Blood. 2002 Feb 15; 99(4):1419-27. View in: Pubmed

      • Arsenic trioxide in multiple myeloma: rationale and future directions. Cancer J. 2002 Jan-Feb; 8(1):12-25. View in: Pubmed

      • Multiple myeloma. Hematology Am Soc Hematol Educ Program. 2002; 214-40. View in: Pubmed

      • Thalidomide: emerging role in cancer medicine. Annu Rev Med. 2002; 53:629-57. View in: Pubmed

      • CD20-directed serotherapy in patients with multiple myeloma: biologic considerations and therapeutic applications. J Immunother. 2002 Jan-Feb; 25(1):72-81. View in: Pubmed

      • Vascular endothelial growth factor-induced migration of multiple myeloma cells is associated with beta 1 integrin- and phosphatidylinositol 3-kinase-dependent PKC alpha activation. J Biol Chem. 2002 Mar 08; 277(10):7875-81. View in: Pubmed

      • Tumor Cell Expression of CD59 Is Associated With Resistance to CD20 Serotherapy in Patients With B-Cell Malignancies. J Immunother (1991). 2001 May; 24(3):263-271. View in: Pubmed

      • Multiple Myeloma: New Insights and Therapeutic Approaches. Hematology Am Soc Hematol Educ Program. 2000; 147-165. View in: Pubmed

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      450 Brookline Avenue Mayer 557 Boston, MA 02215
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      Kenneth C. Anderson, MD

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