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Paul G. Richardson, MD


Medical Oncology

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Physician

  • Clinical Program Leader and Director of Clinical Research, Jerome Lipper Multiple Myeloma Center
  • Institute Physician
  • RJ Corman Professor of Medicine, Harvard Medical School

Centers/Programs

Clinical Interests

  • Experimental therapeutics and cancer pharmacology
  • Multiple myeloma
  • Non-myeloid injury including VOD and mucocytis in bone marrow transplantation
  • Regimen-related toxicity
  • Stem cell transplantation

Diseases Treated

Contact Information

  • Appointments617-632-3823 (new)
    617-632-2127 (follow-up)
  • Office Phone Number617-632-2127
  • Fax617-632-6624

Bio

After comprehensive training and certification in Internal Medicine, Hematology and Medical Oncology, as well as then acquiring additional expertise in Cancer Pharmacology and Transplant at Dana Farber Cancer Institute, I joined the Division of Hematologic Oncology and the Jerome Lipper Multiple Myeloma Center in December 1999. Since joining, I have led several novel, biologically-derived translational efforts in multiple myeloma under the overall direction and mentorship of Kenneth Anderson, M.D. I currently serve as Clinical Program Leader and Director of Clinical Research of the Jerome Lipper Multiple Myeloma Center.

Through my career, I have led the study and clinical development of numerous novel drugs in the treatment of multiple myeloma including thalidomide, lenalidomide, bortezomib, ixazomib, panobinostat, pomalidomide, elotuzumab and recently daratumumab, all of which have contributed to a remarkable improvement in outcome for patients over the last 15 years, with median survival increasing from 2-3 years to 7-10 years and beyond.

I also led the practice-changing work that demonstrated the effectiveness of combination therapy (lenalidomide, bortezomib and dexamethasone - also known as RVD) for multiple myeloma and established this as the standard therapy in the upfront.

This highly effective combination has also provided the foundation for a series of studies examining the timing and evolving role of autologous stem cell transplant in myeloma that we have led in partnership with colleagues in France (DFCI/IFM). Results from the French study show progression free but no overall survival advantage to early ASCT in the era of novel agents, and the pivotal US "DETERMINATION" study performed across 56 centers nationally has just been completed with over 730 patients enrolled and results pending.

Recently, the further development of pomalidomide in combination with bortezomib and the very recent positive results of the global phase 3 randomized "OPTIMISSM" trial will establish this combination in first relapse worldwide. In addition, I have led another global phase 3 study of a next generation CD38 antibody isatuximab with pomalidomide that is fully accrued and the results of which should establish this combination in second relapse.

In addition to these landmark approvals in myeloma, I spearheaded the testing of defibrotide for the treatment and prevention of hepatic veno-occlusive disease, a previously critical unmet need in the care of stem cell transplant patients, from first concept, early phase trials to approval-finding pivotal phase 3 studies. Defibrotide was approved by the FDA in 2016 for this indication, with EMA approval in 2013, and is used worldwide, with further studies in prevention and other settings (including GVHD) now underway.

As a clinical researcher in myeloma and transplant, I have published 340 original papers and 280 reviews, chapters and monographs in many leading peer-reviewed publications, including New England Journal of Medicine, Blood, Journal of Clinical Oncology, Lancet Oncology, Lancet Haematology, Clinical Cancer Research, Blood and Bone Marrow Transplantation, JAMA Oncology and the British Journal of Haematology.

I am grateful to have been recognized for my work with the Warren Alpert Prize from Harvard Medical School in recognition of the discovery, preclinical and clinical development of bortezomib to FDA approval and front line therapy for the treatment of patients with multiple myeloma; the Accelerator Award from the Multiple Myeloma Research Foundation in recognition of the outstanding efforts and exceptional contributions to the rapid completion of clinical trials for multiple myeloma; the Ernest Beutler Prize and Lecture from the American Society of Hematology in recognition of major translational advances related to a single topic, specifically enabling achievements in clinical science in the area of multiple myeloma; the international COMy award in multiple myeloma for global contributions in this disease; and most recently, the highly prestigious Robert Kyle Award from the International Myeloma Foundation for lifetime contributions to the treatment of myeloma and outstanding care of myeloma patients.

Board Certification:

  • Hematology, 1999
  • Internal Medicine, 1997
  • Medical Oncology, 1998

Fellowship:

  • Baystate Medical Center, Tufts University, Hematology & Oncology

Residency:

  • Beth Israel Deaconess Medical Center, Internal Medicine
  • Newcastle General and Freeman Hospitals, Internal Medicine
  • Royal Marsden Hospital, London, Chief Resident

Medical School:

  • University of London, St. Bartholomew's Medical College

Recent Awards:

  • Biochemistry Slot Prize, Hungarian Prize, Honours Colors, Wheelwrights Prize, Ver Heyden de Lancy Prize: Joint Winner, Emil Frei III Fellowship Award, Lee Beckenstein Fellowship Award, The Society of Teaching Scholars, George Canellos Award for Excellence in Clinical Research and Patient Care, Partners in Excellence Award, Medical Book Competition Award for Multiple Myeloma, Tisch Family Outstanding Achievement Award in Translational Research, Compassionate Caregiver Award, Fellow of the Royal College of Physicians 1983 1986 1986 1986 1986 1995 1997 2002 2004 2004,2005 2005 2008 2008 2009

Research

Research in Multiple Myeloma, Reduction of Regimen-Related Toxicity

Under the overall direction and mentorship of Dr. Kenneth Anderson, we are leading several translational efforts in multiple myeloma, including phase I, II, and III clinical trials of new drugs: thalidomide, the thalidomide analog IMiD 3 (also known as lenalidomide, CC-5013, or Revlimid), 2- methoxy estradiol (2-ME2), and the proteasome inhibitor PS 341 (bortezomib or Velcade). Subsequent studies have focused on other novel agents including the histone deacetylase inhibitor SAHA and derivatives of the HSP-90 inhibitor 17-AAG, as well as other small molecules. Our most recent translational research is a phase I trial of the combination of novel agents lenalidomide and bortezomib. In addition to research in myeloma, we have been involved in regimen-related toxicities (RRT), and in particular the development of defibrotide as a novel therapy for hepatic veno-occlusive disease. This work has led to further research in syndromes characterized by endothelial cell injury during high-dose therapy and the study of vascular damage affecting other organ structures, including mucosa. Another important new area of interest in RRT is treatment-emergent neuropathy in myeloma.

Location

Dana-Farber Cancer Institute
450 Brookline Avenue
Dana 1B07
Boston, MA 02215
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